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SI2328616T1 - Sestavki in postopki za protitelesa proti komplementnemu proteinu C5 - Google Patents

Sestavki in postopki za protitelesa proti komplementnemu proteinu C5

Info

Publication number
SI2328616T1
SI2328616T1 SI200931219T SI200931219T SI2328616T1 SI 2328616 T1 SI2328616 T1 SI 2328616T1 SI 200931219 T SI200931219 T SI 200931219T SI 200931219 T SI200931219 T SI 200931219T SI 2328616 T1 SI2328616 T1 SI 2328616T1
Authority
SI
Slovenia
Prior art keywords
compositions
methods
antibodies against
complement protein
against complement
Prior art date
Application number
SI200931219T
Other languages
English (en)
Inventor
Beate Diefenbach-Streiber
Adina Eberth
Braydon Charles Guild
Yong-In Kim
Michael Roguska
Igor Splawski
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI2328616T1 publication Critical patent/SI2328616T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200931219T 2008-08-05 2009-08-03 Sestavki in postopki za protitelesa proti komplementnemu proteinu C5 SI2328616T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8635508P 2008-08-05 2008-08-05
EP09737379.9A EP2328616B1 (en) 2008-08-05 2009-08-03 Compositions and methods for antibodies against complement protein c5
PCT/EP2009/060052 WO2010015608A1 (en) 2008-08-05 2009-08-03 Compositions and methods for antibodies targeting complement protein c5

Publications (1)

Publication Number Publication Date
SI2328616T1 true SI2328616T1 (sl) 2015-08-31

Family

ID=41227252

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931219T SI2328616T1 (sl) 2008-08-05 2009-08-03 Sestavki in postopki za protitelesa proti komplementnemu proteinu C5

Country Status (38)

Country Link
US (5) US8241628B2 (sl)
EP (3) EP2328616B1 (sl)
JP (2) JP5815403B2 (sl)
KR (1) KR101463296B1 (sl)
CN (2) CN104177495B (sl)
AR (1) AR072897A1 (sl)
AU (1) AU2009279197B2 (sl)
BR (1) BRPI0916668B1 (sl)
CA (1) CA2732782C (sl)
CL (1) CL2011000233A1 (sl)
CO (1) CO6351750A2 (sl)
CR (2) CR20110035A (sl)
CU (1) CU23978B1 (sl)
DK (1) DK2328616T3 (sl)
EA (1) EA027575B1 (sl)
EC (1) ECSP11010805A (sl)
ES (2) ES2541142T3 (sl)
HK (1) HK1203156A1 (sl)
HN (1) HN2011000357A (sl)
HR (1) HRP20150799T1 (sl)
HU (1) HUE026179T2 (sl)
IL (1) IL210768B (sl)
JO (1) JO3118B1 (sl)
MA (1) MA32535B1 (sl)
MX (2) MX356218B (sl)
MY (1) MY159396A (sl)
NZ (2) NZ600622A (sl)
PE (1) PE20110225A1 (sl)
PL (1) PL2328616T3 (sl)
PT (1) PT2328616E (sl)
RS (1) RS54113B1 (sl)
SG (1) SG10201405377XA (sl)
SI (1) SI2328616T1 (sl)
SV (1) SV2011003834A (sl)
TW (2) TW201350130A (sl)
UA (1) UA105009C2 (sl)
WO (1) WO2010015608A1 (sl)
ZA (1) ZA201100375B (sl)

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SI2328616T1 (sl) * 2008-08-05 2015-08-31 Novartis Ag Sestavki in postopki za protitelesa proti komplementnemu proteinu C5
EP3330288A1 (en) * 2011-12-21 2018-06-06 Novartis AG Compositions and methods for antibodies targeting factor p
US20170073754A1 (en) * 2014-02-07 2017-03-16 Novartis Ag Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
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