SG11202006311SA - Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators - Google Patents
Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulatorsInfo
- Publication number
- SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA
- Authority
- SG
- Singapore
- Prior art keywords
- intermediates
- preparation
- guanylate cyclase
- soluble guanylate
- novel processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862615678P | 2018-01-10 | 2018-01-10 | |
PCT/CN2018/076982 WO2019161534A1 (en) | 2018-02-22 | 2018-02-22 | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
PCT/US2019/013060 WO2019140095A1 (en) | 2018-01-10 | 2019-01-10 | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202006311SA true SG11202006311SA (en) | 2020-07-29 |
Family
ID=65279655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202006311SA SG11202006311SA (en) | 2018-01-10 | 2019-01-10 | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Country Status (17)
Country | Link |
---|---|
US (4) | US11274096B2 (en) |
EP (3) | EP4249469A3 (en) |
JP (2) | JP7357621B2 (en) |
KR (3) | KR102739727B1 (en) |
CN (3) | CN118184645A (en) |
AU (3) | AU2019206560B2 (en) |
BR (1) | BR112020013985A2 (en) |
CA (1) | CA3087943A1 (en) |
CL (3) | CL2020001814A1 (en) |
ES (1) | ES2963447T3 (en) |
IL (3) | IL319883A (en) |
JO (1) | JOP20200165A1 (en) |
MA (2) | MA71753A (en) |
MX (3) | MX2020007364A (en) |
SG (1) | SG11202006311SA (en) |
TW (1) | TWI821237B (en) |
WO (1) | WO2019140095A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109563077A (en) | 2016-07-07 | 2019-04-02 | 铁木医药有限公司 | It is used to prepare the new method of soluble guanylate cyclase stimulant |
KR102739727B1 (en) | 2018-01-10 | 2024-12-05 | 사이클리온 테라퓨틱스, 인크. | Novel methods and intermediates for the preparation of available guanylate cyclase stimulators |
AU2023412238A1 (en) * | 2022-12-21 | 2025-07-03 | Sunshine Lake Pharma Co., Ltd. | Crystal form of fluorine-substituted indazole compound and use thereof |
WO2024131850A1 (en) * | 2022-12-21 | 2024-06-27 | 广东东阳光药业股份有限公司 | Crystal form of fluorine-substituted indazole compound and use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2588465T3 (en) * | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
RS63108B1 (en) * | 2013-03-15 | 2022-04-29 | Cyclerion Therapeutics Inc | Sgc stimulators |
WO2015106268A1 (en) * | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
BR112017005248A2 (en) * | 2014-09-17 | 2017-12-12 | Ironwood Pharmaceuticals Inc | sgc stimulators |
WO2016044447A1 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
CN108883071A (en) * | 2015-11-30 | 2018-11-23 | 铁木医药有限公司 | Solid dispersions comprising sGC stimulant |
CA3029376A1 (en) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
CN109563077A (en) | 2016-07-07 | 2019-04-02 | 铁木医药有限公司 | It is used to prepare the new method of soluble guanylate cyclase stimulant |
KR102739727B1 (en) | 2018-01-10 | 2024-12-05 | 사이클리온 테라퓨틱스, 인크. | Novel methods and intermediates for the preparation of available guanylate cyclase stimulators |
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2019
- 2019-01-10 KR KR1020207022640A patent/KR102739727B1/en active Active
- 2019-01-10 CN CN202410363182.2A patent/CN118184645A/en active Pending
- 2019-01-10 EP EP23187776.2A patent/EP4249469A3/en active Pending
- 2019-01-10 JO JOP/2020/0165A patent/JOP20200165A1/en unknown
- 2019-01-10 WO PCT/US2019/013060 patent/WO2019140095A1/en active Application Filing
- 2019-01-10 ES ES19703440T patent/ES2963447T3/en active Active
- 2019-01-10 SG SG11202006311SA patent/SG11202006311SA/en unknown
- 2019-01-10 CA CA3087943A patent/CA3087943A1/en active Pending
- 2019-01-10 MA MA71753A patent/MA71753A/en unknown
- 2019-01-10 BR BR112020013985-8A patent/BR112020013985A2/en unknown
- 2019-01-10 IL IL319883A patent/IL319883A/en unknown
- 2019-01-10 MA MA051565A patent/MA51565A/en unknown
- 2019-01-10 KR KR1020257010603A patent/KR20250048609A/en active Pending
- 2019-01-10 IL IL275748A patent/IL275748B2/en unknown
- 2019-01-10 KR KR1020247039985A patent/KR20250002720A/en active Pending
- 2019-01-10 CN CN202410363184.1A patent/CN118221665A/en active Pending
- 2019-01-10 EP EP25174051.0A patent/EP4570797A2/en active Pending
- 2019-01-10 EP EP19703440.8A patent/EP3737679B1/en active Active
- 2019-01-10 CN CN201980017700.2A patent/CN111902410B/en active Active
- 2019-01-10 AU AU2019206560A patent/AU2019206560B2/en active Active
- 2019-01-10 US US16/961,109 patent/US11274096B2/en active Active
- 2019-01-10 TW TW108101044A patent/TWI821237B/en active
- 2019-01-10 MX MX2020007364A patent/MX2020007364A/en unknown
- 2019-01-10 JP JP2020538535A patent/JP7357621B2/en active Active
- 2019-01-10 IL IL314714A patent/IL314714A/en unknown
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2020
- 2020-07-07 CL CL2020001814A patent/CL2020001814A1/en unknown
- 2020-07-13 MX MX2023000045A patent/MX2023000045A/en unknown
- 2020-07-13 MX MX2023000044A patent/MX2023000044A/en unknown
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2021
- 2021-10-08 US US17/497,352 patent/US11708361B2/en active Active
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2022
- 2022-04-08 CL CL2022000907A patent/CL2022000907A1/en unknown
- 2022-04-08 CL CL2022000904A patent/CL2022000904A1/en unknown
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2023
- 2023-04-28 US US18/140,966 patent/US12030874B2/en active Active
- 2023-09-26 JP JP2023162922A patent/JP2023182647A/en active Pending
- 2023-11-22 AU AU2023270260A patent/AU2023270260A1/en active Pending
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2024
- 2024-05-22 US US18/671,182 patent/US12275724B2/en active Active
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2025
- 2025-03-31 AU AU2025202281A patent/AU2025202281A1/en active Pending
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