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SG11202001637PA - Glucagon-like peptide 1 receptor agonists and uses thereof - Google Patents

Glucagon-like peptide 1 receptor agonists and uses thereof

Info

Publication number
SG11202001637PA
SG11202001637PA SG11202001637PA SG11202001637PA SG11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA SG 11202001637P A SG11202001637P A SG 11202001637PA
Authority
SG
Singapore
Prior art keywords
glucagon
peptide
receptor agonists
agonists
receptor
Prior art date
Application number
SG11202001637PA
Inventor
Yang Wei
Haruka Okamoto
Jesper Gromada
Samuel Davis
Andrew Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202001637PA publication Critical patent/SG11202001637PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082Hepadnaviridae, e.g. hepatitis B virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
SG11202001637PA 2017-09-22 2018-09-21 Glucagon-like peptide 1 receptor agonists and uses thereof SG11202001637PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762562283P 2017-09-22 2017-09-22
PCT/US2018/052110 WO2019060653A1 (en) 2017-09-22 2018-09-21 Glucagon-like peptide 1 receptor agonists and uses thereof

Publications (1)

Publication Number Publication Date
SG11202001637PA true SG11202001637PA (en) 2020-03-30

Family

ID=63799082

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001637PA SG11202001637PA (en) 2017-09-22 2018-09-21 Glucagon-like peptide 1 receptor agonists and uses thereof

Country Status (13)

Country Link
US (4) US11045522B2 (en)
EP (1) EP3684793A1 (en)
JP (3) JP7239566B2 (en)
KR (1) KR102696518B1 (en)
CN (2) CN118955732A (en)
AU (2) AU2018338178B2 (en)
CA (1) CA3073964A1 (en)
EA (1) EA202090649A1 (en)
IL (2) IL304574B1 (en)
MX (1) MX2020002977A (en)
SG (1) SG11202001637PA (en)
WO (1) WO2019060653A1 (en)
ZA (1) ZA202001167B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL304574B1 (en) 2017-09-22 2025-04-01 Regeneron Pharma Glucagon-like peptide 1 receptor agonists and uses thereof
US12122817B2 (en) * 2020-09-22 2024-10-22 Serpentide Inc. Long-lasting GLP1 analogue drug for type-2 diabetes
WO2022119076A1 (en) * 2020-12-03 2022-06-09 이뮤노포지 주식회사 Fusion protein including glp-1 receptor agonist and anti-oscar antibody, and use thereof
WO2022117044A1 (en) * 2020-12-03 2022-06-09 Sunshine Lake Pharma Co., Ltd. Glp-1/gcg dual receptor agonist polypeptide and fusion protein thereof
CN112716966B (en) * 2021-02-03 2022-05-03 浙江诺得药业有限公司 Empagliflozin pharmaceutical composition and preparation method thereof
CN113461785B (en) * 2021-04-13 2022-10-14 湖南中晟全肽生化有限公司 GLP-1 receptor agonists and uses thereof
CN114874333B (en) * 2021-10-18 2025-01-24 深圳科兴药业有限公司 A growth hormone fusion protein and its application
CN114788876B (en) * 2022-02-24 2024-07-05 北京医院 MRNA (messenger ribonucleic acid) medicinal preparation for treating diabetes and preparation method and application thereof
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
CN117143242B (en) * 2023-10-30 2024-03-29 南京佰抗生物科技有限公司 Monoclonal antibody composition for resisting Galectin-3 protein and application thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
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DK1641823T3 (en) 2003-06-12 2011-12-12 Lilly Co Eli GLP-1 analog fusion proteins
US8257740B1 (en) 2011-08-15 2012-09-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
US20060275288A1 (en) 2005-01-20 2006-12-07 Grihalde Nelson D GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
AR064623A1 (en) 2006-12-21 2009-04-15 Centocor Inc USE OF LONG-TERM GLP-1 RECEPTOR AGONISTS TO IMPROVE INSULIN SENSITIVITY AND LIPID PROFILES
EP2185178B1 (en) 2007-08-03 2017-08-23 Eli Lilly And Company Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity
WO2009030738A1 (en) 2007-09-05 2009-03-12 Novo Nordisk A/S Glucagon-like peptide-1 derivatives and their pharmaceutical use
DK2373681T3 (en) 2008-12-10 2017-04-24 Glaxosmithkline Llc PHARMACEUTICAL COMPOSITIONS OF ALBIGLUTID
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
WO2011043530A1 (en) * 2009-10-09 2011-04-14 (주)알테오젠 Glp-1 analog fusions, and composition for preventing or treating diabetes containing the fusions as an active ingredient
ES2617281T3 (en) 2009-10-28 2017-06-16 Janssen Biotech, Inc. Anti-glp-1r antibodies and their uses
EP2496249B1 (en) 2009-11-03 2016-03-09 Amylin Pharmaceuticals, LLC Glp-1 receptor agonist for use in treating obstructive sleep apnea
BR112015004734A2 (en) 2012-09-07 2017-11-21 Sanofi Sa fusion proteins to treat a metabolic syndrome
WO2014113357A1 (en) 2013-01-17 2014-07-24 Transtech Pharma, Llc Combinations of a glp1r agonist and metformin and use thereof for the treatment of type 2 diabetes and other disorders
US20150259416A1 (en) 2014-03-12 2015-09-17 Biocrine Ab Methods for treating and/or limiting development of diabetes
CN104371019B (en) 2013-08-13 2019-09-10 鸿运华宁(杭州)生物医药有限公司 It is a kind of can with GLP-1R specifically bind antibody and its with the fused protein of GLP-1
CN104098702B (en) * 2014-07-23 2017-06-16 湖北工业大学 One kind prepares the polypeptides of GLP 1 or its analog methods and applications using MFH fusion proteins
CN111388680B (en) * 2015-01-28 2024-01-05 中国科学院天津工业生物技术研究所 Application of polypeptide complex as polypeptide or protein drug carrier, method and fusion protein complex thereof
AU2016218759B2 (en) 2015-02-11 2021-11-25 Gmax Biopharm Llc. Stabilized solution preparation of pharmaceutical GLP-1R antibody fusion protein
TWI622596B (en) 2015-10-26 2018-05-01 美國禮來大藥廠 Glucagon receptor agonist
WO2017211922A2 (en) * 2016-06-09 2017-12-14 Medimmune Limited Protease-resistant mono-lipidated peptides
IL304574B1 (en) 2017-09-22 2025-04-01 Regeneron Pharma Glucagon-like peptide 1 receptor agonists and uses thereof

Also Published As

Publication number Publication date
AU2023223010A1 (en) 2023-11-09
CN118955732A (en) 2024-11-15
EA202090649A1 (en) 2020-06-29
IL273253A (en) 2020-04-30
KR102696518B1 (en) 2024-08-21
KR20200054303A (en) 2020-05-19
IL273253B2 (en) 2024-07-01
AU2018338178A1 (en) 2020-04-02
US11045522B2 (en) 2021-06-29
JP7559112B2 (en) 2024-10-01
JP2023071827A (en) 2023-05-23
IL273253B1 (en) 2024-03-01
US12090193B2 (en) 2024-09-17
CN111108117A (en) 2020-05-05
JP2024178255A (en) 2024-12-24
US20190091296A1 (en) 2019-03-28
CN111108117B (en) 2024-08-06
WO2019060653A1 (en) 2019-03-28
US20240024428A1 (en) 2024-01-25
IL304574B1 (en) 2025-04-01
JP7239566B2 (en) 2023-03-14
ZA202001167B (en) 2024-06-26
US11779633B2 (en) 2023-10-10
US20250000949A1 (en) 2025-01-02
JP2020534016A (en) 2020-11-26
US20210283225A1 (en) 2021-09-16
CA3073964A1 (en) 2019-03-28
AU2018338178B2 (en) 2023-06-08
EP3684793A1 (en) 2020-07-29
MX2020002977A (en) 2020-11-06
IL304574A (en) 2023-09-01

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