SG11202103045SA - Split interleukin mimetics and their use - Google Patents

Split interleukin mimetics and their use

Info

Publication number: SG11202103045SA
Authority: SG; Singapore
Prior art keywords: mimetics; interleukin; split; split interleukin; interleukin mimetics
Prior art date: 2018-11-20

Application number

SG11202103045SA

Inventor

Rubio Alfredo Quijano

Manzano Daniel Silva

David Baker

Umut Ulge

Marc Lajoie

Original Assignee

Univ Washington

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-11-20

Filing date

2019-11-19

Publication date

2021-04-29

2019-11-19 Application filed by Univ Washington filed Critical Univ Washington

2021-04-29 Publication of SG11202103045SA publication Critical patent/SG11202103045SA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SG11202103045SA 2018-11-20 2019-11-19 Split interleukin mimetics and their use SG11202103045SA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201862770152P	2018-11-20	2018-11-20
PCT/US2019/062198 WO2020106708A1 (en)	2018-11-20	2019-11-19	Split interleukin mimetics and their use

Publications (1)

Publication Number	Publication Date
SG11202103045SA true SG11202103045SA (en)	2021-04-29

Family

ID=69500815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11202103045SA SG11202103045SA (en)	2018-11-20	2019-11-19	Split interleukin mimetics and their use

Country Status (13)

Country	Link
US (2)	US12234572B2 (en)
EP (1)	EP3883956A1 (en)
JP (2)	JP2022511390A (en)
KR (1)	KR20210094531A (en)
CN (2)	CN112912388A (en)
AU (1)	AU2019384523A1 (en)
BR (1)	BR112021008985A2 (en)
CA (1)	CA3119472A1 (en)
EA (1)	EA202190593A1 (en)
IL (1)	IL283217A (en)
MX (1)	MX2021005593A (en)
SG (1)	SG11202103045SA (en)
WO (1)	WO2020106708A1 (en)

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WO2019139987A1 (en)	2018-01-09	2019-07-18	Elstar Therapeutics, Inc.	Calreticulin binding constructs and engineered t cells for the treatment of diseases
EP3765517A1 (en)	2018-03-14	2021-01-20	Elstar Therapeutics, Inc.	Multifunctional molecules that bind to calreticulin and uses thereof
CA3102653A1 (en)	2018-06-25	2020-01-02	University Of Washington	De novo design of potent and selective interleukin mimetics
AU2019297451A1 (en)	2018-07-03	2021-01-28	Marengo Therapeutics, Inc.	Anti-TCR antibody molecules and uses thereof
WO2020106708A1 (en)	2018-11-20	2020-05-28	University Of Washington	Split interleukin mimetics and their use
CA3130754A1 (en)	2019-02-21	2020-08-27	Marengo Therapeutics, Inc.	Multifunctional molecules that bind to t cell related cancer cells and uses thereof
CN117062912A (en) *	2021-02-05	2023-11-14	达尔马科恩有限公司	Fusion proteins for CRISPR-based transcriptional inhibition
WO2023044318A2 (en) *	2021-09-15	2023-03-23	Neoleukin Therapeutics, Inc.	Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
CN118715024A (en) *	2022-01-24	2024-09-27	诺夫免疫股份有限公司	Compositions and methods for selective activation of cytokine signaling pathways
WO2024240233A1 (en) *	2023-05-24	2024-11-28	南通壹宸生物医药科技有限公司	Polypeptide, and conjugate and use thereof
WO2025015322A1 (en) *	2023-07-13	2025-01-16	Outpace Bio, Inc.	Designed interleukin-2 cytokine compositions and methods for use

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US1015080A (en)	1908-04-17	1912-01-16	George I Rockwood	Apparatus for operating alarms or other devices.
US5229109A (en)	1992-04-14	1993-07-20	Board Of Regents, The University Of Texas System	Low toxicity interleukin-2 analogues for use in immunotherapy
US6955807B1 (en)	1998-05-15	2005-10-18	Bayer Pharmaceuticals Corporation	IL-2 selective agonists and antagonists
US6168785B1 (en)	1998-07-16	2001-01-02	Institut Pasteur	Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
GB0019638D0 (en)	2000-08-09	2000-09-27	European Molecular Biology Lab Embl	Peptide mimetics
WO2002101629A1 (en)	2001-06-07	2002-12-19	Wyeth	Solution structure of il-13 and uses thereof
CN1930300A (en) *	2004-03-05	2007-03-14	希龙公司	In vitro test system for predicting patient tolerability of therapeutic agents
WO2008138017A2 (en)	2007-05-08	2008-11-13	Beth Israel Deaconess Medical Center, Inc.	Methods and compositions for modifying t cell immune responses and inflammation
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US9844582B2 (en)	2012-05-22	2017-12-19	Massachusetts Institute Of Technology	Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
EP3134102B1 (en) *	2014-04-24	2019-07-03	The Board of Trustees of The Leland Stanford Junior University	Superagonists, partial agonists and antagonists of interleukin-2
ES2856927T3 (en)	2014-04-30	2021-09-28	Pfizer	Anti-PTK7 Drug-Antibody Conjugates
ES2807260T3 (en)	2014-08-11	2021-02-22	Delinia Inc	Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases
AR105616A1 (en)	2015-05-07	2017-10-25	Lilly Co Eli	FUSION PROTEINS
WO2018153865A1 (en)	2017-02-24	2018-08-30	Philogen S.P.A.	Immunoconjugates with optimized linkers and orientation
EP3949969A3 (en)	2017-03-15	2022-02-16	Silverback Therapeutics, Inc.	Benzazepine compounds, conjugates, and uses thereof
CA3102653A1 (en)	2018-06-25	2020-01-02	University Of Washington	De novo design of potent and selective interleukin mimetics
WO2020106708A1 (en)	2018-11-20	2020-05-28	University Of Washington	Split interleukin mimetics and their use
US20220000921A1 (en)	2018-11-20	2022-01-06	Innovative Cellular Therapeutics Holdings, Ltd.	Modified Cell Expressing Therapeutic Agent and Uses thereof
WO2021081193A1 (en)	2019-10-25	2021-04-29	Neoleukin Therapeutics, Inc.	Methods of administration of if-2 receptor agonists
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CN111040981A (en)	2019-12-26	2020-04-21	南昌大学	Recombinant Escherichia coli Nissle1917 for expressing recombinant IL-2 and function verification method thereof
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2019
- 2019-11-19 WO PCT/US2019/062198 patent/WO2020106708A1/en active IP Right Grant
- 2019-11-19 EA EA202190593A patent/EA202190593A1/en unknown
- 2019-11-19 US US17/294,807 patent/US12234572B2/en active Active
- 2019-11-19 SG SG11202103045SA patent/SG11202103045SA/en unknown
- 2019-11-19 BR BR112021008985-3A patent/BR112021008985A2/en not_active IP Right Cessation
- 2019-11-19 JP JP2021517768A patent/JP2022511390A/en active Pending
- 2019-11-19 KR KR1020217014525A patent/KR20210094531A/en not_active Ceased
- 2019-11-19 AU AU2019384523A patent/AU2019384523A1/en active Pending
- 2019-11-19 CA CA3119472A patent/CA3119472A1/en active Pending
- 2019-11-19 CN CN201980070569.6A patent/CN112912388A/en active Pending
- 2019-11-19 CN CN202510054463.4A patent/CN120040576A/en active Pending
- 2019-11-19 MX MX2021005593A patent/MX2021005593A/en unknown
- 2019-11-19 EP EP19848950.2A patent/EP3883956A1/en active Pending
2021
- 2021-05-16 IL IL283217A patent/IL283217A/en unknown
2024
- 2024-10-07 JP JP2024175673A patent/JP2025013348A/en active Pending
2025
- 2025-01-10 US US19/016,343 patent/US20250179690A1/en active Pending

Also Published As

Publication number	Publication date
JP2022511390A (en)	2022-01-31
WO2020106708A1 (en)	2020-05-28
MX2021005593A (en)	2021-08-11
AU2019384523A1 (en)	2021-04-22
CA3119472A1 (en)	2020-05-28
CN120040576A (en)	2025-05-27
EA202190593A1 (en)	2021-11-18
BR112021008985A2 (en)	2021-10-26
CN112912388A (en)	2021-06-04
JP2025013348A (en)	2025-01-24
US20220017588A1 (en)	2022-01-20
KR20210094531A (en)	2021-07-29
US20250179690A1 (en)	2025-06-05
US12234572B2 (en)	2025-02-25
EP3883956A1 (en)	2021-09-29
IL283217A (en)	2021-06-30

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