[go: up one dir, main page]

SG11201502404WA - Antigens associated with inflammatory bowel disease - Google Patents

Antigens associated with inflammatory bowel disease

Info

Publication number
SG11201502404WA
SG11201502404WA SG11201502404WA SG11201502404WA SG11201502404WA SG 11201502404W A SG11201502404W A SG 11201502404WA SG 11201502404W A SG11201502404W A SG 11201502404WA SG 11201502404W A SG11201502404W A SG 11201502404WA SG 11201502404W A SG11201502404W A SG 11201502404WA
Authority
SG
Singapore
Prior art keywords
inflammatory bowel
bowel disease
antigens associated
antigens
disease
Prior art date
Application number
SG11201502404WA
Inventor
Giovanni Neri
Kathrin Schwager
Melanie Ruzek
Denise O'hara
Jianqing Chen
Original Assignee
Philogen Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50435280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201502404W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Philogen Spa filed Critical Philogen Spa
Publication of SG11201502404WA publication Critical patent/SG11201502404WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2066IL-10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201502404WA 2012-10-03 2012-10-03 Antigens associated with inflammatory bowel disease SG11201502404WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/058574 WO2014055073A1 (en) 2012-10-03 2012-10-03 Antigens associated with inflammatory bowel disease

Publications (1)

Publication Number Publication Date
SG11201502404WA true SG11201502404WA (en) 2015-05-28

Family

ID=50435280

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201502404WA SG11201502404WA (en) 2012-10-03 2012-10-03 Antigens associated with inflammatory bowel disease

Country Status (21)

Country Link
US (2) US9695232B2 (en)
EP (1) EP2903629B1 (en)
JP (1) JP6158933B2 (en)
KR (1) KR102011549B1 (en)
CN (2) CN111329994A (en)
AU (1) AU2012391490B2 (en)
CA (1) CA2886152C (en)
CO (1) CO7380754A2 (en)
DK (1) DK2903629T3 (en)
ES (1) ES2743423T3 (en)
HU (1) HUE044927T2 (en)
IL (1) IL237856B (en)
IN (1) IN2015DN03229A (en)
MX (1) MX364535B (en)
PH (1) PH12015500662B1 (en)
PL (1) PL2903629T3 (en)
PT (1) PT2903629T (en)
RU (1) RU2612878C2 (en)
SG (1) SG11201502404WA (en)
SI (1) SI2903629T1 (en)
WO (1) WO2014055073A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2807753T3 (en) 2007-10-30 2021-02-24 Philogen Spa An antigen associated with rheumatoid arthritis
SG11201502404WA (en) 2012-10-03 2015-05-28 Philogen Spa Antigens associated with inflammatory bowel disease
GB201507908D0 (en) 2015-05-08 2015-06-24 Philogen Spa IL2 and TNF immunoconjugates
WO2017121880A1 (en) 2016-01-15 2017-07-20 Philogen S.P.A Intestinal antigens for pharmacodelivery applications
CN110997718B (en) * 2017-06-07 2023-11-10 菲洛根股份公司 Vascular endothelial growth factor/anti-fibronectin antibody fusion protein
WO2020181235A1 (en) * 2019-03-06 2020-09-10 Deka Biosciences, Inc. Il-10 variant molecules and methods of treating inflammatory disease and oncology
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
MX2023000948A (en) 2020-07-20 2023-04-14 Deka Biosciences Inc Dual cytokine fusion proteins comprising il-10.
US20230285585A1 (en) 2020-07-22 2023-09-14 Philogen S.P.A. Treatment of pulmonary hypertension
EP4493210A1 (en) 2022-03-17 2025-01-22 Universitätsklinikum Jena Anti-ed-a antibodies for the treatment of pulmonary hypertension

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE425839C (en) 1923-08-09 1926-03-02 Optische Anstalt C P Goerz Akt Process for generating the grinding pressure and the relative grinding movement between the object whose surface is to be processed by grinding (glass, lens, etc.) and the grinding surface of the rotating grinding tool
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IT1217724B (en) 1988-05-26 1990-03-30 Ist Naz Ric Sul Cancro SPECIFIC MONOCLONAL ANTIBODY FOR A SEQUENCE OF FIBRONETIN EXPRESSED IN TRANSFORMED HYBRID CELLS ACCORDING TO SUCH ANTIBODY AND USE OF THE MONOCLONAL ANTIBODY FOR THE DIAGNOSIS OF TUMORS
US5420012A (en) 1989-05-08 1995-05-30 Locus Genex Oy Method for the detection of reactive conditions
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
GB9206318D0 (en) 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
EP0580859A4 (en) 1991-03-26 1994-09-14 Otsuka Pharma Co Ltd Anti-eda monoclonal antibody
US6492160B1 (en) 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5858657A (en) 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US5962255A (en) 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
US5871907A (en) 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
ES2136092T3 (en) 1991-09-23 1999-11-16 Medical Res Council PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES.
WO1993011161A1 (en) 1991-11-25 1993-06-10 Enzon, Inc. Multivalent antigen-binding proteins
US5872215A (en) 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
DE69233782D1 (en) 1991-12-02 2010-05-20 Medical Res Council Preparation of Autoantibodies on Phage Surfaces Starting from Antibody Segment Libraries
US5932214A (en) * 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5368854A (en) * 1992-08-20 1994-11-29 Schering Corporation Use of IL-10 to treat inflammatory bowel disease
DK0672142T3 (en) 1992-12-04 2001-06-18 Medical Res Council Multivalent and multi-specific binding proteins as well as their preparation and use
US5644033A (en) 1992-12-22 1997-07-01 Health Research, Inc. Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
AU775076B2 (en) 1998-12-10 2004-07-15 Bristol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
DK1719528T3 (en) 2000-02-24 2012-01-09 Philogen Spa Compositions and Methods for Treating Angiogenesis in Pathological Lesions
WO2001076630A1 (en) 2000-04-06 2001-10-18 Kyowa Hakko Kogyo Co., Ltd. Diagnostics and remedies for rheumatoid arthritis
WO2001083816A2 (en) 2000-05-04 2001-11-08 Philogen S.R.L. Method for detecting tumors
EP1381629B1 (en) 2000-09-07 2008-09-10 Bayer Schering Pharma Aktiengesellschaft RECEPTOR IN THE EDb FIBRONECTIN DOMAIN
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
IT1317108B1 (en) 2000-12-06 2003-05-26 Philogen Srl PROCESS FOR THE SELECTION OF ANTI-ANGIOGENIC ANTI-CORPORAL FRAGMENTS, ANTI-ANGIOGENIC ANTI-CORPMENTAL FRAGMENTS SO OBTAINED AND THEIR USE.
US20020187100A1 (en) 2000-12-21 2002-12-12 David Rizzieri Anti-tenascin monoclonal antibody therapy for lymphoma
EP1224943A1 (en) 2001-01-19 2002-07-24 Crucell Holland B.V. Fibronectin as a tumor marker detected by phage antibodies
US7585491B2 (en) 2002-12-13 2009-09-08 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
GB0209896D0 (en) 2002-04-30 2002-06-05 Molmed Spa Conjugate
AU2003238284A1 (en) 2002-06-21 2004-01-06 Duke University Anti-tenascin antibody fragments and minibodies for treatment of lymphoma
CA2501616C (en) 2002-10-08 2015-05-12 Immunomedics, Inc. Antibody therapy
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
WO2004094612A2 (en) 2003-04-22 2004-11-04 A & G Pharmaceutical, Inc. Cancer specific monoclonal antibodies
WO2005009366A2 (en) 2003-07-24 2005-02-03 Cornell Research Foundation, Inc. Restoring vascular function
JP2007524649A (en) 2003-07-29 2007-08-30 イミューノメディクス、インコーポレイテッド Fluorinated carbohydrate complex
US8048432B2 (en) 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
EP1702069A2 (en) 2004-01-05 2006-09-20 EMD Lexigen Research Center Corp. Interleukin-12 targeted to oncofoetal fibronectin
US7943294B2 (en) 2004-07-30 2011-05-17 Hologic, Inc. Methods for detecting oncofetal fibronectin
US7785591B2 (en) 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
US7968685B2 (en) 2004-11-09 2011-06-28 Philogen S.P.A. Antibodies against Tenascin-C
EP2364995A1 (en) 2004-12-23 2011-09-14 Molmed SpA Conjugation product
ATE459648T1 (en) 2005-05-11 2010-03-15 Philogen Spa FUSION PROTEIN OF ANTIBODIES L19 AGAINST FIBRONECTIN ED-B AND INTERLEUKIN 12
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
CN103146708A (en) * 2005-06-30 2013-06-12 Abbvie公司 Il-12/p40 binding proteins
JP2009535372A (en) 2006-05-03 2009-10-01 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Combination of anti-EDB fibronectin domain antibody L19-SIP and anti-EGFR-antibody
ES2606490T3 (en) 2006-05-08 2017-03-24 Philogen S.P.A. Antibody-directed cytokines for therapy
EA036322B1 (en) 2007-04-02 2020-10-26 Филоджен С.П.А. Novel antigen associated with the neovasculature of tumour metastases
ES2398536T3 (en) * 2007-07-25 2013-03-20 Philogen S.P.A. The fibronectin ED-A antigen is associated with the neovasculature of tumor metastasis
ES2807753T3 (en) * 2007-10-30 2021-02-24 Philogen Spa An antigen associated with rheumatoid arthritis
WO2010078945A2 (en) 2009-01-07 2010-07-15 Philogen S.P.A. Cancer treatment
CA2748401C (en) * 2009-01-07 2017-09-12 Philogen S.P.A. Antigens associated with endometriosis
US8679488B2 (en) 2009-08-05 2014-03-25 Philogen S.P.A. Targeting of bone marrow neovasculature
WO2012041451A1 (en) 2010-09-29 2012-04-05 Philogen S.P.A. Thiazolidine linker for the conjugation of drugs to antibodies
EP2736535B1 (en) 2011-07-27 2018-10-17 Philogen S.p.A. Il-12 immunoconjugate
SG11201502404WA (en) 2012-10-03 2015-05-28 Philogen Spa Antigens associated with inflammatory bowel disease
EP2988784A1 (en) 2013-04-25 2016-03-02 Philogen S.p.A. Antibody-drug conjugates
WO2014173570A1 (en) 2013-04-26 2014-10-30 Philogen S.P.A. Il4 conjugated to antibodies against extracellular matrix components
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Also Published As

Publication number Publication date
DK2903629T3 (en) 2019-08-05
RU2015115399A (en) 2016-11-27
US9695232B2 (en) 2017-07-04
SI2903629T1 (en) 2019-09-30
PH12015500662A1 (en) 2015-05-18
CA2886152A1 (en) 2014-04-10
IL237856A0 (en) 2015-05-31
HUE044927T2 (en) 2019-11-28
EP2903629A4 (en) 2016-07-27
CO7380754A2 (en) 2015-09-10
US20180044408A1 (en) 2018-02-15
IL237856B (en) 2019-11-28
US20150361161A1 (en) 2015-12-17
JP2016500670A (en) 2016-01-14
IN2015DN03229A (en) 2015-10-02
CN104768563A (en) 2015-07-08
CA2886152C (en) 2020-01-14
KR102011549B1 (en) 2019-08-16
RU2612878C2 (en) 2017-03-13
AU2012391490A1 (en) 2015-04-30
NZ631476A (en) 2017-06-30
ES2743423T3 (en) 2020-02-19
PT2903629T (en) 2019-09-10
JP6158933B2 (en) 2017-07-05
PL2903629T3 (en) 2019-12-31
WO2014055073A1 (en) 2014-04-10
MX364535B (en) 2019-04-29
US10239939B2 (en) 2019-03-26
KR20150061648A (en) 2015-06-04
CN104768563B (en) 2020-02-28
MX2015003908A (en) 2015-08-05
CN111329994A (en) 2020-06-26
AU2012391490B2 (en) 2018-02-15
PH12015500662B1 (en) 2019-05-31
HK1212220A1 (en) 2016-06-10
EP2903629A1 (en) 2015-08-12
EP2903629B1 (en) 2019-07-10

Similar Documents

Publication Publication Date Title
IL264558A (en) Anti-il-23p19 antibodies
ZA201407509B (en) Anti-fcrn antibodies
ZA201407897B (en) Protease-regulated antibodies
ZA201409358B (en) Anti-siglec- 15 antibodies
IL237856A0 (en) Antigens associated with inflammatory bowel disease
ZA201407316B (en) Anti-fgfr2 antibody
EP2823928A4 (en) Coupling structure
SG10201709290XA (en) Anti-H7cr Antibodies
ZA201407079B (en) Cdr-modified anti-siglec-15 antibody
GB201214440D0 (en) Kidney disease biomarker
GB201212069D0 (en) Predicting resistance to disease
GB201220242D0 (en) Antibody
GB201223223D0 (en) Inflammatory bowel disease
SG11201504853VA (en) Immunoassay
EP2811018A4 (en) ANTI-sAPPß ANTIBODY
GB201020702D0 (en) Inflammatory disease
GB201018302D0 (en) Inflammatory disease
GB201216749D0 (en) Antigen combinations
GB201200568D0 (en) Antigen combinations
IL235188A0 (en) Anti-pdgf-c antibodies
GB201209584D0 (en) Modified antibodies
GB201222429D0 (en) Nolan