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SG148997A1 - Powders comprising low molecular dextran and methods of producing those powders - Google Patents

Powders comprising low molecular dextran and methods of producing those powders

Info

Publication number
SG148997A1
SG148997A1 SG200808989-8A SG2008089898A SG148997A1 SG 148997 A1 SG148997 A1 SG 148997A1 SG 2008089898 A SG2008089898 A SG 2008089898A SG 148997 A1 SG148997 A1 SG 148997A1
Authority
SG
Singapore
Prior art keywords
powders
methods
low molecular
molecular dextran
producing those
Prior art date
Application number
SG200808989-8A
Inventor
Karoline Bechtold-Peters
Wolfgang Friess
Richard Fuhrherr
Stefan Bassarab
Patrick Garidel
Torsten Schultz-Fademrecht
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of SG148997A1 publication Critical patent/SG148997A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Powders comprising low molecular dextran and methods of producing those powders The present invention relates to powders, preferably spray-dried powders, which contain a pharmaceutical active substance and low-molecular dextran as excipient. The present invention also relates to special processes for preparing such powders and methods of administering them by inhalation.
SG200808989-8A 2003-12-13 2004-12-08 Powders comprising low molecular dextran and methods of producing those powders SG148997A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10358387A DE10358387A1 (en) 2003-12-13 2003-12-13 Powder containing low molecular weight dextran and process for their preparation

Publications (1)

Publication Number Publication Date
SG148997A1 true SG148997A1 (en) 2009-01-29

Family

ID=34638656

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200808989-8A SG148997A1 (en) 2003-12-13 2004-12-08 Powders comprising low molecular dextran and methods of producing those powders

Country Status (8)

Country Link
EP (1) EP1694306B1 (en)
JP (1) JP2007514664A (en)
KR (1) KR20070014113A (en)
CA (1) CA2548132A1 (en)
DE (1) DE10358387A1 (en)
SG (1) SG148997A1 (en)
TW (1) TW200529863A (en)
WO (1) WO2005055976A2 (en)

Families Citing this family (34)

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DK2074141T3 (en) 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
US10189957B2 (en) 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
ES2563038T3 (en) 2007-04-30 2016-03-10 Novo Nordisk A/S Method for drying a protein composition, a dry protein composition and a pharmaceutical composition comprising the dry protein
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5762001B2 (en) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス Protease stabilized insulin analogue
RU2571857C2 (en) 2008-03-18 2015-12-20 Ново Нордиск А/С Acylated insulin analogues stabilised with respect to proteases
WO2010102066A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Dextran polymer powder for inhalation administration of pharmaceuticals
ES2873502T3 (en) 2009-03-27 2021-11-03 Bend Res Inc Spray drying process
JP5670421B2 (en) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Component surface coating method
WO2010132827A1 (en) * 2009-05-15 2010-11-18 Bend Research, Inc. Low-molecular dextran for powder inhalations
EP3508239B1 (en) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalant apparatus and atomizer
JP5658268B2 (en) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
EP2504052B1 (en) 2009-11-25 2022-07-27 Boehringer Ingelheim International GmbH Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5874724B2 (en) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
EP2611529B1 (en) 2010-09-03 2019-01-23 Bend Research, Inc. Spray-drying method
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
US9248584B2 (en) 2010-09-24 2016-02-02 Bend Research, Inc. High-temperature spray drying process and apparatus
PT2691415T (en) * 2011-03-28 2018-10-19 Ablynx Nv Method for producing solid formulations comprising immunoglobulin single variable domains
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
BR112013029803B1 (en) * 2011-05-19 2021-07-13 Savara, Inc DRY POWDER VANCOMICINE COMPOSITIONS
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
ES2836977T3 (en) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
MX366636B (en) 2013-10-07 2019-07-17 Novo Nordisk As Novel derivative of an insulin analogue.
DK3139979T3 (en) 2014-05-07 2023-10-09 Boehringer Ingelheim Int DEVICE, ATOMIZER AND PROCEDURE
CA2948072C (en) 2014-05-07 2023-06-27 Boehringer Ingelheim International Gmbh Nebulizer and container
PL3139984T3 (en) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizer
ES2841933T3 (en) 2014-10-31 2021-07-12 Univ Monash Powder formulation
WO2016067132A1 (en) 2014-10-31 2016-05-06 Bend Research Inc. Process for forming active domains dispersed in a matrix
DK3554534T3 (en) 2016-12-16 2021-08-23 Novo Nordisk As PHARMACEUTICAL COMPOSITION INCLUDING INSULIN

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032144A1 (en) * 1999-10-29 2001-05-10 Inhale Therapeutic Systems, Inc. Dry powder compositions having improved dispersivity
EP1184032A1 (en) * 2000-08-31 2002-03-06 OctoPlus B.V. Dextran hydrogels
AU2003230320A1 (en) * 2002-05-09 2003-11-11 Peptron Co., Ltd Sustained release formulation of protein and preparation method thereof

Also Published As

Publication number Publication date
EP1694306A2 (en) 2006-08-30
EP1694306B1 (en) 2018-09-12
CA2548132A1 (en) 2005-06-23
TW200529863A (en) 2005-09-16
WO2005055976A3 (en) 2006-02-16
DE10358387A1 (en) 2005-07-07
JP2007514664A (en) 2007-06-07
WO2005055976A2 (en) 2005-06-23
KR20070014113A (en) 2007-01-31

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