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SI0804465T1 - Novel elastase inhibitors - Google Patents

Novel elastase inhibitors

Info

Publication number
SI0804465T1
SI0804465T1 SI9530682T SI9530682T SI0804465T1 SI 0804465 T1 SI0804465 T1 SI 0804465T1 SI 9530682 T SI9530682 T SI 9530682T SI 9530682 T SI9530682 T SI 9530682T SI 0804465 T1 SI0804465 T1 SI 0804465T1
Authority
SI
Slovenia
Prior art keywords
inhibitors
elastase inhibitors
elastase
compounds
novel elastase
Prior art date
Application number
SI9530682T
Other languages
English (en)
Slovenian (sl)
Inventor
William A. Metz Jr.
Steven L. Gallion
Joseph P. Burkhart
Michael R. Angelastro
Norton P. Peet
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SI0804465T1 publication Critical patent/SI0804465T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9530682T 1994-06-02 1995-05-05 Novel elastase inhibitors SI0804465T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25279994A 1994-06-02 1994-06-02
EP95918993A EP0804465B1 (fr) 1994-06-02 1995-05-05 Nouveaux inhibitieurs d'elastase
PCT/US1995/005618 WO1995033763A1 (fr) 1994-06-02 1995-05-05 Nouveaux inhibitieurs d'elastase

Publications (1)

Publication Number Publication Date
SI0804465T1 true SI0804465T1 (en) 2003-12-31

Family

ID=22957608

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530682T SI0804465T1 (en) 1994-06-02 1995-05-05 Novel elastase inhibitors

Country Status (20)

Country Link
EP (1) EP0804465B1 (fr)
JP (1) JP3623799B2 (fr)
KR (1) KR100347285B1 (fr)
CN (1) CN1149877A (fr)
AT (1) ATE246708T1 (fr)
AU (1) AU689589B2 (fr)
CA (1) CA2189527C (fr)
DE (1) DE69531459T2 (fr)
DK (1) DK0804465T3 (fr)
ES (1) ES2199992T3 (fr)
FI (1) FI964781L (fr)
HU (1) HU221197B1 (fr)
IL (1) IL113940A (fr)
NO (1) NO965097L (fr)
NZ (1) NZ285565A (fr)
PT (1) PT804465E (fr)
SI (1) SI0804465T1 (fr)
TW (1) TW403762B (fr)
WO (1) WO1995033763A1 (fr)
ZA (1) ZA954430B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
ATE186305T1 (de) * 1994-06-02 1999-11-15 Merrell Pharma Inc Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6767991B1 (en) 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
KR101115294B1 (ko) 2003-05-21 2012-04-12 베링거 인겔하임 인터내셔날 게엠베하 Ｃ형 간염 억제제 화합물
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
ES2366478T3 (es) 2004-07-20 2011-10-20 Boehringer Ingelheim International Gmbh Análogos peptídicos inhibidores de la hepatitis c.
BRPI0712021A2 (pt) 2006-05-23 2012-01-03 Irm Llc composto e composiÇÕes como inibidores da protease ativadora de canal
AU2008214217B2 (en) 2007-02-09 2011-10-13 Irm Llc Compounds and compositions as channel activating protease inhibitors
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
WO2021209740A1 (fr) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Procédés impliquant l'alvélestat, un inhibiteur de l'élastase des neutrophiles, pour le traitement d'une infection à coronavirus
WO2023067103A1 (fr) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Inhibiteurs de l'élastase neutrophile utilisés dans le traitement de la fibrose

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0204571B1 (fr) * 1985-06-07 1992-01-22 Ici Americas Inc. Dérivés difluoro choisis
CA2021660A1 (fr) * 1989-07-26 1991-01-27 Philippe Bey Inhibiteurs de la peptidose
JPH06504547A (ja) * 1990-12-28 1994-05-26 ジョージア・テック・リサーチ・コーポレーション ペプチドケトアミド、ケト酸およびケトエステル
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.

Also Published As

Publication number Publication date
JP3623799B2 (ja) 2005-02-23
NO965097D0 (no) 1996-11-29
AU689589B2 (en) 1998-04-02
CA2189527A1 (fr) 1995-12-14
KR100347285B1 (ko) 2003-01-15
FI964781A7 (fi) 1997-01-29
EP0804465B1 (fr) 2003-08-06
PT804465E (pt) 2003-12-31
CA2189527C (fr) 2000-12-19
JPH10500992A (ja) 1998-01-27
HU221197B1 (en) 2002-08-28
HU9603312D0 (en) 1997-01-28
FI964781A0 (fi) 1996-11-29
ES2199992T3 (es) 2004-03-01
HUT76926A (hu) 1998-01-28
DK0804465T3 (da) 2003-11-24
ZA954430B (en) 1996-02-13
DE69531459D1 (de) 2003-09-11
IL113940A (en) 1999-12-31
CN1149877A (zh) 1997-05-14
DE69531459T2 (de) 2004-06-24
EP0804465A1 (fr) 1997-11-05
ATE246708T1 (de) 2003-08-15
AU2470995A (en) 1996-01-04
WO1995033763A1 (fr) 1995-12-14
NO965097L (no) 1997-01-31
IL113940A0 (en) 1995-08-31
TW403762B (en) 2000-09-01
NZ285565A (en) 1998-08-26
MX9606030A (es) 1998-05-31
FI964781L (fi) 1997-01-29

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