SG11201604505QA - Tailed Mirtron Effectors For RNAi-Mediated Gene Silencing - Google Patents
Tailed Mirtron Effectors For RNAi-Mediated Gene SilencingInfo
- Publication number
- SG11201604505QA SG11201604505QA SG11201604505QA SG11201604505QA SG11201604505QA SG 11201604505Q A SG11201604505Q A SG 11201604505QA SG 11201604505Q A SG11201604505Q A SG 11201604505QA SG 11201604505Q A SG11201604505Q A SG 11201604505QA SG 11201604505Q A SG11201604505Q A SG 11201604505QA
- Authority
- SG
- Singapore
- Prior art keywords
- mirtron
- tailed
- effectors
- rnai
- gene silencing
- Prior art date
Links
- 108091035664 Mirtron Proteins 0.000 title 1
- 108091030071 RNAI Proteins 0.000 title 1
- 239000012636 effector Substances 0.000 title 1
- 230000030279 gene silencing Effects 0.000 title 1
- 230000009368 gene silencing by RNA Effects 0.000 title 1
- 238000012226 gene silencing method Methods 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361911208P | 2013-12-03 | 2013-12-03 | |
PCT/SG2014/000490 WO2015084254A1 (en) | 2013-12-03 | 2014-10-17 | Tailed Mirtron Effectors For RNAi-Mediated Gene Silencing |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201604505QA true SG11201604505QA (en) | 2016-07-28 |
Family
ID=53273850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201604505QA SG11201604505QA (en) | 2013-12-03 | 2014-10-17 | Tailed Mirtron Effectors For RNAi-Mediated Gene Silencing |
Country Status (3)
Country | Link |
---|---|
US (1) | US20170002350A1 (en) |
SG (1) | SG11201604505QA (en) |
WO (1) | WO2015084254A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10202001102XA (en) | 2014-11-14 | 2020-03-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
CN110214187B (en) | 2016-05-18 | 2024-01-30 | 沃雅戈治疗公司 | Regulatory polynucleotides |
JP7220080B2 (en) | 2016-05-18 | 2023-02-09 | ボイジャー セラピューティクス インコーポレイテッド | Compositions and methods for treating Huntington's disease |
WO2018204786A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
MX2019013172A (en) | 2017-05-05 | 2020-09-07 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease. |
WO2019060779A1 (en) * | 2017-09-22 | 2019-03-28 | City Of Hope | Splice inhibiting oligonucleotides |
EP3697908A1 (en) | 2017-10-16 | 2020-08-26 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
CA3077426A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
CN112204141A (en) * | 2018-02-22 | 2021-01-08 | 美国陶氏益农公司 | Short/small hairpin RNA molecules |
GB201817470D0 (en) * | 2018-10-26 | 2018-12-12 | Univ Oxford Innovation Ltd | Gene therapy |
SG11202107334RA (en) * | 2019-02-18 | 2021-08-30 | Agency Science Tech & Res | A membrane-bound fit-1 decoy and uses thereof |
WO2024105663A1 (en) * | 2022-11-16 | 2024-05-23 | Geneneer Ltd. | Transgenic plants containing artificial mirtrons |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998048004A1 (en) * | 1997-04-18 | 1998-10-29 | The Wistar Institute Of Anatomy And Biology | Method and compositions for stabilizing unstable gene transcripts |
US9567591B2 (en) * | 2003-05-15 | 2017-02-14 | Mello Biotechnology, Inc. | Generation of human embryonic stem-like cells using intronic RNA |
GB0816778D0 (en) * | 2008-09-12 | 2008-10-22 | Isis Innovation | Gene silencing |
GB201004475D0 (en) * | 2010-03-17 | 2010-05-05 | Isis Innovation | Gene silencing |
-
2014
- 2014-10-17 US US15/100,630 patent/US20170002350A1/en not_active Abandoned
- 2014-10-17 SG SG11201604505QA patent/SG11201604505QA/en unknown
- 2014-10-17 WO PCT/SG2014/000490 patent/WO2015084254A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20170002350A1 (en) | 2017-01-05 |
WO2015084254A1 (en) | 2015-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20190197T1 (en) | Rna purification methods | |
SG11201604505QA (en) | Tailed Mirtron Effectors For RNAi-Mediated Gene Silencing | |
HK1219021A1 (en) | Talen-based gene correction | |
IL243445B (en) | Silencer | |
IL241426A0 (en) | Nucleic acid amplification | |
RS58268B2 (en) | Rhizomania-resistant gene | |
IL241269A0 (en) | Nucleic acid amplification | |
PT3889173T (en) | Optimized factor viii gene | |
GB2516035B (en) | Adaptive powertrain control for optimized performance | |
EP2944783A4 (en) | Muffler | |
IL241273A0 (en) | Nucleic acid amplification | |
HK1232259A1 (en) | Nucleic acid amplification | |
GB201303283D0 (en) | An end port regenerative furnace | |
EP2943578A4 (en) | Dnazyme for silencing the expression of egfr | |
EP2989292A4 (en) | Communicating acoustically | |
GB201309132D0 (en) | Regulatable gene expression | |
GB201303304D0 (en) | An improved rifle sling | |
AU2013904184A0 (en) | Spacing means | |
GB201307838D0 (en) | Improved nucleic acid expressions |