SG121739A1 - Stabilized protein crystals, formulations containing them and methods of making them - Google Patents
Stabilized protein crystals, formulations containing them and methods of making themInfo
- Publication number
- SG121739A1 SG121739A1 SG200206394A SG200206394A SG121739A1 SG 121739 A1 SG121739 A1 SG 121739A1 SG 200206394 A SG200206394 A SG 200206394A SG 200206394 A SG200206394 A SG 200206394A SG 121739 A1 SG121739 A1 SG 121739A1
- Authority
- SG
- Singapore
- Prior art keywords
- making
- methods
- formulations containing
- protein crystals
- stabilized protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/84—Penicillin amidase (3.5.1.11)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8314898P | 1998-04-27 | 1998-04-27 | |
US22447598A | 1998-12-31 | 1998-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG121739A1 true SG121739A1 (en) | 2006-05-26 |
Family
ID=26768988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200206394A SG121739A1 (en) | 1998-04-27 | 1999-04-27 | Stabilized protein crystals, formulations containing them and methods of making them |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1073421A1 (en) |
JP (1) | JP4965022B2 (en) |
AU (1) | AU757991B2 (en) |
CA (1) | CA2330476A1 (en) |
SG (1) | SG121739A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050090430A (en) | 2002-12-31 | 2005-09-13 | 알투스 파마슈티컬스 인코포레이티드 | Human growth hormone crystals and methods for preparing them |
BR0317896A (en) * | 2002-12-31 | 2005-12-06 | Altus Pharmaceuticals Inc | Protein crystal complexes and ionic polymers |
US20050142201A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for fabrication, uses and compositions of small spherical particles of hGH prepared by controlled phase separation |
EP1928551B1 (en) * | 2005-06-10 | 2012-05-30 | Althea Technologies, Inc. | Methods to reduce oxalate concentration by administration of oxalate oxidase crystals |
US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
CN116328782B (en) * | 2021-12-24 | 2024-10-15 | 中国石油天然气股份有限公司 | Hydrodemetallization catalyst for titanium-containing residual oil and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0134318A2 (en) * | 1983-06-10 | 1985-03-20 | Connaught Laboratories Limited | Controlled release of injectable and implantable insulin compositions |
WO1996018417A1 (en) * | 1994-12-14 | 1996-06-20 | Schering Corporation | Crystalline protein controlled release compositions |
WO1996041873A1 (en) * | 1995-06-09 | 1996-12-27 | The Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
WO1998042749A1 (en) * | 1997-03-20 | 1998-10-01 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
WO1998046732A1 (en) * | 1997-04-11 | 1998-10-22 | Altus Biologics Inc. | Controlled dissolution cross-linked protein crystals |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585466A (en) * | 1994-12-06 | 1996-12-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Crystals of serum albumin for use in genetic engineering and rational drug design |
EP0894091B1 (en) * | 1996-03-15 | 2003-03-05 | Novozymes A/S | Method for purification of a protein from a protein containing solution |
US5932212A (en) * | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
-
1999
- 1999-04-27 AU AU37646/99A patent/AU757991B2/en not_active Ceased
- 1999-04-27 EP EP99920064A patent/EP1073421A1/en not_active Withdrawn
- 1999-04-27 JP JP2000545510A patent/JP4965022B2/en not_active Expired - Lifetime
- 1999-04-27 CA CA002330476A patent/CA2330476A1/en not_active Abandoned
- 1999-04-27 SG SG200206394A patent/SG121739A1/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0134318A2 (en) * | 1983-06-10 | 1985-03-20 | Connaught Laboratories Limited | Controlled release of injectable and implantable insulin compositions |
WO1996018417A1 (en) * | 1994-12-14 | 1996-06-20 | Schering Corporation | Crystalline protein controlled release compositions |
WO1996041873A1 (en) * | 1995-06-09 | 1996-12-27 | The Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
WO1998042749A1 (en) * | 1997-03-20 | 1998-10-01 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
WO1998046732A1 (en) * | 1997-04-11 | 1998-10-22 | Altus Biologics Inc. | Controlled dissolution cross-linked protein crystals |
Also Published As
Publication number | Publication date |
---|---|
JP4965022B2 (en) | 2012-07-04 |
CA2330476A1 (en) | 1999-11-04 |
AU757991B2 (en) | 2003-03-13 |
AU3764699A (en) | 1999-11-16 |
EP1073421A1 (en) | 2001-02-07 |
JP2002512949A (en) | 2002-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL339463A1 (en) | April - novel protein of growth promoting action | |
EP1113799A4 (en) | Protein formulations | |
PL330841A1 (en) | Benzosulphonic derivatives, method of obtaining them and therapeutic agents containing such derivatives | |
ZA986822B (en) | Reduction of hair growth | |
PL318277A1 (en) | Novel substituted axazolydinones, method of obtaining and drugs containing them | |
IL141403A0 (en) | Deleted adenoviruses and methods of making and administering the same | |
EP1033994A4 (en) | Methods of preparation of bioginkgo | |
HK1026151A1 (en) | Stabilized protein compositions | |
AU3789399A (en) | Indolicidin analogs and methods of using same | |
HK1041827B (en) | Compounds for the treatment of estrogen-defendent illnesses and methods for making and using the same | |
AU1201099A (en) | Stabilized whitening compositions and method of preparing same | |
AU4992299A (en) | Uncoupling protein 4 (ucp-4) and methods of use | |
SG121739A1 (en) | Stabilized protein crystals, formulations containing them and methods of making them | |
AU3964499A (en) | Agouti-related protein analogs and methods of use | |
EP1140975A4 (en) | Stable subtilin and methods of manufacture | |
EP1140121A4 (en) | Cryogranulation of activated protein c | |
HUP0102577A3 (en) | Seeding crystals for the preparation of peptides or proteins, process for their preparation and their use | |
HUP9902855A3 (en) | Preparation of sterol- and stanol-esters | |
AU5649299A (en) | Protein solution preparation and method for stabilizing the same | |
PL334144A1 (en) | Novel derivatives of pyrolydine, composition containing and method of obtaining them | |
AU2221400A (en) | Compositions containing and methods of using n-acyl-1h-aminoindenes | |
AU2766597A (en) | Biologically active protein (collagen fragment hf-coll-18/514cf) for inhibiting the growth of tumours and capillary profilerations | |
GB9811962D0 (en) | Vertebrate homologue of UNC-53 protein of C.elegans | |
AU5470099A (en) | Products containing unpleasant tasting bio-affecting agents and methods of making them | |
AU6427899A (en) | Preparation of mono- and di-arylphosphines |