SG11201909229SA - Crystalline forms of (s)-afoxolaner - Google Patents
Crystalline forms of (s)-afoxolanerInfo
- Publication number
- SG11201909229SA SG11201909229SA SG11201909229SA SG11201909229SA SG 11201909229S A SG11201909229S A SG 11201909229SA SG 11201909229S A SG11201909229S A SG 11201909229SA SG 11201909229S A SG11201909229S A SG 11201909229SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- crystalline forms
- pct
- duluth
- chemin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Secondary Cells (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
WO 18/187 6 23 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit IIl °nolo mono mil (10) International Publication Number WO 2018/187623 Al (51) International Patent Classification: CO7D 261/04 (2006.01) A61P 33/00 (2006.01) A61K 31/42 (2006.01) (21) International Application Number: PCT/US2018/026328 (22) International Filing Date: 05 April 2018 (05.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,175 05 April 2017 (05.04.2017) US (71) Applicant: MERIAL, INC. [US/US]; 3239 Satellite Blvd., Duluth, GA 30096 (US). (72) Inventors: GORTER DE VRIES, Roelof, Johannes; 50 Avenue Marcel Merieux, 69290 St. Genis Les 011ieres (FR). BAILLON, Bruno; 9 Chemin De Pierre Grosse, 05300 Le Poet (FR). LAFONT, Sylvaine; 9 Rue Des Romarines, Lieu Dit Les Saiettes, 04160 Chateau-amoux (FR). GAY DE SAINT MICHEL, Myriam; 1 Chemin Du Pra De L'intra, 04310 Peyruis (FR). KOZLOVIC, Stephane; 22 Rue Du Bosquet, 04200 Sisteron (FR). (74) Agent: JARECKI-BLACK, Judy; 3239 Satelite Blvd., Duluth, GA 30096 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: CRYSTALLINE FORMS OF (S)-AFOXOLANER CI CF 3 CF 3 (Ia) (57) : The present invention provides crystalline forms of compound of formula (la) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and crystalline forms for treating or preventing parasitic in- fections in an animal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482175P | 2017-04-05 | 2017-04-05 | |
| PCT/US2018/026328 WO2018187623A1 (en) | 2017-04-05 | 2018-04-05 | Crystalline forms of (s)-afoxolaner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201909229SA true SG11201909229SA (en) | 2019-11-28 |
Family
ID=62092252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201909229S SG11201909229SA (en) | 2017-04-05 | 2018-04-05 | Crystalline forms of (s)-afoxolaner |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10662163B2 (en) |
| EP (1) | EP3606911A1 (en) |
| JP (1) | JP7222909B2 (en) |
| KR (1) | KR102612648B1 (en) |
| AR (1) | AR111412A1 (en) |
| AU (1) | AU2018250304B2 (en) |
| BR (1) | BR112019021072A2 (en) |
| CA (1) | CA3059114A1 (en) |
| CL (1) | CL2019002840A1 (en) |
| CO (1) | CO2019011980A2 (en) |
| EA (1) | EA201992360A1 (en) |
| IL (1) | IL269792B (en) |
| MD (1) | MD20190080A2 (en) |
| MX (1) | MX2019011931A (en) |
| MY (1) | MY188420A (en) |
| NZ (1) | NZ757869A (en) |
| PH (1) | PH12019502277A1 (en) |
| SG (1) | SG11201909229SA (en) |
| TW (1) | TWI782976B (en) |
| UA (1) | UA125727C2 (en) |
| UY (1) | UY37665A (en) |
| WO (1) | WO2018187623A1 (en) |
| ZA (1) | ZA201906464B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118536571A (en) * | 2024-05-31 | 2024-08-23 | 北京无问芯穹科技有限公司 | Method, system, equipment and storage medium for constructing diffusion converter model |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201909229SA (en) * | 2017-04-05 | 2019-11-28 | Boehringer Ingelheim Animal Health Usa Inc | Crystalline forms of (s)-afoxolaner |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI412322B (en) | 2005-12-30 | 2013-10-21 | Du Pont | Isoxazolines for controlling invertebrate pests |
| TWI430995B (en) | 2007-06-26 | 2014-03-21 | Du Pont | Naphthalene isoxazoline invertebrate pest control agents |
| TWI600639B (en) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | Compound for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
| AU2011258621B2 (en) | 2010-05-27 | 2014-08-14 | Corteva Agriscience Llc | Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4, 5 - dihydro - 5 - (trifluoromethyl) -3 - isoxazolyl] -N- [2-0x0-2- [ ( 2, 2, 2 - trifluoroethyl) amino] ethyl] -1- naphthalenecarboxamide |
| UY36570A (en) * | 2015-02-26 | 2016-10-31 | Merial Inc | INJECTABLE FORMULATIONS OF PROLONGED ACTION THAT INCLUDE AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES OF THE SAME |
| RS62755B1 (en) * | 2016-04-06 | 2022-01-31 | Boehringer Ingelheim Animal Health Usa Inc | Process for the preparation of enantiomerically enriched isoxazoline compounds - crystalline toluene solvate of (s)-afoxolaner |
| SG11201909229SA (en) * | 2017-04-05 | 2019-11-28 | Boehringer Ingelheim Animal Health Usa Inc | Crystalline forms of (s)-afoxolaner |
-
2018
- 2018-04-05 SG SG11201909229S patent/SG11201909229SA/en unknown
- 2018-04-05 AU AU2018250304A patent/AU2018250304B2/en active Active
- 2018-04-05 CA CA3059114A patent/CA3059114A1/en active Pending
- 2018-04-05 JP JP2019554802A patent/JP7222909B2/en active Active
- 2018-04-05 BR BR112019021072-5A patent/BR112019021072A2/en active Search and Examination
- 2018-04-05 EP EP18721541.3A patent/EP3606911A1/en active Pending
- 2018-04-05 UA UAA201910863A patent/UA125727C2/en unknown
- 2018-04-05 NZ NZ757869A patent/NZ757869A/en unknown
- 2018-04-05 MY MYPI2019005850A patent/MY188420A/en unknown
- 2018-04-05 MX MX2019011931A patent/MX2019011931A/en unknown
- 2018-04-05 MD MDA20190080A patent/MD20190080A2/en unknown
- 2018-04-05 US US15/946,642 patent/US10662163B2/en active Active
- 2018-04-05 UY UY0001037665A patent/UY37665A/en unknown
- 2018-04-05 WO PCT/US2018/026328 patent/WO2018187623A1/en active Application Filing
- 2018-04-05 KR KR1020197032461A patent/KR102612648B1/en active Active
- 2018-04-05 EA EA201992360A patent/EA201992360A1/en unknown
- 2018-04-05 AR ARP180100859A patent/AR111412A1/en unknown
- 2018-04-09 TW TW107112164A patent/TWI782976B/en active
-
2019
- 2019-10-01 ZA ZA2019/06464A patent/ZA201906464B/en unknown
- 2019-10-02 PH PH12019502277A patent/PH12019502277A1/en unknown
- 2019-10-03 IL IL269792A patent/IL269792B/en unknown
- 2019-10-04 CL CL2019002840A patent/CL2019002840A1/en unknown
- 2019-10-28 CO CONC2019/0011980A patent/CO2019011980A2/en unknown
-
2020
- 2020-03-20 US US16/825,616 patent/US11130739B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118536571A (en) * | 2024-05-31 | 2024-08-23 | 北京无问芯穹科技有限公司 | Method, system, equipment and storage medium for constructing diffusion converter model |
Also Published As
| Publication number | Publication date |
|---|---|
| CL2019002840A1 (en) | 2020-01-10 |
| ZA201906464B (en) | 2021-08-25 |
| CA3059114A1 (en) | 2018-10-11 |
| MX2019011931A (en) | 2020-01-13 |
| UA125727C2 (en) | 2022-05-25 |
| MD20190080A2 (en) | 2020-04-30 |
| TWI782976B (en) | 2022-11-11 |
| EP3606911A1 (en) | 2020-02-12 |
| AU2018250304A1 (en) | 2019-10-31 |
| CO2019011980A2 (en) | 2020-02-18 |
| JP2020513010A (en) | 2020-04-30 |
| WO2018187623A1 (en) | 2018-10-11 |
| KR20190136055A (en) | 2019-12-09 |
| AU2018250304B2 (en) | 2022-03-03 |
| US10662163B2 (en) | 2020-05-26 |
| US20200270219A1 (en) | 2020-08-27 |
| KR102612648B1 (en) | 2023-12-11 |
| CN111032634A (en) | 2020-04-17 |
| BR112019021072A2 (en) | 2020-05-12 |
| JP7222909B2 (en) | 2023-02-15 |
| WO2018187623A8 (en) | 2019-10-24 |
| IL269792B (en) | 2022-04-01 |
| EA201992360A1 (en) | 2020-09-02 |
| IL269792A (en) | 2019-11-28 |
| US20180354917A1 (en) | 2018-12-13 |
| PH12019502277A1 (en) | 2020-09-14 |
| US11130739B2 (en) | 2021-09-28 |
| TW201841895A (en) | 2018-12-01 |
| UY37665A (en) | 2018-10-31 |
| MY188420A (en) | 2021-12-08 |
| NZ757869A (en) | 2024-11-29 |
| AR111412A1 (en) | 2019-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201902938TA (en) | Compounds, devices, and uses thereof | |
| SG11201909949XA (en) | Targeted immunotolerance | |
| SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
| SG11201809499UA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
| SG11201808108XA (en) | Synthesis of indazoles | |
| SG11201806583XA (en) | Compositions containing tucaresol or its analogs | |
| SG11201907840RA (en) | Fused imidazo-piperidine jak inhibitors | |
| SG11201900947RA (en) | Tlr7/8 antagonists and uses thereof | |
| SG11201907435PA (en) | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases | |
| SG11201810420YA (en) | Antibodies to alpha-synuclein and uses thereof | |
| SG11201811442UA (en) | Formulation of a peptide vaccine | |
| SG11201806544XA (en) | Compounds and methods of treating rna-mediated diseases | |
| SG11201807809XA (en) | A transient commensal microorganism for improving gut health | |
| SG11201907023UA (en) | Method of reducing neutropenia | |
| SG11201808686VA (en) | Synthesis of indazoles | |
| SG11201808222RA (en) | Methods of treatment of cholestatic diseases | |
| SG11201809830WA (en) | Selective reduction of cysteine-engineered antibodies | |
| SG11201811706RA (en) | Process for the preparation of microcapsules | |
| SG11201909807TA (en) | Methods of manufacturing of niraparib | |
| SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
| SG11201809497RA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
| SG11201906464UA (en) | Csf1r-based chimeric proteins | |
| SG11201909263XA (en) | Improvements in or relating to organic compounds | |
| SG11201806424TA (en) | Therapeutic compounds | |
| SG11201908691PA (en) | Compounds and methods for the treatment of parasitic diseases |