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SG11202112537YA - A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator - Google Patents

A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator

Info

Publication number
SG11202112537YA
SG11202112537YA SG11202112537YA SG11202112537YA SG11202112537YA SG 11202112537Y A SG11202112537Y A SG 11202112537YA SG 11202112537Y A SG11202112537Y A SG 11202112537YA SG 11202112537Y A SG11202112537Y A SG 11202112537YA SG 11202112537Y A SG11202112537Y A SG 11202112537YA
Authority
SG
Singapore
Prior art keywords
positive allosteric
allosteric modulator
tetrahydroisoquinoline derivative
substituted tetrahydroisoquinoline
substituted
Prior art date
Application number
SG11202112537YA
Inventor
Ali Ates
David Skolc
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of SG11202112537YA publication Critical patent/SG11202112537YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11202112537YA 2019-07-01 2020-06-29 A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator SG11202112537YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19183643 2019-07-01
PCT/EP2020/068183 WO2021001288A1 (en) 2019-07-01 2020-06-29 A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator

Publications (1)

Publication Number Publication Date
SG11202112537YA true SG11202112537YA (en) 2021-12-30

Family

ID=67137843

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202112537YA SG11202112537YA (en) 2019-07-01 2020-06-29 A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator

Country Status (21)

Country Link
US (1) US20220259179A1 (en)
EP (1) EP3993794A1 (en)
JP (1) JP7510444B2 (en)
KR (1) KR20220029686A (en)
CN (2) CN117700395A (en)
AR (1) AR119318A1 (en)
AU (1) AU2020299953A1 (en)
BR (1) BR112021022378A2 (en)
CA (1) CA3139571A1 (en)
CL (1) CL2021002946A1 (en)
CO (1) CO2021018155A2 (en)
EC (1) ECSP21093559A (en)
IL (1) IL289314A (en)
MA (1) MA56440A (en)
MX (1) MX2021015873A (en)
PE (1) PE20221020A1 (en)
PH (1) PH12021552825A1 (en)
SA (1) SA521431279B1 (en)
SG (1) SG11202112537YA (en)
WO (1) WO2021001288A1 (en)
ZA (1) ZA202109193B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023553457A (en) 2020-12-18 2023-12-21 ユーシービー バイオファルマ エスアールエル amorphous solid dispersion
CN116601161A (en) 2020-12-18 2023-08-15 Ucb生物制药有限责任公司 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl Prodrug of -ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
PT4263517T (en) 2020-12-18 2024-12-17 UCB Biopharma SRL A substituted tetrahydroisoquinoline derivative as a d1 positive allosteric modulator
JP2024509272A (en) * 2021-03-09 2024-02-29 イーライ リリー アンド カンパニー Use of mevidalen and other D1 positive allosteric modulators to slow progression of Parkinson's disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109336A1 (en) 2007-03-01 2008-09-12 Janssen Pharmaceutica N.V. Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor
KR101284796B1 (en) 2011-10-05 2013-07-10 (주)포인트엔지니어링 method for light emitting device with can package and the light emitting device
JO3316B1 (en) 2013-05-30 2019-03-13 Lilly Co Eli 3,4-dihydroisoquinolin-2(1h)-yl compounds
JP6622299B2 (en) 2014-10-08 2019-12-18 ユーシービー バイオファルマ エスピーアールエル Tetrahydroisoquinoline derivatives
US10370355B2 (en) * 2016-04-13 2019-08-06 Ucb Biopharma Sprl Tetrahydroisoquinoline derivatives
TWI725408B (en) 2018-04-20 2021-04-21 美商美國禮來大藥廠 Dopamine d1 receptor positive allosteric modulators

Also Published As

Publication number Publication date
CN113993857B (en) 2024-01-02
BR112021022378A2 (en) 2022-03-08
CN117700395A (en) 2024-03-15
MA56440A (en) 2022-05-11
AR119318A1 (en) 2021-12-09
JP7510444B2 (en) 2024-07-03
JP2022539152A (en) 2022-09-07
CA3139571A1 (en) 2021-01-07
TW202115010A (en) 2021-04-16
PE20221020A1 (en) 2022-06-16
PH12021552825A1 (en) 2022-10-03
US20220259179A1 (en) 2022-08-18
AU2020299953A1 (en) 2022-01-06
CL2021002946A1 (en) 2022-07-15
MX2021015873A (en) 2022-02-03
IL289314A (en) 2022-02-01
CO2021018155A2 (en) 2022-01-17
ECSP21093559A (en) 2022-02-25
EP3993794A1 (en) 2022-05-11
KR20220029686A (en) 2022-03-08
WO2021001288A9 (en) 2021-09-02
SA521431279B1 (en) 2024-01-09
ZA202109193B (en) 2023-11-29
CN113993857A (en) 2022-01-28
WO2021001288A1 (en) 2021-01-07

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