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SG11201803584RA - 1,4-dicarbonyl-piperidyl derivatives - Google Patents

1,4-dicarbonyl-piperidyl derivatives

Info

Publication number
SG11201803584RA
SG11201803584RA SG11201803584RA SG11201803584RA SG11201803584RA SG 11201803584R A SG11201803584R A SG 11201803584RA SG 11201803584R A SG11201803584R A SG 11201803584RA SG 11201803584R A SG11201803584R A SG 11201803584RA SG 11201803584R A SG11201803584R A SG 11201803584RA
Authority
SG
Singapore
Prior art keywords
dicarbonyl
piperidyl derivatives
piperidyl
derivatives
Prior art date
Application number
SG11201803584RA
Other languages
English (en)
Inventor
Hans-Peter Buchstaller
Dieter Dorsch
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201803584RA publication Critical patent/SG11201803584RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201803584RA 2015-11-02 2016-10-07 1,4-dicarbonyl-piperidyl derivatives SG11201803584RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15192489 2015-11-02
PCT/EP2016/001668 WO2017076484A1 (en) 2015-11-02 2016-10-07 1,4-dicarbonyl-piperidyl derivatives

Publications (1)

Publication Number Publication Date
SG11201803584RA true SG11201803584RA (en) 2018-05-30

Family

ID=54365114

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201803584RA SG11201803584RA (en) 2015-11-02 2016-10-07 1,4-dicarbonyl-piperidyl derivatives

Country Status (14)

Country Link
US (1) US10570116B2 (he)
EP (1) EP3371166B1 (he)
JP (1) JP6885962B2 (he)
KR (1) KR20180073681A (he)
CN (1) CN108137556B (he)
AU (1) AU2016349148C1 (he)
BR (1) BR112018007358A2 (he)
CA (1) CA3003600A1 (he)
ES (1) ES2773511T3 (he)
IL (1) IL258977B (he)
MX (1) MX2018005515A (he)
RU (1) RU2018119935A (he)
SG (1) SG11201803584RA (he)
WO (1) WO2017076484A1 (he)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019084060A1 (en) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
CA3121697A1 (en) * 2018-12-03 2020-06-11 Merck Patent Gmbh 4-heteroarylcarbonyl-n-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
IL292466A (he) * 2019-10-30 2022-06-01 Digmbio Inc נגזרות של איזוקווינולון, שיטה להכנתן ותכשירים רוקחיים המכילים אותן כחומר פעיל למניע או לטיפול של מחלות הקשורות ל-poly(adp-ribose) polymerase 1
CN116143743A (zh) * 2023-01-08 2023-05-23 太仓市茜泾化工有限公司 一种3-异丁基戊二酸酐的制备工艺及其制备装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014000536A (es) 2011-07-13 2014-12-05 Novartis Ag Compuestos de 4-piperidinilo para usarse como inhibidores de tanquirasa.
JP2014520858A (ja) * 2011-07-13 2014-08-25 ノバルティス アーゲー タンキラーゼ阻害剤として用いるための新規な2−ピペリジン−1−イル−アセトアミド化合物
EP2890696A1 (en) * 2012-08-29 2015-07-08 Amgen, Inc. Quinazolinone compounds and derivatives thereof
JP6423875B2 (ja) * 2013-07-31 2018-11-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung オキソキナゾリニル−ブタンアミド誘導体
SG11201609205WA (en) 2014-05-07 2016-12-29 Merck Patent Gmbh Heterocyclyl-butanamide derivatives

Also Published As

Publication number Publication date
WO2017076484A1 (en) 2017-05-11
BR112018007358A2 (pt) 2018-10-23
US20190092751A1 (en) 2019-03-28
EP3371166A1 (en) 2018-09-12
JP2019501954A (ja) 2019-01-24
AU2016349148C1 (en) 2021-08-26
EP3371166B1 (en) 2019-11-20
KR20180073681A (ko) 2018-07-02
JP6885962B2 (ja) 2021-06-16
ES2773511T3 (es) 2020-07-13
MX2018005515A (es) 2018-08-01
US10570116B2 (en) 2020-02-25
AU2016349148A1 (en) 2018-06-14
CN108137556B (zh) 2021-07-30
IL258977A (he) 2018-06-28
CA3003600A1 (en) 2017-05-11
RU2018119935A (ru) 2019-12-04
AU2016349148B2 (en) 2021-05-13
CN108137556A (zh) 2018-06-08
IL258977B (he) 2020-06-30

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