SI3147292T1 - Označeni nukleotidi - Google Patents
Označeni nukleotidiInfo
- Publication number
- SI3147292T1 SI3147292T1 SI200332583T SI200332583T SI3147292T1 SI 3147292 T1 SI3147292 T1 SI 3147292T1 SI 200332583 T SI200332583 T SI 200332583T SI 200332583 T SI200332583 T SI 200332583T SI 3147292 T1 SI3147292 T1 SI 3147292T1
- Authority
- SI
- Slovenia
- Prior art keywords
- labelled nucleotides
- labelled
- nucleotides
- nucleoside
- linker
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Electrophonic Musical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/227,131 US7057026B2 (en) | 2001-12-04 | 2002-08-23 | Labelled nucleotides |
EP16193088.8A EP3147292B1 (en) | 2002-08-23 | 2003-08-22 | Labelled nucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3147292T1 true SI3147292T1 (sl) | 2019-01-31 |
Family
ID=31946334
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332500A SI2119722T1 (sl) | 2002-08-23 | 2003-08-22 | Označeni nukleotidi |
SI200332618T SI3438116T1 (sl) | 2002-08-23 | 2003-08-22 | Označeni nukleotidi |
SI200332583T SI3147292T1 (sl) | 2002-08-23 | 2003-08-22 | Označeni nukleotidi |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332500A SI2119722T1 (sl) | 2002-08-23 | 2003-08-22 | Označeni nukleotidi |
SI200332618T SI3438116T1 (sl) | 2002-08-23 | 2003-08-22 | Označeni nukleotidi |
Country Status (12)
Country | Link |
---|---|
EP (5) | EP3438116B1 (sl) |
AT (1) | ATE431354T1 (sl) |
AU (1) | AU2003259352A1 (sl) |
CY (3) | CY1118471T1 (sl) |
DE (1) | DE60327649D1 (sl) |
DK (4) | DK3147292T3 (sl) |
ES (4) | ES2326077T3 (sl) |
GB (1) | GB2395953A (sl) |
HU (2) | HUE032483T2 (sl) |
PT (3) | PT2119722T (sl) |
SI (3) | SI2119722T1 (sl) |
WO (1) | WO2004018493A1 (sl) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9708358B2 (en) | 2000-10-06 | 2017-07-18 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
CA2425112C (en) | 2000-10-06 | 2011-09-27 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding dna and rna |
GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
EP3438116B1 (en) | 2002-08-23 | 2021-02-17 | Illumina Cambridge Limited | Labelled nucleotides |
EP2607369B1 (en) | 2002-08-23 | 2015-09-23 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
WO2005044836A2 (de) | 2003-11-05 | 2005-05-19 | Genovoxx Gmbh | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
EP1730307A4 (en) | 2004-03-03 | 2008-11-05 | Univ Columbia | PHOTOSPACTABLE FLUORESCENZ NUCLEOTIDES FOR DNA SEQUENCING ON A MEASUREMENT BASED BY STATION-SPECIFIC COUPLING SCHEME CONSTRUCTED CHIP |
GB0427236D0 (en) | 2004-12-13 | 2005-01-12 | Solexa Ltd | Improved method of nucleotide detection |
EP1828412B2 (en) * | 2004-12-13 | 2019-01-09 | Illumina Cambridge Limited | Improved method of nucleotide detection |
GB0509508D0 (en) * | 2005-05-10 | 2005-06-15 | Solexa Ltd | Improved polymerases |
WO2007002204A2 (en) | 2005-06-21 | 2007-01-04 | The Trustees Of Columbia University In The City Of New York | Pyrosequencing methods and related compostions |
GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
US8796432B2 (en) | 2005-10-31 | 2014-08-05 | The Trustees Of Columbia University In The City Of New York | Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods |
WO2007053702A2 (en) | 2005-10-31 | 2007-05-10 | The Trustees Of Columbia University In The City Of New York | Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods |
SG170802A1 (en) | 2006-03-31 | 2011-05-30 | Solexa Inc | Systems and devices for sequence by synthesis analysis |
ES2545264T3 (es) | 2006-04-04 | 2015-09-09 | Keygene N.V. | Detección de alto rendimiento de marcadores moleculares basada en fragmentos de restricción |
WO2007135368A2 (en) * | 2006-05-18 | 2007-11-29 | Solexa Limited | Dye compounds and the use of their labelled conjugates |
EP2032686B1 (en) | 2006-06-23 | 2022-01-12 | Illumina, Inc. | System and method for creation of dna cluster arrays |
CN103333949B (zh) | 2006-07-12 | 2015-05-06 | 凯津公司 | 使用aflp的高通量物理作图 |
EP2071927A2 (en) | 2006-09-28 | 2009-06-24 | Illumina, Inc. | Compositions and methods for nucleotide sequencing |
US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
US8568979B2 (en) | 2006-10-10 | 2013-10-29 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
DE112007002932B4 (de) | 2006-12-01 | 2015-08-06 | The Trustees Of Columbia University In The City Of New York | Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren |
WO2008070749A2 (en) | 2006-12-05 | 2008-06-12 | Lasergen, Inc. | Photocleavable labeled nucleotides and nucleosides and labeled nucleotides and nucleosides and methods for their use in dna sequencing |
US11035823B2 (en) | 2009-03-17 | 2021-06-15 | Qiagen Sciences, Llc | Methods and devices for sequencing nucleic acids in smaller batches |
US8481259B2 (en) | 2007-02-05 | 2013-07-09 | Intelligent Bio-Systems, Inc. | Methods and devices for sequencing nucleic acids in smaller batches |
US11940413B2 (en) | 2007-02-05 | 2024-03-26 | IsoPlexis Corporation | Methods and devices for sequencing nucleic acids in smaller batches |
US7678894B2 (en) * | 2007-05-18 | 2010-03-16 | Helicos Biosciences Corporation | Nucleotide analogs |
US9163053B2 (en) | 2007-05-18 | 2015-10-20 | Fluidigm Corporation | Nucleotide analogs |
EP2725107B1 (en) | 2007-10-19 | 2018-08-29 | The Trustees of Columbia University in the City of New York | DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified ddNTPs and nucleic acid comprising inosine with reversible terminators |
EP2940029B1 (en) * | 2007-10-19 | 2023-11-29 | The Trustees of Columbia University in the City of New York | Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis |
US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
BRPI0908734A2 (pt) | 2008-03-17 | 2015-07-28 | Expressive Res Bv | Métodos para a identificação de dna genômico em uma amostra e para a indentificação de polimorfismos, e, kit |
US9017973B2 (en) | 2008-03-19 | 2015-04-28 | Intelligent Biosystems, Inc. | Methods and compositions for incorporating nucleotides |
WO2009134469A1 (en) | 2008-04-29 | 2009-11-05 | Life Technologies | Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use |
CN102264917B (zh) | 2008-06-11 | 2015-06-10 | 激光基因公司 | 核苷酸和核苷以及将其用于dna测序的方法 |
JP2012514977A (ja) | 2009-01-13 | 2012-07-05 | キージーン・エン・フェー | 新規ゲノム配列決定戦略 |
EP2494073B1 (de) | 2009-10-26 | 2017-11-29 | AGCT GmbH | Konjugate von nukleotiden und methoden zu deren anwendung |
WO2012034007A2 (en) | 2010-09-10 | 2012-03-15 | Bio-Rad Laboratories, Inc. | Size selection of dna for chromatin analysis |
ES2627851T3 (es) | 2011-01-31 | 2017-07-31 | Illumina, Inc. | Métodos para reducir el daño en ácidos nucleicos |
DE102012008375A1 (de) | 2011-04-27 | 2012-10-31 | Genovoxx Gmbh | Methoden und Komponenten zur Detektion von Nukleinsäureketten |
US20150086981A1 (en) | 2011-05-04 | 2015-03-26 | Genovoxx Gmbh | Nucleoside-triphosphate conjugate and methods for the use thereof |
US9624539B2 (en) | 2011-05-23 | 2017-04-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using Raman and infrared spectroscopy detection |
JP6028025B2 (ja) | 2011-07-08 | 2016-11-16 | キージーン・エン・フェー | オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定 |
AU2012308518B2 (en) | 2011-09-13 | 2017-08-17 | Agilent Technologies, Inc. | 5-methoxy, 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing |
SMT202100624T1 (it) | 2011-09-23 | 2022-01-10 | Illumina Inc | Composizioni per il sequenziamento di acido nucleico |
US8754244B1 (en) | 2013-03-08 | 2014-06-17 | Illumina Cambridge Limited | Rhodamine compounds and their use as fluorescent labels |
CA2902982C (en) | 2013-03-08 | 2020-08-04 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
ES2662598T3 (es) | 2013-03-08 | 2018-04-09 | F. Hoffmann-La Roche Ag | Análisis de sangre para la detección de mutaciones de EGFR |
AU2013380647B2 (en) | 2013-03-08 | 2017-05-04 | Illumina Cambridge Ltd | Rhodamine compounds and their use as fluorescent labels |
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
WO2014144883A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
CA2903095C (en) | 2013-03-15 | 2018-02-13 | Xiaohai Liu | Modified nucleosides or nucleotides |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
WO2015015913A1 (ja) | 2013-07-31 | 2015-02-05 | 株式会社 日立ハイテクノロジーズ | 核酸分析用フローセル、及び核酸分析装置 |
CN103667469A (zh) * | 2013-11-29 | 2014-03-26 | 武汉科技大学 | 一种基于万能碱基的dna测序方法 |
US10537889B2 (en) | 2013-12-31 | 2020-01-21 | Illumina, Inc. | Addressable flow cell using patterned electrodes |
GB201408077D0 (en) | 2014-05-07 | 2014-06-18 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
WO2016065248A1 (en) | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
GB201508858D0 (en) | 2015-05-22 | 2015-07-01 | Illumina Cambridge Ltd | Polymethine compounds with long stokes shifts and their use as fluorescent labels |
GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
US10465232B1 (en) | 2015-10-08 | 2019-11-05 | Trace Genomics, Inc. | Methods for quantifying efficiency of nucleic acid extraction and detection |
WO2017065194A1 (ja) | 2015-10-13 | 2017-04-20 | 国立研究開発法人海洋研究開発機構 | 二本鎖rnaの断片化方法およびその利用 |
WO2017185026A1 (en) | 2016-04-22 | 2017-10-26 | Complete Genomics, Inc. | Reversibly blocked nucleoside analogues and their use |
US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
CA3025880C (en) | 2016-12-22 | 2020-01-28 | Illumina Cambridge Limited | Coumarin compounds and their uses as fluorescent labels |
GB2567124A (en) | 2017-05-08 | 2019-04-10 | Vysoka Akola Chemicko Tech V Praze | Imaging agents and methods |
AU2018272302A1 (en) | 2017-05-26 | 2019-12-19 | Nuclera Nucleics Ltd | Use of terminal transferase enzyme in nucleic acid synthesis |
CN118086479A (zh) | 2017-08-01 | 2024-05-28 | 深圳华大智造科技有限公司 | 核酸测序方法 |
GB201716931D0 (en) | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
EP3870593A4 (en) * | 2018-10-25 | 2022-11-16 | Singular Genomics Systems, Inc. | NUCLEOTIDE ANALOGS |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
US11390753B2 (en) | 2019-03-01 | 2022-07-19 | Illumina Cambridge Limited | Exocyclic amine substituted coumarin compounds and uses as fluorescent labels |
NL2023327B1 (en) | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
CA3103636A1 (en) | 2019-03-01 | 2020-09-10 | Illumina Cambridge Limited | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels |
US11421271B2 (en) | 2019-03-28 | 2022-08-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing using photoswitchable labels |
EP4065646A1 (en) | 2019-11-27 | 2022-10-05 | Illumina Cambridge Limited | Cyclooctatetraene containing dyes and compositions |
US11188778B1 (en) | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
PE20230492A1 (es) | 2020-06-22 | 2023-03-23 | Illumina Cambridge Ltd | Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3' |
US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
GB2617481A (en) | 2020-10-30 | 2023-10-11 | Element Biosciences Inc | Reagents for massively parallel nucleic acid sequencing |
US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
CA3215598A1 (en) | 2021-05-05 | 2022-11-10 | Michael Callingham | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
AU2022277632A1 (en) | 2021-05-20 | 2023-11-09 | Illumina Cambridge Limited | Compositions and methods for sequencing by synthesis |
EP4364150A1 (en) | 2021-06-29 | 2024-05-08 | Illumina, Inc. | Self-learned base caller, trained using organism sequences |
JP2024532004A (ja) | 2021-07-19 | 2024-09-04 | イルミナ インコーポレイテッド | ベースコールのための補間及び適合による強度抽出 |
US11455487B1 (en) | 2021-10-26 | 2022-09-27 | Illumina Software, Inc. | Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling |
WO2023009758A1 (en) | 2021-07-28 | 2023-02-02 | Illumina, Inc. | Quality score calibration of basecalling systems |
JP2024529843A (ja) | 2021-08-03 | 2024-08-14 | イルミナ インコーポレイテッド | 複数のベースコーラモデルを使用するベースコール |
US12077789B2 (en) | 2021-08-14 | 2024-09-03 | Illumina, Inc. | Polymerases, compositions, and methods of use |
WO2023186815A1 (en) | 2022-03-28 | 2023-10-05 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
EP4499758A1 (en) | 2022-03-29 | 2025-02-05 | Illumina Inc. | Chromenoquinoline dyes and uses in sequencing |
US20230332197A1 (en) | 2022-03-31 | 2023-10-19 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group |
WO2023186982A1 (en) | 2022-03-31 | 2023-10-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
US20230383342A1 (en) | 2022-05-31 | 2023-11-30 | Illumina Cambridge Limited | Compositions and methods for nucleic acid sequencing |
AU2023296605A1 (en) | 2022-06-28 | 2025-01-09 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
AU2023342375A1 (en) | 2022-09-16 | 2025-01-16 | Illumina, Inc. | Cluster segmentation and conditional base calling |
US20240140939A1 (en) | 2022-09-30 | 2024-05-02 | Illumina Cambridge Limited | Compositions and methods for reducing photo damage during sequencing |
US20240240217A1 (en) | 2022-12-09 | 2024-07-18 | Illumina, Inc. | Nucleosides and nucleotides with 3' blocking groups and cleavable linkers |
WO2024137886A1 (en) | 2022-12-21 | 2024-06-27 | Illumina, Inc. | Context-dependent base calling |
WO2024137765A1 (en) | 2022-12-22 | 2024-06-27 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
AU2023409219A1 (en) | 2022-12-22 | 2024-10-03 | Illumina, Inc. | Palladium catalyst compositions and methods for sequencing by synthesis |
CN119095984A (zh) | 2022-12-27 | 2024-12-06 | 伊路米纳有限公司 | 使用3'烯丙基封端的核苷酸的测序方法 |
WO2024206407A2 (en) | 2023-03-29 | 2024-10-03 | Illumina, Inc. | Naphthalimide dyes and uses in nucleic acid sequencing |
AU2024247902A1 (en) | 2023-03-30 | 2024-12-12 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US227131A (en) | 1880-05-04 | Heney o | ||
DE3906357A1 (de) | 1989-03-01 | 1990-09-06 | Boehringer Mannheim Gmbh | Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel |
US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
PT693065E (pt) | 1993-04-13 | 2002-05-31 | Naxcor | Derivados de cumarina nao-nucleosidicos como agentes reticulantes de polionucleotidos |
WO1996027025A1 (en) | 1995-02-27 | 1996-09-06 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
JP3813818B2 (ja) | 1998-05-01 | 2006-08-23 | アリゾナ ボード オブ リージェンツ | オリゴヌクレオチドおよびdna分子のヌクレオチド配列の決定方法 |
IL141148A0 (en) | 1998-07-30 | 2002-02-10 | Solexa Ltd | Arrayed biomolecules and their use in sequencing |
ATE508200T1 (de) | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | Sequenzierung durch inkorporation |
EP1961826A3 (en) | 1999-03-10 | 2008-09-17 | ASM Scientific, Inc. | A method for direct nucleic acid sequencing |
US6309836B1 (en) | 1999-10-05 | 2001-10-30 | Marek Kwiatkowski | Compounds for protecting hydroxyls and methods for their use |
GB0013276D0 (en) | 2000-06-01 | 2000-07-26 | Amersham Pharm Biotech Uk Ltd | Nucleotide analogues |
CA2425112C (en) | 2000-10-06 | 2011-09-27 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding dna and rna |
DE10120797B4 (de) | 2001-04-27 | 2005-12-22 | Genovoxx Gmbh | Verfahren zur Analyse von Nukleinsäureketten |
US6753449B2 (en) | 2001-10-09 | 2004-06-22 | Arqule, Inc. | Cleavable linker for solid phase synthesis |
US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
EP2607369B1 (en) | 2002-08-23 | 2015-09-23 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
EP3438116B1 (en) | 2002-08-23 | 2021-02-17 | Illumina Cambridge Limited | Labelled nucleotides |
GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
-
2003
- 2003-08-22 EP EP18195197.1A patent/EP3438116B1/en not_active Revoked
- 2003-08-22 ES ES03792520T patent/ES2326077T3/es not_active Expired - Lifetime
- 2003-08-22 HU HUE09005942A patent/HUE032483T2/en unknown
- 2003-08-22 DK DK16193088.8T patent/DK3147292T3/en active
- 2003-08-22 DK DK18195197.1T patent/DK3438116T3/da active
- 2003-08-22 ES ES18195197T patent/ES2864086T3/es not_active Expired - Lifetime
- 2003-08-22 EP EP16193088.8A patent/EP3147292B1/en not_active Revoked
- 2003-08-22 PT PT90059429T patent/PT2119722T/pt unknown
- 2003-08-22 GB GB0405882A patent/GB2395953A/en not_active Withdrawn
- 2003-08-22 EP EP09005942.9A patent/EP2119722B1/en not_active Revoked
- 2003-08-22 AU AU2003259352A patent/AU2003259352A1/en not_active Abandoned
- 2003-08-22 ES ES16193088.8T patent/ES2694651T3/es not_active Expired - Lifetime
- 2003-08-22 DK DK09005942.9T patent/DK2119722T3/en active
- 2003-08-22 PT PT181951971T patent/PT3438116T/pt unknown
- 2003-08-22 AT AT03792520T patent/ATE431354T1/de not_active IP Right Cessation
- 2003-08-22 EP EP21156755.7A patent/EP3848380A1/en not_active Withdrawn
- 2003-08-22 SI SI200332500A patent/SI2119722T1/sl unknown
- 2003-08-22 DK DK03792520T patent/DK1560838T3/da active
- 2003-08-22 SI SI200332618T patent/SI3438116T1/sl unknown
- 2003-08-22 EP EP03792520A patent/EP1560838B1/en not_active Expired - Lifetime
- 2003-08-22 HU HUE18195197A patent/HUE055068T2/hu unknown
- 2003-08-22 ES ES09005942.9T patent/ES2604951T3/es not_active Expired - Lifetime
- 2003-08-22 PT PT16193088T patent/PT3147292T/pt unknown
- 2003-08-22 WO PCT/GB2003/003690 patent/WO2004018493A1/en not_active Application Discontinuation
- 2003-08-22 DE DE60327649T patent/DE60327649D1/de not_active Expired - Lifetime
- 2003-08-22 SI SI200332583T patent/SI3147292T1/sl unknown
-
2016
- 2016-11-21 CY CY20161101200T patent/CY1118471T1/el unknown
-
2018
- 2018-11-06 CY CY181101161T patent/CY1120882T1/el unknown
-
2021
- 2021-03-17 CY CY20211100229T patent/CY1123971T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2326077T3 (es) | 2009-09-30 |
EP2119722A1 (en) | 2009-11-18 |
CY1118471T1 (el) | 2017-07-12 |
ES2864086T3 (es) | 2021-10-13 |
EP3438116B1 (en) | 2021-02-17 |
CY1120882T1 (el) | 2019-12-11 |
DK3147292T3 (en) | 2018-12-03 |
DE60327649D1 (de) | 2009-06-25 |
DK1560838T3 (da) | 2009-09-07 |
ES2604951T3 (es) | 2017-03-10 |
PT2119722T (pt) | 2016-12-12 |
PT3438116T (pt) | 2021-03-23 |
PT3147292T (pt) | 2018-11-22 |
SI2119722T1 (sl) | 2017-03-31 |
WO2004018493A1 (en) | 2004-03-04 |
EP2119722B1 (en) | 2016-10-26 |
EP1560838A1 (en) | 2005-08-10 |
HUE055068T2 (hu) | 2021-10-28 |
EP3147292A1 (en) | 2017-03-29 |
EP3848380A1 (en) | 2021-07-14 |
DK2119722T3 (en) | 2016-12-12 |
DK3438116T3 (da) | 2021-03-22 |
GB0405882D0 (en) | 2004-04-21 |
GB2395953A (en) | 2004-06-09 |
HUE032483T2 (en) | 2017-09-28 |
EP1560838B1 (en) | 2009-05-13 |
SI3438116T1 (sl) | 2021-07-30 |
EP3147292B1 (en) | 2018-09-26 |
EP3438116A1 (en) | 2019-02-06 |
ES2694651T3 (es) | 2018-12-26 |
CY1123971T1 (el) | 2022-05-27 |
AU2003259352A1 (en) | 2004-03-11 |
ATE431354T1 (de) | 2009-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1123971T1 (el) | Επισημασμενα νουκλεοτιδια | |
WO2003048387A3 (en) | Labelled nucleotides | |
CY1120186T1 (el) | Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιωn | |
GB0129012D0 (en) | Labelled nucleotides | |
GB2380461B (en) | Article carrier having single sided releasable cross bar | |
MXPA04000179A (es) | Oligonucleotidos sinteticos de hebra doble para inhibicion especifica de expresion de gene. | |
WO2000029623A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
AU2003231058A8 (en) | Single nucleotide polymorphism analysis using surface invasive cleavage reactions | |
AU2003250983A1 (en) | The use of nucleotide sequences as carrier of information | |
WO2001040521A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
CY1123506T1 (el) | Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιων | |
WO2001051670A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
WO2000029622A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
WO2001038586A3 (en) | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof | |
GB0213651D0 (en) | Nucleotide sequences and uses thereof | |
GB0213658D0 (en) | Nucleotide sequences and uses thereof | |
UA9276S (uk) | Етикетка «емблема виставки «decotex» | |
UA9155S (uk) | Етикетка «емблема виставки «santechnika» | |
UA7137S (uk) | Етикетка «напій десертний» | |
UA7582S (uk) | Етикетка для пляшки олії «наше масло» | |
UA8860S (uk) | Етикетка «емблема виставки с. е. м.» | |
UA6700S (uk) | Етикетка «світоч-шоколад десертний» | |
FR2846451B1 (fr) | Afficheur d'indication de prix d'articles | |
GB0118903D0 (en) | Nucleotide sequences and uses thereof | |
GB0106787D0 (en) | Nucleotide sequences and uses thereof |