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SG11201805787YA - Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same - Google Patents

Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same

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Publication number
SG11201805787YA
SG11201805787YA SG11201805787YA SG11201805787YA SG11201805787YA SG 11201805787Y A SG11201805787Y A SG 11201805787YA SG 11201805787Y A SG11201805787Y A SG 11201805787YA SG 11201805787Y A SG11201805787Y A SG 11201805787YA SG 11201805787Y A SG11201805787Y A SG 11201805787YA
Authority
SG
Singapore
Prior art keywords
international
wavelength
go1n
rule
san diego
Prior art date
Application number
SG11201805787YA
Inventor
Dietrich Dehlinger
Cheng Zhong
Juraj Topolancik
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Illumina Inc
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Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of SG11201805787YA publication Critical patent/SG11201805787YA/en

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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

310 Detection Circuit 312 321 322 321 321 322 (a) FIG.3 330 1 1 1 1 1 1 1 1 i A i 313 A l l e 2 314 311 300 \" 1 / (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/165703 Al 28 September 2017 (28.09.2017) WIPO I PCT 111111111111110111011111111111010111110 011111111100111011111011111111111110111111 W O 20 171657 / 03 Al (51) International Patent Classification: GO1N 21/64 (2006.01) GO1N 21/03 (2006.01) GO1N 21/77 (2006.01) GO1N 21/25 (2006.01) BOIL 3/00 (2006.01) (21) International Application Number: PCT/US2017/023900 (22) International Filing Date: 23 March 2017 (23.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/312,704 24 March 2016 (24.03.2016) US (71) Applicant: ILLUMINA, INC. [AE/US]; 5200 Illumina Way, San Diego, CA 92122 (US). (72) Inventors: DEHLINGER, Dietrich; 5200 Illumina Way, San Diego, CA 92122 (US). ZHONG, Cheng, Frank; 5200 Illumina Way, San Diego, CA 92122 (US). TO- POLANCIK, Juraj; 5200 Illumina Way, San Diego, CA 92122 (US). (74) Agent: FULLER, Michael, L.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: PHOTONIC SUPERLATTICE-BASED DEVICES AND COMPOSITIONS FOR USE IN LUMINESCENT IMAGING, = AND METHODS OF USING THE SAME (57) : Under one aspect, a device (300) is provided for use in luminescent imaging. The device (300) can include a photon- ic superlattice (310) including a first material, the first material having a first refractive index. The first material can include first and second major surfaces (311, 312) and first and second pluralities of features (313, 314) defined through at least one of the first and second major surfaces (311, 312), the features of the first plurality (313) differing in at least one characteristic from the features of the second plurality (314). The photonic superlattice (310) can support propagation of a first wavelength (ki) and a second wavelength (k2) approximately at a first angle out of the photonic superlattice (310), the first and second wavelengths (k 1 , k 2 ) being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice (310). The device further can include a second material having a second refractive index that is different than the first refractive index. The second material can be disposed within, between, or over the first and second pluralities of features (313, 314) and can include first and second luminophores (321, 322). The device (300) further can include a first optical component (330) disposed over one of the first and second major surfaces (311, 312) of the first material. The first optical component (330) can [Continued on next page] WO 2017/165703 Al MIDEDIMOMOIDEIR010130HIONMEHMODEVOIMIE Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) receive luminescence emitted by the first luminophore (321) at the first wavelength (k i ) approximately at the first angle, and can receive luminescence emitted by the second luminophore (322) at the second wavelength (?2) approximately at the first angle.
SG11201805787YA 2016-03-24 2017-03-23 Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same SG11201805787YA (en)

Applications Claiming Priority (2)

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US201662312704P 2016-03-24 2016-03-24
PCT/US2017/023900 WO2017165703A1 (en) 2016-03-24 2017-03-23 Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3446157B1 (en) * 2016-04-22 2023-05-17 Illumina, Inc. Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
US11896944B2 (en) 2017-02-01 2024-02-13 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
GB201701691D0 (en) * 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
US11340383B2 (en) * 2017-11-07 2022-05-24 Corning Incorporated Hydroxide-catalysis bonding of optical components used in DUV optical systems
NL2021258B1 (en) * 2018-06-14 2019-12-20 Illumina Inc Device for luminescent imaging
NL2023516B1 (en) 2019-05-28 2020-12-08 Illumina Inc Manufacturing a flowcell with a planar waveguide

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349796A (en) * 1980-12-15 1982-09-14 Bell Telephone Laboratories, Incorporated Devices incorporating phonon filters
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5026148A (en) * 1989-12-26 1991-06-25 Hughes Aircraft Company High efficiency multiple quantum well structure and operating method
CN100462433C (en) 2000-07-07 2009-02-18 维西根生物技术公司 Real-time sequence determination
US7615780B2 (en) * 2000-10-23 2009-11-10 General Electric Company DNA biosensor and methods for making and using the same
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
DK3363809T3 (en) 2002-08-23 2020-05-04 Illumina Cambridge Ltd MODIFIED NUCLEOTIDES FOR POLYNUCLEOTIDE SEQUENCE
US7098589B2 (en) * 2003-04-15 2006-08-29 Luminus Devices, Inc. Light emitting devices with high light collimation
EP3175914A1 (en) 2004-01-07 2017-06-07 Illumina Cambridge Limited Improvements in or relating to molecular arrays
US20060062531A1 (en) 2004-09-17 2006-03-23 Stephen Turner Fabrication of optical confinements
EP1817571B1 (en) * 2004-11-04 2011-09-07 Renishaw Diagnostics Limited Metal nano-void photonic crystal for enhanced raman spectroscopy
US8262998B2 (en) * 2005-04-15 2012-09-11 Branislav Vlahovic Detection methods and detection devices based on the quantum confinement effects
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
WO2007123744A2 (en) 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US7768640B2 (en) 2007-05-07 2010-08-03 The Board Of Trustees Of The University Of Illinois Fluorescence detection enhancement using photonic crystal extraction
ITTO20080614A1 (en) * 2008-08-04 2010-02-05 Consiglio Naz Delle Ricerche Infm Istituto PROCEDURE FOR THE REVELATION OF ANALYTES, WITH THE USE OF PHONES OF RESISTANT PHOTOS AND RELATIVE DEVICE.
US8636955B2 (en) 2009-08-03 2014-01-28 Omega Optics, Inc. Packaged chip for multiplexing photonic crystal waveguide and photonic crystal slot waveguide devices for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity
DE102009057780A1 (en) * 2009-12-10 2011-06-16 Osram Opto Semiconductors Gmbh Optoelectronic semiconductor component and photonic crystal
EP2537019B1 (en) 2010-02-19 2016-09-07 Pacific Biosciences Of California, Inc. Device for measuring analytical reactions
US8344333B2 (en) 2010-07-08 2013-01-01 The Board Of Trustees Of The University Of Illinois Multi-color fluorescence enhancement from a photonic crystal surface
US9304234B2 (en) * 2011-03-10 2016-04-05 The Regents Of The University Of California Plasmonic dark field and fluorescence microscopy
CN102157132B (en) 2011-05-13 2015-07-15 刘敬梅 Panel-controlled display system
CN102305774A (en) * 2011-05-24 2012-01-04 北京邮电大学 Method for implementing single-hole-ring-resonator-based photonic crystal biosensor
CN102243165B (en) * 2011-06-20 2013-07-17 东南大学 Photonic crystal coded microsphere biochip detection device
HRP20211523T1 (en) 2011-09-23 2021-12-24 Illumina, Inc. Compositions for nucleic acid sequencing
WO2013058051A1 (en) * 2011-10-20 2013-04-25 国立大学法人東京大学 Solar battery
CN103323428B (en) * 2012-03-23 2016-06-08 香港科技大学 Photon resonance device, photon resonance detection system and detection method thereof
KR20130117301A (en) * 2012-04-18 2013-10-25 삼성테크윈 주식회사 Lateral flow device and method for analyzing sample
CN102628805B (en) * 2012-04-26 2014-10-15 大连理工大学 Microfluidic chip fluorescence detection system based on photonic crystal filter plates
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8969831B2 (en) * 2013-02-15 2015-03-03 Massachusetts Institute Of Technology Excitation enhancement and extraction enhancement with photonic crystals
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
WO2014171457A1 (en) * 2013-04-17 2014-10-23 独立行政法人科学技術振興機構 Photonic crystal and optical function device using same
CN103398974B (en) * 2013-07-30 2016-08-03 深圳大学 A kind of Fibre Optical Sensor, preparation method and the system of measurement
US10107807B2 (en) * 2014-05-22 2018-10-23 The University Of Maryland, Baltimore One dimensional photonic crystals for enhanced fluorescence based sensing, imaging and assays

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