SG11202001637PA - Glucagon-like peptide 1 receptor agonists and uses thereof - Google Patents
Glucagon-like peptide 1 receptor agonists and uses thereofInfo
- Publication number
- SG11202001637PA SG11202001637PA SG11202001637PA SG11202001637PA SG11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA
- Authority
- SG
- Singapore
- Prior art keywords
- glucagon
- peptide
- receptor agonists
- agonists
- receptor
- Prior art date
Links
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762562283P | 2017-09-22 | 2017-09-22 | |
PCT/US2018/052110 WO2019060653A1 (en) | 2017-09-22 | 2018-09-21 | Glucagon-like peptide 1 receptor agonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202001637PA true SG11202001637PA (en) | 2020-03-30 |
Family
ID=63799082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202001637PA SG11202001637PA (en) | 2017-09-22 | 2018-09-21 | Glucagon-like peptide 1 receptor agonists and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (4) | US11045522B2 (en) |
EP (1) | EP3684793A1 (en) |
JP (3) | JP7239566B2 (en) |
KR (1) | KR102696518B1 (en) |
CN (2) | CN118955732A (en) |
AU (2) | AU2018338178B2 (en) |
CA (1) | CA3073964A1 (en) |
EA (1) | EA202090649A1 (en) |
IL (2) | IL304574B1 (en) |
MX (1) | MX2020002977A (en) |
SG (1) | SG11202001637PA (en) |
WO (1) | WO2019060653A1 (en) |
ZA (1) | ZA202001167B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL304574B1 (en) | 2017-09-22 | 2025-04-01 | Regeneron Pharma | Glucagon-like peptide 1 receptor agonists and uses thereof |
US12122817B2 (en) * | 2020-09-22 | 2024-10-22 | Serpentide Inc. | Long-lasting GLP1 analogue drug for type-2 diabetes |
WO2022119076A1 (en) * | 2020-12-03 | 2022-06-09 | 이뮤노포지 주식회사 | Fusion protein including glp-1 receptor agonist and anti-oscar antibody, and use thereof |
WO2022117044A1 (en) * | 2020-12-03 | 2022-06-09 | Sunshine Lake Pharma Co., Ltd. | Glp-1/gcg dual receptor agonist polypeptide and fusion protein thereof |
CN112716966B (en) * | 2021-02-03 | 2022-05-03 | 浙江诺得药业有限公司 | Empagliflozin pharmaceutical composition and preparation method thereof |
CN113461785B (en) * | 2021-04-13 | 2022-10-14 | 湖南中晟全肽生化有限公司 | GLP-1 receptor agonists and uses thereof |
CN114874333B (en) * | 2021-10-18 | 2025-01-24 | 深圳科兴药业有限公司 | A growth hormone fusion protein and its application |
CN114788876B (en) * | 2022-02-24 | 2024-07-05 | 北京医院 | MRNA (messenger ribonucleic acid) medicinal preparation for treating diabetes and preparation method and application thereof |
WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
CN117143242B (en) * | 2023-10-30 | 2024-03-29 | 南京佰抗生物科技有限公司 | Monoclonal antibody composition for resisting Galectin-3 protein and application thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1641823T3 (en) | 2003-06-12 | 2011-12-12 | Lilly Co Eli | GLP-1 analog fusion proteins |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
US20060275288A1 (en) | 2005-01-20 | 2006-12-07 | Grihalde Nelson D | GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof |
US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
AR064623A1 (en) | 2006-12-21 | 2009-04-15 | Centocor Inc | USE OF LONG-TERM GLP-1 RECEPTOR AGONISTS TO IMPROVE INSULIN SENSITIVITY AND LIPID PROFILES |
EP2185178B1 (en) | 2007-08-03 | 2017-08-23 | Eli Lilly And Company | Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity |
WO2009030738A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
DK2373681T3 (en) | 2008-12-10 | 2017-04-24 | Glaxosmithkline Llc | PHARMACEUTICAL COMPOSITIONS OF ALBIGLUTID |
US20120148586A1 (en) | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
WO2011043530A1 (en) * | 2009-10-09 | 2011-04-14 | (주)알테오젠 | Glp-1 analog fusions, and composition for preventing or treating diabetes containing the fusions as an active ingredient |
ES2617281T3 (en) | 2009-10-28 | 2017-06-16 | Janssen Biotech, Inc. | Anti-glp-1r antibodies and their uses |
EP2496249B1 (en) | 2009-11-03 | 2016-03-09 | Amylin Pharmaceuticals, LLC | Glp-1 receptor agonist for use in treating obstructive sleep apnea |
BR112015004734A2 (en) | 2012-09-07 | 2017-11-21 | Sanofi Sa | fusion proteins to treat a metabolic syndrome |
WO2014113357A1 (en) | 2013-01-17 | 2014-07-24 | Transtech Pharma, Llc | Combinations of a glp1r agonist and metformin and use thereof for the treatment of type 2 diabetes and other disorders |
US20150259416A1 (en) | 2014-03-12 | 2015-09-17 | Biocrine Ab | Methods for treating and/or limiting development of diabetes |
CN104371019B (en) | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | It is a kind of can with GLP-1R specifically bind antibody and its with the fused protein of GLP-1 |
CN104098702B (en) * | 2014-07-23 | 2017-06-16 | 湖北工业大学 | One kind prepares the polypeptides of GLP 1 or its analog methods and applications using MFH fusion proteins |
CN111388680B (en) * | 2015-01-28 | 2024-01-05 | 中国科学院天津工业生物技术研究所 | Application of polypeptide complex as polypeptide or protein drug carrier, method and fusion protein complex thereof |
AU2016218759B2 (en) | 2015-02-11 | 2021-11-25 | Gmax Biopharm Llc. | Stabilized solution preparation of pharmaceutical GLP-1R antibody fusion protein |
TWI622596B (en) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | Glucagon receptor agonist |
WO2017211922A2 (en) * | 2016-06-09 | 2017-12-14 | Medimmune Limited | Protease-resistant mono-lipidated peptides |
IL304574B1 (en) | 2017-09-22 | 2025-04-01 | Regeneron Pharma | Glucagon-like peptide 1 receptor agonists and uses thereof |
-
2018
- 2018-09-21 IL IL304574A patent/IL304574B1/en unknown
- 2018-09-21 JP JP2020516667A patent/JP7239566B2/en active Active
- 2018-09-21 CA CA3073964A patent/CA3073964A1/en active Pending
- 2018-09-21 SG SG11202001637PA patent/SG11202001637PA/en unknown
- 2018-09-21 CN CN202410964216.3A patent/CN118955732A/en active Pending
- 2018-09-21 IL IL273253A patent/IL273253B2/en unknown
- 2018-09-21 US US16/137,662 patent/US11045522B2/en active Active
- 2018-09-21 WO PCT/US2018/052110 patent/WO2019060653A1/en not_active Application Discontinuation
- 2018-09-21 EA EA202090649A patent/EA202090649A1/en unknown
- 2018-09-21 MX MX2020002977A patent/MX2020002977A/en unknown
- 2018-09-21 EP EP18783613.5A patent/EP3684793A1/en active Pending
- 2018-09-21 CN CN201880061327.6A patent/CN111108117B/en active Active
- 2018-09-21 KR KR1020207011414A patent/KR102696518B1/en active Active
- 2018-09-21 AU AU2018338178A patent/AU2018338178B2/en active Active
-
2020
- 2020-02-25 ZA ZA2020/01167A patent/ZA202001167B/en unknown
-
2021
- 2021-05-27 US US17/332,215 patent/US11779633B2/en active Active
-
2023
- 2023-03-01 JP JP2023030635A patent/JP7559112B2/en active Active
- 2023-08-29 US US18/457,482 patent/US12090193B2/en active Active
- 2023-09-04 AU AU2023223010A patent/AU2023223010A1/en active Pending
-
2024
- 2024-08-14 US US18/804,421 patent/US20250000949A1/en active Pending
- 2024-09-17 JP JP2024159697A patent/JP2024178255A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2023223010A1 (en) | 2023-11-09 |
CN118955732A (en) | 2024-11-15 |
EA202090649A1 (en) | 2020-06-29 |
IL273253A (en) | 2020-04-30 |
KR102696518B1 (en) | 2024-08-21 |
KR20200054303A (en) | 2020-05-19 |
IL273253B2 (en) | 2024-07-01 |
AU2018338178A1 (en) | 2020-04-02 |
US11045522B2 (en) | 2021-06-29 |
JP7559112B2 (en) | 2024-10-01 |
JP2023071827A (en) | 2023-05-23 |
IL273253B1 (en) | 2024-03-01 |
US12090193B2 (en) | 2024-09-17 |
CN111108117A (en) | 2020-05-05 |
JP2024178255A (en) | 2024-12-24 |
US20190091296A1 (en) | 2019-03-28 |
CN111108117B (en) | 2024-08-06 |
WO2019060653A1 (en) | 2019-03-28 |
US20240024428A1 (en) | 2024-01-25 |
IL304574B1 (en) | 2025-04-01 |
JP7239566B2 (en) | 2023-03-14 |
ZA202001167B (en) | 2024-06-26 |
US11779633B2 (en) | 2023-10-10 |
US20250000949A1 (en) | 2025-01-02 |
JP2020534016A (en) | 2020-11-26 |
US20210283225A1 (en) | 2021-09-16 |
CA3073964A1 (en) | 2019-03-28 |
AU2018338178B2 (en) | 2023-06-08 |
EP3684793A1 (en) | 2020-07-29 |
MX2020002977A (en) | 2020-11-06 |
IL304574A (en) | 2023-09-01 |
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