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SG11201605602XA - Duocarmycin adcs showing improved in vivo antitumor activity - Google Patents

Duocarmycin adcs showing improved in vivo antitumor activity

Info

Publication number
SG11201605602XA
SG11201605602XA SG11201605602XA SG11201605602XA SG11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA SG 11201605602X A SG11201605602X A SG 11201605602XA
Authority
SG
Singapore
Prior art keywords
antitumor activity
vivo antitumor
showing improved
duocarmycin
duocarmycin adcs
Prior art date
Application number
SG11201605602XA
Other languages
English (en)
Inventor
Willem Dokter
Peter Johannes Goedings
Gijsbertus Franciscus Maria Verheijden
Patrick Henry Beusker
Original Assignee
Synthon Biopharmaceuticals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals Bv filed Critical Synthon Biopharmaceuticals Bv
Publication of SG11201605602XA publication Critical patent/SG11201605602XA/en

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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