SG11202012555UA - Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels - Google Patents
Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labelsInfo
- Publication number
- SG11202012555UA SG11202012555UA SG11202012555UA SG11202012555UA SG11202012555UA SG 11202012555U A SG11202012555U A SG 11202012555UA SG 11202012555U A SG11202012555U A SG 11202012555UA SG 11202012555U A SG11202012555U A SG 11202012555UA SG 11202012555U A SG11202012555U A SG 11202012555UA
- Authority
- SG
- Singapore
- Prior art keywords
- fluorescent labels
- coumarin compounds
- exocyclic amine
- substituted coumarin
- substituted
- Prior art date
Links
- 125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- C09B57/02—Coumarine dyes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B55/00—Azomethine dyes
- C09B55/009—Azomethine dyes, the C-atom of the group -C=N- being part of a ring (Image)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962812837P | 2019-03-01 | 2019-03-01 | |
| PCT/EP2020/055248 WO2020178162A1 (en) | 2019-03-01 | 2020-02-28 | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012555UA true SG11202012555UA (en) | 2021-01-28 |
Family
ID=69743223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012555UA SG11202012555UA (en) | 2019-03-01 | 2020-02-28 | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11390753B2 (en) |
| EP (1) | EP3931263A1 (en) |
| JP (1) | JP7587424B2 (en) |
| KR (1) | KR20210134209A (en) |
| CN (1) | CN112654681B (en) |
| AU (1) | AU2020230955A1 (en) |
| BR (1) | BR112020026528B1 (en) |
| CA (1) | CA3103900A1 (en) |
| IL (1) | IL279674B1 (en) |
| MX (1) | MX2020013384A (en) |
| SG (1) | SG11202012555UA (en) |
| WO (1) | WO2020178162A1 (en) |
| ZA (1) | ZA202007842B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| SG11202012555UA (en) | 2019-03-01 | 2021-01-28 | Illumina Cambridge Ltd | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
| CN114829369A (en) | 2019-11-27 | 2022-07-29 | 伊鲁米纳剑桥有限公司 | Dyes and compositions containing cyclooctatetraene |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| MX2023012659A (en) | 2021-05-20 | 2023-12-07 | Illumina Inc | Compositions and methods for sequencing by synthesis. |
| EP4499862A1 (en) | 2022-03-28 | 2025-02-05 | Illumina, Inc. | Labeled avidin and methods for sequencing |
| EP4499870A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| AU2023244351A1 (en) | 2022-03-31 | 2024-01-18 | Illumina, Inc. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
| CN119301275A (en) | 2022-05-31 | 2025-01-10 | 伊路米纳有限公司 | Compositions and methods for nucleic acid sequencing |
| US20240140939A1 (en) | 2022-09-30 | 2024-05-02 | Illumina Cambridge Limited | Compositions and methods for reducing photo damage during sequencing |
| CN119095983A (en) | 2022-12-22 | 2024-12-06 | 伊路米纳有限公司 | Transition metal catalyst compositions and methods for sequencing by synthesis |
| CN119095982A (en) | 2022-12-22 | 2024-12-06 | 伊路米纳有限公司 | Palladium catalyst compositions and methods for sequencing by synthesis |
| WO2024145154A1 (en) | 2022-12-27 | 2024-07-04 | Illumina, Inc. | Methods of sequencing using 3´ allyl blocked nucleotides |
| US20240327909A1 (en) | 2023-03-30 | 2024-10-03 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| US20250075269A1 (en) | 2023-08-31 | 2025-03-06 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
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| DE2925546A1 (en) * | 1979-06-25 | 1981-01-15 | Bayer Ag | CUMARINE COMPOUNDS AND THEIR PRODUCTION AND USE AS DYES |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| JP2999841B2 (en) | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | Resin composition for luminescent screen |
| EP0527433B1 (en) | 1991-08-13 | 1997-01-08 | Bayer Corporation | Novel fluorescent label |
| DE4302459A1 (en) * | 1993-01-29 | 1994-08-04 | Bayer Ag | Nucleotides containing sulfocoumarin and their use in detection methods for nucleic acids |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| JP3838695B2 (en) * | 1996-04-25 | 2006-10-25 | 三井化学株式会社 | Coumarin compounds and their uses |
| ES2563643T3 (en) | 1997-04-01 | 2016-03-15 | Illumina Cambridge Limited | Nucleic acid sequencing method |
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| SG11202012555UA (en) | 2019-03-01 | 2021-01-28 | Illumina Cambridge Ltd | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
-
2020
- 2020-02-28 SG SG11202012555UA patent/SG11202012555UA/en unknown
- 2020-02-28 BR BR112020026528-4A patent/BR112020026528B1/en active IP Right Grant
- 2020-02-28 KR KR1020207036679A patent/KR20210134209A/en active Pending
- 2020-02-28 MX MX2020013384A patent/MX2020013384A/en unknown
- 2020-02-28 JP JP2020572446A patent/JP7587424B2/en active Active
- 2020-02-28 CA CA3103900A patent/CA3103900A1/en active Pending
- 2020-02-28 IL IL279674A patent/IL279674B1/en unknown
- 2020-02-28 WO PCT/EP2020/055248 patent/WO2020178162A1/en active Application Filing
- 2020-02-28 AU AU2020230955A patent/AU2020230955A1/en active Pending
- 2020-02-28 US US16/805,015 patent/US11390753B2/en active Active
- 2020-02-28 CN CN202080003516.5A patent/CN112654681B/en active Active
- 2020-02-28 EP EP20709145.5A patent/EP3931263A1/en active Pending
- 2020-12-15 ZA ZA2020/07842A patent/ZA202007842B/en unknown
-
2022
- 2022-07-01 US US17/856,307 patent/US11884825B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11390753B2 (en) | 2022-07-19 |
| BR112020026528A2 (en) | 2021-09-08 |
| CA3103900A1 (en) | 2020-09-10 |
| US20200277529A1 (en) | 2020-09-03 |
| ZA202007842B (en) | 2023-04-26 |
| BR112020026528B1 (en) | 2024-02-15 |
| AU2020230955A1 (en) | 2021-01-07 |
| CN112654681A (en) | 2021-04-13 |
| US11884825B2 (en) | 2024-01-30 |
| WO2020178162A1 (en) | 2020-09-10 |
| JP2022522553A (en) | 2022-04-20 |
| IL279674A (en) | 2021-03-01 |
| CN112654681B (en) | 2023-01-06 |
| JP7587424B2 (en) | 2024-11-20 |
| IL279674B1 (en) | 2024-12-01 |
| KR20210134209A (en) | 2021-11-09 |
| MX2020013384A (en) | 2021-04-28 |
| EP3931263A1 (en) | 2022-01-05 |
| WO2020178162A8 (en) | 2021-04-22 |
| US20230022437A1 (en) | 2023-01-26 |
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