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SG11202011541SA - Chimeric antigen receptor t cell therapy - Google Patents

Chimeric antigen receptor t cell therapy

Info

Publication number
SG11202011541SA
SG11202011541SA SG11202011541SA SG11202011541SA SG11202011541SA SG 11202011541S A SG11202011541S A SG 11202011541SA SG 11202011541S A SG11202011541S A SG 11202011541SA SG 11202011541S A SG11202011541S A SG 11202011541SA SG 11202011541S A SG11202011541S A SG 11202011541SA
Authority
SG
Singapore
Prior art keywords
antigen receptor
chimeric antigen
cell therapy
therapy
chimeric
Prior art date
Application number
SG11202011541SA
Inventor
Adrian I Bot
William Y Go
Yizhou Jiang
John M Rossi
Xiaodong Xue
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of SG11202011541SA publication Critical patent/SG11202011541SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/421Immunoglobulin superfamily
    • A61K40/4211CD19 or B4
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Primary Health Care (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
SG11202011541SA 2018-06-01 2019-06-03 Chimeric antigen receptor t cell therapy SG11202011541SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862679755P 2018-06-01 2018-06-01
US201862774157P 2018-11-30 2018-11-30
PCT/US2019/035123 WO2019232510A1 (en) 2018-06-01 2019-06-03 Chimeric antigen receptor t cell therapy

Publications (1)

Publication Number Publication Date
SG11202011541SA true SG11202011541SA (en) 2020-12-30

Family

ID=68697134

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011541SA SG11202011541SA (en) 2018-06-01 2019-06-03 Chimeric antigen receptor t cell therapy

Country Status (12)

Country Link
US (1) US20200003758A1 (en)
EP (2) EP3801572B1 (en)
JP (3) JP7174777B2 (en)
KR (4) KR20240170582A (en)
CN (1) CN112512537A (en)
AU (2) AU2019276592B2 (en)
CA (1) CA3101856A1 (en)
ES (1) ES2989910T3 (en)
IL (2) IL278992B2 (en)
SG (1) SG11202011541SA (en)
TW (1) TWI856961B (en)
WO (1) WO2019232510A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116917737A (en) * 2021-01-10 2023-10-20 凯德药业股份有限公司 T cell therapy
WO2024218318A1 (en) 2023-04-21 2024-10-24 Charité - Universitätsmedizin Berlin Markers for predicting therapeutic efficacy of a t cell

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG192010A1 (en) 2011-01-18 2013-08-30 Univ Pennsylvania Compositions and methods for treating cancer
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
MX2014003176A (en) 2011-09-16 2015-08-05 Univ Pennsylvania T-CELLS DESIGNED BY ARN FOR CANCER TREATMENT.
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
TWI654206B (en) * 2013-03-16 2019-03-21 諾華公司 Treatment of cancer with a humanized anti-CD19 chimeric antigen receptor
MX2016010171A (en) 2014-02-04 2017-02-15 Us Health Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof.
KR20230148387A (en) * 2015-05-28 2023-10-24 카이트 파마 인코포레이티드 Diagnostic methods for t cell therapy
KR102349677B1 (en) 2015-05-28 2022-01-12 카이트 파마 인코포레이티드 How to Condition a Patient for T Cell Therapy
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
JP6952029B2 (en) 2015-10-20 2021-10-20 カイト ファーマ インコーポレイテッドKite Pharma, Inc How to prepare T cells for T cell therapy
BR112018070073A2 (en) 2016-04-01 2019-02-12 Kite Pharma, Inc. chimeric antigen and t-cell receptors and methods of use
AU2017297347B2 (en) 2016-07-12 2020-05-21 Kite Pharma, Inc. Antigen binding molecules and methods of use thereof
WO2018064205A1 (en) 2016-09-28 2018-04-05 Kite Pharma, Inc. Antigen binding molecules and methods of use thereof
JP7142009B2 (en) * 2016-12-01 2022-09-26 ブライトコブ インコーポレイテッド Coding profile optimization for media streaming
MA46963A (en) * 2016-12-03 2019-10-09 Juno Therapeutics Inc METHODS FOR DETERMINING THE DOSAGE OF CAR-T CELLS
US20190358262A1 (en) * 2016-12-03 2019-11-28 Juno Therapeutics, Inc. Methods for modulation of car-t cells
EP4008728A1 (en) 2017-02-14 2022-06-08 Kite Pharma, Inc. Cd70 binding molecules and methods of use thereof
WO2018169922A2 (en) 2017-03-13 2018-09-20 Kite Pharma, Inc. Chimeric antigen receptors for melanoma and uses thereof
TW201902493A (en) 2017-04-03 2019-01-16 美商凱特製藥公司 Treatment with chimeric receptor T cells incorporating optimized multifunctional T cells
EP3684803A1 (en) 2017-09-22 2020-07-29 Kite Pharma, Inc. Antigen binding molecules and methods of use thereof
CA3076099A1 (en) 2017-09-22 2019-03-28 Kite Pharma, Inc. Linkers for chimeric antigen receptors
BR112020007493A2 (en) 2017-10-18 2020-10-27 Kite Pharma, Inc. methods of administering chimeric antigen receptor immunotherapy
WO2019099707A1 (en) 2017-11-16 2019-05-23 Kite Pharma, Inc Modified chimeric antigen receptors and methods of use

Also Published As

Publication number Publication date
TWI856961B (en) 2024-10-01
AU2023200909A1 (en) 2023-03-23
JP7174777B2 (en) 2022-11-17
WO2019232510A1 (en) 2019-12-05
EP3801572A4 (en) 2022-03-09
KR102734592B1 (en) 2024-11-27
EP3801572A1 (en) 2021-04-14
JP7553529B2 (en) 2024-09-18
KR102544086B1 (en) 2023-06-16
TW202003021A (en) 2020-01-16
JP2023024996A (en) 2023-02-21
IL278992B1 (en) 2025-01-01
KR20240119173A (en) 2024-08-06
IL278992A (en) 2021-01-31
CA3101856A1 (en) 2019-12-05
EP4403224A3 (en) 2024-07-31
KR20210014688A (en) 2021-02-09
CN112512537A (en) 2021-03-16
ES2989910T3 (en) 2024-11-28
KR20230093066A (en) 2023-06-26
KR20240170582A (en) 2024-12-03
EP3801572C0 (en) 2024-07-03
AU2019276592A1 (en) 2020-12-10
IL317487A (en) 2025-02-01
AU2019276592B2 (en) 2022-11-24
US20200003758A1 (en) 2020-01-02
IL278992B2 (en) 2025-05-01
EP4403224A2 (en) 2024-07-24
JP2024178207A (en) 2024-12-24
JP2021525863A (en) 2021-09-27
EP3801572B1 (en) 2024-07-03

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