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SG11201906731XA - Media and methods for enhancing the survival and proliferation of stem cells - Google Patents

Media and methods for enhancing the survival and proliferation of stem cells

Info

Publication number
SG11201906731XA
SG11201906731XA SG11201906731XA SG11201906731XA SG11201906731XA SG 11201906731X A SG11201906731X A SG 11201906731XA SG 11201906731X A SG11201906731X A SG 11201906731XA SG 11201906731X A SG11201906731X A SG 11201906731XA SG 11201906731X A SG11201906731X A SG 11201906731XA
Authority
SG
Singapore
Prior art keywords
vancouver
suite
international
british columbia
street
Prior art date
Application number
SG11201906731XA
Inventor
Adam Hirst
Melanie Kardel
Wing Chang
Michael Hiatt
Eric Jervis
Arwen Hunter
Original Assignee
Stemcell Technologies Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62907538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201906731X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stemcell Technologies Canada Inc filed Critical Stemcell Technologies Canada Inc
Publication of SG11201906731XA publication Critical patent/SG11201906731XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIPO I PCT omit VIII °nolo 0111 011101110010111 IIII 1111101 ow (10) International Publication Number WO 2018/132926 Al (51) International Patent Classification: C12N 5/071 (2010.01) C12N 5/0735 (2010.01) C12N 5/02 (2006.01) C12N 5/074 (2010.01) (21) International Application Number: PCT/CA2018/050076 (22) International Filing Date: 23 January 2018 (23.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/449,413 23 January 2017 (23.01.2017) US 62/518,776 13 June 2017 (13.06.2017) US 62/608,875 21 December 2017 (21.12.2017) US (71) Applicant: STEMCELL TECHNOLOGIES CANADA INC. [CA/CA]; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). (72) Inventors: HIRST, Adam; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). KARDEL, Melanie; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). CHANG, Wing; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). HIATT, Michael; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). JERVIS, Er- ic; 1618 Station Street, Suite 500, Vancouver, British Co- lumbia V6A 1B6 (CA). HUNTER, Arwen; 1618 Station Street, Suite 500, Vancouver, British Columbia V6A 1B6 (CA). (74) Agent: BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; Scotia Plaza, 40 King Street West, 40th Floor, Toronto, On- tario M5H 3Y2 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — (54) Title: MEDIA AND METHODS FOR ENHANCING THE SURVIVAL AND PROLIFERATION OF STEM CELLS FIGURE 12 50 40 . 52 30 w w c)20 10 0 H1 cz lq. ( ..8 , . 0 ., .4, \ 6 3 , . 6 , .0 .0. .0 .. cs e v s , v s, „v.. ( 4\" • ks , N .ct • . E. oq tz1:: , c ,1 7. 0\" \ c x R . „ . x c p, 0 . G y x ~x x v.. c y. \Q'Z' yP ( vV. `(` cn‘ \" <0 q? Y ' 4 b 1-1 (57) : The present disclosure relates to improved supplements, culture media and methods for enhancing the survival or proliferation of mammalian stem cells. In particular, adding a lipid supplement, such as a lipid-enriched carrier (e.g. a lipid-enriched albumin), to the culture medium may enhance the survival and/or proliferation of the stem cells by at least 5% to 65% as compared to 0 a culture medium that does not contain the lipid supplement. C [Continued on next page] WO 2018/132926 Al MIDEDIMOMOIDEIREE30111001001010111110MEMNIE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
SG11201906731XA 2017-01-23 2018-01-23 Media and methods for enhancing the survival and proliferation of stem cells SG11201906731XA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762449413P 2017-01-23 2017-01-23
US201762518776P 2017-06-13 2017-06-13
US201762608875P 2017-12-21 2017-12-21
PCT/CA2018/050076 WO2018132926A1 (en) 2017-01-23 2018-01-23 Media and methods for enhancing the survival and proliferation of stem cells

Publications (1)

Publication Number Publication Date
SG11201906731XA true SG11201906731XA (en) 2019-08-27

Family

ID=62907538

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201906731XA SG11201906731XA (en) 2017-01-23 2018-01-23 Media and methods for enhancing the survival and proliferation of stem cells

Country Status (9)

Country Link
US (2) US11697796B2 (en)
EP (2) EP4361256A3 (en)
JP (1) JP7049347B2 (en)
CN (1) CN110462025B (en)
AU (1) AU2018209127B2 (en)
CA (1) CA3051141C (en)
IL (1) IL268194B (en)
SG (1) SG11201906731XA (en)
WO (1) WO2018132926A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018132926A1 (en) 2017-01-23 2018-07-26 Stemcell Technologies Canada Inc. Media and methods for enhancing the survival and proliferation of stem cells
CN111808797A (en) * 2020-07-28 2020-10-23 湖南赛诺生物科技股份有限公司 Application of Necrostatin-1 and preparation for promoting maturation of islet cells of newborn pigs
EP4208177A1 (en) 2020-09-02 2023-07-12 Yztherapeutic Performance Ltd. Cellular composition for treatment of diseases, disorders or conditions and method of use
WO2022114724A1 (en) * 2020-11-27 2022-06-02 (주)엑셀세라퓨틱스 Medium composition for producing exosome with high efficacy and high purity
US20240117313A1 (en) * 2021-02-15 2024-04-11 Toppan Inc. Method for producing three-dimensional tissue body and method for promoting differentiation of adipose-derived stem cells
CN116121186A (en) * 2023-01-03 2023-05-16 内蒙古奥普赛生物科技有限公司 Method for culturing adipose-derived mesenchymal stem cells by using palmitoleic acid
WO2024216399A1 (en) * 2023-04-20 2024-10-24 Stemcell Technologies Canada Inc. Methods for large scale expansion of pluripotent stem cells (pscs)
CN116814532B (en) * 2023-07-10 2025-02-11 上海迈邦生物科技有限公司 A lipid complex for mammalian cell culture medium and its preparation method and application

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030679A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
BRPI0514778B1 (en) * 2004-09-08 2018-07-10 Wisconsin Alumni Research Foundation MEASURE TO GROW EMBRYONIC STEM CELLS
KR101107835B1 (en) * 2006-01-13 2012-02-09 가부시키가이샤 투셀 Culture Medium Additive for Use in Serum-Free Culturing of Animal Cell, Kit, and Use Thereof
US8241908B2 (en) * 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
GB0613756D0 (en) * 2006-07-12 2006-08-23 Univ Sheffield Cell culture medium
ES2360782B1 (en) 2009-07-28 2012-03-12 Grifols, S.A. Means for culturing mammalian cells comprising supernatant of stages of Cohn fractionation and use thereof.
FI20096288A0 (en) * 2009-12-04 2009-12-04 Kristiina Rajala Formulations and Methods for Culturing Stem Cells
US10323919B2 (en) 2010-01-06 2019-06-18 Ervin Industries, Inc. Frangible, ceramic-metal composite objects and methods of making the same
JP6148429B2 (en) * 2011-01-31 2017-06-14 協和発酵バイオ株式会社 Method for culturing human pluripotent stem cells
US8497124B2 (en) * 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
MX354775B (en) 2012-03-07 2018-03-20 Janssen Biotech Inc Defined media for expansion and maintenance of pluripotent stem cells.
JP2016521971A (en) * 2013-04-23 2016-07-28 イェダ リサーチ アンド ディベロップメント カンパニー リミテッド US Patent Provisional Application No. 61/932, filed Jan. 29, 2014, based on US Patent Act 119, paragraph (e). No. 935, US Provisional Application No. 61 / 878,769, filed September 17, 2013, and US Provisional Application No. 61 / 814,920, filed April 23, 2013. In addition, this application is a U.S. patent application filed simultaneously with the same applicant's co-pending applications YacubHANNA, NoaNOVERSHTERN, and YoachRAIS (name of invention "isolated naive pluripotent stem cells and methods for generating them" It also relates to ISOLATEDNAIVEPLURIPOTENSTEMCELLSANDMETHODSOFGENERATINGSAME))) (agent case record book No. 58870). The contents of the above application are incorporated herein by reference in their entirety.
KR102229266B1 (en) * 2013-05-30 2021-03-19 아지노모토 가부시키가이샤 Medium for culturing stem cells
US20160230143A1 (en) 2013-09-19 2016-08-11 The U.S.A., As Represented By The Secretary, Department Of Health & Human Services Chemically defined culture medium for stem cell maintenance and differentiation
SG11201707858TA (en) * 2015-03-30 2017-10-30 Ajinomoto Kk Human serum albumin-containing culture medium for growth of neural stem cells
WO2018132926A1 (en) 2017-01-23 2018-07-26 Stemcell Technologies Canada Inc. Media and methods for enhancing the survival and proliferation of stem cells

Also Published As

Publication number Publication date
JP7049347B2 (en) 2022-04-06
JP2020505038A (en) 2020-02-20
EP4361256A3 (en) 2024-07-31
US11697796B2 (en) 2023-07-11
CN110462025A (en) 2019-11-15
IL268194A (en) 2019-09-26
WO2018132926A1 (en) 2018-07-26
CA3051141C (en) 2021-06-22
EP3571290A1 (en) 2019-11-27
AU2018209127B2 (en) 2021-10-21
EP3571290A4 (en) 2020-10-28
US20200017825A1 (en) 2020-01-16
CN110462025B (en) 2023-11-21
US20230250392A1 (en) 2023-08-10
EP3571290B1 (en) 2024-04-10
EP4361256A2 (en) 2024-05-01
CA3051141A1 (en) 2018-07-26
IL268194B (en) 2022-05-01
AU2018209127A1 (en) 2019-08-08

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