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SG11201701458YA - Stable anti-il-4r-alpha antibody formulation - Google Patents

Stable anti-il-4r-alpha antibody formulation

Info

Publication number
SG11201701458YA
SG11201701458YA SG11201701458YA SG11201701458YA SG11201701458YA SG 11201701458Y A SG11201701458Y A SG 11201701458YA SG 11201701458Y A SG11201701458Y A SG 11201701458YA SG 11201701458Y A SG11201701458Y A SG 11201701458YA SG 11201701458Y A SG11201701458Y A SG 11201701458YA
Authority
SG
Singapore
Prior art keywords
antibody formulation
alpha antibody
stable anti
stable
alpha
Prior art date
Application number
SG11201701458YA
Inventor
Per-Olof Eriksson
Wachenfeldt Karin Von
Suzanne Cohen
Claire Dobson
Deborah Lane
Katrina Day
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of SG11201701458YA publication Critical patent/SG11201701458YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201701458YA 2014-09-03 2015-09-02 Stable anti-il-4r-alpha antibody formulation SG11201701458YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462045338P 2014-09-03 2014-09-03
PCT/EP2015/070091 WO2016034648A1 (en) 2014-09-03 2015-09-02 Stable anti-il-4r-alpha antibody formulation

Publications (1)

Publication Number Publication Date
SG11201701458YA true SG11201701458YA (en) 2017-03-30

Family

ID=54035254

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201701458YA SG11201701458YA (en) 2014-09-03 2015-09-02 Stable anti-il-4r-alpha antibody formulation

Country Status (12)

Country Link
US (1) US20170281769A1 (en)
EP (1) EP3188757A1 (en)
JP (1) JP2017527560A (en)
KR (1) KR20170044739A (en)
CN (1) CN106604744A (en)
AU (1) AU2015310879A1 (en)
BR (1) BR112017003419A2 (en)
CA (1) CA2959571A1 (en)
IL (1) IL250363A0 (en)
RU (1) RU2017107847A (en)
SG (1) SG11201701458YA (en)
WO (1) WO2016034648A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS64263B1 (en) 2015-08-19 2023-07-31 Astrazeneca Ab Stable anti-ifnar1 formulation
JP2019511531A (en) * 2016-04-13 2019-04-25 メディミューン,エルエルシー Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein based therapeutics
JOP20170170B1 (en) * 2016-08-31 2022-09-15 Omeros Corp High concentration, low viscosity MASP-2 inhibitory antibody formulations, kits, and methods
US10646569B2 (en) 2017-05-16 2020-05-12 Bhami's Research Laboratory, Pvt. Ltd. High concentration protein formulations with reduced viscosity
CN110540590B (en) * 2018-05-29 2023-08-18 康诺亚生物医药科技(成都)有限公司 Development and application of an autoimmune suppressant
WO2020016417A1 (en) * 2018-07-19 2020-01-23 Ichnos Sciences S.A. Liquid antibody formulation
BR112021002989A2 (en) * 2018-08-24 2021-05-11 Jiangsu Hengrui Medicine Co., Ltd. antibody for human il-4r binding, fragment for antigen binding and medical use thereof
EP3878868B1 (en) 2018-11-09 2024-10-09 Ajou University Industry-Academic Cooperation Foundation Human antibody having high affinity to human il-4 receptor alpha, and use thereof
CN111494626B (en) * 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 Pharmaceutical compositions for the treatment of IL-4 and/or IL-13 mediated signal transduction related disorders
MX2021007845A (en) * 2018-12-27 2021-09-30 Akeso Biopharma Inc ANTIBODIES AGAINST HUMAN IL-4RA AND USE THEREOF.
CN120241997A (en) 2019-02-18 2025-07-04 伊莱利利公司 Therapeutic antibody formulations
CN111686247B (en) * 2019-03-13 2022-07-29 苏州康乃德生物医药有限公司 Liquid composition comprising antibody to human interleukin-4 receptor alpha
CN111592597B (en) * 2019-05-29 2022-04-26 山东博安生物技术股份有限公司 Interleukin 4 receptor (IL-4R) binding proteins and uses thereof
TWI865727B (en) 2020-02-21 2024-12-11 大陸商江蘇恆瑞醫藥股份有限公司 Anti-il-4r antibody pharmaceutical composition and use thereof
US20230131324A1 (en) * 2020-02-24 2023-04-27 Medimmune, Llc Formulations of anti-endothelial lipase antibodies
KR20220147642A (en) * 2020-02-27 2022-11-03 치아타이 티안큉 파마수티컬 그룹 주식회사 Antibodies that bind IL4R and uses thereof
RS65199B1 (en) 2020-03-26 2024-03-29 Univ Vanderbilt Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
CN113527485B (en) * 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 Anti-human interleukin-4 receptor alpha antibody and preparation method and application thereof
CN113549151A (en) * 2020-04-24 2021-10-26 苏州康乃德生物医药有限公司 Antibody binding with specific epitope in human IL-4R alpha and application thereof
KR102169476B1 (en) * 2020-05-20 2020-10-23 (주)신테카바이오 Composition for preventing or treating sars coronavirus 2 infection disease
CN113797331A (en) * 2020-06-16 2021-12-17 三生国健药业(上海)股份有限公司 Stable anti-IL-4R alpha monoclonal antibody liquid preparation
CN111690066B (en) * 2020-06-22 2022-07-22 南京融捷康生物科技有限公司 anti-IL-4R alpha single-domain antibody and application and medicament thereof
KR20230045613A (en) * 2020-08-10 2023-04-04 아스트라제네카 유케이 리미티드 SARS-COV-2 Antibodies for Treatment and Prevention of COVID-19
EP4211169A4 (en) * 2020-09-10 2024-12-04 Staidson (Beijing) Biopharmaceuticals Co., Ltd. ANTIBODIES SPECIFICALLY RECOGNIZING INTERLEUKIN 4 ALPHA RECEPTOR AND THEIR USES
TW202342510A (en) 2022-02-18 2023-11-01 英商Rq生物科技有限公司 Antibodies
KR20240038841A (en) * 2022-09-16 2024-03-26 연세대학교 산학협력단 A Novel Nanobody Binding to Human Interleukin-4 Receptor and Uses Thereof
WO2024259656A1 (en) * 2023-06-21 2024-12-26 Shanghai Mabgeek Biotech Co., Ltd. Formulation of an anti-il-4 receptor alpha mab or an antigen-binding fragment thereof comprising 2hpbetacd and leucine
CN119215163A (en) * 2023-06-30 2024-12-31 百奥泰生物制药股份有限公司 Anti-IL-4Rα antibody preparation and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1409018B1 (en) * 2001-07-25 2010-01-06 Facet Biotech Corporation Stable lyophilized pharmaceutical formulation the igg antibody daclizumab
CN104788563A (en) * 2007-12-21 2015-07-22 米迪缪尼有限公司 Binding members for interleukin-4 receptor alpha (Il-4Ra) - 173
US8092804B2 (en) * 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
NZ609557A (en) * 2010-10-06 2014-12-24 Regeneron Pharma Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies
US8613919B1 (en) * 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations

Also Published As

Publication number Publication date
WO2016034648A1 (en) 2016-03-10
RU2017107847A (en) 2018-10-03
US20170281769A1 (en) 2017-10-05
KR20170044739A (en) 2017-04-25
BR112017003419A2 (en) 2017-11-28
CN106604744A (en) 2017-04-26
EP3188757A1 (en) 2017-07-12
JP2017527560A (en) 2017-09-21
CA2959571A1 (en) 2016-03-10
IL250363A0 (en) 2017-03-30
AU2015310879A1 (en) 2017-03-02

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