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SG11201602477YA - Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof - Google Patents

Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof

Info

Publication number
SG11201602477YA
SG11201602477YA SG11201602477YA SG11201602477YA SG11201602477YA SG 11201602477Y A SG11201602477Y A SG 11201602477YA SG 11201602477Y A SG11201602477Y A SG 11201602477YA SG 11201602477Y A SG11201602477Y A SG 11201602477YA SG 11201602477Y A SG11201602477Y A SG 11201602477YA
Authority
SG
Singapore
Prior art keywords
compound
pharmaceutical use
somatostatin receptor
agonistic activity
receptor agonistic
Prior art date
Application number
SG11201602477YA
Inventor
Akiharu Ishida
Takeshi Matsushita
Tetsuya Sekiguchi
Yasuyuki Okabe
Tatsuya Komagata
Takuya Nishio
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of SG11201602477YA publication Critical patent/SG11201602477YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG11201602477YA 2013-09-30 2014-09-29 Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof SG11201602477YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013205027 2013-09-30
JP2013268902 2013-12-26
PCT/JP2014/075794 WO2015046482A1 (en) 2013-09-30 2014-09-29 Compound having agonistic activity to somatostatin receptor and medicinal use thereof

Publications (1)

Publication Number Publication Date
SG11201602477YA true SG11201602477YA (en) 2016-05-30

Family

ID=52743606

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201602477YA SG11201602477YA (en) 2013-09-30 2014-09-29 Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof

Country Status (20)

Country Link
US (1) US9643951B2 (en)
EP (1) EP3053916B1 (en)
JP (1) JP6380402B2 (en)
KR (1) KR20160062023A (en)
CN (1) CN105593221B (en)
AU (1) AU2014325078B2 (en)
BR (1) BR112016007078A2 (en)
CA (1) CA2925651A1 (en)
DK (1) DK3053916T3 (en)
ES (1) ES2716151T3 (en)
HU (1) HUE043374T2 (en)
IL (1) IL244813A0 (en)
MX (1) MX2016004088A (en)
PH (1) PH12016500573B1 (en)
PL (1) PL3053916T3 (en)
PT (1) PT3053916T (en)
RU (1) RU2666352C2 (en)
SG (1) SG11201602477YA (en)
TW (1) TWI628175B (en)
WO (1) WO2015046482A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX390120B (en) * 2016-07-14 2025-03-20 Crinetics Pharmaceuticals Inc SOMATOSTATIN MODULATORS AND THEIR USES.
MX2019009419A (en) 2017-02-08 2019-10-02 Ono Pharmaceutical Co Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof.
EP3596062A4 (en) * 2017-03-16 2020-08-26 Crinetics Pharmaceuticals, Inc. SOMATOSTAT IN MODULATORS AND USES THEREOF
EP3658560A4 (en) 2017-07-25 2021-01-06 Crinetics Pharmaceuticals, Inc. SOMATOSTATIN MODULATORS AND USES OF THESE LATEST
EP4092018A1 (en) * 2018-01-17 2022-11-23 Crinetics Pharmaceuticals, Inc. Process of making somatostatin modulators
US11608335B2 (en) 2018-02-12 2023-03-21 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
WO2019240246A1 (en) * 2018-06-15 2019-12-19 小野薬品工業株式会社 Novel salts and novel crystal forms of piperidinol derivatives
ES3022912T3 (en) 2018-09-18 2025-05-29 Crinetics Pharmaceuticals Inc Somatostatin modulators and uses thereof
TWI841768B (en) * 2019-08-14 2024-05-11 美商克林提克斯醫藥股份有限公司 Nonpeptide somatostatin type 5 receptor agonists and uses thereof
MD4210700T2 (en) 2020-09-09 2025-11-30 Crinetics Pharmaceuticals Inc Formulations of a somatostatin modulator
EP4294797A1 (en) 2021-02-17 2023-12-27 Crinetics Pharmaceuticals, Inc. Crystalline forms of a somatostatin modulator
CN116789674B (en) * 2022-08-24 2024-05-24 杭州高光制药有限公司 NLRP3 inflammasome inhibitors
CR20250214A (en) * 2022-10-28 2025-08-22 Basecamp Bio Inc Somatostatin receptor 2 agonists and uses thereof
KR20250117433A (en) 2022-12-13 2025-08-04 크리네틱스 파마슈티칼스, 인크. Somatostatin subtype 2 receptor (SST2R) targeted therapeutic agents and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6944296A (en) 1995-09-13 1997-04-01 Takeda Chemical Industries Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
US6025372A (en) 1997-04-04 2000-02-15 Merck & Co., Inc. Somatostatin agonists
US6057338A (en) * 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
AU1285499A (en) 1997-10-30 1999-05-24 Merck & Co., Inc. Somatostatin agonists
AU766831B2 (en) 1998-05-11 2003-10-23 Takeda Pharmaceutical Company Limited Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
AR035016A1 (en) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd COMPOSITION OF AZOL PROMOTER OF PRODUCTION / SECRETION OF NEUROTROFINE, COMPOSITE PRODROGA OF THE SAME, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE OF THE SAME TO PREPARE THIS LAST.
CA2386517A1 (en) 1999-10-07 2001-04-12 Takeda Chemical Industries, Ltd. Amine derivatives
HK1045991B (en) 1999-11-10 2004-12-10 Takeda Pharmaceutical Company Limited 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
FR2802206B1 (en) * 1999-12-14 2005-04-22 Sod Conseils Rech Applic 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS
EP1285651B1 (en) 2000-04-28 2010-09-01 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonists
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
EP1437351A4 (en) 2001-10-19 2005-06-01 Takeda Pharmaceutical AMINE DERIVATIVE
AR044852A1 (en) * 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
US20090196912A1 (en) 2004-07-30 2009-08-06 Gpc Botech Ag Pyridinylamines
TW200726767A (en) 2005-07-04 2007-07-16 Astrazeneca Ab Chemical compounds 2
CN101258152A (en) * 2005-07-04 2008-09-03 阿斯利康(瑞典)有限公司 Pyridopyrimidine derivatives as PDE4 inhibitors for the treatment of inflammatory and immune diseases
EP1996196A2 (en) * 2006-03-13 2008-12-03 Merck & Co., Inc. Somatostatin agonists
AU2007286344A1 (en) * 2006-08-15 2008-02-21 F. Hoffmann-La Roche Ag Phenyl, pyridine and quinoline derivatives
GB0818241D0 (en) 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
JP6299591B2 (en) 2012-07-03 2018-03-28 小野薬品工業株式会社 Compound having somatostatin receptor agonist activity and pharmaceutical use thereof

Also Published As

Publication number Publication date
JPWO2015046482A1 (en) 2017-03-09
MX2016004088A (en) 2016-06-06
AU2014325078A1 (en) 2016-04-21
RU2016111659A3 (en) 2018-03-20
RU2016111659A (en) 2017-11-13
US9643951B2 (en) 2017-05-09
EP3053916A1 (en) 2016-08-10
EP3053916B1 (en) 2019-01-30
EP3053916A4 (en) 2017-03-08
US20160311794A1 (en) 2016-10-27
DK3053916T3 (en) 2019-04-15
BR112016007078A2 (en) 2017-12-12
PT3053916T (en) 2019-03-26
WO2015046482A1 (en) 2015-04-02
TW201602092A (en) 2016-01-16
TWI628175B (en) 2018-07-01
PH12016500573A1 (en) 2016-07-04
PL3053916T3 (en) 2019-06-28
KR20160062023A (en) 2016-06-01
CN105593221A (en) 2016-05-18
PH12016500573B1 (en) 2016-07-04
CA2925651A1 (en) 2015-04-02
HK1223356A1 (en) 2017-07-28
JP6380402B2 (en) 2018-08-29
RU2666352C2 (en) 2018-09-07
AU2014325078B2 (en) 2018-10-25
CN105593221B (en) 2017-09-22
ES2716151T3 (en) 2019-06-10
IL244813A0 (en) 2016-05-31
HUE043374T2 (en) 2019-08-28

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