SI2271626T1 - Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina - Google Patents
Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulinaInfo
- Publication number
- SI2271626T1 SI2271626T1 SI200931124T SI200931124T SI2271626T1 SI 2271626 T1 SI2271626 T1 SI 2271626T1 SI 200931124 T SI200931124 T SI 200931124T SI 200931124 T SI200931124 T SI 200931124T SI 2271626 T1 SI2271626 T1 SI 2271626T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetrahydrophenanthridinones
- tetrahydrocyclopentaquinolinones
- parp
- polymerization inhibitors
- tubulin polymerization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153432 | 2008-03-27 | ||
| PCT/EP2009/053598 WO2009118382A1 (en) | 2008-03-27 | 2009-03-26 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
| EP09725177.1A EP2271626B1 (en) | 2008-03-27 | 2009-03-26 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2271626T1 true SI2271626T1 (sl) | 2015-03-31 |
Family
ID=39665796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200931124T SI2271626T1 (sl) | 2008-03-27 | 2009-03-26 | Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8889866B2 (sl) |
| EP (1) | EP2271626B1 (sl) |
| JP (1) | JP5492183B2 (sl) |
| CN (1) | CN101981013B (sl) |
| AU (1) | AU2009228943B2 (sl) |
| BR (1) | BRPI0909017A2 (sl) |
| CA (1) | CA2716726C (sl) |
| DK (1) | DK2271626T3 (sl) |
| ES (1) | ES2529545T3 (sl) |
| HK (1) | HK1151796A1 (sl) |
| HR (1) | HRP20150139T1 (sl) |
| MX (1) | MX2010010406A (sl) |
| RU (1) | RU2490260C2 (sl) |
| SI (1) | SI2271626T1 (sl) |
| WO (1) | WO2009118382A1 (sl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2271626T1 (sl) * | 2008-03-27 | 2015-03-31 | Janssen Pharmaceutica, N.V. | Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina |
| ES2616238T3 (es) | 2010-10-06 | 2017-06-12 | Glaxosmithkline Llc, Corporation Service Company | Derivados de bencimidazol como inhibidores de PI3 quinasa |
| US9181266B2 (en) | 2011-07-13 | 2015-11-10 | Novartis Ag | 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| AP2014007400A0 (en) | 2011-07-13 | 2014-01-31 | Novartis Ag | 4-Piperidinyl compounds for use as tankyrase inhibitors |
| JP2014520860A (ja) * | 2011-07-13 | 2014-08-25 | ノバルティス アーゲー | タンキラーゼ阻害剤として使用するための４−オキソ−３，５，７，８−テトラヒドロ−４Ｈ−ピラノ｛４，３−ｄ｝ピルミニジニル化合物 |
| US9719970B2 (en) | 2012-11-30 | 2017-08-01 | Waters Technologies Corporation | Methods and apparatus for the analysis of vitamin D metabolites |
| CN103304494B (zh) * | 2013-06-20 | 2015-05-27 | 河北大学 | 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途 |
| ES2901152T3 (es) * | 2015-09-30 | 2022-03-21 | Hubei Bio Pharmaceutical Industrial Tech Institute Inc | Tipo de sal y tipo de cristal de un compuesto de 4H-pirazol[1,5-alfa]bencimidazol y método de preparación e intermedio del mismo |
| HUE066216T2 (hu) * | 2016-06-24 | 2024-07-28 | Univ California | Ftalazin származékok, mint a parp1, parp2 és/vagy tubulin inhibitorai, hasznosak a rák kezelésében |
| CN109761902B (zh) * | 2017-11-09 | 2022-06-10 | 四川大学 | 6-菲啶酮衍生物及其制备方法和用途 |
| CN111936143A (zh) * | 2018-04-05 | 2020-11-13 | 诺维嘉研究公司 | 用于治疗癌症的微管蛋白聚合抑制剂和聚(adp-核糖)聚合酶(parp)抑制剂的新型联用药品 |
| CA3098585A1 (en) * | 2018-04-30 | 2019-11-07 | Ribon Therapeutics Inc. | Pyridazinones as parp7 inhibitors |
| CN108707147A (zh) * | 2018-06-20 | 2018-10-26 | 桑文军 | 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
| CN114761086A (zh) | 2019-10-30 | 2022-07-15 | 里邦医疗公司 | 作为parp7抑制剂的哒嗪酮 |
| TW202409036A (zh) * | 2022-05-17 | 2024-03-01 | 美商858療法股份有限公司 | Parg抑制劑 |
| AU2023271807A1 (en) | 2022-05-17 | 2025-01-02 | 858 Therapeutics, Inc. | Inhibitors of parg |
| EP4506003A1 (en) | 2023-08-07 | 2025-02-12 | S.Yu Yunusov Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan | Halogen derivatives of (4´,5´- methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline for use in the treatment of leukemia |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1006423B (de) | 1952-01-18 | 1957-04-18 | Ciba Geigy | Verfahren zur Herstellung von Hydrazinophthalazinen |
| GB732581A (en) | 1952-01-18 | 1955-06-29 | Ciba Ltd | Manufacture of hydrazine compounds |
| US3274194A (en) | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
| GB1062357A (en) | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| US3919425A (en) | 1971-04-09 | 1975-11-11 | Miles Lab | Method of producing vasodilation using certain 3-substituted-quinazoline derivatives |
| BE792206A (sl) | 1971-12-02 | 1973-06-01 | Byk Gulden Lomberg Chem Fab | |
| US3879393A (en) | 1973-06-18 | 1975-04-22 | Miles Lab | Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones |
| FR2436781A1 (fr) | 1978-09-19 | 1980-04-18 | Berri Balzac | Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique |
| US4335127A (en) | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| JPS5976082A (ja) | 1982-10-23 | 1984-04-28 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| JPS60120872A (ja) | 1983-12-01 | 1985-06-28 | Kyowa Hakko Kogyo Co Ltd | 新規なヘテロ環状化合物及び強心剤 |
| US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| PL147465B1 (en) | 1984-03-26 | 1989-06-30 | Janssen Pharmaceutica Nv | Method of obtaining novel pyridazionoamine compounds |
| DK623586A (da) | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| US5231184A (en) | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
| US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| GB8827822D0 (en) | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| US5374637A (en) | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| EP0391462A1 (en) | 1989-04-05 | 1990-10-10 | Janssen Pharmaceutica N.V. | Synergistic compositions containing ketanserin |
| US5160727A (en) | 1990-02-13 | 1992-11-03 | Warner-Lambert Company | Tumor cell sensitization method using quinazolinedione derivatives |
| IE913473A1 (en) | 1990-10-15 | 1992-04-22 | Fujisawa Pharmaceutical Co | Quinazoline derivatives and their preparation |
| WO1993022309A1 (en) | 1992-04-23 | 1993-11-11 | Merrell Dow Pharmaceuticals Inc. | 4-imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy |
| TW294595B (sl) | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv | |
| CA2118117A1 (en) | 1993-02-18 | 1994-08-19 | Shigeki Fujiwara | Adenosine uptake inhibitor |
| US6270867B1 (en) * | 1993-06-24 | 2001-08-07 | Pechiney Plastic Packaging, Inc. | Structures of polymers made from single site catalysts |
| GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| TW445263B (en) | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
| JPH107572A (ja) | 1996-06-17 | 1998-01-13 | Sumitomo Pharmaceut Co Ltd | 腫瘍壊死因子産生阻害剤 |
| ES2314305T3 (es) | 1996-09-10 | 2009-03-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Aminoacidos modificados, medicamentos que contienen estos compuestos y procedimiento para su obtencion. |
| TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
| CA2291630A1 (en) | 1997-05-30 | 1998-12-03 | Tetsutaro Niizato | Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same |
| JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| US20030069231A1 (en) | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
| US6407116B1 (en) | 1997-09-16 | 2002-06-18 | Takeda Chemical Industries, Inc. | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs |
| US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| JP2000191659A (ja) | 1999-01-04 | 2000-07-11 | Sumitomo Pharmaceut Co Ltd | 腫瘍壊死因子産生阻害剤 |
| CZ20012716A3 (cs) | 1999-01-29 | 2001-11-14 | Abbott Laboratories | Diazabicyklické deriváty jako ligandy nikotinového receptoru acetylcholinu |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| IL155163A0 (en) | 2000-10-02 | 2003-10-31 | Janssen Pharmaceutica Nv | Metabotropic glutamate receptor antagonists |
| ITMI20002358A1 (it) | 2000-10-31 | 2002-05-01 | Flavio Moroni | Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi |
| AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| JP2002284699A (ja) | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | 視細胞変性疾患治療剤 |
| JPWO2002094790A1 (ja) | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| JP2005501848A (ja) | 2001-08-15 | 2005-01-20 | アイコス コーポレイション | ２ｈ−フタラジン−１−オンおよびその使用方法 |
| JP2005511581A (ja) | 2001-11-07 | 2005-04-28 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| AUPR975601A0 (en) | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| UA78548C2 (en) | 2002-03-29 | 2007-04-10 | Janssen Pharmaceutica Nv | Radiolabelled quinoline and quinolinone derivatives and use thereof as metabotropic ligands of glutamate receptor |
| US7119111B2 (en) | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
| AR043059A1 (es) | 2002-11-12 | 2005-07-13 | Bayer Pharmaceuticals Corp | Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos |
| US20050075364A1 (en) | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
| JP4864718B2 (ja) * | 2003-11-20 | 2012-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤としての６−アルケニルおよび６−フェニルアルキル置換２−キノリノンおよび２−キノキサリノン |
| EP1687277B1 (en) | 2003-11-20 | 2018-04-04 | Janssen Pharmaceutica NV | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| EA011211B1 (ru) | 2003-11-20 | 2009-02-27 | Янссен Фармацевтика Н. В. | 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы |
| AU2004294354B2 (en) | 2003-12-03 | 2009-02-19 | Ym Biosciences Australia Pty Ltd | Tubulin inhibitors |
| ES2551299T3 (es) | 2003-12-05 | 2015-11-17 | Janssen Pharmaceutica Nv | 2-Quinolinonas y 2-quinoxalinonas 6-sustituidas como inhibidores de poli(ADP-ribosa) polimerasa |
| KR101149031B1 (ko) | 2003-12-10 | 2012-05-29 | 얀센 파마슈티카 엔.브이. | 폴리(ａｄｐ-리보스)폴리머라제 저해제로서의 치환된6-사이클로헥실알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| CN1988907B (zh) | 2004-06-01 | 2010-12-22 | 弗吉尼亚大学专利基金会 | 癌瘤及血管生成的双重小分子抑制剂 |
| CA2568835C (en) | 2004-06-30 | 2014-05-27 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
| EP1771175B1 (en) | 2004-06-30 | 2015-12-23 | Janssen Pharmaceutica NV | Phthalazine derivatives as parp inhibitors |
| CN1980913B (zh) | 2004-06-30 | 2011-12-14 | 詹森药业有限公司 | 作为parp抑制剂的喹唑啉二酮衍生物 |
| AU2005327921A1 (en) * | 2004-11-01 | 2006-08-31 | University Of Southern California | Novel compounds for treatment of cancer and disorders associated with angiogenesis function |
| AU2006214164B2 (en) | 2005-02-17 | 2010-12-09 | Synta Pharmaceuticals Corp. | Isoxazole combretastin derivatives for the treatment of disorders |
| JP5075624B2 (ja) | 2005-04-28 | 2012-11-21 | 田辺三菱製薬株式会社 | シアノピリジン誘導体及びその医薬としての用途 |
| CA2620052A1 (en) | 2005-08-24 | 2007-03-01 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
| WO2007041076A2 (en) * | 2005-09-30 | 2007-04-12 | Janssen Pharmaceutica N.V. | 1,2,3,5-tetrahydro-cyclopental[c]quinolin-4-one derivatives as rxr agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes |
| JP5315060B2 (ja) | 2006-02-03 | 2013-10-16 | バイオノミックス リミテッド | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
| KR20080094729A (ko) | 2006-02-15 | 2008-10-23 | 아보트 러보러터리즈 | 강력한 ｐａｒｐ 억제제인 피라졸로퀴놀론 |
| US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| CA2678248C (en) * | 2007-03-08 | 2016-06-28 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp and tank inhibitors |
| AU2008269128B2 (en) | 2007-06-25 | 2012-08-02 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| SI2271626T1 (sl) * | 2008-03-27 | 2015-03-31 | Janssen Pharmaceutica, N.V. | Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina |
-
2009
- 2009-03-26 SI SI200931124T patent/SI2271626T1/sl unknown
- 2009-03-26 WO PCT/EP2009/053598 patent/WO2009118382A1/en active Application Filing
- 2009-03-26 MX MX2010010406A patent/MX2010010406A/es active IP Right Grant
- 2009-03-26 US US12/934,753 patent/US8889866B2/en active Active
- 2009-03-26 CN CN2009801123862A patent/CN101981013B/zh active Active
- 2009-03-26 RU RU2010143857/04A patent/RU2490260C2/ru active
- 2009-03-26 AU AU2009228943A patent/AU2009228943B2/en not_active Ceased
- 2009-03-26 ES ES09725177.1T patent/ES2529545T3/es active Active
- 2009-03-26 BR BRPI0909017-7A patent/BRPI0909017A2/pt not_active Application Discontinuation
- 2009-03-26 EP EP09725177.1A patent/EP2271626B1/en active Active
- 2009-03-26 DK DK09725177.1T patent/DK2271626T3/en active
- 2009-03-26 CA CA2716726A patent/CA2716726C/en active Active
- 2009-03-26 JP JP2011501234A patent/JP5492183B2/ja active Active
-
2011
- 2011-06-10 HK HK11105902.3A patent/HK1151796A1/xx not_active IP Right Cessation
-
2014
- 2014-10-14 US US14/513,814 patent/US9150540B2/en active Active
-
2015
- 2015-02-04 HR HRP20150139TT patent/HRP20150139T1/hr unknown
- 2015-08-18 US US14/829,493 patent/US9598396B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009228943B2 (en) | 2013-04-04 |
| US20110263622A1 (en) | 2011-10-27 |
| CA2716726C (en) | 2017-01-24 |
| BRPI0909017A2 (pt) | 2020-11-10 |
| JP5492183B2 (ja) | 2014-05-14 |
| AU2009228943A1 (en) | 2009-10-01 |
| US8889866B2 (en) | 2014-11-18 |
| CN101981013A (zh) | 2011-02-23 |
| US20150038521A1 (en) | 2015-02-05 |
| JP2011515450A (ja) | 2011-05-19 |
| RU2490260C2 (ru) | 2013-08-20 |
| CN101981013B (zh) | 2013-05-29 |
| HRP20150139T1 (hr) | 2015-05-22 |
| EP2271626B1 (en) | 2014-11-26 |
| WO2009118382A1 (en) | 2009-10-01 |
| DK2271626T3 (en) | 2015-02-23 |
| RU2010143857A (ru) | 2012-05-10 |
| US9598396B2 (en) | 2017-03-21 |
| US9150540B2 (en) | 2015-10-06 |
| EP2271626A1 (en) | 2011-01-12 |
| MX2010010406A (es) | 2010-10-25 |
| US20150353526A1 (en) | 2015-12-10 |
| HK1151796A1 (en) | 2012-02-10 |
| CA2716726A1 (en) | 2009-10-01 |
| ES2529545T3 (es) | 2015-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1151796A1 (en) | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors | |
| IL211549A0 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
| HK1161583A1 (en) | Deacetylase inhibitors and uses thereof | |
| ZA201404552B (en) | Benzoxepin pi3k inhibitor compound and use thereof | |
| PH12012500491A1 (en) | P13 kinase inhibitors and uses thereof | |
| ZA201008041B (en) | Combinations comprising methotrexate and dhodh inhibitors | |
| HK1160119A1 (en) | Kinase inhibitors and methods of use | |
| EP2252293A4 (en) | KINASEHEMMER AND USE PROCESS | |
| EP2200977A4 (en) | F1F0-ATPASE INHIBITOR AND ASSOCIATED METHODS | |
| IL213625A0 (en) | Combinations comprising methotrexate and dhodh inhibitors | |
| IL212755A0 (en) | Pyrazinopyrazines and derivatives as kinase inhibitors | |
| IL208483A (en) | 2 limk inhibitors and preparations containing them | |
| DK2358710T3 (da) | AKT- og P70-S6-kinaseinhibitorer | |
| IL223202A0 (en) | Substituted isoquinolines and their use as tubulin polymerization inhibitors | |
| HRP20171390T1 (hr) | Inhibitor tolerancije na analgetike | |
| GB0918601D0 (en) | Decahydro-1H-Indenoquinolinone and decahydro-3H-cyclopenaphenanthridinone CYP17 inhibitors | |
| ZA201102837B (en) | Phosphodiestarase inhibitors | |
| IL215552A0 (en) | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3- carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | |
| IL214333A0 (en) | Carbamoylphosphonates as inhibitors and uses thereof | |
| TWI366394B (en) | Synchronnization devices and methods | |
| GB201019387D0 (en) | Inhibitors | |
| GB0805693D0 (en) | Combinations of P13-delta and P13-gamma kinase inhibitor compounds |