SG194896A1 - Compositions, methods & systems for respiratory delivery of two or more active agents - Google Patents

Compositions, methods & systems for respiratory delivery of two or more active agents Download PDF

Info

Publication number: SG194896A1
Authority: SG; Singapore
Prior art keywords: active agent; suspension; less; particles; hours
Prior art date: 2011-05-17

Application number

SG2013083431A

Other languages

English (en)

Inventor

Reinhard Vehring

Michael Steven Hartman

David Lechuga-Ballesteros

Adrian Edward Smith

Vidya B Joshi

Sarvajna Kumar Dwivedi

Original Assignee

Pearl Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-17

Filing date

2011-05-17

Publication date

2013-12-30

2011-05-17 Application filed by Pearl Therapeutics Inc filed Critical Pearl Therapeutics Inc

2013-12-30 Publication of SG194896A1 publication Critical patent/SG194896A1/en

Links

239000013543 active substance Substances 0.000 title claims abstract description 627
239000000203 mixture Substances 0.000 title claims abstract description 449
238000000034 method Methods 0.000 title claims abstract description 166
230000000241 respiratory effect Effects 0.000 title description 18
239000002245 particle Substances 0.000 claims abstract description 630
239000000725 suspension Substances 0.000 claims abstract description 500
230000002685 pulmonary effect Effects 0.000 claims abstract description 15
VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims description 109
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239000003380 propellant Substances 0.000 claims description 106
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims description 95
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150000002148 esters Chemical class 0.000 claims description 72
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VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 47
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GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 42
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LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 37
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QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims description 31
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BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims description 21
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ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims description 10
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QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims description 10
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BMKINZUHKYLSKI-DQEYMECFSA-N n-[2-hydroxy-5-[(1r)-1-hydroxy-2-[2-[4-[[(2r)-2-hydroxy-2-phenylethyl]amino]phenyl]ethylamino]ethyl]phenyl]formamide Chemical compound C1([C@@H](O)CNC2=CC=C(C=C2)CCNC[C@H](O)C=2C=C(NC=O)C(O)=CC=2)=CC=CC=C1 BMKINZUHKYLSKI-DQEYMECFSA-N 0.000 claims description 10
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OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 claims description 10
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG2013083431A 2011-05-17 2011-05-17 Compositions, methods & systems for respiratory delivery of two or more active agents SG194896A1 (en)

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PCT/US2011/036868 WO2012158166A1 (en)	2011-05-17	2011-05-17	Compositions, methods & systems for respiratory delivery of two or more active agents

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EP (1)	EP2709447A4 (ko)
JP (1)	JP2014518871A (ko)
KR (1)	KR20140032404A (ko)
CN (1)	CN103687483A (ko)
AU (1)	AU2011368334A1 (ko)
BR (1)	BR112013029507A2 (ko)
CA (1)	CA2835927A1 (ko)
EA (1)	EA201490991A1 (ko)
IL (1)	IL229260A0 (ko)
MX (1)	MX2013013440A (ko)
PH (1)	PH12013502270A1 (ko)
RU (1)	RU2013155903A (ko)
SG (1)	SG194896A1 (ko)
WO (1)	WO2012158166A1 (ko)

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US8815258B2 (en)	2009-05-29	2014-08-26	Pearl Therapeutics, Inc.	Compositions, methods and systems for respiratory delivery of two or more active agents
TWI707700B (zh)	2009-05-29	2020-10-21	美商沛爾醫療股份有限公司	用於經由肺部遞送長效蕈毒鹼拮抗劑及長效β2腎上腺素受體激動劑之組成物，及相關方法及系統
EA201591415A1 (ru)	2013-01-31	2016-01-29	Просоникс Лимитед	Фармацевтические композиции, включающие многокомпонентные кристаллические частицы, подходящие для применения в ингаляционной терапии
CA2905542C (en)	2013-03-15	2022-05-03	Pearl Therapeutics, Inc.	Methods and systems for conditioning of particulate crystalline materials
CN105392471A (zh) *	2013-05-22	2016-03-09	珍珠治疗公司	用于呼吸递送三种或更多种活性剂的组合物、方法和系统
TN2016000261A1 (en)	2013-12-30	2017-10-06	Chiesi Farm Spa	Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination.
PL3096737T3 (pl) *	2013-12-30	2018-08-31	Chiesi Farmaceutici S.P.A.	Stabilna kompozycja w postaci ciśnieniowego roztworu aerozolowego kombinacji bromku glikopironium i formoterolu
SMT202000280T1 (it)	2014-09-09	2020-07-08	Vectura Ltd	Formulazione comprendente glicopirrolato, metodo ed apparecchiatura
WO2016170518A1 (en)	2015-04-24	2016-10-27	Glenmark Specialty S.A.	Pharmaceutical compositions comprising arformoterol and glycopyrronium
EP3288541B1 (en) *	2015-05-01	2020-09-02	Board of Regents, The University of Texas System	Multidrug brittle matrix compositions
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2011
- 2011-05-17 WO PCT/US2011/036868 patent/WO2012158166A1/en active Application Filing
- 2011-05-17 RU RU2013155903/15A patent/RU2013155903A/ru not_active Application Discontinuation
- 2011-05-17 AU AU2011368334A patent/AU2011368334A1/en not_active Abandoned
- 2011-05-17 MX MX2013013440A patent/MX2013013440A/es unknown
- 2011-05-17 JP JP2014511329A patent/JP2014518871A/ja active Pending
- 2011-05-17 BR BR112013029507A patent/BR112013029507A2/pt not_active IP Right Cessation
- 2011-05-17 PH PH1/2013/502270A patent/PH12013502270A1/en unknown
- 2011-05-17 KR KR1020137030446A patent/KR20140032404A/ko not_active Application Discontinuation
- 2011-05-17 CN CN201180072341.4A patent/CN103687483A/zh active Pending
- 2011-05-17 SG SG2013083431A patent/SG194896A1/en unknown
- 2011-05-17 EA EA201490991A patent/EA201490991A1/ru unknown
- 2011-05-17 CA CA2835927A patent/CA2835927A1/en not_active Abandoned
- 2011-05-17 EP EP11865780.8A patent/EP2709447A4/en not_active Withdrawn
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Publication number	Publication date
CA2835927A1 (en)	2012-11-22
RU2013155903A (ru)	2015-06-27
AU2011368334A1 (en)	2013-11-21
EA201490991A1 (ru)	2014-09-30
KR20140032404A (ko)	2014-03-14
EP2709447A1 (en)	2014-03-26
JP2014518871A (ja)	2014-08-07
BR112013029507A2 (pt)	2019-09-24
CN103687483A (zh)	2014-03-26
WO2012158166A1 (en)	2012-11-22
IL229260A0 (en)	2014-01-30
EP2709447A4 (en)	2014-10-22
PH12013502270A1 (en)	2014-01-27
MX2013013440A (es)	2014-06-05

Publication	Publication Date	Title
US20240024229A1 (en)	2024-01-25	Compositions, methods & systems for respiratory delivery of two or more active agents
US20250009652A1 (en)	2025-01-09	Compositions for respiratory delivery of active agents and associated methods and systems
SG194896A1 (en)	2013-12-30	Compositions, methods & systems for respiratory delivery of two or more active agents
AU2020210160B2 (en)	2022-06-30	Compositions, methods & systems for respiratory delivery of two or more active agents
AU2019203814A1 (en)	2019-06-20	Compositions for respiratory delivery of active agents and associated methods and systems