SI1284978T2 - Postopek äśiĺ äśenja soli klavulanske kisline - Google Patents
Postopek äśiĺ äśenja soli klavulanske kislineInfo
- Publication number
- SI1284978T2 SI1284978T2 SI200130207T SI200130207T SI1284978T2 SI 1284978 T2 SI1284978 T2 SI 1284978T2 SI 200130207 T SI200130207 T SI 200130207T SI 200130207 T SI200130207 T SI 200130207T SI 1284978 T2 SI1284978 T2 SI 1284978T2
- Authority
- SI
- Slovenia
- Prior art keywords
- salt
- clavulanic acid
- purification
- exposed
- typically
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 2
- 229960003324 clavulanic acid Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title 1
- -1 amine salt Chemical class 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0011521A GB0011521D0 (en) | 2000-05-13 | 2000-05-13 | Process |
GB0011519A GB0011519D0 (en) | 2000-05-13 | 2000-05-13 | Process |
EP01925753A EP1284978B2 (en) | 2000-05-13 | 2001-05-09 | Process for the purification of a salt of clavulanic acid |
PCT/GB2001/002025 WO2001087891A1 (en) | 2000-05-13 | 2001-05-09 | Process for the purification of a salt of clavulanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
SI1284978T1 SI1284978T1 (sl) | 2005-02-28 |
SI1284978T2 true SI1284978T2 (sl) | 2008-12-31 |
Family
ID=26244256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200130207T SI1284978T2 (sl) | 2000-05-13 | 2001-05-09 | Postopek äśiĺ äśenja soli klavulanske kisline |
Country Status (24)
Country | Link |
---|---|
US (1) | US7767823B2 (sl) |
EP (1) | EP1284978B2 (sl) |
JP (1) | JP4954421B2 (sl) |
KR (1) | KR100827898B1 (sl) |
CN (1) | CN1222528C (sl) |
AT (1) | ATE273982T1 (sl) |
AU (1) | AU776184B2 (sl) |
BR (1) | BRPI0110774B8 (sl) |
CA (1) | CA2408853C (sl) |
CZ (1) | CZ304775B6 (sl) |
DE (1) | DE60105016T3 (sl) |
DK (1) | DK1284978T4 (sl) |
ES (1) | ES2225524T5 (sl) |
HK (1) | HK1055111A1 (sl) |
HU (1) | HU228593B1 (sl) |
IL (2) | IL152643A0 (sl) |
MX (1) | MXPA02011192A (sl) |
NO (1) | NO328528B1 (sl) |
NZ (1) | NZ522414A (sl) |
PL (1) | PL206316B1 (sl) |
PT (1) | PT1284978E (sl) |
SI (1) | SI1284978T2 (sl) |
WO (1) | WO2001087891A1 (sl) |
ZA (1) | ZA200209141B (sl) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2225524T5 (es) | 2000-05-13 | 2009-03-01 | Smithkline Beecham Plc | Procedimiento para la purificacion de una sal de acido clavulanico. |
CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
AU2017295866A1 (en) | 2016-07-14 | 2019-01-17 | Achaogen, Inc. | Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections |
CN109305978A (zh) * | 2017-07-26 | 2019-02-05 | 山东睿鹰先锋制药有限公司 | 一种制备克拉维酸盐的新方法 |
CN109535184B (zh) * | 2017-09-21 | 2020-11-20 | 联邦制药(内蒙古)有限公司 | 一种克拉维酸叔辛胺制备克拉维酸钾的方法 |
CN108558909B (zh) * | 2018-05-17 | 2019-09-17 | 国药集团威奇达药业有限公司 | 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法 |
EP3994154A1 (en) | 2019-07-05 | 2022-05-11 | GlaxoSmithKline Intellectual Property (No.2) Limited | Streptomyces clavuligerus |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1299883A (fr) | 1961-09-06 | 1962-07-27 | Pfizer & Co C | Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses |
GB1508977A (en) | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB2003863B (en) | 1977-09-01 | 1982-03-31 | Beecham Group Ltd | Chemical process |
DE3063683D1 (en) | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
US4449182A (en) * | 1981-10-05 | 1984-05-15 | Digital Equipment Corporation | Interface between a pair of processors, such as host and peripheral-controlling processors in data processing systems |
MX7417E (es) | 1984-10-27 | 1988-10-14 | Antibioticos Sa | Metodo para la preparacion de acido clavulanico y sus derivados |
AT399154B (de) | 1987-01-29 | 1995-03-27 | Beecham Group Plc | Neue kristalline form von kaliumclavulanat |
GB2204944B (en) | 1987-05-18 | 1991-10-02 | Frederick John Anderson | Rechargeable light |
DE3729338A1 (de) | 1987-09-02 | 1989-03-23 | Biotechnolog Forschung Gmbh | Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion |
US5318896A (en) | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
RO116648B1 (ro) | 1991-10-15 | 2001-04-30 | Merck & Co Inc | Bioprocedeu pentru prepararea acidului 7-amino-3-deacetil-cefalosporanic si a acidului 7-aminocefalosporanic |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9300296B (sl) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
GB9305565D0 (en) | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
US5821364A (en) * | 1993-03-26 | 1998-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
KR100336174B1 (ko) | 1993-07-30 | 2002-11-01 | 디에스엠 기스트 베.파우. | 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법 |
AT400846B (de) | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
SI9500074A (en) | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
KR100200242B1 (ko) | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
WO1997005143A1 (fr) * | 1995-07-25 | 1997-02-13 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveaux composes a base de metaux de transition du groupe 4 |
GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
JP2001503763A (ja) * | 1996-11-11 | 2001-03-21 | ギスト ブロカデス ベスローテン フェンノートシャップ | クラバラン酸の塩及びエステルの調製法 |
AT404728B (de) * | 1996-11-27 | 1999-02-25 | Biochemie Gmbh | Verfahren zur herstellung von clavulansäure-aminsalzen |
WO1998042858A1 (en) * | 1997-03-24 | 1998-10-01 | Cipan-Companhia Industrial Produtora De Antibióticos, S.A. | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
US6319684B1 (en) | 1997-04-22 | 2001-11-20 | Dms N.V. | Process for the fermentative production of cephalosporin |
AU5411099A (en) * | 1998-07-16 | 2000-02-07 | Dsm N.V. | Improved process for the preparation of salts and esters of clavulanic acid |
ES2225524T5 (es) | 2000-05-13 | 2009-03-01 | Smithkline Beecham Plc | Procedimiento para la purificacion de una sal de acido clavulanico. |
-
2001
- 2001-05-09 ES ES01925753T patent/ES2225524T5/es not_active Expired - Lifetime
- 2001-05-09 HU HU0300869A patent/HU228593B1/hu unknown
- 2001-05-09 JP JP2001584285A patent/JP4954421B2/ja not_active Expired - Lifetime
- 2001-05-09 CA CA2408853A patent/CA2408853C/en not_active Expired - Lifetime
- 2001-05-09 NZ NZ522414A patent/NZ522414A/en not_active IP Right Cessation
- 2001-05-09 MX MXPA02011192A patent/MXPA02011192A/es active IP Right Grant
- 2001-05-09 EP EP01925753A patent/EP1284978B2/en not_active Expired - Lifetime
- 2001-05-09 CZ CZ2002-3723A patent/CZ304775B6/cs not_active IP Right Cessation
- 2001-05-09 CN CNB018094236A patent/CN1222528C/zh not_active Expired - Lifetime
- 2001-05-09 BR BRPI0110774A patent/BRPI0110774B8/pt not_active IP Right Cessation
- 2001-05-09 PT PT01925753T patent/PT1284978E/pt unknown
- 2001-05-09 WO PCT/GB2001/002025 patent/WO2001087891A1/en active Application Filing
- 2001-05-09 AT AT01925753T patent/ATE273982T1/de active
- 2001-05-09 KR KR1020027015169A patent/KR100827898B1/ko not_active Expired - Lifetime
- 2001-05-09 DE DE60105016T patent/DE60105016T3/de not_active Expired - Lifetime
- 2001-05-09 US US10/275,852 patent/US7767823B2/en active Active
- 2001-05-09 DK DK01925753T patent/DK1284978T4/da active
- 2001-05-09 IL IL15264301A patent/IL152643A0/xx unknown
- 2001-05-09 SI SI200130207T patent/SI1284978T2/sl unknown
- 2001-05-09 AU AU52432/01A patent/AU776184B2/en not_active Expired
- 2001-05-09 PL PL358368A patent/PL206316B1/pl unknown
-
2002
- 2002-11-04 IL IL152643A patent/IL152643A/en active IP Right Grant
- 2002-11-11 ZA ZA2002/09141A patent/ZA200209141B/en unknown
- 2002-11-12 NO NO20025422A patent/NO328528B1/no not_active IP Right Cessation
-
2003
- 2003-08-21 HK HK03106008A patent/HK1055111A1/xx not_active IP Right Cessation
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