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SG11202009844SA - Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof - Google Patents

Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof

Info

Publication number
SG11202009844SA
SG11202009844SA SG11202009844SA SG11202009844SA SG11202009844SA SG 11202009844S A SG11202009844S A SG 11202009844SA SG 11202009844S A SG11202009844S A SG 11202009844SA SG 11202009844S A SG11202009844S A SG 11202009844SA SG 11202009844S A SG11202009844S A SG 11202009844SA
Authority
SG
Singapore
Prior art keywords
peptide
tyrosine
glp
glucagon
conjugates
Prior art date
Application number
SG11202009844SA
Inventor
Raul Camacho
Martin A Case
Yue-Mei Zhang
Ellen Chi
Suzanne Edavettal
Wilson Edwards
Lisa Norquay
Mark J Wall
Rui Zhang
Songmao Zheng
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11202009844SA publication Critical patent/SG11202009844SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57545Neuropeptide Y
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SG11202009844SA 2018-04-25 2019-04-24 Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof SG11202009844SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862662313P 2018-04-25 2018-04-25
US2018029284 2018-04-25
PCT/IB2019/053384 WO2019207505A1 (en) 2018-04-25 2019-04-24 Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof

Publications (1)

Publication Number Publication Date
SG11202009844SA true SG11202009844SA (en) 2020-11-27

Family

ID=66676857

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009844SA SG11202009844SA (en) 2018-04-25 2019-04-24 Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof

Country Status (24)

Country Link
EP (1) EP3784692A1 (en)
JP (1) JP7676148B2 (en)
KR (1) KR20210005674A (en)
CN (2) CN112004822B (en)
AU (2) AU2019259790B2 (en)
BR (1) BR112020021562A2 (en)
CA (1) CA3096792A1 (en)
CL (1) CL2020002718A1 (en)
CO (1) CO2020013221A2 (en)
CR (1) CR20200487A (en)
DO (1) DOP2020000192A (en)
EC (1) ECSP20067968A (en)
IL (2) IL319050A (en)
JO (1) JOP20200265A1 (en)
MA (1) MA52361A (en)
MX (1) MX2020011293A (en)
NI (1) NI202000071A (en)
PE (1) PE20211457A1 (en)
PH (1) PH12020551659A1 (en)
SA (1) SA520420401B1 (en)
SG (1) SG11202009844SA (en)
TW (1) TWI847981B (en)
UY (1) UY38200A (en)
WO (1) WO2019207505A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190097A1 (en) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv Immunoglobulins and uses thereof
CN114874333B (en) * 2021-10-18 2025-01-24 深圳科兴药业有限公司 A growth hormone fusion protein and its application
EP4458863A1 (en) * 2021-12-31 2024-11-06 Sunshine Lake Pharma Co., Ltd. Fusion protein of glp-1 and gdf15 and use thereof
EP4572782A1 (en) 2022-08-18 2025-06-25 Boehringer Ingelheim International GmbH Combination therapy comprising long acting glp-1/glucagon and npy2 receptor agonists
CN117327200B (en) * 2023-11-28 2024-02-09 西宝生物科技(上海)股份有限公司 Dual-functional recombinant protein GIK for regulating and controlling glycolipid metabolism and resisting aging and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1961000B (en) * 2004-02-11 2011-05-04 安米林药品公司 Hybrid polypeptides with selectable properties
MXPA06010347A (en) * 2004-03-17 2007-06-19 7Tm Pharma As Y2 selective receptor agonists for therapeutic interventions.
CN101128487B (en) * 2004-12-02 2012-10-10 杜门蒂斯有限公司 Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY
US20090175795A1 (en) * 2005-07-29 2009-07-09 Amprotein Corporation Chimeric therapeutic agents
EA014647B1 (en) * 2005-08-11 2010-12-30 Амилин Фармасьютикалз, Инк. Hybrid polypeptides with selectable properties
EP2057188B1 (en) * 2006-08-17 2013-07-31 Amylin Pharmaceuticals, LLC Dpp-iv resistant gip hybrid polypeptides with selectable properties
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
JP2013506628A (en) * 2009-09-30 2013-02-28 グラクソ グループ リミテッド Drug fusions and conjugates with extended half-life
EP3368556B1 (en) * 2015-10-28 2024-04-10 Tufts University Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
JOP20190097A1 (en) 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv Immunoglobulins and uses thereof

Also Published As

Publication number Publication date
TWI847981B (en) 2024-07-11
CR20200487A (en) 2021-03-11
MA52361A (en) 2021-03-03
IL319050A (en) 2025-04-01
AU2019259790B2 (en) 2023-08-31
JOP20200265A1 (en) 2020-10-21
PH12020551659A1 (en) 2021-07-26
NI202000071A (en) 2021-01-21
ECSP20067968A (en) 2020-11-30
TW202014433A (en) 2020-04-16
CN112004822B (en) 2025-01-14
CL2020002718A1 (en) 2021-01-29
CO2020013221A2 (en) 2020-11-10
BR112020021562A2 (en) 2021-03-02
PE20211457A1 (en) 2021-08-05
CA3096792A1 (en) 2019-10-31
DOP2020000192A (en) 2021-04-30
AU2019259790A1 (en) 2020-10-22
IL278197A (en) 2020-11-30
AU2023274117B2 (en) 2025-04-10
MX2020011293A (en) 2020-11-13
EP3784692A1 (en) 2021-03-03
IL278197B1 (en) 2025-03-01
JP2021522258A (en) 2021-08-30
KR20210005674A (en) 2021-01-14
CN119708256A (en) 2025-03-28
AU2023274117A1 (en) 2023-12-21
SA520420401B1 (en) 2023-01-26
JP7676148B2 (en) 2025-05-14
CN112004822A (en) 2020-11-27
WO2019207505A1 (en) 2019-10-31
UY38200A (en) 2019-10-31
IL278197B2 (en) 2025-07-01

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