SG11201600933QA - Application of andrographolide in the preparation of a pharmaceutical for treatment of inflammatory bowel disease, andrographolide enteric targeting micropellet, and method for preparation thereof - Google Patents
Application of andrographolide in the preparation of a pharmaceutical for treatment of inflammatory bowel disease, andrographolide enteric targeting micropellet, and method for preparation thereofInfo
- Publication number
- SG11201600933QA SG11201600933QA SG11201600933QA SG11201600933QA SG11201600933QA SG 11201600933Q A SG11201600933Q A SG 11201600933QA SG 11201600933Q A SG11201600933Q A SG 11201600933QA SG 11201600933Q A SG11201600933Q A SG 11201600933QA SG 11201600933Q A SG11201600933Q A SG 11201600933QA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- andrographolide
- pharmaceutical
- treatment
- application
- Prior art date
Links
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 title 2
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 title 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310338444 | 2013-08-06 | ||
| PCT/CN2014/083810 WO2015018344A1 (en) | 2013-08-06 | 2014-08-06 | Application of andrographolide in the preparation of a pharmaceutical for treatment of inflammatory bowel disease, andrographolide enteric targeting micropellet, and method for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201600933QA true SG11201600933QA (en) | 2016-03-30 |
Family
ID=52460670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201600933QA SG11201600933QA (en) | 2013-08-06 | 2014-08-06 | Application of andrographolide in the preparation of a pharmaceutical for treatment of inflammatory bowel disease, andrographolide enteric targeting micropellet, and method for preparation thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9889093B2 (en) |
| EP (1) | EP3031456A4 (en) |
| JP (1) | JP6389889B2 (en) |
| KR (1) | KR20160040697A (en) |
| CN (2) | CN104337773B (en) |
| AU (1) | AU2014305430B2 (en) |
| CA (1) | CA2920533A1 (en) |
| HK (1) | HK1220909A1 (en) |
| MY (1) | MY176758A (en) |
| PH (1) | PH12016500258A1 (en) |
| RU (1) | RU2681930C2 (en) |
| SG (1) | SG11201600933QA (en) |
| WO (1) | WO2015018344A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030764B (en) * | 2015-06-15 | 2019-04-19 | 广州喜鹊医药有限公司 | Application of the andrographolidume derivative in preparation treatment inflammatory bowel medicine |
| CN110420179A (en) * | 2019-08-12 | 2019-11-08 | 韩育娟 | A kind of andrographolide dry suspensoid agent and preparation method thereof |
| KR102104507B1 (en) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | Pharmaceutical formulations comprising sodium palmitoyl-l-prolyl-l-prolyl-glycyl-l-tyrosinate and methods for preparing the same |
| CN110585138B (en) * | 2019-09-29 | 2021-08-03 | 黑龙江中医药大学 | Andrographis paniculata granules and preparation method thereof |
| IT201900017555A1 (en) * | 2019-09-30 | 2021-03-30 | Dymalife Res S R L | Association for use in the treatment and prevention of inflammatory disorders of the intestinal tract |
| CN113116862B (en) * | 2019-12-30 | 2022-05-27 | 辽宁上药好护士药业（集团）有限公司 | Blood stasis arthralgia micro-pill and preparation method and application thereof |
| WO2022047730A1 (en) | 2020-09-04 | 2022-03-10 | Shanghai Pharmaceuticals Holding Co., Ltd. | Methods to treat inflammatory bowel disease |
| CN112245596B (en) * | 2020-11-09 | 2022-01-18 | 浙江大学 | Method for screening drug effect substances based on zebra fish inflammatory bowel disease model |
| CN113069429A (en) * | 2021-04-07 | 2021-07-06 | 临沂大学 | Hyaluronic acid modified halloysite nanotube/chitosan enteric coated microsphere loaded with paeoniflorin and preparation method thereof |
| CN116326537A (en) * | 2021-12-22 | 2023-06-27 | 成都海枫生物科技有限公司 | A kind of construction method of rat Crohn's disease model |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5914132A (en) * | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5843479A (en) * | 1993-02-26 | 1998-12-01 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| IT1318376B1 (en) * | 2000-03-07 | 2003-08-25 | Pharmatec Internat S R L | ORAL SOLID FORMS WITH CONTROLLED RELEASE CONTAINING MESALAZINE AS AN ACTIVE PRINCIPLE. |
| ES2241478B1 (en) * | 2004-02-13 | 2006-11-16 | Lacer S.A. | PHARMACEUTICAL PREPARATION FOR THE SUSTAINED RELEASE OF A PHARMACEUTICALLY ACTIVE PRINCIPLE. |
| JP2007528421A (en) * | 2004-03-11 | 2007-10-11 | ハッチソン メディファーマ リミテッド | Andrographolide and its analogs as inhibitors of TNFα and IL-1β |
| CN1689628B (en) * | 2004-04-29 | 2010-04-21 | 和记黄埔医药企业有限公司 | Medical purpose of creat extract |
| CN1969895A (en) * | 2005-11-22 | 2007-05-30 | 徐小彬 | Enteric-coated formulation of creat and preparation process thereof |
| CN1981743A (en) | 2005-12-13 | 2007-06-20 | 珠海天翼医药技术开发有限公司 | Colon positioned releasing micropills and production thereof |
| WO2008059522A2 (en) * | 2006-09-28 | 2008-05-22 | Unijules Life Sciences Ltd | Herbal gastrointenstinal controlled drug delivery dosage forms including pellets and process for their preparation |
| CN101209246A (en) | 2006-12-29 | 2008-07-02 | 天津医科大学 | A novel pH-dependent colon-localized drug delivery system |
| CN101422494B (en) * | 2007-11-02 | 2012-08-01 | 和记黄埔医药（上海）有限公司 | Creat extract and medical use thereof |
| US20090117209A1 (en) * | 2007-11-02 | 2009-05-07 | Hutchison Medipharma Enterprises Limited | Andrographis paniculata extract |
| US20120141584A1 (en) * | 2009-08-26 | 2012-06-07 | Aptapharma, Inc. | Multilayer Minitablets |
| CN102552171B (en) * | 2012-03-02 | 2016-03-09 | 北京科信必成医药科技发展有限公司 | A kind of andrographolide colon-targeted micropellet and preparation method thereof |
| CN102579363B (en) * | 2012-03-02 | 2016-03-09 | 北京科信必成医药科技发展有限公司 | Micropill of a kind of colon positioning release and preparation method thereof |
| CN103315959B (en) | 2012-03-21 | 2015-05-06 | 上海市第一人民医院 | Orally taken colon-targeted preparation for treatment of inflammatory bowel diseases and preparation method thereof |
| CN102614133A (en) * | 2012-04-10 | 2012-08-01 | 沈阳药科大学 | Andrographolide ground suspending liquid, preparation method thereof, and application of pharmaceutical preparation |
| CN103070843A (en) * | 2013-01-16 | 2013-05-01 | 司鹏 | Oral preparation containing andrographolide and preparation method thereof |
| CN103908535A (en) * | 2014-03-19 | 2014-07-09 | 锦州博泽医药科技开发有限公司 | Enteric capsule containing andrographolide |
-
2014
- 2014-08-06 WO PCT/CN2014/083810 patent/WO2015018344A1/en active Application Filing
- 2014-08-06 CN CN201410386505.6A patent/CN104337773B/en active Active
- 2014-08-06 CA CA2920533A patent/CA2920533A1/en not_active Abandoned
- 2014-08-06 CN CN201480044529.1A patent/CN105451734A/en active Pending
- 2014-08-06 US US14/910,173 patent/US9889093B2/en active Active
- 2014-08-06 RU RU2016107440A patent/RU2681930C2/en active
- 2014-08-06 EP EP14835361.8A patent/EP3031456A4/en active Pending
- 2014-08-06 JP JP2016532228A patent/JP6389889B2/en active Active
- 2014-08-06 AU AU2014305430A patent/AU2014305430B2/en not_active Ceased
- 2014-08-06 SG SG11201600933QA patent/SG11201600933QA/en unknown
- 2014-08-06 KR KR1020167005980A patent/KR20160040697A/en not_active Abandoned
- 2014-08-06 MY MYPI2016700447A patent/MY176758A/en unknown
-
2016
- 2016-02-05 PH PH12016500258A patent/PH12016500258A1/en unknown
- 2016-07-28 HK HK16109062.6A patent/HK1220909A1/en unknown
-
2017
- 2017-03-27 US US15/469,711 patent/US20170224623A1/en not_active Abandoned
- 2017-03-27 US US15/469,834 patent/US20170224622A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170224622A1 (en) | 2017-08-10 |
| CA2920533A1 (en) | 2015-02-12 |
| JP6389889B2 (en) | 2018-09-12 |
| HK1220909A1 (en) | 2017-05-19 |
| CN105451734A (en) | 2016-03-30 |
| RU2016107440A (en) | 2017-09-15 |
| KR20160040697A (en) | 2016-04-14 |
| US20170224623A1 (en) | 2017-08-10 |
| US9889093B2 (en) | 2018-02-13 |
| AU2014305430A1 (en) | 2016-03-03 |
| MY176758A (en) | 2020-08-21 |
| EP3031456A1 (en) | 2016-06-15 |
| US20160175253A1 (en) | 2016-06-23 |
| CN104337773A (en) | 2015-02-11 |
| RU2681930C2 (en) | 2019-03-14 |
| CN104337773B (en) | 2018-11-30 |
| EP3031456A4 (en) | 2016-12-28 |
| PH12016500258A1 (en) | 2016-05-16 |
| WO2015018344A1 (en) | 2015-02-12 |
| JP2016527281A (en) | 2016-09-08 |
| AU2014305430B2 (en) | 2019-02-07 |
| RU2016107440A3 (en) | 2018-05-03 |
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