SI2809150T1 - Humanizirane miši, ki izražajo težke verige z domenami VL - Google Patents

Humanizirane miši, ki izražajo težke verige z domenami VL

Info

Publication number: SI2809150T1
Authority: SI; Slovenia
Prior art keywords: domains; heavy chains; chains containing; humanized mice; express heavy
Prior art date: 2012-02-01

Application number

SI201331592T

Other languages

English (en)

Inventor

Lynn Macdonald

Cagan Gurer

Karolina A Meagher

Sean Stevens

Andrew J Murphy

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-02-01

Filing date

2013-02-01

Publication date

2019-11-29

2013-02-01 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

2019-11-29 Publication of SI2809150T1 publication Critical patent/SI2809150T1/sl

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24046—Adamalysin (3.4.24.46)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Environmental Sciences (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Housing For Livestock And Birds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI201331592T 2012-02-01 2013-02-01 Humanizirane miši, ki izražajo težke verige z domenami VL SI2809150T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201261593463P	2012-02-01	2012-02-01
US201261677538P	2012-07-31	2012-07-31
EP13704329.5A EP2809150B1 (en)	2012-02-01	2013-02-01	Humanized mice that express heavy chains containing vl domains
PCT/US2013/024295 WO2013116609A1 (en)	2012-02-01	2013-02-01	Humanized rodents that express heavy chains containing vl domains

Publications (1)

Publication Number	Publication Date
SI2809150T1 true SI2809150T1 (sl)	2019-11-29

Family

ID=47714588

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201331882T SI3597038T1 (sl)	2012-02-01	2013-02-01	Humanizirani glodalci, ki izražajo težke verige, ki vsebujejo domene VL
SI201331592T SI2809150T1 (sl)	2012-02-01	2013-02-01	Humanizirane miši, ki izražajo težke verige z domenami VL

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SI201331882T SI3597038T1 (sl)	2012-02-01	2013-02-01	Humanizirani glodalci, ki izražajo težke verige, ki vsebujejo domene VL

Country Status (26)

Country	Link
US (3)	US20130212719A1 (sl)
EP (3)	EP3597038B1 (sl)
JP (6)	JP2015505477A (sl)
KR (2)	KR20140123983A (sl)
CN (2)	CN104202971B (sl)
AU (3)	AU2013204758B2 (sl)
BR (1)	BR112014018843B1 (sl)
CA (1)	CA2863175A1 (sl)
CY (2)	CY1122419T1 (sl)
DK (2)	DK2809150T3 (sl)
ES (2)	ES2753774T3 (sl)
HR (2)	HRP20192218T1 (sl)
HU (2)	HUE046744T2 (sl)
IL (3)	IL233827A0 (sl)
LT (2)	LT2809150T (sl)
ME (1)	ME03611B (sl)
MX (2)	MX2020003491A (sl)
NZ (4)	NZ793447A (sl)
PL (2)	PL3597038T3 (sl)
PT (2)	PT3597038T (sl)
RS (2)	RS59699B1 (sl)
RU (2)	RU2664185C2 (sl)
SG (3)	SG11201404477YA (sl)
SI (2)	SI3597038T1 (sl)
SM (2)	SMT201900685T1 (sl)
WO (1)	WO2013116609A1 (sl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2725169A1 (en) *	2008-05-23	2009-11-26	Aliva Biopharmaceuticals, Inc.	Method of generating single vl domain antibodies in transgenic animals
ES2978496T3 (es)	2009-07-08	2024-09-13	Kymab Ltd	Modelos animales y moléculas terapéuticas
US9445581B2 (en)	2012-03-28	2016-09-20	Kymab Limited	Animal models and therapeutic molecules
RU2612903C2 (ru)	2010-08-02	2017-03-13	Ридженерон Фармасьютикалз, Инк.	Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены
US10130081B2 (en)	2011-08-05	2018-11-20	Regeneron Pharmaceuticals, Inc.	Humanized universal light chain mice
JP5813880B2 (ja)	2011-09-19	2015-11-17	カイマブ・リミテッド	ヒトへの使用に合わせて作製された抗体、可変ドメインおよび鎖
WO2013045916A1 (en)	2011-09-26	2013-04-04	Kymab Limited	Chimaeric surrogate light chains (slc) comprising human vpreb
GB201122047D0 (en) *	2011-12-21	2012-02-01	Kymab Ltd	Transgenic animals
US9253965B2 (en)	2012-03-28	2016-02-09	Kymab Limited	Animal models and therapeutic molecules
LT2793567T (lt)	2011-12-20	2019-04-10	Regeneron Pharmaceuticals, Inc.	Humanizuotos lengvosios grandinės pelės
US20130212719A1 (en) *	2012-02-01	2013-08-15	Regeneron Pharmaceuticals, Inc.	Humanized Rodents that Express Heavy Chain Containing VL Domains
GB2502127A (en)	2012-05-17	2013-11-20	Kymab Ltd	Multivalent antibodies and in vivo methods for their production
US10251377B2 (en)	2012-03-28	2019-04-09	Kymab Limited	Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
EP2858487B1 (en)	2012-06-12	2019-10-23	Regeneron Pharmaceuticals, Inc.	Humanized non-human animals with restricted immunoglobulin heavy chain loci
HUE039214T2 (hu)	2013-02-20	2018-12-28	Regeneron Pharma	Módosított szekvenciájú immunglobulin-nehézlánccal rendelkezõ, nem humán élõlények
US9788534B2 (en)	2013-03-18	2017-10-17	Kymab Limited	Animal models and therapeutic molecules
US9783618B2 (en)	2013-05-01	2017-10-10	Kymab Limited	Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US9783593B2 (en)	2013-05-02	2017-10-10	Kymab Limited	Antibodies, variable domains and chains tailored for human use
US11707056B2 (en)	2013-05-02	2023-07-25	Kymab Limited	Animals, repertoires and methods
TW201546284A (zh)	2013-10-01	2015-12-16	Kymab Ltd	動物模式及治療分子
KR102276752B1 (ko)	2014-03-21	2021-07-13	리제너론 파마슈티칼스 인코포레이티드	단일 도메인 결합 단백질을 생산하는 비-인간 동물
US20150266976A1 (en)	2014-03-21	2015-09-24	Regeneron Pharmaceuticals, Inc.	Vl antigen binding proteins exhibiting distinct binding characteristics
CA2979702A1 (en) *	2015-03-19	2016-09-22	Regeneron Pharmaceuticals, Inc.	Non-human animals that select for light chain variable regions that bind antigen
AU2016243052C1 (en) *	2015-04-03	2022-11-24	Dana-Farber Cancer Institute, Inc.	Composition and methods of genome editing of B-cells
EP4368637A3 (en)	2016-05-20	2024-07-10	Regeneron Pharmaceuticals, Inc.	Methods for breaking immunological tolerance using multiple guide rnas
US11089767B2 (en) *	2017-03-30	2021-08-17	Utah State University	Transgenic silkworms expressing spider silk
SG11202003044SA (en) *	2017-12-05	2020-04-29	Regeneron Pharma	Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
KR20200135397A (ko) *	2018-03-24	2020-12-02	리제너론 파마슈티칼스 인코포레이티드	펩티드-mhc 복합체에 대한 치료 항체를 생성하기 위한 유전적으로 변형된 비인간 동물, 이의 제조 방법
IL318469A (en) *	2018-06-14	2025-03-01	Regeneron Pharma	Non-human animals capable of reorganizing transgenic DH-DH, and their uses
EP4211155A1 (en)	2020-09-11	2023-07-19	Regeneron Pharmaceuticals, Inc.	Identification and production of antigen-specific antibodies
AU2021400584A1 (en)	2020-12-16	2023-06-29	Regeneron Pharmaceuticals, Inc.	Mice expressing humanized fc alpha receptors
CN114645042A (zh) *	2020-12-18	2022-06-21	中国食品药品检定研究院	一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法
CN114196626A (zh) *	2022-02-16	2022-03-18	北京国卫生物科技有限公司	脐带间充质干细胞及其分离培养扩增方法
AU2024329875A1 (en) *	2024-01-02	2025-07-17	Gempharmatech Co., Ltd	Animal model generating humanized antibody and construction method thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6774279B2 (en)	1997-05-30	2004-08-10	Carnegie Institution Of Washington	Use of FLP recombinase in mice
MXPA03001915A (es) *	2000-08-03	2004-09-10	Therapeutic Human Polyclonals	Produccion de anticuerpos humanizados en animales transgenicos.
US7105348B2 (en)	2000-10-31	2006-09-12	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
US6596541B2 (en)	2000-10-31	2003-07-22	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
US6586251B2 (en)	2000-10-31	2003-07-01	Regeneron Pharmaceuticals, Inc.	Methods of modifying eukaryotic cells
CN101016543A (zh) *	2000-11-17	2007-08-15	罗切斯特大学	筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法
US7473557B2 (en)	2001-06-06	2009-01-06	Regeneron Pharmaceuticals, Inc.	Method for targeting transcriptionally active loci
CN100526455C (zh)	2001-12-21	2009-08-12	斯路姆-X股份有限公司	用于体外分离和培养具有种系传递能力的胚胎干细胞(es)细胞系的组合物
WO2003081993A2 (en) *	2002-03-22	2003-10-09	Origen Therapeutics	Transgenic aves producing human polyclonal antibodies
AU2004257292A1 (en) *	2003-07-15	2005-01-27	Therapeutic Human Polyclonals, Inc.	Humanized immunoglobulin loci
ES2667169T3 (es)	2004-10-19	2018-05-09	Regeneron Pharmaceuticals, Inc.	Método para generar un animal no humano homocigótico para una modificación genética
US20080184380A1 (en) *	2004-10-22	2008-07-31	Therapeutic Human Polyclonals Inc.	Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals
EP2003960B1 (en) *	2006-03-31	2015-06-10	E. R. Squibb & Sons, L.L.C.	Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
WO2008027986A2 (en) *	2006-09-01	2008-03-06	Therapeutic Human Polyclonals, Inc.	Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
CN101970491A (zh) *	2007-08-30	2011-02-09	沃尔特及伊莱萨霍尔医学研究院	树突状细胞标记物及其用途
CA2700394C (en) *	2007-09-26	2017-10-24	Chugai Seiyaku Kabushiki Kaisha	Modified antibody constant region
US7659842B2 (en)	2007-10-24	2010-02-09	Infineon Technologies Ag	Quantization error reduction in PWM full-MASH converters
CA2725169A1 (en) *	2008-05-23	2009-11-26	Aliva Biopharmaceuticals, Inc.	Method of generating single vl domain antibodies in transgenic animals
SI2147594T1 (sl) *	2008-06-27	2014-02-28	Merus B.V.	Protitelo proizvajajoči ne-humani sesalci
MX2011001930A (es) *	2008-08-29	2011-04-21	Symphogen As	Metodo para clonar anticuerpos derivados de aves.
US9085795B2 (en) *	2009-02-04	2015-07-21	Molecular Innovations, Inc.	Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies
ES2978496T3 (es) *	2009-07-08	2024-09-13	Kymab Ltd	Modelos animales y moléculas terapéuticas
RU2425880C2 (ru) *	2009-07-30	2011-08-10	Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН	Способ получения трансгенных мышей
CN105695415A (zh) *	2010-06-17	2016-06-22	科马布有限公司	动物模型及治疗分子
RU2612903C2 (ru) *	2010-08-02	2017-03-13	Ридженерон Фармасьютикалз, Инк.	Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены
DK4067496T5 (da) *	2011-02-25	2024-07-22	Regeneron Pharma	ADAM6-mus
US10130081B2 (en) *	2011-08-05	2018-11-20	Regeneron Pharmaceuticals, Inc.	Humanized universal light chain mice
LT2793567T (lt) *	2011-12-20	2019-04-10	Regeneron Pharmaceuticals, Inc.	Humanizuotos lengvosios grandinės pelės
US20130212719A1 (en) *	2012-02-01	2013-08-15	Regeneron Pharmaceuticals, Inc.	Humanized Rodents that Express Heavy Chain Containing VL Domains
EP2858487B1 (en) *	2012-06-12	2019-10-23	Regeneron Pharmaceuticals, Inc.	Humanized non-human animals with restricted immunoglobulin heavy chain loci
KR102492433B1 (ko) *	2016-11-04	2023-01-30	리제너론 파마슈티칼스 인코포레이티드	조작된 면역글로불린 람다 경쇄 유전자좌를 갖는 비인간 동물

2013
- 2013-02-01 US US13/756,889 patent/US20130212719A1/en not_active Abandoned
- 2013-02-01 HU HUE13704329A patent/HUE046744T2/hu unknown
- 2013-02-01 CA CA2863175A patent/CA2863175A1/en active Pending
- 2013-02-01 RU RU2014133653A patent/RU2664185C2/ru active
- 2013-02-01 WO PCT/US2013/024295 patent/WO2013116609A1/en active Application Filing
- 2013-02-01 JP JP2014555736A patent/JP2015505477A/ja not_active Withdrawn
- 2013-02-01 MX MX2020003491A patent/MX2020003491A/es unknown
- 2013-02-01 EP EP19191081.9A patent/EP3597038B1/en active Active
- 2013-02-01 PL PL19191081T patent/PL3597038T3/pl unknown
- 2013-02-01 SM SM20190685T patent/SMT201900685T1/it unknown
- 2013-02-01 CN CN201380017544.2A patent/CN104202971B/zh active Active
- 2013-02-01 SI SI201331882T patent/SI3597038T1/sl unknown
- 2013-02-01 RS RS20191615A patent/RS59699B1/sr unknown
- 2013-02-01 HU HUE19191081A patent/HUE055610T2/hu unknown
- 2013-02-01 AU AU2013204758A patent/AU2013204758B2/en active Active
- 2013-02-01 EP EP13704329.5A patent/EP2809150B1/en active Active
- 2013-02-01 HR HRP20192218TT patent/HRP20192218T1/hr unknown
- 2013-02-01 PL PL13704329T patent/PL2809150T3/pl unknown
- 2013-02-01 RS RS20210791A patent/RS62023B1/sr unknown
- 2013-02-01 LT LT13704329T patent/LT2809150T/lt unknown
- 2013-02-01 LT LTEP19191081.9T patent/LT3597038T/lt unknown
- 2013-02-01 NZ NZ793447A patent/NZ793447A/en unknown
- 2013-02-01 NZ NZ734504A patent/NZ734504A/en unknown
- 2013-02-01 DK DK13704329T patent/DK2809150T3/da active
- 2013-02-01 NZ NZ627977A patent/NZ627977A/en active IP Right Revival
- 2013-02-01 NZ NZ719228A patent/NZ719228A/en unknown
- 2013-02-01 BR BR112014018843-2A patent/BR112014018843B1/pt active IP Right Grant
- 2013-02-01 SG SG11201404477YA patent/SG11201404477YA/en unknown
- 2013-02-01 KR KR1020147024417A patent/KR20140123983A/ko not_active Ceased
- 2013-02-01 PT PT191910819T patent/PT3597038T/pt unknown
- 2013-02-01 ES ES13704329T patent/ES2753774T3/es active Active
- 2013-02-01 MX MX2019002517A patent/MX373286B/es active IP Right Grant
- 2013-02-01 SG SG10201606256TA patent/SG10201606256TA/en unknown
- 2013-02-01 SM SM20210401T patent/SMT202100401T1/it unknown
- 2013-02-01 RU RU2018122695A patent/RU2770016C2/ru active
- 2013-02-01 SI SI201331592T patent/SI2809150T1/sl unknown
- 2013-02-01 DK DK19191081.9T patent/DK3597038T3/da active
- 2013-02-01 EP EP21167681.2A patent/EP3912465A1/en active Pending
- 2013-02-01 PT PT137043295T patent/PT2809150T/pt unknown
- 2013-02-01 ME MEP-2019-348A patent/ME03611B/me unknown
- 2013-02-01 CN CN201610371631.3A patent/CN106117364B/zh active Active
- 2013-02-01 SG SG10201913428QA patent/SG10201913428QA/en unknown
- 2013-02-01 ES ES19191081T patent/ES2870703T3/es active Active
- 2013-02-01 KR KR1020187037872A patent/KR20190006029A/ko not_active Ceased
2014
- 2014-07-27 IL IL233827A patent/IL233827A0/en active IP Right Grant
2015
- 2015-10-23 AU AU2015246154A patent/AU2015246154B2/en active Active
2016
- 2016-10-14 US US15/294,488 patent/US20170094955A1/en not_active Abandoned
2017
- 2017-10-27 AU AU2017251848A patent/AU2017251848B2/en active Active
2018
- 2018-02-09 JP JP2018022012A patent/JP6698718B2/ja active Active
- 2018-08-21 IL IL261280A patent/IL261280B/en active IP Right Grant
2019
- 2019-07-12 JP JP2019130027A patent/JP6942757B2/ja active Active
- 2019-08-13 IL IL268675A patent/IL268675B/en active IP Right Grant
- 2019-12-10 CY CY20191101302T patent/CY1122419T1/el unknown
2021
- 2021-04-07 US US17/224,524 patent/US20210368751A1/en not_active Abandoned
- 2021-06-15 JP JP2021099420A patent/JP7187615B2/ja active Active
- 2021-06-23 HR HRP20210987TT patent/HRP20210987T1/hr unknown
- 2021-07-20 CY CY20211100659T patent/CY1124361T1/el unknown
2022
- 2022-11-30 JP JP2022191963A patent/JP7525579B2/ja active Active
2023
- 2023-10-05 JP JP2023173593A patent/JP2023168590A/ja active Pending

Also Published As

Publication number	Publication date
CN104202971A (zh)	2014-12-10
SG10201606256TA (en)	2016-09-29
EP2809150A1 (en)	2014-12-10
ES2753774T3 (es)	2020-04-14
EP3597038B1 (en)	2021-04-21
US20130212719A1 (en)	2013-08-15
NZ793447A (en)	2024-05-31
NZ719228A (en)	2022-08-26
SMT202100401T1 (it)	2021-09-14
EP3912465A1 (en)	2021-11-24
PL3597038T3 (pl)	2021-11-08
MX2020003491A (es)	2022-10-25
JP6942757B2 (ja)	2021-09-29
NZ734504A (en)	2022-10-28
JP6698718B2 (ja)	2020-05-27
BR112014018843A8 (pt)	2019-01-29
CN104202971B (zh)	2016-07-06
HUE046744T2 (hu)	2020-03-30
CN106117364A (zh)	2016-11-16
SG10201913428QA (en)	2020-03-30
RU2018122695A (ru)	2019-03-06
IL268675B (en)	2020-11-30
LT3597038T (lt)	2021-05-25
AU2013204758B2 (en)	2015-07-23
LT2809150T (lt)	2019-10-25
JP2015505477A (ja)	2015-02-23
MX373286B (es)	2020-05-20
NZ627977A (en)	2016-06-24
JP7187615B2 (ja)	2022-12-12
JP2019170395A (ja)	2019-10-10
HK1202771A1 (en)	2015-10-09
SI3597038T1 (sl)	2021-07-30
PT2809150T (pt)	2019-12-09
RU2664185C2 (ru)	2018-08-15
MX2019002517A (es)	2019-06-17
EP2809150B1 (en)	2019-09-18
BR112014018843A2 (pt)	2017-07-04
SMT201900685T1 (it)	2020-01-14
KR20190006029A (ko)	2019-01-16
AU2017251848A1 (en)	2017-11-16
RU2014133653A (ru)	2016-03-20
JP7525579B2 (ja)	2024-07-30
IL268675A (en)	2019-10-31
AU2013204758A1 (en)	2013-08-15
DK2809150T3 (da)	2019-12-09
HRP20210987T1 (hr)	2021-09-17
CY1122419T1 (el)	2021-01-27
IL261280A (en)	2018-10-31
PL2809150T3 (pl)	2020-04-30
CA2863175A1 (en)	2013-08-08
RS62023B1 (sr)	2021-07-30
RU2770016C2 (ru)	2022-04-14
IL233827A0 (en)	2014-09-30
RS59699B1 (sr)	2020-01-31
BR112014018843B1 (pt)	2024-02-20
EP3597038A1 (en)	2020-01-22
US20170094955A1 (en)	2017-04-06
HUE055610T2 (hu)	2021-12-28
KR20140123983A (ko)	2014-10-23
AU2015246154A1 (en)	2015-11-12
JP2023014242A (ja)	2023-01-26
JP2021137030A (ja)	2021-09-16
CY1124361T1 (el)	2022-07-22
CN106117364B (zh)	2021-08-31
US20210368751A1 (en)	2021-12-02
ES2870703T3 (es)	2021-10-27
AU2015246154B2 (en)	2017-11-23
AU2017251848B2 (en)	2020-02-20
PT3597038T (pt)	2021-05-10
SG11201404477YA (en)	2014-08-28
JP2018075041A (ja)	2018-05-17
IL261280B (en)	2019-08-29
ME03611B (me)	2020-07-20
DK3597038T3 (da)	2021-06-28
WO2013116609A1 (en)	2013-08-08
RU2018122695A3 (sl)	2021-10-06
JP2023168590A (ja)	2023-11-24
HRP20192218T1 (hr)	2020-03-06

Publication	Publication Date	Title
IL268675B (en)	2020-11-30	Humanized rodents expressing heavy chains comprising vl complexes
IL292030B1 (en)	2023-03-01	Mice with restricted immunoglobulin heavy chain
LT2958937T (lt)	2018-11-26	Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą
GB201414168D0 (en)	2014-09-24	Hydrocarbon modelling
EP2801018A4 (en)	2015-11-25	ACTIVATION OF PERFORMANT CASCADING OPERATIONS
GB201223171D0 (en)	2013-02-06	Hydrocarbons
AU342768S (en)	2012-05-30	Latch for lunchbox