SI0975347T1 - Sinergistična kombinacija PDE inhibitorjev in agonistov adenilat ciklaze oziroma agonistov gvanil ciklize - Google Patents
Sinergistična kombinacija PDE inhibitorjev in agonistov adenilat ciklaze oziroma agonistov gvanil ciklizeInfo
- Publication number
- SI0975347T1 SI0975347T1 SI9830909T SI9830909T SI0975347T1 SI 0975347 T1 SI0975347 T1 SI 0975347T1 SI 9830909 T SI9830909 T SI 9830909T SI 9830909 T SI9830909 T SI 9830909T SI 0975347 T1 SI0975347 T1 SI 0975347T1
- Authority
- SI
- Slovenia
- Prior art keywords
- agonists
- adenylate cyclase
- cyclyse
- guanyl
- synergistic combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19708049 | 1997-02-28 | ||
PCT/EP1998/001047 WO1998037894A1 (de) | 1997-02-28 | 1998-02-24 | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
EP98913584A EP0975347B1 (de) | 1997-02-28 | 1998-02-24 | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0975347T1 true SI0975347T1 (sl) | 2008-08-31 |
Family
ID=7821764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9830909T SI0975347T1 (sl) | 1997-02-28 | 1998-02-24 | Sinergistična kombinacija PDE inhibitorjev in agonistov adenilat ciklaze oziroma agonistov gvanil ciklize |
Country Status (12)
Country | Link |
---|---|
US (1) | US6333354B1 (sl) |
EP (1) | EP0975347B1 (sl) |
JP (2) | JP2001513097A (sl) |
AT (1) | ATE386531T1 (sl) |
AU (1) | AU6823098A (sl) |
CY (1) | CY2607B2 (sl) |
DE (1) | DE59814173D1 (sl) |
DK (1) | DK0975347T3 (sl) |
ES (1) | ES2302350T3 (sl) |
PT (1) | PT975347E (sl) |
SI (1) | SI0975347T1 (sl) |
WO (1) | WO1998037894A1 (sl) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999014239A1 (de) * | 1997-09-12 | 1999-03-25 | Wolf Georg Forssmann | Zusammensetzung zur therapie von diabetes mellitus und fettsucht |
IL141335A0 (en) * | 1998-08-26 | 2002-03-10 | Smithkline Beecham Corp | Therapies for treating pulmonary diseases |
IL137429A0 (en) * | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
AU779991B2 (en) * | 1999-08-10 | 2005-02-24 | Board Of Regents, The University Of Texas System | Method for increasing optic nerve, choroidal and retinal blood flow to facilitate the preservation of sight |
HRP20020158B1 (en) * | 1999-08-21 | 2007-08-31 | Altana Pharma Ag | Action of synergistic combination |
TWI224966B (en) * | 1999-11-02 | 2004-12-11 | Pfizer | Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient |
HUP0301240A3 (en) | 2000-06-05 | 2004-03-29 | Altana Pharma B V | Pyridazine compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors and pharmaceutical compositions containing them |
AU2000270300A1 (en) * | 2000-09-13 | 2002-03-26 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
DE10061137B4 (de) * | 2000-12-07 | 2016-10-06 | Takeda Gmbh | Neue pharmazeutische Zubereitung |
WO2003032964A2 (en) * | 2001-10-17 | 2003-04-24 | University Of Wales College Of Medecine | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
AU2002361417A1 (en) * | 2001-12-17 | 2003-06-30 | Altana Pharma Ag | Use of selective PDE5 inhibitors for treating partial and global respiratory failure |
US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
NZ536050A (en) * | 2002-04-12 | 2007-11-30 | Celgene Corp | Methods of identifying modulators of angiogenesis using stem cells with the proviso the stems cells are not totipotent |
US20050118715A1 (en) * | 2002-04-12 | 2005-06-02 | Hariri Robert J. | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
AU2003232148A1 (en) * | 2002-05-16 | 2003-12-02 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
MXPA04011404A (es) * | 2002-05-16 | 2005-02-14 | Pharmacia Corp | Procedimientos para el tratamiento de enfermedades y afecciones respiratorias usando un inhibidor selectivo de inos. |
CN1681510A (zh) * | 2002-09-16 | 2005-10-12 | 爱尔康制造有限公司 | Pde ⅳ抑制剂治疗血管生成的用途 |
EA009935B1 (ru) * | 2002-11-27 | 2008-04-28 | Никомед Гмбх | Новая синергетическая комбинация, включающая рофлумиласт и формотерол |
SI1567140T1 (sl) * | 2002-11-27 | 2008-12-31 | Nycomed Gmbh | Sinergistična kombinacija, ki obsega roflumilastin (R;R)-formoterol |
US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
RU2543350C2 (ru) | 2003-01-28 | 2015-02-27 | Айронвуд Фармасьютикалз, Инк. | Способы и композиции для лечения желудочно-кишечных расстройств |
EP1620083A2 (en) * | 2003-04-18 | 2006-02-01 | Pharmacia & Upjohn Company LLC | Combination therapies |
ES2433661T3 (es) | 2005-04-19 | 2013-12-12 | Takeda Gmbh | Roflumilast para el tratamiento de hipertensión pulmonar |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
AU2006282896A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
CA2662491A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP2011515469A (ja) * | 2008-03-24 | 2011-05-19 | セルジーン コーポレイション | シクロプロピル−n−{2−[(1s)−1−(3−エトキシ−4−メトキシフェニル)−2−(メチルスルホニル)エチル]−3−オキソイソインドリン−4−イル}カルボキサミドを使用した乾癬又は乾癬性関節炎の治療 |
WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
CA2748607A1 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
WO2010098839A1 (en) * | 2009-02-25 | 2010-09-02 | Intra-Cellular Therapies, Inc. | Pde 1 inhibitors for ophthalmic disorders |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 nhe-매개된 역수송 저해를 위한 화합물 및 방법 |
EP3988120A1 (en) | 2013-04-12 | 2022-04-27 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
WO2015200177A1 (en) | 2014-06-23 | 2015-12-30 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
CN106333953A (zh) * | 2015-07-08 | 2017-01-18 | 珠海津之敦医药科技有限公司 | 尤克那非新用途 |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
CN110267944B (zh) | 2017-01-09 | 2024-03-08 | 阿德利克斯股份有限公司 | 可用于治疗胃肠道病症的化合物 |
EP3937969A1 (en) | 2019-03-14 | 2022-01-19 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPH01153634A (ja) * | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 吸入剤 |
IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
US5602110A (en) * | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
-
1998
- 1998-02-24 PT PT98913584T patent/PT975347E/pt unknown
- 1998-02-24 DE DE59814173T patent/DE59814173D1/de not_active Expired - Lifetime
- 1998-02-24 EP EP98913584A patent/EP0975347B1/de not_active Expired - Lifetime
- 1998-02-24 ES ES98913584T patent/ES2302350T3/es not_active Expired - Lifetime
- 1998-02-24 SI SI9830909T patent/SI0975347T1/sl unknown
- 1998-02-24 US US09/367,850 patent/US6333354B1/en not_active Expired - Lifetime
- 1998-02-24 DK DK98913584T patent/DK0975347T3/da active
- 1998-02-24 WO PCT/EP1998/001047 patent/WO1998037894A1/de active IP Right Grant
- 1998-02-24 AT AT98913584T patent/ATE386531T1/de active
- 1998-02-24 AU AU68230/98A patent/AU6823098A/en not_active Abandoned
- 1998-02-24 JP JP53729498A patent/JP2001513097A/ja not_active Withdrawn
-
2008
- 2008-11-13 JP JP2008290751A patent/JP2009073853A/ja active Pending
-
2009
- 2009-06-11 CY CY0900008A patent/CY2607B2/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ATE386531T1 (de) | 2008-03-15 |
WO1998037894A1 (de) | 1998-09-03 |
EP0975347B1 (de) | 2008-02-20 |
DE59814173D1 (de) | 2008-04-03 |
AU6823098A (en) | 1998-09-18 |
JP2009073853A (ja) | 2009-04-09 |
EP0975347A1 (de) | 2000-02-02 |
PT975347E (pt) | 2008-05-23 |
ES2302350T3 (es) | 2008-07-01 |
JP2001513097A (ja) | 2001-08-28 |
US6333354B1 (en) | 2001-12-25 |
CY2607B2 (en) | 2010-04-28 |
DK0975347T3 (da) | 2008-06-16 |
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