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SG11201601182QA - Method for the clarification of high density crude cell culture harvest - Google Patents

Method for the clarification of high density crude cell culture harvest

Info

Publication number
SG11201601182QA
SG11201601182QA SG11201601182QA SG11201601182QA SG11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA SG 11201601182Q A SG11201601182Q A SG 11201601182QA
Authority
SG
Singapore
Prior art keywords
clarification
cell culture
high density
crude cell
culture harvest
Prior art date
Application number
SG11201601182QA
Inventor
Villiers Ann-Marie De
Charles M H Hensgens
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of SG11201601182QA publication Critical patent/SG11201601182QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02Separating microorganisms from their culture media

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201601182QA 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest SG11201601182QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13186692 2013-09-30
PCT/EP2014/070786 WO2015044418A1 (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Publications (1)

Publication Number Publication Date
SG11201601182QA true SG11201601182QA (en) 2016-04-28

Family

ID=49261472

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201808061WA SG10201808061WA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest
SG11201601182QA SG11201601182QA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201808061WA SG10201808061WA (en) 2013-09-30 2014-09-29 Method for the clarification of high density crude cell culture harvest

Country Status (11)

Country Link
US (1) US10421986B2 (en)
EP (1) EP3052613A1 (en)
JP (1) JP6683604B2 (en)
KR (1) KR102245547B1 (en)
CN (1) CN105579572B (en)
AU (1) AU2014326706A1 (en)
BR (1) BR112016006063A2 (en)
CA (1) CA2924042C (en)
EA (1) EA201690684A1 (en)
SG (2) SG10201808061WA (en)
WO (1) WO2015044418A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6683604B2 (en) 2013-09-30 2020-04-22 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. Method for clarification of high density crude cell culture harvest
CN106474466B (en) * 2016-12-07 2018-04-13 申联生物医药(上海)股份有限公司 A kind of preparation method of aftosa vaccine
CA3107770C (en) 2018-08-16 2023-09-05 Emd Millipore Corporation Closed bioprocessing device
AU2020329234A1 (en) * 2019-08-13 2022-03-24 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE445705T1 (en) 1995-06-15 2009-10-15 Crucell Holland Bv PACKAGING SYSTEMS FOR HUMAN RECOMBINANT ADENOVIRUSES FOR GENE THERAPY
BRPI0409895B8 (en) 2003-05-09 2021-05-25 Crucell Holland Bv method of culturing cells derived from per.c6 cells capable of growing in suspension to increase the product yield of said cells
JP2007525984A (en) 2004-03-05 2007-09-13 ディーエスエム アイピー アセッツ ビー.ブイ. Cell culture method by continuous perfusion and alternating tangential flow
CN101490239A (en) * 2006-07-14 2009-07-22 帝斯曼知识产权资产管理有限公司 Improved process for the culturing of cells
MX340242B (en) 2006-07-14 2016-07-01 Dpx Holdings Bv IMPROVED PROCESS FOR CELL CULTURE.
WO2009054226A1 (en) * 2007-10-26 2009-04-30 Asahi Kasei Chemicals Corporation Protein purification method
JP5665733B2 (en) * 2008-04-21 2015-02-04 ノボ ノルディスク ヘルス ケア アーゲー Highly glycosylated human coagulation factor IX
TWI432255B (en) * 2008-09-26 2014-04-01 Asahi Kasei Chemicals Corp The use of porous hollow fiber membranes for the manufacture of clarified biomedical culture media
AU2009305343A1 (en) 2008-10-17 2010-04-22 Percivia Llc. Clarification process at higher cell density
DK2488635T3 (en) * 2009-10-15 2014-02-24 Crucell Holland Bv A method for purifying adenovirus of cultures with high cell density
ES2642629T3 (en) * 2009-11-17 2017-11-17 E. R. Squibb & Sons, L.L.C. Methods for improved protein production
SG182611A1 (en) * 2010-01-22 2012-08-30 Lonza Walkersville Inc High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
CN107190034A (en) 2010-10-05 2017-09-22 诺沃—诺迪斯克保健股份有限公司 Produce method of protein
WO2013061859A1 (en) * 2011-10-24 2013-05-02 株式会社カネカ Method for producing cell concentrate
JP6683604B2 (en) 2013-09-30 2020-04-22 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. Method for clarification of high density crude cell culture harvest

Also Published As

Publication number Publication date
US10421986B2 (en) 2019-09-24
KR20160060058A (en) 2016-05-27
SG10201808061WA (en) 2018-10-30
CN105579572A (en) 2016-05-11
CN105579572B (en) 2018-08-10
WO2015044418A1 (en) 2015-04-02
AU2014326706A1 (en) 2016-03-10
EP3052613A1 (en) 2016-08-10
CA2924042C (en) 2023-04-18
EA201690684A1 (en) 2016-09-30
KR102245547B1 (en) 2021-04-28
US20160222429A1 (en) 2016-08-04
JP2016531558A (en) 2016-10-13
CA2924042A1 (en) 2015-04-02
JP6683604B2 (en) 2020-04-22
BR112016006063A2 (en) 2017-08-01

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