[go: up one dir, main page]

SI3147292T1 - Označeni nukleotidi - Google Patents

Označeni nukleotidi

Info

Publication number
SI3147292T1
SI3147292T1 SI200332583T SI200332583T SI3147292T1 SI 3147292 T1 SI3147292 T1 SI 3147292T1 SI 200332583 T SI200332583 T SI 200332583T SI 200332583 T SI200332583 T SI 200332583T SI 3147292 T1 SI3147292 T1 SI 3147292T1
Authority
SI
Slovenia
Prior art keywords
labelled nucleotides
labelled
nucleotides
nucleoside
linker
Prior art date
Application number
SI200332583T
Other languages
English (en)
Inventor
John Milton
Silke Ruediger
Xiaohai Liu
Original Assignee
Illumina Cambridge Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31946334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3147292(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/227,131 external-priority patent/US7057026B2/en
Application filed by Illumina Cambridge Limited filed Critical Illumina Cambridge Limited
Publication of SI3147292T1 publication Critical patent/SI3147292T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200332583T 2002-08-23 2003-08-22 Označeni nukleotidi SI3147292T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
EP16193088.8A EP3147292B1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Publications (1)

Publication Number Publication Date
SI3147292T1 true SI3147292T1 (sl) 2019-01-31

Family

ID=31946334

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200332500A SI2119722T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332618T SI3438116T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332583T SI3147292T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200332500A SI2119722T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332618T SI3438116T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi

Country Status (12)

Country Link
EP (5) EP3438116B1 (sl)
AT (1) ATE431354T1 (sl)
AU (1) AU2003259352A1 (sl)
CY (3) CY1118471T1 (sl)
DE (1) DE60327649D1 (sl)
DK (4) DK3147292T3 (sl)
ES (4) ES2326077T3 (sl)
GB (1) GB2395953A (sl)
HU (2) HUE032483T2 (sl)
PT (3) PT2119722T (sl)
SI (3) SI2119722T1 (sl)
WO (1) WO2004018493A1 (sl)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
CA2425112C (en) 2000-10-06 2011-09-27 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
EP3438116B1 (en) 2002-08-23 2021-02-17 Illumina Cambridge Limited Labelled nucleotides
EP2607369B1 (en) 2002-08-23 2015-09-23 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
WO2005044836A2 (de) 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
EP1730307A4 (en) 2004-03-03 2008-11-05 Univ Columbia PHOTOSPACTABLE FLUORESCENZ NUCLEOTIDES FOR DNA SEQUENCING ON A MEASUREMENT BASED BY STATION-SPECIFIC COUPLING SCHEME CONSTRUCTED CHIP
GB0427236D0 (en) 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
EP1828412B2 (en) * 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US8796432B2 (en) 2005-10-31 2014-08-05 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
WO2007053702A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis
ES2545264T3 (es) 2006-04-04 2015-09-09 Keygene N.V. Detección de alto rendimiento de marcadores moleculares basada en fragmentos de restricción
WO2007135368A2 (en) * 2006-05-18 2007-11-29 Solexa Limited Dye compounds and the use of their labelled conjugates
EP2032686B1 (en) 2006-06-23 2022-01-12 Illumina, Inc. System and method for creation of dna cluster arrays
CN103333949B (zh) 2006-07-12 2015-05-06 凯津公司 使用aflp的高通量物理作图
EP2071927A2 (en) 2006-09-28 2009-06-24 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
DE112007002932B4 (de) 2006-12-01 2015-08-06 The Trustees Of Columbia University In The City Of New York Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren
WO2008070749A2 (en) 2006-12-05 2008-06-12 Lasergen, Inc. Photocleavable labeled nucleotides and nucleosides and labeled nucleotides and nucleosides and methods for their use in dna sequencing
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
US9163053B2 (en) 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
EP2725107B1 (en) 2007-10-19 2018-08-29 The Trustees of Columbia University in the City of New York DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified ddNTPs and nucleic acid comprising inosine with reversible terminators
EP2940029B1 (en) * 2007-10-19 2023-11-29 The Trustees of Columbia University in the City of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US8617811B2 (en) 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
BRPI0908734A2 (pt) 2008-03-17 2015-07-28 Expressive Res Bv Métodos para a identificação de dna genômico em uma amostra e para a indentificação de polimorfismos, e, kit
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
WO2009134469A1 (en) 2008-04-29 2009-11-05 Life Technologies Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
CN102264917B (zh) 2008-06-11 2015-06-10 激光基因公司 核苷酸和核苷以及将其用于dna测序的方法
JP2012514977A (ja) 2009-01-13 2012-07-05 キージーン・エン・フェー 新規ゲノム配列決定戦略
EP2494073B1 (de) 2009-10-26 2017-11-29 AGCT GmbH Konjugate von nukleotiden und methoden zu deren anwendung
WO2012034007A2 (en) 2010-09-10 2012-03-15 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
ES2627851T3 (es) 2011-01-31 2017-07-31 Illumina, Inc. Métodos para reducir el daño en ácidos nucleicos
DE102012008375A1 (de) 2011-04-27 2012-10-31 Genovoxx Gmbh Methoden und Komponenten zur Detektion von Nukleinsäureketten
US20150086981A1 (en) 2011-05-04 2015-03-26 Genovoxx Gmbh Nucleoside-triphosphate conjugate and methods for the use thereof
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
JP6028025B2 (ja) 2011-07-08 2016-11-16 キージーン・エン・フェー オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定
AU2012308518B2 (en) 2011-09-13 2017-08-17 Agilent Technologies, Inc. 5-methoxy, 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
SMT202100624T1 (it) 2011-09-23 2022-01-10 Illumina Inc Composizioni per il sequenziamento di acido nucleico
US8754244B1 (en) 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
CA2902982C (en) 2013-03-08 2020-08-04 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
ES2662598T3 (es) 2013-03-08 2018-04-09 F. Hoffmann-La Roche Ag Análisis de sangre para la detección de mutaciones de EGFR
AU2013380647B2 (en) 2013-03-08 2017-05-04 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
CA2903095C (en) 2013-03-15 2018-02-13 Xiaohai Liu Modified nucleosides or nucleotides
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
WO2015015913A1 (ja) 2013-07-31 2015-02-05 株式会社 日立ハイテクノロジーズ 核酸分析用フローセル、及び核酸分析装置
CN103667469A (zh) * 2013-11-29 2014-03-26 武汉科技大学 一种基于万能碱基的dna测序方法
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
WO2016065248A1 (en) 2014-10-23 2016-04-28 Complete Genomics, Inc. Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
WO2017065194A1 (ja) 2015-10-13 2017-04-20 国立研究開発法人海洋研究開発機構 二本鎖rnaの断片化方法およびその利用
WO2017185026A1 (en) 2016-04-22 2017-10-26 Complete Genomics, Inc. Reversibly blocked nucleoside analogues and their use
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
CA3025880C (en) 2016-12-22 2020-01-28 Illumina Cambridge Limited Coumarin compounds and their uses as fluorescent labels
GB2567124A (en) 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
AU2018272302A1 (en) 2017-05-26 2019-12-19 Nuclera Nucleics Ltd Use of terminal transferase enzyme in nucleic acid synthesis
CN118086479A (zh) 2017-08-01 2024-05-28 深圳华大智造科技有限公司 核酸测序方法
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
EP3870593A4 (en) * 2018-10-25 2022-11-16 Singular Genomics Systems, Inc. NUCLEOTIDE ANALOGS
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
US11390753B2 (en) 2019-03-01 2022-07-19 Illumina Cambridge Limited Exocyclic amine substituted coumarin compounds and uses as fluorescent labels
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
CA3103636A1 (en) 2019-03-01 2020-09-10 Illumina Cambridge Limited Tertiary amine substituted coumarin compounds and their uses as fluorescent labels
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
EP4065646A1 (en) 2019-11-27 2022-10-05 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
PE20230492A1 (es) 2020-06-22 2023-03-23 Illumina Cambridge Ltd Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3'
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
GB2617481A (en) 2020-10-30 2023-10-11 Element Biosciences Inc Reagents for massively parallel nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
CA3215598A1 (en) 2021-05-05 2022-11-10 Michael Callingham Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
AU2022277632A1 (en) 2021-05-20 2023-11-09 Illumina Cambridge Limited Compositions and methods for sequencing by synthesis
EP4364150A1 (en) 2021-06-29 2024-05-08 Illumina, Inc. Self-learned base caller, trained using organism sequences
JP2024532004A (ja) 2021-07-19 2024-09-04 イルミナ インコーポレイテッド ベースコールのための補間及び適合による強度抽出
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023009758A1 (en) 2021-07-28 2023-02-02 Illumina, Inc. Quality score calibration of basecalling systems
JP2024529843A (ja) 2021-08-03 2024-08-14 イルミナ インコーポレイテッド 複数のベースコーラモデルを使用するベースコール
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
WO2023186815A1 (en) 2022-03-28 2023-10-05 Illumina Cambridge Limited Labeled avidin and methods for sequencing
EP4499758A1 (en) 2022-03-29 2025-02-05 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
US20230332197A1 (en) 2022-03-31 2023-10-19 Illumina Singapore Pte. Ltd. Nucleosides and nucleotides with 3' vinyl blocking group
WO2023186982A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
AU2023296605A1 (en) 2022-06-28 2025-01-09 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
AU2023342375A1 (en) 2022-09-16 2025-01-16 Illumina, Inc. Cluster segmentation and conditional base calling
US20240140939A1 (en) 2022-09-30 2024-05-02 Illumina Cambridge Limited Compositions and methods for reducing photo damage during sequencing
US20240240217A1 (en) 2022-12-09 2024-07-18 Illumina, Inc. Nucleosides and nucleotides with 3' blocking groups and cleavable linkers
WO2024137886A1 (en) 2022-12-21 2024-06-27 Illumina, Inc. Context-dependent base calling
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
AU2023409219A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
CN119095984A (zh) 2022-12-27 2024-12-06 伊路米纳有限公司 使用3'烯丙基封端的核苷酸的测序方法
WO2024206407A2 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
AU2024247902A1 (en) 2023-03-30 2024-12-12 Illumina, Inc. Compositions and methods for nucleic acid sequencing

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US227131A (en) 1880-05-04 Heney o
DE3906357A1 (de) 1989-03-01 1990-09-06 Boehringer Mannheim Gmbh Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
PT693065E (pt) 1993-04-13 2002-05-31 Naxcor Derivados de cumarina nao-nucleosidicos como agentes reticulantes de polionucleotidos
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
JP3813818B2 (ja) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ オリゴヌクレオチドおよびdna分子のヌクレオチド配列の決定方法
IL141148A0 (en) 1998-07-30 2002-02-10 Solexa Ltd Arrayed biomolecules and their use in sequencing
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
EP1961826A3 (en) 1999-03-10 2008-09-17 ASM Scientific, Inc. A method for direct nucleic acid sequencing
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
GB0013276D0 (en) 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
CA2425112C (en) 2000-10-06 2011-09-27 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
EP2607369B1 (en) 2002-08-23 2015-09-23 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
EP3438116B1 (en) 2002-08-23 2021-02-17 Illumina Cambridge Limited Labelled nucleotides
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays

Also Published As

Publication number Publication date
ES2326077T3 (es) 2009-09-30
EP2119722A1 (en) 2009-11-18
CY1118471T1 (el) 2017-07-12
ES2864086T3 (es) 2021-10-13
EP3438116B1 (en) 2021-02-17
CY1120882T1 (el) 2019-12-11
DK3147292T3 (en) 2018-12-03
DE60327649D1 (de) 2009-06-25
DK1560838T3 (da) 2009-09-07
ES2604951T3 (es) 2017-03-10
PT2119722T (pt) 2016-12-12
PT3438116T (pt) 2021-03-23
PT3147292T (pt) 2018-11-22
SI2119722T1 (sl) 2017-03-31
WO2004018493A1 (en) 2004-03-04
EP2119722B1 (en) 2016-10-26
EP1560838A1 (en) 2005-08-10
HUE055068T2 (hu) 2021-10-28
EP3147292A1 (en) 2017-03-29
EP3848380A1 (en) 2021-07-14
DK2119722T3 (en) 2016-12-12
DK3438116T3 (da) 2021-03-22
GB0405882D0 (en) 2004-04-21
GB2395953A (en) 2004-06-09
HUE032483T2 (en) 2017-09-28
EP1560838B1 (en) 2009-05-13
SI3438116T1 (sl) 2021-07-30
EP3147292B1 (en) 2018-09-26
EP3438116A1 (en) 2019-02-06
ES2694651T3 (es) 2018-12-26
CY1123971T1 (el) 2022-05-27
AU2003259352A1 (en) 2004-03-11
ATE431354T1 (de) 2009-05-15

Similar Documents

Publication Publication Date Title
CY1123971T1 (el) Επισημασμενα νουκλεοτιδια
WO2003048387A3 (en) Labelled nucleotides
CY1120186T1 (el) Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιωn
GB0129012D0 (en) Labelled nucleotides
GB2380461B (en) Article carrier having single sided releasable cross bar
MXPA04000179A (es) Oligonucleotidos sinteticos de hebra doble para inhibicion especifica de expresion de gene.
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU2003231058A8 (en) Single nucleotide polymorphism analysis using surface invasive cleavage reactions
AU2003250983A1 (en) The use of nucleotide sequences as carrier of information
WO2001040521A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
CY1123506T1 (el) Τροποποιημενα νουκλεοτιδια για αλληλουχιση πολυνουκλεοτιδιων
WO2001051670A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2000029622A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001038586A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
GB0213651D0 (en) Nucleotide sequences and uses thereof
GB0213658D0 (en) Nucleotide sequences and uses thereof
UA9276S (uk) Етикетка «емблема виставки «decotex»
UA9155S (uk) Етикетка «емблема виставки «santechnika»
UA7137S (uk) Етикетка «напій десертний»
UA7582S (uk) Етикетка для пляшки олії «наше масло»
UA8860S (uk) Етикетка «емблема виставки с. е. м.»
UA6700S (uk) Етикетка «світоч-шоколад десертний»
FR2846451B1 (fr) Afficheur d'indication de prix d'articles
GB0118903D0 (en) Nucleotide sequences and uses thereof
GB0106787D0 (en) Nucleotide sequences and uses thereof