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SG11201606832YA - Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) - Google Patents

Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)

Info

Publication number
SG11201606832YA
SG11201606832YA SG11201606832YA SG11201606832YA SG11201606832YA SG 11201606832Y A SG11201606832Y A SG 11201606832YA SG 11201606832Y A SG11201606832Y A SG 11201606832YA SG 11201606832Y A SG11201606832Y A SG 11201606832YA SG 11201606832Y A SG11201606832Y A SG 11201606832YA
Authority
SG
Singapore
Prior art keywords
osteoprogenitors
biophysically
mscs
sorted
bone marrow
Prior art date
Application number
SG11201606832YA
Inventor
Zhiyong Poon
Wong Cheng Lee
Vliet Krystyn J Van
Original Assignee
Massachusetts Inst Technology
Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Univ Singapore filed Critical Massachusetts Inst Technology
Publication of SG11201606832YA publication Critical patent/SG11201606832YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201606832YA 2014-02-18 2015-02-18 Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) SG11201606832YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461941081P 2014-02-18 2014-02-18
PCT/US2015/000029 WO2015126528A1 (en) 2014-02-18 2015-02-18 Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)

Publications (1)

Publication Number Publication Date
SG11201606832YA true SG11201606832YA (en) 2016-09-29

Family

ID=53878789

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201606832YA SG11201606832YA (en) 2014-02-18 2015-02-18 Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)

Country Status (4)

Country Link
US (1) US10047344B2 (en)
EP (1) EP3107995B1 (en)
SG (1) SG11201606832YA (en)
WO (1) WO2015126528A1 (en)

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WO2022081909A1 (en) 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN116783283A (en) * 2020-11-13 2023-09-19 Gpb科学有限公司 Methods of generating a population of cells with increased nucleic acid uptake
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CN117363565B (en) * 2023-09-28 2024-05-17 南方医科大学口腔医院 A method for constructing vascularized stem cell spheres for bone regeneration

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Also Published As

Publication number Publication date
EP3107995A4 (en) 2017-08-02
EP3107995A1 (en) 2016-12-28
US10047344B2 (en) 2018-08-14
WO2015126528A1 (en) 2015-08-27
EP3107995B1 (en) 2019-10-30
US20170009208A1 (en) 2017-01-12

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