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SG11202001479RA - Rar selective agonists in combination with immune modulators for cancer immunotherapy - Google Patents

Rar selective agonists in combination with immune modulators for cancer immunotherapy

Info

Publication number
SG11202001479RA
SG11202001479RA SG11202001479RA SG11202001479RA SG11202001479RA SG 11202001479R A SG11202001479R A SG 11202001479RA SG 11202001479R A SG11202001479R A SG 11202001479RA SG 11202001479R A SG11202001479R A SG 11202001479RA SG 11202001479R A SG11202001479R A SG 11202001479RA
Authority
SG
Singapore
Prior art keywords
combination
cancer immunotherapy
selective agonists
immune modulators
rar selective
Prior art date
Application number
SG11202001479RA
Inventor
Roshantha A Chandraratna
Martin E Sanders
Original Assignee
Io Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Therapeutics Inc filed Critical Io Therapeutics Inc
Publication of SG11202001479RA publication Critical patent/SG11202001479RA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K35/14—Blood; Artificial blood
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    • A—HUMAN NECESSITIES
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    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A—HUMAN NECESSITIES
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]

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SG11202001479RA 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy SG11202001479RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762552814P 2017-08-31 2017-08-31
PCT/US2018/048876 WO2019046591A1 (en) 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy

Publications (1)

Publication Number Publication Date
SG11202001479RA true SG11202001479RA (en) 2020-03-30

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ID=65436409

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Application Number Title Priority Date Filing Date
SG11202001479RA SG11202001479RA (en) 2017-08-31 2018-08-30 Rar selective agonists in combination with immune modulators for cancer immunotherapy

Country Status (13)

Country Link
US (5) US10363272B2 (en)
EP (1) EP3675843A4 (en)
JP (1) JP2020532537A (en)
KR (1) KR20200044889A (en)
CN (1) CN111148514A (en)
AU (1) AU2018326617B2 (en)
CA (1) CA3073953A1 (en)
IL (1) IL272971A (en)
MX (1) MX2020002262A (en)
NZ (1) NZ761401A (en)
SG (1) SG11202001479RA (en)
WO (1) WO2019046591A1 (en)
ZA (1) ZA202001884B (en)

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