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SG87776A1 - Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals - Google Patents

Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals

Info

Publication number
SG87776A1
SG87776A1 SG9804225A SG1998004225A SG87776A1 SG 87776 A1 SG87776 A1 SG 87776A1 SG 9804225 A SG9804225 A SG 9804225A SG 1998004225 A SG1998004225 A SG 1998004225A SG 87776 A1 SG87776 A1 SG 87776A1
Authority
SG
Singapore
Prior art keywords
carboxamides
pharmaceuticals
preparation
substituted isoquinoline
isoquinoline
Prior art date
Application number
SG9804225A
Other languages
English (en)
Inventor
Weidmann Klaus
Baringhaus Karl-Heinz
Tschank Georg
Werner Ulrich
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of SG87776A1 publication Critical patent/SG87776A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SG9804225A 1997-10-20 1998-10-20 Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals SG87776A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19746287A DE19746287A1 (de) 1997-10-20 1997-10-20 Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
SG87776A1 true SG87776A1 (en) 2002-04-16

Family

ID=7846053

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9804225A SG87776A1 (en) 1997-10-20 1998-10-20 Substituted isoquinoline-3-carboxamides, their preparation and their use as pharmaceuticals

Country Status (25)

Country Link
US (1) US6093730A (id)
EP (2) EP0911340B1 (id)
JP (2) JP3782591B2 (id)
KR (1) KR100618922B1 (id)
CN (1) CN1117079C (id)
AR (1) AR013696A1 (id)
AT (2) ATE299148T1 (id)
AU (1) AU755714B2 (id)
BR (1) BR9804504B1 (id)
CA (2) CA2250664A1 (id)
CZ (1) CZ337298A3 (id)
DE (3) DE19746287A1 (id)
DK (2) DK1538160T3 (id)
ES (2) ES2328156T3 (id)
HK (1) HK1019605A1 (id)
HU (1) HUP9802422A3 (id)
ID (1) ID21115A (id)
IL (1) IL126638A0 (id)
NO (1) NO312365B1 (id)
NZ (1) NZ332363A (id)
PL (1) PL192354B1 (id)
PT (1) PT911340E (id)
SG (1) SG87776A1 (id)
TR (1) TR199802106A3 (id)
ZA (1) ZA989505B (id)

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US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
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US20060251638A1 (en) * 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
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US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
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KR100949975B1 (ko) * 2006-03-30 2010-03-29 엘지전자 주식회사 비디오 신호를 디코딩/인코딩하기 위한 방법 및 장치
EP3124489B1 (en) 2006-04-04 2020-07-15 Fibrogen, Inc. Thiazolo-pyridine compounds as hif modulators
PL2044005T3 (pl) 2006-06-26 2011-04-29 Akebia Therapeutics Inc Inhibitory hydroksylazy prolilowej oraz metody ich wykorzystania
US7635715B2 (en) 2006-12-18 2009-12-22 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
CA2672652C (en) 2006-12-18 2012-04-17 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048894B2 (en) 2007-04-18 2011-11-01 Amgen Inc. Quinolones and azaquinolones that inhibit prolyl hydroxylase
AU2008241577B2 (en) 2007-04-18 2011-04-07 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
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US8097620B2 (en) 2007-05-04 2012-01-17 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
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PT2294066E (pt) 2008-04-28 2014-11-21 Janssen Pharmaceutica Nv Benzoimidazoles como inibidores da prolil-hidroxilase
CN102272117B (zh) 2008-11-14 2015-06-17 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
KR101706803B1 (ko) * 2009-07-17 2017-02-14 니뽄 다바코 산교 가부시키가이샤 트리아졸로피리딘 화합물, 그리고 그 프롤릴 수산화효소 저해제 및 에리트로포이에틴 생성 유도제로서의 작용
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EP0650961A1 (de) * 1993-11-02 1995-05-03 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
EP0661269A1 (de) * 1993-12-30 1995-07-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
EP0765871A1 (de) * 1995-09-28 1997-04-02 Hoechst Aktiengesellschaft Substituierte Chinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Prolyl-4-hydroylase Inhibitoren

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EP0650961A1 (de) * 1993-11-02 1995-05-03 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
EP0661269A1 (de) * 1993-12-30 1995-07-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
EP0765871A1 (de) * 1995-09-28 1997-04-02 Hoechst Aktiengesellschaft Substituierte Chinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Prolyl-4-hydroylase Inhibitoren

Also Published As

Publication number Publication date
CA2251647C (en) 2011-08-30
NO984877L (no) 1999-04-21
IL126638A0 (en) 1999-08-17
BR9804504B1 (pt) 2009-01-13
EP0911340B1 (de) 2005-07-06
KR19990037182A (ko) 1999-05-25
AU755714B2 (en) 2002-12-19
AR013696A1 (es) 2001-01-10
ATE432940T1 (de) 2009-06-15
CN1117079C (zh) 2003-08-06
NZ332363A (en) 2000-04-28
JP3782591B2 (ja) 2006-06-07
NO984877D0 (no) 1998-10-19
HUP9802422A2 (hu) 1999-08-30
PL192354B1 (pl) 2006-10-31
ES2245471T3 (es) 2006-01-01
JPH11302257A (ja) 1999-11-02
BR9804504A (pt) 2001-05-22
EP1538160A1 (de) 2005-06-08
AU8941398A (en) 1999-05-06
JP2006056894A (ja) 2006-03-02
CA2251647A1 (en) 1999-04-20
DE19746287A1 (de) 1999-04-22
HK1019605A1 (en) 2000-02-18
PL329274A1 (en) 1999-04-26
JP4691419B2 (ja) 2011-06-01
TR199802106A2 (xx) 1999-05-21
HUP9802422A3 (en) 2002-02-28
ES2328156T3 (es) 2009-11-10
PT911340E (pt) 2005-09-30
ATE299148T1 (de) 2005-07-15
HU9802422D0 (en) 1998-12-28
CN1218802A (zh) 1999-06-09
DE59812907D1 (de) 2005-08-11
CA2250664A1 (en) 1999-04-20
EP1538160B1 (de) 2009-06-03
TR199802106A3 (tr) 1999-05-21
KR100618922B1 (ko) 2007-04-25
EP0911340A2 (de) 1999-04-28
DK1538160T3 (da) 2009-10-05
DE59814365D1 (de) 2009-07-16
CZ337298A3 (cs) 1999-05-12
US6093730A (en) 2000-07-25
EP0911340A3 (de) 1999-07-07
DK0911340T3 (da) 2005-11-07
ZA989505B (en) 1999-04-20
NO312365B1 (no) 2002-04-29
ID21115A (id) 1999-04-22

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