SG11202104601PA - Terminal deoxynucleotidyl transferase variants and uses thereof - Google Patents
Terminal deoxynucleotidyl transferase variants and uses thereofInfo
- Publication number
- SG11202104601PA SG11202104601PA SG11202104601PA SG11202104601PA SG11202104601PA SG 11202104601P A SG11202104601P A SG 11202104601PA SG 11202104601P A SG11202104601P A SG 11202104601PA SG 11202104601P A SG11202104601P A SG 11202104601PA SG 11202104601P A SG11202104601P A SG 11202104601PA
- Authority
- SG
- Singapore
- Prior art keywords
- terminal deoxynucleotidyl
- deoxynucleotidyl transferase
- transferase variants
- variants
- terminal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07031—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal deoxynucleotidyl transferase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18206298 | 2018-11-14 | ||
| EP19305677 | 2019-05-28 | ||
| EP19195662 | 2019-09-05 | ||
| PCT/EP2019/081099 WO2020099451A1 (en) | 2018-11-14 | 2019-11-13 | Terminal deoxynucleotidyl transferase variants and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104601PA true SG11202104601PA (en) | 2021-06-29 |
Family
ID=68536875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104601PA SG11202104601PA (en) | 2018-11-14 | 2019-11-13 | Terminal deoxynucleotidyl transferase variants and uses thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11859217B2 (zh) |
| EP (1) | EP3880808A1 (zh) |
| JP (1) | JP2022513031A (zh) |
| CN (1) | CN113302289A (zh) |
| AU (1) | AU2019379287A1 (zh) |
| CA (1) | CA3119845A1 (zh) |
| IL (1) | IL283068A (zh) |
| SG (1) | SG11202104601PA (zh) |
| WO (1) | WO2020099451A1 (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202107921SA (en) | 2019-02-12 | 2021-08-30 | Dna Script | Efficient product cleavage in template-free enzymatic synthesis of polynucleotides. |
| WO2020239737A1 (en) * | 2019-05-28 | 2020-12-03 | Dna Script | Variants of terminal deoxynucleotidyl transferase and uses thereof. |
| CA3145912A1 (en) | 2019-08-01 | 2021-02-04 | Adrian Horgan | Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides. |
| US20220403436A1 (en) | 2019-09-23 | 2022-12-22 | Dna Script | Increasing Long-Sequence Yields in Template-Free Enzymatic Synthesis of Polynucleotides |
| EP4073240A1 (en) * | 2019-12-12 | 2022-10-19 | DNA Script | Chimeric terminal deoxynucleotidyl transferases for template-free enzymatic synthesis of polynucleotides |
| EP4077703A1 (en) * | 2019-12-16 | 2022-10-26 | DNA Script | Template-free enzymatic polynucleotide synthesis using dismutationless terminal deoxynucleotidyl transferase variants |
| WO2021213903A1 (en) * | 2020-04-20 | 2021-10-28 | Dna Script | Terminal deoxynucleotidyl transferase variants and uses thereof |
| WO2021254934A1 (en) | 2020-06-16 | 2021-12-23 | Dna Script | Systems, apparatus and kits for enzymatic polynucleotide synthesis |
| US20230313255A1 (en) | 2020-07-15 | 2023-10-05 | Dna Script | Massively Parallel Enzymatic Synthesis of Polynucleotides |
| WO2022063835A1 (en) * | 2020-09-22 | 2022-03-31 | Dna Script | Stabilized n-terminally truncated terminal deoxynucleotidyl transferase variants and uses thereof |
| US20230416708A1 (en) | 2020-10-26 | 2023-12-28 | Dna Script | Novel Variants of Endonuclease V and Uses Thereof |
| WO2022207934A1 (en) | 2021-04-02 | 2022-10-06 | Dna Script | Methods and kits for enzymatic synthesis of g4-prone polynucleotides |
| NL2032097B1 (en) | 2021-06-10 | 2024-03-29 | Dna Script | Enzymatic synthesis of polynucleotides using 3'-o-amino-2'-deoxyribonucleoside triphosphate monomers |
| AU2022388772A1 (en) | 2021-11-10 | 2024-05-16 | Dna Script | Novel terminal deoxynucleotidyl |
| EP4430176A2 (en) | 2021-11-10 | 2024-09-18 | DNA Script | Novel terminal deoxynucleotidyl transferase (tdt) variants |
| WO2024083883A1 (en) | 2022-10-19 | 2024-04-25 | Dna Script | Methods and products for removal of uracil containing polynucleotides |
| WO2024141628A1 (en) | 2022-12-31 | 2024-07-04 | Dna Script | Variable viscosity inks for inkjet delivery of enzyme reagents |
| WO2024146937A1 (en) | 2023-01-06 | 2024-07-11 | Dna Script | Methods for obtaining correctly assembled nucleic acids |
| WO2024153642A1 (en) | 2023-01-16 | 2024-07-25 | Dna Script | Scarless template-free enzymatic synthesis of polynucleotides |
| WO2024153643A1 (en) | 2023-01-16 | 2024-07-25 | Dna Script | Inkjet-assisted enzymatic nucleic acid synthesis |
| WO2024227846A2 (en) | 2023-05-03 | 2024-11-07 | Dna Script | Reagent used in deprotection of 3'-o-amino polynucleotides |
| WO2025003434A1 (en) | 2023-06-30 | 2025-01-02 | Dna Script | Nucleic acid synthesis on reusable support |
| CN118995661A (zh) * | 2024-09-27 | 2024-11-22 | 浙江大学 | 一种热稳定性高的末端脱氧核苷酸转移酶突变体及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US5436143A (en) | 1992-12-23 | 1995-07-25 | Hyman; Edward D. | Method for enzymatic synthesis of oligonucleotides |
| US5739386A (en) | 1994-06-23 | 1998-04-14 | Affymax Technologies N.V. | Photolabile compounds and methods for their use |
| US5763594A (en) | 1994-09-02 | 1998-06-09 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
| US5808045A (en) | 1994-09-02 | 1998-09-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
| JP3469247B2 (ja) * | 1996-02-21 | 2003-11-25 | アメリカ合衆国 | 組換えリボヌクレアーゼタンパク質 |
| SG86311A1 (en) * | 1997-04-10 | 2002-02-19 | Univ Singapore | Bacillus stearothermophilus dna polymerase i (klenow) clones with reduced 3'-to-5' exonuclease activity |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| CA2491925A1 (en) | 2002-07-08 | 2004-01-15 | Shell Canada Limited | Choke for controlling the flow of drilling mud |
| US7947817B2 (en) | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
| US7544794B1 (en) | 2005-03-11 | 2009-06-09 | Steven Albert Benner | Method for sequencing DNA and RNA by synthesis |
| US8399188B2 (en) | 2006-09-28 | 2013-03-19 | Illumina, Inc. | Compositions and methods for nucleotide sequencing |
| CN105264085B (zh) * | 2013-10-15 | 2020-10-13 | 分子组装有限责任公司 | 合成核酸的方法和设备 |
| FR3020071B1 (fr) | 2014-04-17 | 2017-12-22 | Dna Script | Procede de synthese d'acides nucleiques, notamment d'acides nucleiques de grande longueur, utilisation du procede et kit pour la mise en œuvre du procede |
| EP3699283A1 (en) * | 2014-10-20 | 2020-08-26 | Molecular Assemblies Inc. | Modified template-independent enzymes for polydeoxynucleotide systhesis |
| US11390858B2 (en) * | 2014-10-20 | 2022-07-19 | Molecular Assemblies, Inc. | Modified template-independent enzymes for polydeoxynucleotide synthesis |
| US10774316B2 (en) * | 2014-10-20 | 2020-09-15 | Molecular Assemblies, Inc. | Modified template-independent enzymes for polydeoxynucleotide synthesis |
| GB201502152D0 (en) * | 2015-02-10 | 2015-03-25 | Nuclera Nucleics Ltd | Novel use |
| FR3052462A1 (fr) * | 2016-06-14 | 2017-12-15 | Dna Script | Variants d'une adn polymerase de la famille polx |
-
2019
- 2019-11-13 SG SG11202104601PA patent/SG11202104601PA/en unknown
- 2019-11-13 EP EP19801879.8A patent/EP3880808A1/en active Pending
- 2019-11-13 JP JP2021526276A patent/JP2022513031A/ja active Pending
- 2019-11-13 CN CN201980089035.8A patent/CN113302289A/zh active Pending
- 2019-11-13 WO PCT/EP2019/081099 patent/WO2020099451A1/en unknown
- 2019-11-13 AU AU2019379287A patent/AU2019379287A1/en active Pending
- 2019-11-13 CA CA3119845A patent/CA3119845A1/en active Pending
- 2019-11-13 US US17/293,017 patent/US11859217B2/en active Active
-
2021
- 2021-05-10 IL IL283068A patent/IL283068A/en unknown
-
2023
- 2023-11-07 US US18/504,010 patent/US20240093165A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3119845A1 (en) | 2020-05-22 |
| US11859217B2 (en) | 2024-01-02 |
| AU2019379287A1 (en) | 2021-06-03 |
| CN113302289A (zh) | 2021-08-24 |
| IL283068A (en) | 2021-06-30 |
| JP2022513031A (ja) | 2022-02-07 |
| US20240093165A1 (en) | 2024-03-21 |
| EP3880808A1 (en) | 2021-09-22 |
| US20220002687A1 (en) | 2022-01-06 |
| WO2020099451A1 (en) | 2020-05-22 |
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