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SG11201903899VA - Amnion tissue grafts and methods of preparing and using same - Google Patents

Amnion tissue grafts and methods of preparing and using same

Info

Publication number
SG11201903899VA
SG11201903899VA SG11201903899VA SG11201903899VA SG11201903899VA SG 11201903899V A SG11201903899V A SG 11201903899VA SG 11201903899V A SG11201903899V A SG 11201903899VA SG 11201903899V A SG11201903899V A SG 11201903899VA SG 11201903899V A SG11201903899V A SG 11201903899VA
Authority
SG
Singapore
Prior art keywords
international
preparing
pct
amnion
tissue grafts
Prior art date
Application number
SG11201903899VA
Inventor
Curt Deister
Original Assignee
Axogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axogen Corp filed Critical Axogen Corp
Publication of SG11201903899VA publication Critical patent/SG11201903899VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/22Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/40Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pens And Brushes (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM Organization 0 011101 0 01111111111111111111111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/085527 A2 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61L 27/36 (2006.01) (21) International Application Number: PCT/US2017/059700 (22) International Filing Date: 02 November 2017 (02.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/416,528 02 November 2016 (02.11.2016) US (71) Applicant: AXOGEN CORPORATION [US/US]; 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). (72) Inventor: DEISTER, Curt; 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). (74) Agent: SALIWANCHIK, David, R. et al.; Saliwanchik, Lloyd & Eisenschenk, P.O. Box 142950, Gainesville, FL 32614-2950 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, TJ, (AM, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished ei upon receipt of that report (Rule 48.2(g)) IN ei ir) ir) GC 0 --.... 00 1-1 (54) Title: AMNION TISSUE GRAFTS AND METHODS OF PREPARING AND USING 0 SAME ei (57) : The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embod- C invents, the tissue graft comprises a single layer of dried amnion from an umbilical cord.
SG11201903899VA 2016-11-02 2017-11-02 Amnion tissue grafts and methods of preparing and using same SG11201903899VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662416528P 2016-11-02 2016-11-02
PCT/US2017/059700 WO2018085527A2 (en) 2016-11-02 2017-11-02 Amnion tissue grafts and methods of preparing and using same

Publications (1)

Publication Number Publication Date
SG11201903899VA true SG11201903899VA (en) 2019-05-30

Family

ID=62076479

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201903899VA SG11201903899VA (en) 2016-11-02 2017-11-02 Amnion tissue grafts and methods of preparing and using same

Country Status (12)

Country Link
US (2) US11577001B2 (en)
EP (1) EP3534981A4 (en)
JP (2) JP7171588B2 (en)
KR (3) KR102514753B1 (en)
AU (2) AU2017353847B2 (en)
CA (1) CA3042751A1 (en)
CL (1) CL2019001212A1 (en)
IL (2) IL301474B1 (en)
MX (3) MX2019005172A (en)
NZ (1) NZ753034A (en)
SG (1) SG11201903899VA (en)
WO (1) WO2018085527A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11577001B2 (en) * 2016-11-02 2023-02-14 Axogen Corporation Amnion tissue grafts and methods of preparing and using same
WO2023021525A1 (en) * 2021-08-16 2023-02-23 Lifecell International Pvt. Ltd A human amnion-chorion based wound dressing material and method thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
DE69416124T2 (en) 1993-06-18 1999-08-05 Polymer Technology Corp COMPOSITION FOR CLEANING AND MOISTURIZING CONTACT LENSES
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US8100872B2 (en) 2002-10-23 2012-01-24 Tyco Healthcare Group Lp Medical dressing containing antimicrobial agent
PL2322599T3 (en) * 2003-06-27 2015-10-30 Depuy Synthes Products Inc Postpartum cells derived from umbilical cord tissue and methods of making and using the same for repair and regeneration of soft tissue
CA2857051A1 (en) * 2004-03-17 2005-09-29 David Ayares Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
US7928280B2 (en) * 2005-07-13 2011-04-19 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric
WO2007013331A1 (en) 2005-07-25 2007-02-01 Arblast Co., Ltd. Sheet-like composition
EP1932549B1 (en) 2005-08-26 2016-12-28 AMNOS Co., Ltd. Dried amnion and method for drying treatment of amnion
WO2007029676A1 (en) * 2005-09-07 2007-03-15 Arblast Co., Ltd. Biological tissue sheet and method for preparation thereof
US8187639B2 (en) * 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
CN2905071Y (en) * 2006-04-07 2007-05-30 苗九昌 Biological amnion
JP2008022715A (en) * 2006-07-18 2008-02-07 Nipro Corp Method for culturing cell sheet and cell culture vessel
WO2008021391A1 (en) * 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
US8357403B2 (en) * 2007-09-07 2013-01-22 Mimedx Group, Inc. Placental tissue grafts
KR100947553B1 (en) * 2008-02-14 2010-03-12 주식회사 바이오랜드 Living tissue implants and methods for manufacturing the same
US9480549B2 (en) * 2008-04-25 2016-11-01 Allosource Multi-layer tissue patches
US20120141595A1 (en) * 2009-08-25 2012-06-07 Tissuetech, Inc. Umbilical cord amniotic membrane products
WO2012003377A2 (en) * 2010-06-30 2012-01-05 Tissuetech, Inc. Methods of preparing chorion tissue and products derived therefrom
KR20140114277A (en) * 2011-02-14 2014-09-26 미메딕스 그룹 인크. Laminated tissue grafts composed of wharton's jelly and methods of making and using the same
CA2844115C (en) * 2011-08-26 2021-11-23 Tissuetech, Inc. Methods of sterilizing fetal support tissues
ES2695579T3 (en) * 2011-12-30 2019-01-09 Vivex Biomedical Inc Tissue regeneration matrix
CN105521523A (en) * 2015-11-20 2016-04-27 金艺鹏 Preparation and preservation method of canine and amniotic membrane
TW201733600A (en) * 2016-01-29 2017-10-01 帝聖工業公司 Fetal support tissue products and methods of use
US11577001B2 (en) * 2016-11-02 2023-02-14 Axogen Corporation Amnion tissue grafts and methods of preparing and using same

Also Published As

Publication number Publication date
KR102514753B1 (en) 2023-03-27
WO2018085527A3 (en) 2018-06-28
IL301474A (en) 2023-05-01
MX2019005172A (en) 2019-09-26
JP2019536596A (en) 2019-12-19
NZ793788A (en) 2024-10-25
NZ753034A (en) 2023-04-28
US12263276B2 (en) 2025-04-01
IL301474B1 (en) 2025-05-01
MX2023007919A (en) 2023-07-13
IL266381A (en) 2019-06-30
WO2018085527A2 (en) 2018-05-11
JP7171588B2 (en) 2022-11-15
AU2022206749B2 (en) 2024-05-30
KR20240110869A (en) 2024-07-16
US20190282732A1 (en) 2019-09-19
KR20190104991A (en) 2019-09-11
JP7482958B2 (en) 2024-05-14
KR20230031381A (en) 2023-03-07
IL266381B1 (en) 2023-12-01
AU2017353847B2 (en) 2022-04-21
EP3534981A2 (en) 2019-09-11
EP3534981A4 (en) 2020-06-24
MX2024008143A (en) 2024-07-15
US11577001B2 (en) 2023-02-14
CA3042751A1 (en) 2018-05-11
CL2019001212A1 (en) 2019-09-23
IL266381B2 (en) 2024-04-01
AU2017353847A1 (en) 2019-05-23
AU2022206749A1 (en) 2022-08-18
JP2022184888A (en) 2022-12-13
US20230191001A1 (en) 2023-06-22

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