SG11202012597UA - Using alternating electric fields to increase cell membrane permeability - Google Patents
Using alternating electric fields to increase cell membrane permeabilityInfo
- Publication number
- SG11202012597UA SG11202012597UA SG11202012597UA SG11202012597UA SG11202012597UA SG 11202012597U A SG11202012597U A SG 11202012597UA SG 11202012597U A SG11202012597U A SG 11202012597UA SG 11202012597U A SG11202012597U A SG 11202012597UA SG 11202012597U A SG11202012597U A SG 11202012597UA
- Authority
- SG
- Singapore
- Prior art keywords
- cell membrane
- electric fields
- alternating electric
- membrane permeability
- increase cell
- Prior art date
Links
- 210000000170 cell membrane Anatomy 0.000 title 1
- 230000005684 electric field Effects 0.000 title 1
- 230000035699 permeability Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Vascular Medicine (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693811P | 2018-07-03 | 2018-07-03 | |
| US201862728255P | 2018-09-07 | 2018-09-07 | |
| US201962795136P | 2019-01-22 | 2019-01-22 | |
| PCT/US2019/040479 WO2020010188A1 (en) | 2018-07-03 | 2019-07-03 | Using alternating electric fields to increase cell membrane permeability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012597UA true SG11202012597UA (en) | 2021-01-28 |
Family
ID=67441670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012597UA SG11202012597UA (en) | 2018-07-03 | 2019-07-03 | Using alternating electric fields to increase cell membrane permeability |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11529511B2 (en) |
| EP (7) | EP3773877B1 (en) |
| JP (4) | JP7055906B2 (en) |
| KR (2) | KR102592927B1 (en) |
| CN (7) | CN116173401A (en) |
| AU (2) | AU2019299533B2 (en) |
| BR (1) | BR112020025760A2 (en) |
| CA (1) | CA3100859A1 (en) |
| DK (1) | DK3838333T3 (en) |
| ES (3) | ES2934669T3 (en) |
| IL (1) | IL279465A (en) |
| MX (1) | MX2020012673A (en) |
| NZ (1) | NZ770871A (en) |
| PL (1) | PL3838333T3 (en) |
| SG (1) | SG11202012597UA (en) |
| WO (1) | WO2020010188A1 (en) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5903735B2 (en) | 2009-05-11 | 2016-04-13 | バーグ エルエルシー | Method of treating diseases using epimetabolic shifter (Coenzyme Q10) |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US20170189350A1 (en) | 2015-11-16 | 2017-07-06 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| WO2018005511A1 (en) | 2016-06-27 | 2018-01-04 | Gala Therapeutics, Inc. | Generator and a catheter with an electrode and a method for treating a lung passageway |
| US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN111683613B (en) | 2017-12-26 | 2024-05-28 | 盖能适治疗股份有限公司 | Optimization of energy delivery for various applications |
| EP3773877B1 (en) | 2018-07-03 | 2024-01-17 | The Board of Trustees of the Leland Stanford Junior University | Using alternating electric fields to increase cell membrane permeability |
| KR102794415B1 (en) | 2018-07-10 | 2025-04-09 | 노보큐어 게엠베하 | Inhibition of viral infection using alternating electric fields |
| BR112020025269A2 (en) | 2018-07-18 | 2021-03-09 | Novocure Gmbh | USE OF ENERGY LOSS DENSITY AND RELATED MEASURES TO QUANTIFY THE DOSE OF TUMOR TREATMENT FIELDS (TTFIELDS) |
| PL3773291T3 (en) | 2018-08-23 | 2022-01-31 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| WO2020049482A1 (en) | 2018-09-07 | 2020-03-12 | Yaniv Alon | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP4137195B1 (en) | 2018-10-15 | 2024-12-11 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| US11369790B2 (en) | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
| ES2976808T3 (en) | 2018-11-19 | 2024-08-08 | Novocure Gmbh | Tumor Treatment Fields (TTFields) Delivery Arrays with Selectively Addressable Subelements |
| US11224741B2 (en) | 2018-11-29 | 2022-01-18 | Novocure Gmbh | Enhanced-flexibility transducer arrays for delivering TTFields (tumor treating fields) |
| EP3909015B1 (en) | 2019-01-08 | 2024-08-14 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| EP3974022B1 (en) | 2019-02-26 | 2024-04-17 | Novocure GmbH | Determining a frequency for ttfields treatment based on a physical parameter of targeted cancer cells |
| ES3002779T3 (en) | 2019-02-27 | 2025-03-07 | Novocure Gmbh | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| EP3977991A1 (en) | 2019-03-29 | 2022-04-06 | Novocure GmbH | Methods for reducing viability of ttfields-resistant cancer cells |
| EP3960232B1 (en) | 2019-04-17 | 2023-01-04 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
| CN113727753B (en) | 2019-04-22 | 2024-09-13 | 波士顿科学国际有限公司 | Electrical stimulation devices for cancer treatment |
| EP4480526A3 (en) * | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958956B1 (en) | 2019-04-23 | 2024-02-28 | Boston Scientific Scimed Inc. | Electrodes for electrical stimulation to treat cancer |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| CN113766950A (en) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | Electrical stimulation with thermal therapy or thermal monitoring |
| EP4085967B1 (en) | 2019-07-31 | 2023-09-06 | Novocure GmbH | Applying tumor treating fields (ttfields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| WO2021038510A1 (en) | 2019-08-30 | 2021-03-04 | Novocure Gmbh | Delivering tumor treating fields (ttfields) to the neck |
| WO2021102356A1 (en) * | 2019-11-20 | 2021-05-27 | Berg Llc | Combination therapy of a coenzyme q10 compound and radiation therapy for treatment of glioma |
| US20210177994A1 (en) * | 2019-12-11 | 2021-06-17 | Novocure Gmbh | Compositions And Methods For Imaging A Cell |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| MX2022006136A (en) | 2019-12-31 | 2022-06-17 | Novocure Gmbh | MATRICES TO SUPPLY TUMORS TREATMENT FIELDS (TTFIELDS) WITH INDIVIDUALLY ACCESSIBLE ELECTRODE ELEMENTS AND TEMPERATURE SENSORS. |
| BR112022012431A2 (en) | 2019-12-31 | 2022-08-30 | Novocure Gmbh | HIGH VOLTAGE AND HIGH EFFICIENCY SINE WAVE GENERATOR THAT AVOIDS Surges DURING AMPLITUDE ADJUSTMENTS AND CHANNEL SWITCHING |
| WO2021173509A1 (en) | 2020-02-24 | 2021-09-02 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| WO2021198864A1 (en) | 2020-03-30 | 2021-10-07 | Novocure Gmbh | Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases |
| KR20230002800A (en) | 2020-04-24 | 2023-01-05 | 노보큐어 게엠베하 | Use of an alternating electric field to improve the permeability of the blood-brain barrier |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| EP4223363B1 (en) | 2020-09-25 | 2024-04-24 | Novocure GmbH | Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating |
| CN116867544A (en) | 2020-11-25 | 2023-10-10 | 诺沃库勒有限责任公司 | Increasing the efficacy of a tumor treatment field (TTField) by applying the TTField at peak intensity in less than half of the time |
| WO2022130183A2 (en) | 2020-12-17 | 2022-06-23 | Novocure Gmbh | Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields) |
| WO2022137171A2 (en) * | 2020-12-24 | 2022-06-30 | Novocure Gmbh | Methods and compositions for using alternating electric fields in gene therapy |
| IT202100000119A1 (en) * | 2021-01-05 | 2022-07-05 | Telea Electronic Eng Srl | DEVICE AND ANTICANCER DRUG FOR THE TREATMENT OF NEOPLASTIC CELLS |
| JP2024513854A (en) | 2021-03-31 | 2024-03-27 | ノボキュア ゲーエムベーハー | Impedance tomography using electrodes of the Tumor Treatment Electric Fields (TTFields) system |
| WO2023275804A1 (en) | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using alternating electric fields at different frequencies to increase the permeability of the blood brain barrier and also to provide other benefits |
| US11877838B2 (en) * | 2021-08-14 | 2024-01-23 | Nano Hesgarsazan Salamat Arya | Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields |
| JP2025501686A (en) | 2021-12-15 | 2025-01-23 | スミス アンド ネフュー インコーポレイテッド | Method and system for fiducial marker deployment in medical procedures - Patents.com |
| WO2023126842A1 (en) | 2021-12-29 | 2023-07-06 | Novocure Gmbh | Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes |
| CN118591405A (en) | 2021-12-30 | 2024-09-03 | 诺沃库勒有限责任公司 | Selecting treatment parameter values using tumor treating fields (TTFIELDS) |
| KR20240167784A (en) | 2022-03-30 | 2024-11-28 | 노보큐어 게엠베하 | By pairing transducer arrays together, the sensory relief from electrical stimulation is achieved while treating the subject using alternating electric fields. |
| TW202404658A (en) | 2022-03-30 | 2024-02-01 | 瑞士商諾沃庫勒有限責任公司 | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| CN114891777B (en) * | 2022-05-19 | 2024-05-14 | 江苏大学 | Device and method for improving secretion of microalgae extracellular polysaccharide by using high-voltage electric field discharge stimulation |
| EP4539924A1 (en) | 2022-06-20 | 2025-04-23 | Novocure GmbH | Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors |
| JP2025520663A (en) * | 2022-06-21 | 2025-07-03 | ノボキュア ゲーエムベーハー | Systems and methods for treating conditions and diseases using alternating electric fields and CRISPR-CAS systems |
| EP4514445A1 (en) | 2022-06-30 | 2025-03-05 | Novocure GmbH | Electrode assembly for applying tumor treating fields (ttfields) that includes a plurality of thermally linked but electrically isolated graphite sheets |
| US20240108699A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for reducing electrosensation and/or skin irritation |
| WO2024079719A1 (en) * | 2022-10-14 | 2024-04-18 | Novocure Gmbh | Method and apparatus for delivering alternating electric fields to a target tissue |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN116284483B (en) * | 2023-03-24 | 2024-06-21 | 中国药科大学 | Method for extracting eucommia ulmoides leaf polysaccharide with assistance of low-frequency polarized electric field |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3323415C2 (en) * | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Use of a method and a device for the determination of cells secreting cell constituents |
| EP1003847A4 (en) * | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | CELL SEPARATION BY ELECTRIC FIELDS |
| US6537272B2 (en) | 1998-07-07 | 2003-03-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
| US7070595B2 (en) | 1998-12-14 | 2006-07-04 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
| US6853864B2 (en) * | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7333852B2 (en) | 2000-02-17 | 2008-02-19 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US8313908B2 (en) * | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
| US7465566B2 (en) * | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
| IT1321296B1 (en) | 2000-06-16 | 2004-01-08 | Group Talamonti Di Talamonti A | HUMAN BODY ELECTROSTIMULATION EQUIPMENT. |
| US7332313B2 (en) | 2001-06-05 | 2008-02-19 | Applied Biophysics, Inc. | Electrical wounding assay for cells in vitro |
| US20040147984A1 (en) | 2001-11-29 | 2004-07-29 | Palomar Medical Technologies, Inc. | Methods and apparatus for delivering low power optical treatments |
| US20060199992A1 (en) | 2003-03-17 | 2006-09-07 | Eisenberg Solomon R | Magnetic stimulator |
| WO2005115535A2 (en) * | 2004-04-23 | 2005-12-08 | Novocure Ltd. | Treating a tumor or the like with electric fields at different frequencies |
| PT2364748T (en) | 2004-12-07 | 2018-03-26 | Novocure Ltd | Electrodes for applying an electric field in-vivo over an extended period of time |
| CA2594231C (en) | 2004-12-27 | 2016-04-19 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| TW200716140A (en) * | 2005-06-17 | 2007-05-01 | Dynamis Therapeutics Inc | Treatment of inflammatory conditions |
| DE102005035456A1 (en) * | 2005-07-28 | 2007-03-08 | Eppendorf Ag | A method of electromanipulating cells to alter the membrane permeability of these cells using lipophilic ions as a medium supplement |
| CN101321555B (en) | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | Optimizing electric field characteristics to increase the effect of an electric field on proliferating cells |
| US20070141106A1 (en) * | 2005-10-19 | 2007-06-21 | Bonutti Peter M | Drug eluting implant |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| EP2167194B1 (en) | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| DK2183024T3 (en) | 2007-08-14 | 2019-06-24 | Novocure Ltd | FINISHING PARASITES WITH ELECTRIC FIELDS |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
| US20100259251A1 (en) | 2007-12-13 | 2010-10-14 | Koninklijke Philips Electronics N.V. | Arangement and method for influencing and/or detecting magnetic particles in a region of action |
| US9616245B2 (en) | 2009-03-16 | 2017-04-11 | Rajah Vijay Kumar | Method of treating cells with drug and radiation according to proton density |
| US9020605B2 (en) * | 2012-10-25 | 2015-04-28 | Oncosec Medical Incorporated | Electroporation device |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10117563B2 (en) * | 2014-01-09 | 2018-11-06 | Gyrus Acmi, Inc. | Polyp detection from an image |
| US10342606B2 (en) | 2014-05-06 | 2019-07-09 | Cosman Instruments, Llc | Electrosurgical generator |
| GB201408119D0 (en) * | 2014-05-08 | 2014-06-25 | Univ Cork | Method |
| EP3143124B1 (en) | 2014-05-12 | 2025-01-22 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| PL3277368T3 (en) * | 2015-03-31 | 2021-01-25 | Oncosec Medical Incorporated | Systems for improved tissue-sensing based electroporation |
| WO2016180934A1 (en) | 2015-05-12 | 2016-11-17 | Umc Utrecht Holding B.V. | Asymmetric balanced waveform for ac cardiac irreversible electroporation |
| EP3307378B1 (en) | 2015-05-14 | 2024-06-26 | London Health Sciences Centre Research Inc. | Intratumoral modulation therapy |
| US9910453B2 (en) | 2015-09-25 | 2018-03-06 | Novocure Limited | High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| CN105903014A (en) * | 2016-05-05 | 2016-08-31 | 北京大学 | Method for promoting nanoparticles to enter cells efficiently based on nanosecond pulsed electric field |
| US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| US20180008708A1 (en) | 2016-07-10 | 2018-01-11 | Novocure Limited | Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents |
| NZ750440A (en) | 2016-08-18 | 2023-03-31 | Novocure Gmbh | Temperature measurement in arrays for delivering ttfields |
| CN109843204B (en) | 2016-10-20 | 2024-02-13 | 莱彻韦斯科勒公司 | Methods and devices for enhanced delivery of compositions |
| JP7184774B2 (en) * | 2016-12-13 | 2022-12-06 | ノボキュア ゲーエムベーハー | Treat a patient with a TT field with electrode positions optimized using a deformable template |
| WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN106823145A (en) * | 2017-03-24 | 2017-06-13 | 长沙普特斯科技有限公司 | A kind of device of use amplitude modulation electric field treatment tumour |
| US20190117969A1 (en) | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| WO2019197973A1 (en) * | 2018-04-09 | 2019-10-17 | Moshe Giladi | Treating tumors with ttfields and an aurora kinase inhibitor |
| EP3832335A1 (en) | 2018-04-10 | 2021-06-09 | Zeev Bomzon | Low frequency (< 1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| EP3773877B1 (en) | 2018-07-03 | 2024-01-17 | The Board of Trustees of the Leland Stanford Junior University | Using alternating electric fields to increase cell membrane permeability |
| PL3773291T3 (en) * | 2018-08-23 | 2022-01-31 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
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