SG11201803153RA - Oxadiazaspiro compounds for the treatment of drug abuse and addiction - Google Patents
Oxadiazaspiro compounds for the treatment of drug abuse and addictionInfo
- Publication number
- SG11201803153RA SG11201803153RA SG11201803153RA SG11201803153RA SG11201803153RA SG 11201803153R A SG11201803153R A SG 11201803153RA SG 11201803153R A SG11201803153R A SG 11201803153RA SG 11201803153R A SG11201803153R A SG 11201803153RA SG 11201803153R A SG11201803153R A SG 11201803153RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- compounds
- barcelona
- addiction
- drug abuse
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 May 2017(26.05.2017) WIPOIPCT (10) International Publication Number WO 2017/084752 A1 (51) International Patent Classification: C07D 498/10 (2006.01) A61P 25/34 (2006.01) A61K 31/5386 (2006.01) A61P 25/36 (2006.01) A61P 25/32 (2006.01) (21) International Application Number: PCT/EP2016/001907 (22) International Filing Date: (25) Filing Language: (26) Publication Language: 15 November 2016 (15.11.2016) English English (30) Priority Data: 15382566.6 16 November 2015 (16.11.2015) EP (71) Applicant: LABORATORIOS DEL DR. ESTEVE, S.A. [ES/ES]; Avda. Mare de Deu de Montserrat 221, 08041 Barcelona (ES). (72) Inventors: VIRGILI-BERNADO, Marina; c/Baldiri Reixac 10, 08028 Barcelona (ES). ALMANSA-ROS- ALES, Carmen; C/Teodora Lamadrid no. 41, Ent. 4a, 08022 Barcelona (ES). ALEGRET-MOLINA, Carlos; C/Baldiri Reixac 10, 08028 Barcelona (ES). (74) Agents: PETERS, Hajo et al.; Zacco GmbH, Bayerstrasse 83, 80335 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) < n Tf 00 n O (54) Title: OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION (57) : The present invention relates to compounds having pharmacological activity towards the sigma (o) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382566 | 2015-11-16 | ||
| PCT/EP2016/001907 WO2017084752A1 (en) | 2015-11-16 | 2016-11-15 | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201803153RA true SG11201803153RA (en) | 2018-06-28 |
Family
ID=54707728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803153RA SG11201803153RA (en) | 2015-11-16 | 2016-11-15 | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10927128B2 (en) |
| EP (1) | EP3377500B1 (en) |
| JP (1) | JP6884974B2 (en) |
| KR (2) | KR20180080327A (en) |
| CN (1) | CN108349999A (en) |
| AR (1) | AR106697A1 (en) |
| AU (1) | AU2016356488B2 (en) |
| CA (1) | CA3002286A1 (en) |
| CO (1) | CO2018004665A2 (en) |
| DK (1) | DK3377500T3 (en) |
| ES (1) | ES2932000T3 (en) |
| HR (1) | HRP20221343T1 (en) |
| HU (1) | HUE060275T2 (en) |
| IL (1) | IL259035B (en) |
| LT (1) | LT3377500T (en) |
| MA (1) | MA43250B1 (en) |
| MX (1) | MX384637B (en) |
| MY (1) | MY193423A (en) |
| PH (1) | PH12018500814A1 (en) |
| PL (1) | PL3377500T3 (en) |
| PT (1) | PT3377500T (en) |
| RS (1) | RS63734B1 (en) |
| SG (1) | SG11201803153RA (en) |
| SI (1) | SI3377500T1 (en) |
| SM (1) | SMT202200460T1 (en) |
| TN (1) | TN2018000122A1 (en) |
| TW (1) | TWI756196B (en) |
| UA (1) | UA123775C2 (en) |
| WO (1) | WO2017084752A1 (en) |
| ZA (1) | ZA201802845B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108349999A (en) | 2015-11-16 | 2018-07-31 | 埃斯蒂文博士实验室股份有限公司 | Oxa- diazaspiracyclic compounds for medicine abuse and habituation |
| WO2020157026A1 (en) * | 2019-01-28 | 2020-08-06 | Esteve Pharmaceuticals, S.A. | Hydroxylated derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain |
| CA3230908A1 (en) | 2021-09-20 | 2023-03-23 | Jose-Miguel Vela-Hernandez | Oxadiazaspiro compounds for use in the treatment of motoneuron degeneration or in neuroprotection |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244961A (en) * | 1978-10-26 | 1981-01-13 | Syntex (U.S.A.) Inc. | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents |
| US4332804A (en) | 1981-03-23 | 1982-06-01 | Syntex (U.S.A.) Inc. | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
| US4353900A (en) | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones |
| US4353901A (en) * | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones |
| US6114541A (en) | 1997-03-10 | 2000-09-05 | Hoffmann-La Roche Inc. | Method for the preparation of α-Bromo-Lactam derivatives |
| JP2007522160A (en) * | 2004-02-10 | 2007-08-09 | エフ．ホフマン−ラ ロシュ アーゲー | Chemokine CCR5 receptor modulator |
| AU2005202477B2 (en) | 2004-03-03 | 2005-12-15 | Vital Health Sciences Pty Ltd | Alkaloid formulations |
| EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| EP1790639B1 (en) * | 2004-08-27 | 2014-03-26 | Ono Pharmaceutical Co., Ltd. | Spirocyclic compounds and their use as cxcr4-antagonists |
| CN101228127B (en) * | 2005-05-30 | 2012-05-16 | Msdk.K.公司 | Piperidine derivatives |
| CN101203567A (en) * | 2005-06-07 | 2008-06-18 | 西巴特殊化学品控股有限公司 | Scratch resistant polyolefin |
| DE102005030051A1 (en) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma |
| PL1940821T3 (en) | 2005-10-19 | 2013-08-30 | Gruenenthal Gmbh | Novel vanilloid receptor ligands and their use for producing medicaments |
| EP1961744B1 (en) | 2005-11-18 | 2013-04-17 | Ono Pharmaceutical Co., Ltd. | Basic group-containing compound and use thereof |
| EP1829869A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands |
| EP1847542A1 (en) | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
| EP2128154B1 (en) | 2007-03-01 | 2015-04-08 | Mitsubishi Tanabe Pharma Corporation | Benzimidazole compound and pharmaceutical use thereof |
| EP1982714A1 (en) | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-amines |
| EP2020414A1 (en) | 2007-06-20 | 2009-02-04 | Laboratorios del Dr. Esteve S.A. | spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis |
| JP2010538003A (en) | 2007-08-29 | 2010-12-09 | グラクソスミスクライン エルエルシー | Thiazole and oxazole kinase inhibitors |
| EP2070933A1 (en) | 2007-12-07 | 2009-06-17 | Laboratorios del Dr. Esteve S.A. | Tricyclic triazolic compounds |
| BRPI0908353B8 (en) | 2008-02-06 | 2021-05-25 | Astrazeneca Ab | compound or a pharmaceutically acceptable salt thereof and pharmaceutical composition |
| EP2108643A1 (en) * | 2008-04-10 | 2009-10-14 | Laboratorios Del. Dr. Esteve, S.A. | 4-methyl-4, 5-dihydro-1H-pyrazole-3-carboxamide useful as a cannabinoid CB1 neutral antagonist |
| GB201016912D0 (en) * | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| WO2012125613A1 (en) | 2011-03-14 | 2012-09-20 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
| GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| WO2013052716A1 (en) * | 2011-10-07 | 2013-04-11 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
| WO2013115294A1 (en) * | 2012-01-31 | 2013-08-08 | 東レ株式会社 | Diazaspiro urea derivative and pharmaceutical use thereof |
| US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| TW201615642A (en) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain |
| TWI685497B (en) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain |
| TW201615643A (en) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain |
| EP3250204B1 (en) | 2015-01-29 | 2019-10-30 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| CN108349999A (en) | 2015-11-16 | 2018-07-31 | 埃斯蒂文博士实验室股份有限公司 | Oxa- diazaspiracyclic compounds for medicine abuse and habituation |
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2016
- 2016-11-15 CN CN201680066748.9A patent/CN108349999A/en active Pending
- 2016-11-15 MY MYPI2018701503A patent/MY193423A/en unknown
- 2016-11-15 KR KR1020187017092A patent/KR20180080327A/en not_active Ceased
- 2016-11-15 LT LTEPPCT/EP2016/001907T patent/LT3377500T/en unknown
- 2016-11-15 DK DK16797458.3T patent/DK3377500T3/en active
- 2016-11-15 TN TNP/2018/000122A patent/TN2018000122A1/en unknown
- 2016-11-15 UA UAA201806353A patent/UA123775C2/en unknown
- 2016-11-15 SM SM20220460T patent/SMT202200460T1/en unknown
- 2016-11-15 HR HRP20221343TT patent/HRP20221343T1/en unknown
- 2016-11-15 SI SI201631621T patent/SI3377500T1/en unknown
- 2016-11-15 RS RS20221052A patent/RS63734B1/en unknown
- 2016-11-15 PT PT167974583T patent/PT3377500T/en unknown
- 2016-11-15 US US15/774,407 patent/US10927128B2/en active Active
- 2016-11-15 KR KR1020257015708A patent/KR20250069710A/en active Pending
- 2016-11-15 ES ES16797458T patent/ES2932000T3/en active Active
- 2016-11-15 MA MA43250A patent/MA43250B1/en unknown
- 2016-11-15 AU AU2016356488A patent/AU2016356488B2/en active Active
- 2016-11-15 SG SG11201803153RA patent/SG11201803153RA/en unknown
- 2016-11-15 CA CA3002286A patent/CA3002286A1/en active Pending
- 2016-11-15 WO PCT/EP2016/001907 patent/WO2017084752A1/en active IP Right Grant
- 2016-11-15 EP EP16797458.3A patent/EP3377500B1/en active Active
- 2016-11-15 MX MX2018005439A patent/MX384637B/en unknown
- 2016-11-15 PL PL16797458.3T patent/PL3377500T3/en unknown
- 2016-11-15 JP JP2018524257A patent/JP6884974B2/en active Active
- 2016-11-15 HU HUE16797458A patent/HUE060275T2/en unknown
- 2016-11-15 TW TW105137236A patent/TWI756196B/en active
- 2016-11-15 AR ARP160103486A patent/AR106697A1/en unknown
-
2018
- 2018-04-16 PH PH12018500814A patent/PH12018500814A1/en unknown
- 2018-04-30 ZA ZA2018/02845A patent/ZA201802845B/en unknown
- 2018-04-30 IL IL259035A patent/IL259035B/en active IP Right Grant
- 2018-04-30 CO CONC2018/0004665A patent/CO2018004665A2/en unknown
-
2020
- 2020-12-21 US US17/128,738 patent/US11649248B2/en active Active
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