[go: up one dir, main page]

SG11202003254SA - Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation - Google Patents

Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation

Info

Publication number
SG11202003254SA
SG11202003254SA SG11202003254SA SG11202003254SA SG11202003254SA SG 11202003254S A SG11202003254S A SG 11202003254SA SG 11202003254S A SG11202003254S A SG 11202003254SA SG 11202003254S A SG11202003254S A SG 11202003254SA SG 11202003254S A SG11202003254S A SG 11202003254SA
Authority
SG
Singapore
Prior art keywords
hsd17b13
pnpla3
inhibition
variation
treatment
Prior art date
Application number
SG11202003254SA
Inventor
Yurong Xin
Jesper Gromada
Xiping Cheng
Frederick Dewey
Dostal Tanya Teslovich
Claudia Schurmann
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64316974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11202003254S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202003254SA publication Critical patent/SG11202003254SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202003254SA 2017-10-11 2018-10-11 Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation SG11202003254SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762570985P 2017-10-11 2017-10-11
PCT/US2018/055377 WO2019075181A1 (en) 2017-10-11 2018-10-11 Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation

Publications (1)

Publication Number Publication Date
SG11202003254SA true SG11202003254SA (en) 2020-05-28

Family

ID=64316974

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003254SA SG11202003254SA (en) 2017-10-11 2018-10-11 Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation

Country Status (12)

Country Link
US (3) US10961583B2 (en)
EP (2) EP4234719A3 (en)
JP (2) JP7434151B2 (en)
KR (2) KR102694809B1 (en)
CN (1) CN111183234A (en)
AU (2) AU2018348195B2 (en)
CA (1) CA3078883A1 (en)
IL (2) IL273550B1 (en)
MX (1) MX2020003561A (en)
RU (1) RU2020115526A (en)
SG (1) SG11202003254SA (en)
WO (1) WO2019075181A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
RU2760851C2 (en) 2017-01-23 2021-11-30 Регенерон Фармасьютикалз, Инк. Hsd17b13 options and their applications
KR102694809B1 (en) 2017-10-11 2024-08-16 리제너론 파마슈티칼스 인코포레이티드 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M mutation
AU2019239971A1 (en) 2018-03-21 2020-09-03 Regeneron Pharmaceuticals, Inc. 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof
EP3899024A4 (en) * 2018-12-21 2023-05-31 Ionis Pharmaceuticals, Inc. HSD17B13 EXPRESSION MODULATORS
EP3994125A1 (en) 2019-07-02 2022-05-11 Regeneron Pharmaceuticals, Inc. Modulators of hsd17b13 and methods of use thereof
WO2021211981A1 (en) * 2020-04-18 2021-10-21 Inipharm, Inc. Substrate selective hsd17b13 inhibitors and uses thereof
WO2021211959A2 (en) * 2020-04-18 2021-10-21 Inipharm, Inc. Methods and compositions for treating drug induced steatohepatitis
JP7626423B6 (en) 2020-10-16 2025-03-03 公立大学法人大阪 Fibrosis Treatment Drugs
MX2023007587A (en) * 2020-12-23 2023-09-21 Regeneron Pharma TREATMENT OF LIVER DISEASES WITH DFFA TYPE B EFFECTOR INHIBITORS THAT INDUCE CELL DEATH (CIDEB).
CN112626199A (en) * 2021-01-04 2021-04-09 杭州艾迪康医学检验中心有限公司 Primer and method for detecting risk prediction site for converting chronic hepatitis into liver cirrhosis
MX2024007463A (en) 2021-12-20 2024-09-02 Regeneron Pharma Methods of identifying and evaluating liver inflammation and liver fibrosis in a subject by determining a stratified score based on gene expression.
CN114262738B (en) * 2021-12-31 2023-03-31 吉林大学第一医院 Application of HSD17B13 gene polymorphism in diagnosis of moderate and severe MAFLD (myeloproliferative disorder)
TW202400791A (en) * 2022-05-06 2024-01-01 大陸商蘇州瑞博生物技術股份有限公司 Nucleic acid, composition and conjugate comprising same, preparation method therefor, and use thereof
AU2023358062A1 (en) * 2022-10-07 2025-03-20 Pfizer Inc. Hsd17b13 inhibitors and/or degraders
WO2024173343A1 (en) 2023-02-14 2024-08-22 Regeneron Pharmaceuticals, Inc. Compounds targeting hydroxysteroid 17-beta dehydrogenase (hsd17b) and uses thereof
WO2025012422A1 (en) 2023-07-13 2025-01-16 Enyo Pharma L-arginine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025012425A1 (en) 2023-07-13 2025-01-16 Enyo Pharma Tromethamine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025012038A1 (en) 2023-07-13 2025-01-16 Enyo Pharma L-lysine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025098440A1 (en) * 2023-11-08 2025-05-15 浙江扬厉医药技术有限公司 Double-stranded sirna for inhibiting pnpla3 expression and conjugate comprising same

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US38170A (en) 1863-04-14 Improvement in lamps
US5294533A (en) 1988-07-05 1994-03-15 Baylor College Of Medicine Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria
US5135917A (en) 1990-07-12 1992-08-04 Nova Pharmaceutical Corporation Interleukin receptor expression inhibiting antisense oligonucleotides
US5271941A (en) 1990-11-02 1993-12-21 Cho Chung Yoon S Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases
US5786138A (en) 1993-01-29 1998-07-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Hyperstabilizing antisense nucleic acid binding agents
EP0703979B1 (en) 1993-06-04 2000-09-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for treating kaposi's sarcoma with antisense oligonucleotides
US5578716A (en) 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
US5641754A (en) 1994-01-10 1997-06-24 The Board Of Regents Of The University Of Nebraska Antisense oligonucleotide compositions for selectively killing cancer cells
US5624813A (en) 1994-04-21 1997-04-29 Mahant; Vijay K. NAD(P)+ /NAD(P)H based chemiluminescent diagnostics
WO1996005298A1 (en) 1994-08-09 1996-02-22 Ciba-Geigy Ag Antitumor antisense oligonucleotides
US5856103A (en) 1994-10-07 1999-01-05 Board Of Regents The University Of Texas Method for selectively ranking sequences for antisense targeting
US5994320A (en) 1995-02-06 1999-11-30 Regents Of The University Of Minnesota Antisense oligonucleotides and methods for treating central nervous system tumors
IT1275862B1 (en) 1995-03-03 1997-10-24 Consiglio Nazionale Ricerche ANTI-SENSE TRANSCRIPT ASSOCIATED WITH SOME TYPES OF TUMOR CELLS AND SYNTHETIC OLIGODEOXYNUCLEOTIDES USEFUL IN DIAGNOSIS AND TREATMENT
US6040296A (en) 1995-06-07 2000-03-21 East Carolina University Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
FR2739029B1 (en) 1995-09-21 1997-11-21 Roussel Uclaf NEW THERAPEUTIC APPLICATION OF ANTIMINERALOCORTICOID COMPOUNDS
AU7286696A (en) 1995-10-13 1997-05-07 F. Hoffmann-La Roche Ag Antisense oligomers
CZ154898A3 (en) 1995-11-21 1998-09-16 Icn Pharmaceuticals, Inc. Oligonucleotides for inhibiting growth of tumors mediated by il-8 and il-8 receptor
AU1067697A (en) 1995-12-05 1997-06-27 Jouko Antero Oikarinen Hsd17b1 promoter, enhancer, silencer and use thereof
CN1215994A (en) 1996-02-15 1999-05-05 国家健康学会 Rnase L activators and antisense oligonucleotides effective to treat RSV infections
US5955590A (en) 1996-07-15 1999-09-21 Worcester Foundation For Biomedical Research Conjugates of minor groove DNA binders with antisense oligonucleotides
US6046004A (en) 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
JPH1142091A (en) 1997-07-25 1999-02-16 Toagosei Co Ltd Anti-sense nucleic acid compound
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
CA2248762A1 (en) 1997-10-22 1999-04-22 University Technologies International, Inc. Antisense oligodeoxynucleotides regulating expression of tnf-.alpha.
NZ507435A (en) 1998-03-10 2003-12-19 Genentech Inc Novel polypeptides and nucleic acids with homology to cornichon
PL343862A1 (en) 1998-03-11 2001-09-10 Endorech Inhibitors of type 5 and type 3 17β−hydroxysteroid dehydrogenase and methods for their use
US6007995A (en) 1998-06-26 1999-12-28 Isis Pharmaceuticals Inc. Antisense inhibition of TNFR1 expression
US6013522A (en) 1999-02-23 2000-01-11 Isis Pharmaceuticals Inc. Antisense inhibition of human Smad1 expression
US6025198A (en) 1999-06-25 2000-02-15 Isis Pharmaceuticals Inc. Antisense modulation of Ship-2 expression
US6033910A (en) 1999-07-19 2000-03-07 Isis Pharmaceuticals Inc. Antisense inhibition of MAP kinase kinase 6 expression
FR2801218B1 (en) 1999-11-23 2001-12-28 Hoechst Marion Roussel Inc PHARMACEUTICAL COMPOSITIONS COMPRISING TRIMEGESTONE, THEIR PREPARATION METHODS AND THE PRIMARY PACKAGING CONTAINING THEM
US7754709B2 (en) 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US20090169585A1 (en) 2003-10-23 2009-07-02 Resveratrol Partners, Llc Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
US20050158376A1 (en) 2003-10-23 2005-07-21 Sardi William F. Dietary supplement and method of processing same
WO2005108415A2 (en) 2004-04-30 2005-11-17 Biogen Idec Ma Inc. Membrane associated molecules
EP2423326B1 (en) 2004-05-07 2014-01-08 Celera Corporation Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
FR2904000A1 (en) 2006-07-19 2008-01-25 Galderma Res & Dev S N C Snc MODULATORS OF HSD17B7 IN THE TREATMENT OF ACNE OR HYPERSEBORRHEA
US20090203602A1 (en) 2006-09-01 2009-08-13 Cohava Gelber Compositions and methods for diagnosis and treatment of type 2 diabetes
US7951776B2 (en) 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US20100267052A1 (en) 2006-09-01 2010-10-21 American Type Culture Collection Compositions and methods for diagnosis and treatment of type 2 diabetes
US20080300170A1 (en) 2006-09-01 2008-12-04 Cohava Gelber Compositions and methods for diagnosis and treatment for type 2 diabetes
WO2008091873A2 (en) 2007-01-24 2008-07-31 Dana-Farber Cancer Institute, Inc. Compositions and methods for the identification, assessment, prevention and therapy of thymic lymphoma or hamartomatous tumours
EP2197434A4 (en) 2007-09-20 2011-08-10 Resveratrol Partners Llc Resveratrol-containing compositions for modulating gene product concentration or activity
EP2298359A1 (en) 2008-06-04 2011-03-23 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of controlling degranulation of mast cell
WO2010028110A2 (en) 2008-09-04 2010-03-11 Board Of Regents, The University Of Texas System Sequence variations in pnpla3 associated with hepatic steatosis
US20100209427A1 (en) 2008-09-24 2010-08-19 Yu Li Lysine acetylation sites
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
WO2010064702A1 (en) 2008-12-05 2010-06-10 国立大学法人 東京大学 Biomarker for predicting prognosis of cancer
US20100266618A1 (en) 2009-03-18 2010-10-21 Children's Hospital Of Eastern Ontario Research Institute Compositions and methods for augmenting activity of oncolytic viruses
WO2010120526A2 (en) 2009-03-31 2010-10-21 Emory University Methods and systems for screening for and diagnosing dna methylation associated with autism spectrum disorders
US9051567B2 (en) 2009-06-15 2015-06-09 Tekmira Pharmaceuticals Corporation Methods for increasing efficacy of lipid formulated siRNA
EP2949208B1 (en) 2009-07-15 2017-11-15 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
WO2011006214A1 (en) 2009-07-16 2011-01-20 Peter Maccallum Cancer Institute Method of detecting radiation exposure and adverse toxicity thereto
MX2012005995A (en) 2009-11-25 2012-08-08 Prometheus Lab Inc Novel genomic biomarkers for irritable bowel syndrome diagnosis.
WO2011084747A2 (en) 2009-12-21 2011-07-14 The Johns Hopkins University Compositions and methods for somatic tissue induced pluripotent stem cells having an endoderm origin
CA2795901A1 (en) 2010-04-12 2011-10-20 University Health Network Methods and compositions for diagnosing pulmonary fibrosis subtypes and assessing the risk of primary graft dysfunction after lung transplantation
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
EP2569446B1 (en) 2010-05-12 2018-07-11 Steven E. Schutzer Diagnostic markers for neuropsychiatric diseasen
US8945847B2 (en) 2010-05-24 2015-02-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for ascertaining biosafety of an agent
US20120058088A1 (en) 2010-06-28 2012-03-08 Resveratrol Partners, Llc Resveratrol-Containing Compositions And Methods Of Use
US20120015904A1 (en) 2010-07-14 2012-01-19 Regents Of The University Of California Biomarkers for diagnosis of transient ischemic attacks
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
WO2012052953A1 (en) 2010-10-20 2012-04-26 Fondazione Centro San Raffaele Del Monte Tabor MiRNA
RU2603731C2 (en) 2010-10-26 2016-11-27 Бак Инститьют Фор Эйдж Рисёрч Down regulation of transcription of sine/alu retrotransposons for inducing or recovery of proliferation and/or pluripotency of stem cell
EP2638163B1 (en) 2010-11-12 2017-05-17 The General Hospital Corporation Polycomb-associated non-coding rnas
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
WO2012070014A2 (en) 2010-11-26 2012-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells
US20140057800A1 (en) 2010-12-16 2014-02-27 Norwegian Univeristy of Science and Technology (NTNU) Single nucleotide polymorphism associated with risk of insulin resistance development
DK2655621T3 (en) 2010-12-20 2018-08-13 Massachusetts Gen Hospital Polycomb-associated non-coding RNAS
EP2704728A4 (en) 2011-05-03 2015-04-22 Dermachip Inc Expression signatures of genes and gene networks associated with skin aging
GB201112246D0 (en) 2011-07-15 2011-08-31 Univ Birmingham Diagnosis of alzheimer's disease
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
WO2013126565A1 (en) 2012-02-24 2013-08-29 Lunyak Victoria V Downregulation of sine/alu retrotransposon transcription to induce or restore proliferative capacity and/or pluripotency to a stem cell
WO2013166264A2 (en) 2012-05-02 2013-11-07 University Of Georgia Research Foundation, Inc. Methods for altering virus replication
US9677138B2 (en) 2012-05-20 2017-06-13 Trustees Of Boston University Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease
LT2800811T (en) 2012-05-25 2017-09-11 The Regents Of The University Of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
WO2013190075A2 (en) 2012-06-20 2013-12-27 Meyer Helmut E Specific biomarkers for hepatocellular carcinoma (hcc)
US20140004153A1 (en) 2012-07-02 2014-01-02 Lancell, L.L.C. Use of somatic mutations in the extracellular domain of transmembrane proteins in a patient's tumor as immunogens for active humoral immunotherapy of cancer
US9526720B2 (en) 2012-08-17 2016-12-27 The Broad Institute, Inc. Modulators of hepatic lipoprotein metabolism
US9375433B2 (en) 2012-09-26 2016-06-28 Tangent Reprofiling Limited Modulators of androgen synthesis
HK1211868A1 (en) 2012-09-26 2016-06-03 Tangent Reprofiling Limited Modulators of androgen synthesis
CN108220295B (en) 2012-12-05 2022-09-02 阿尔尼拉姆医药品有限公司 PCSK9 iRNA compositions and methods of use thereof
EP2929035A1 (en) 2012-12-07 2015-10-14 Shire Human Genetic Therapies, Inc. Lipidic nanoparticles for mrna delivering
US20160032395A1 (en) 2013-03-14 2016-02-04 Elai Davicioni Cancer biomarkers and classifiers and uses thereof
US20160184458A1 (en) 2013-03-14 2016-06-30 Shire Human Genetic Therapies, Inc. Mrna therapeutic compositions and use to treat diseases and disorders
US20140378425A1 (en) 2013-03-15 2014-12-25 Veracyte, Inc. Biomarkers for diagnosis of lung diseases and methods of use thereof
US20140329704A1 (en) 2013-03-28 2014-11-06 President And Fellows Of Harvard College Markers for mature beta-cells and methods of using the same
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2014197453A1 (en) 2013-06-03 2014-12-11 The Trustees Of Columbia University In The City Of New York Recurrent mutations in epigenetic regulators, rhoa and fyn kinase in peripheral t-cell lymphomas
EP3004376B1 (en) 2013-06-03 2018-05-09 Nestec S.A. Methods for diagnosing chronic valvular disease
KR20160030187A (en) 2013-06-17 2016-03-16 더 브로드 인스티튜트, 인코퍼레이티드 Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
DK3011032T3 (en) 2013-06-17 2020-01-20 Broad Inst Inc MANUFACTURING, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR TARGETING AGAINST AND MODELING DISEASES AND DISORDERS IN POSTMITOTIC CELLS
US20150079062A1 (en) 2013-07-12 2015-03-19 Patrick J. Casey Method for harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment
US20150079061A1 (en) 2013-07-12 2015-03-19 Patrick J. Casey Method for the harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment
RU2545990C2 (en) 2013-07-16 2015-04-10 Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр Департамента здравоохранения города Москвы Differential diagnostic technique for hepatic steatosis and steatohepatitis
JP6525435B2 (en) 2013-10-22 2019-06-12 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド Lipid formulations for the delivery of messenger RNA
CN103520724B (en) * 2013-10-23 2016-05-25 江苏美迪森生物医药有限公司 The new purposes of the inhibitor of HSD17B13 albumen or its encoding gene
GB201320061D0 (en) 2013-11-13 2013-12-25 Electrophoretics Ltd Materials nad methods for diagnosis and prognosis of liver cancer
CA2950800C (en) 2014-05-09 2023-01-10 Tangent Reprofiling Limited Modulators of androgen synthesis
EP3155116A4 (en) 2014-06-10 2017-12-27 Massachusetts Institute Of Technology Method for gene editing
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2016004387A1 (en) 2014-07-02 2016-01-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Gene expression signature for cancer prognosis
CA2955157A1 (en) 2014-07-14 2016-01-21 Patrick J. Casey Method for the harvesting, processing, and storage of proteins from the mammalian feto-placental unit and use of such proteins in compositions and medical treatment
WO2016028638A1 (en) 2014-08-18 2016-02-25 Drexel University Methods, computer-readable media, and systems for assessing samples and wounds, predicting whether a wound will heal, and monitoring effectiveness of a treatment
EP3770274A1 (en) 2014-11-05 2021-01-27 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
JP2018510621A (en) 2015-02-13 2018-04-19 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Patatin-like phospholipase domain-containing 3 (PNPLA3) iRNA compositions and methods of use thereof
CN104698108B (en) 2015-03-26 2016-11-09 中国药科大学 A method for screening type I 17β hydroxysteroid dehydrogenase inhibitors using immobilized enzymes
EP3350328A1 (en) * 2015-09-14 2018-07-25 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
EP3159407A1 (en) 2015-10-23 2017-04-26 Silence Therapeutics (London) Ltd Guide rnas, methods and uses
EP3387129A1 (en) 2015-12-10 2018-10-17 Alnylam Pharmaceuticals, Inc. STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
CA3005245A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Antisense oligomers for treatment of alagille syndrome
WO2017106283A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Compositions and methods for treatment of liver diseases
WO2017106370A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Compositions and methods for treatment of eye diseases
WO2017106375A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Antisense oligomers for treatment of tuberous sclerosis complex
WO2017106364A2 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Compositions and methods for treatment of retinitis pigmentosa 18 and retinitis pigmentosa 13
WO2017106292A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Compositions and methods for treatment of kidney diseases
EP4104867A3 (en) 2015-12-14 2023-03-01 Cold Spring Harbor Laboratory Compositions and methods for treatment of central nervous system diseases
WO2017156310A1 (en) 2016-03-09 2017-09-14 Molecular Stethoscope, Inc. Methods and systems for detecting tissue conditions
CN109640649A (en) 2016-03-16 2019-04-16 斯波根生物技术公司 Promote the method for plant health using resolvase and the microorganism for being overexpressed enzyme
WO2017191274A2 (en) 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
US10036024B2 (en) 2016-06-03 2018-07-31 Purdue Research Foundation siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
US10767175B2 (en) 2016-06-08 2020-09-08 Agilent Technologies, Inc. High specificity genome editing using chemically modified guide RNAs
GB201609977D0 (en) 2016-06-08 2016-07-20 Cancer Rec Tech Ltd Chemosensitivity predictive biomarkers
CN119464289A (en) 2016-12-08 2025-02-18 因特利亚治疗公司 Modified guide RNA
JP2020500539A (en) 2016-12-09 2020-01-16 サンガモ セラピューティクス， インコーポレイテッド Delivery of target-specific nucleases
WO2018112278A1 (en) 2016-12-14 2018-06-21 Ligandal, Inc. Methods and compositions for nucleic acid and protein payload delivery
RU2760851C2 (en) 2017-01-23 2021-11-30 Регенерон Фармасьютикалз, Инк. Hsd17b13 options and their applications
CN118581154A (en) 2017-06-02 2024-09-03 国家健康与医学研究院 Genome editing approaches and gene therapy combined with viral vectors for gene therapy of genetic disorders
KR102694809B1 (en) * 2017-10-11 2024-08-16 리제너론 파마슈티칼스 인코포레이티드 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M mutation
AU2019239971A1 (en) 2018-03-21 2020-09-03 Regeneron Pharmaceuticals, Inc. 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof
EP3768854A4 (en) 2018-03-21 2022-03-02 Ionis Pharmaceuticals, Inc. Modulation of hsd17b13 expression
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
KR20210029772A (en) 2018-06-08 2021-03-16 인텔리아 테라퓨틱스, 인크. Modified guide RNA for gene editing
JP2021528426A (en) 2018-06-19 2021-10-21 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Lipid nanoparticle composition for delivery of mRNA and long nucleic acids
EP3994125A1 (en) 2019-07-02 2022-05-11 Regeneron Pharmaceuticals, Inc. Modulators of hsd17b13 and methods of use thereof

Also Published As

Publication number Publication date
RU2020115526A3 (en) 2021-11-26
AU2018348195A1 (en) 2020-04-23
JP2020536560A (en) 2020-12-17
EP4234719A2 (en) 2023-08-30
KR20200062314A (en) 2020-06-03
US20190106749A1 (en) 2019-04-11
EP3695012B1 (en) 2023-03-08
IL319615A (en) 2025-05-01
KR20240125690A (en) 2024-08-19
CA3078883A1 (en) 2019-04-18
US20230383353A1 (en) 2023-11-30
US10961583B2 (en) 2021-03-30
WO2019075181A1 (en) 2019-04-18
CN111183234A (en) 2020-05-19
US20210246508A1 (en) 2021-08-12
EP4234719A3 (en) 2023-10-18
RU2020115526A (en) 2021-11-12
AU2025203267A1 (en) 2025-05-29
AU2018348195B2 (en) 2025-05-15
IL273550A (en) 2020-05-31
IL273550B1 (en) 2025-05-01
MX2020003561A (en) 2020-08-03
US12286677B2 (en) 2025-04-29
JP2024045454A (en) 2024-04-02
JP7434151B2 (en) 2024-02-20
EP3695012A1 (en) 2020-08-19
KR102694809B1 (en) 2024-08-16
US11702700B2 (en) 2023-07-18

Similar Documents

Publication Publication Date Title
IL273550A (en) Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation
ZA201908165B (en) Compounds for the prevention and treatment of diseases and the use thereof
IL266047A (en) Methods and compositions for the treatment of fabry disease
IL254142B (en) Tradipitant for use in the treatment of a tradipitant-responsive disease or condition
IL269096A (en) Treatment of glycogen storage disease iii
IL269083A (en) Methods for the prevention and treatment of heart diseases
IL290251A (en) Combination for the effective treatment of metastatic cancer in patients
SI3722291T1 (en) Indolinone compounds and their use in the treatment of fibrotic diseases
IL281585B (en) Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof
GB201504387D0 (en) Materials and methods for the treatment of vascular disease
PL3484475T3 (en) 1-methylnicotinamide for the treatment of cardiovascular disease
GB201519557D0 (en) Compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions
PT3302523T (en) Composition for the treatment of tissue lesions
IL254252A0 (en) Tetrahydrofurane-fused aminohydrothiazine derivatives which are useful in the treatment of alzheimer's disease
IL269121A (en) Usl-311 for use in the treatment of cancer
IL251024A0 (en) Anti eotaxin 2 antibodies for use in the treatment of hepatic diseases
IL251135A (en) Method for the synthesis of hydroxy-triglycerides and use thereof for the prevention and treatment of diseases
ZA202006886B (en) R-fadrozole for use in the treatment of aldostonerism
PT3236967T (en) Prevention and treatment of metastatic disease in thrombocytotic cancer patients
IL275906B (en) Use of heterocyclic compounds in the treatment of pigmented skin
HK40098035A (en) Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation
GB201622116D0 (en) Treatment of liver disease
GB201808964D0 (en) Treatment of liver disease
HK40025688A (en) Cobitolimod for use in the treatment of inflammatory bowel disease
HK1248110A1 (en) Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases