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SI1461360T1 - Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours - Google Patents

Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours

Info

Publication number
SI1461360T1
SI1461360T1 SI200331895T SI200331895T SI1461360T1 SI 1461360 T1 SI1461360 T1 SI 1461360T1 SI 200331895 T SI200331895 T SI 200331895T SI 200331895 T SI200331895 T SI 200331895T SI 1461360 T1 SI1461360 T1 SI 1461360T1
Authority
SI
Slovenia
Prior art keywords
tumours
fibronectin
treatment
domain
conjugates
Prior art date
Application number
SI200331895T
Other languages
Slovenian (sl)
Inventor
Christoph-Stephan Hilger
Dietmar Berndorff
Ludger Dinkelborg
Dieter Moosmayer
Giovanni Neri
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Priority claimed from PCT/EP2003/000009 external-priority patent/WO2003055917A2/en
Publication of SI1461360T1 publication Critical patent/SI1461360T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to methods for diagnosis and treatment of tumours, using peptides for binding radionuclides. The peptides comprise an antigen- binding site for the extra domain B (ED-B) of fibronectin.
SI200331895T 2002-01-03 2003-01-02 Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours SI1461360T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02000315 2002-01-03
US35870202P 2002-02-25 2002-02-25
PCT/EP2003/000009 WO2003055917A2 (en) 2002-01-03 2003-01-02 Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours
EP03726977A EP1461360B1 (en) 2002-01-03 2003-01-02 Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours

Publications (1)

Publication Number Publication Date
SI1461360T1 true SI1461360T1 (en) 2010-12-31

Family

ID=35976951

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331895T SI1461360T1 (en) 2002-01-03 2003-01-02 Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours

Country Status (8)

Country Link
KR (2) KR100998803B1 (en)
AT (1) ATE478095T1 (en)
DE (1) DE60333820D1 (en)
DK (1) DK1461360T3 (en)
ES (1) ES2346750T3 (en)
PT (1) PT1461360E (en)
SI (1) SI1461360T1 (en)
ZA (1) ZA200406162B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3691771B1 (en) 2017-10-02 2023-08-16 Battelle Energy Alliance, LLC Methods and systems for the electrochemical reduction of carbon dioxide using switchable polarity materials

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI259837B (en) * 1998-05-11 2006-08-11 Eidgenossische Tech Hochscule Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis

Also Published As

Publication number Publication date
ZA200406162B (en) 2005-09-27
KR20100077052A (en) 2010-07-06
ATE478095T1 (en) 2010-09-15
KR100998803B1 (en) 2010-12-06
PT1461360E (en) 2010-11-23
DE60333820D1 (en) 2010-09-30
ES2346750T3 (en) 2010-10-20
KR20040073540A (en) 2004-08-19
DK1461360T3 (en) 2010-11-15

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