SG11201501055SA - Arylethynyl pyrimidines - Google Patents

Arylethynyl pyrimidines

Info

Publication number: SG11201501055SA
Authority: SG; Singapore
Prior art keywords: arylethynyl; pyrimidines; arylethynyl pyrimidines
Prior art date: 2012-08-13

Application number

SG11201501055SA

Inventor

Georg Jaeschke

Lothar Lindemann

Heinz Stadler

Eric Vieira

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-08-13

Filing date

2013-08-06

Publication date

2015-03-30

2013-08-06 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2015-03-30 Publication of SG11201501055SA publication Critical patent/SG11201501055SA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SG11201501055SA 2012-08-13 2013-08-06 Arylethynyl pyrimidines SG11201501055SA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP12180209		2012-08-13
PCT/EP2013/066443 WO2014026880A1 (en)	2012-08-13	2013-08-06	Arylethynyl pyrimidines

Publications (1)

Publication Number	Publication Date
SG11201501055SA true SG11201501055SA (en)	2015-03-30

Family

ID=46851291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201501055SA SG11201501055SA (en)	2012-08-13	2013-08-06	Arylethynyl pyrimidines

Country Status (35)

Country	Link
US (1)	US9199971B2 (en)
EP (1)	EP2882742B1 (en)
JP (1)	JP5974179B2 (en)
KR (1)	KR101747005B1 (en)
CN (1)	CN104540815B (en)
AR (1)	AR092097A1 (en)
AU (1)	AU2013304212B2 (en)
BR (1)	BR112015002921A2 (en)
CA (1)	CA2880257C (en)
CL (1)	CL2015000290A1 (en)
CO (1)	CO7180198A2 (en)
CR (1)	CR20150028A (en)
CY (1)	CY1118595T1 (en)
DK (1)	DK2882742T3 (en)
EA (1)	EA025165B1 (en)
ES (1)	ES2601511T3 (en)
HR (1)	HRP20161692T1 (en)
HU (1)	HUE030237T2 (en)
IL (1)	IL237015A (en)
LT (1)	LT2882742T (en)
MA (1)	MA37895B1 (en)
MX (1)	MX358011B (en)
MY (1)	MY170255A (en)
NZ (1)	NZ704858A (en)
PE (1)	PE20150685A1 (en)
PH (1)	PH12015500261B1 (en)
PL (1)	PL2882742T3 (en)
PT (1)	PT2882742T (en)
RS (1)	RS55397B1 (en)
SG (1)	SG11201501055SA (en)
SI (1)	SI2882742T1 (en)
TW (1)	TWI501958B (en)
UA (1)	UA113223C2 (en)
WO (1)	WO2014026880A1 (en)
ZA (1)	ZA201500582B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8729263B2 (en)	2012-08-13	2014-05-20	Novartis Ag	1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
CN104603110B (en) *	2012-10-18	2016-08-31	霍夫曼-拉罗奇有限公司	Ethynyl derivatives serving as the regulator of mGluR5 receptor active
RU2712633C1 (en)	2015-06-03	2020-01-30	Ф. Хоффманн-Ля Рош Аг	Ethynyl derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005118568A1 (en) *	2004-06-01	2005-12-15	F. Hoffmann-La Roche Ag	Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
GB0325956D0 (en)	2003-11-06	2003-12-10	Addex Pharmaceuticals Sa	Novel compounds
WO2006048771A1 (en)	2004-11-04	2006-05-11	Addex Pharmaceuticals Sa	Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0503646D0 (en) *	2005-02-22	2005-03-30	Novartis Ag	Organic compounds
GB0510139D0 (en)	2005-05-18	2005-06-22	Addex Pharmaceuticals Sa	Novel compounds B1
TW200811157A (en) *	2006-05-05	2008-03-01	Astrazeneca Ab	mGluR5 modulators I
MX2009013169A (en)	2007-06-03	2010-04-30	Univ Vanderbilt	Benzamide mglur5 positive allosteric modulators and methods of making and using same.
WO2009054794A1 (en) *	2007-10-26	2009-04-30	Astrazeneca Ab	Amino 1,2,4-triazole derivatives as modulators of mglur5
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles
US8389536B2 (en) *	2009-10-27	2013-03-05	Hoffmann-La Roche Inc.	Positive allosteric modulators (PAM)
US8420661B2 (en)	2010-04-13	2013-04-16	Hoffmann-La Roche Inc.	Arylethynyl derivatives
NZ603868A (en) *	2010-07-09	2014-08-29	Recordati Ireland Ltd	Novel spiroheterocyclic compounds as mglu5 antagonists
WO2012015024A1 (en) *	2010-07-29	2012-02-02	大正製薬株式会社	Ethinyl-pyrazole derivative
MX2013011107A (en) *	2011-04-26	2013-10-17	Hoffmann La Roche	Pyrazolidin-3-one derivatives.
US20130123254A1 (en) *	2011-09-30	2013-05-16	Barbara Biemans	Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110995C2 (en) *	2011-10-07	2016-03-10	Ф. Хоффманн-Ля Рош Аг	ETHINYL DERIVATIVES AS MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR
UA110862C2 (en) *	2011-10-07	2016-02-25	Ф. Хоффманн-Ля Рош Аг	Ethinyl derivatives as allosteric modulators of metabotropic glutamate receptor 5 mglur
EP2875000B1 (en) *	2012-07-17	2016-09-21	F. Hoffmann-La Roche AG	Arylethynyl derivatives
AU2013329739B2 (en) *	2012-09-27	2017-04-20	F. Hoffmann-La Roche Ag	Arylethynyl derivatives

2013
- 2013-06-08 UA UAA201501613A patent/UA113223C2/en unknown
- 2013-08-06 MA MA37895A patent/MA37895B1/en unknown
- 2013-08-06 EA EA201590252A patent/EA025165B1/en not_active IP Right Cessation
- 2013-08-06 KR KR1020157006196A patent/KR101747005B1/en not_active Expired - Fee Related
- 2013-08-06 WO PCT/EP2013/066443 patent/WO2014026880A1/en not_active Ceased
- 2013-08-06 NZ NZ704858A patent/NZ704858A/en not_active IP Right Cessation
- 2013-08-06 JP JP2015526930A patent/JP5974179B2/en active Active
- 2013-08-06 CA CA2880257A patent/CA2880257C/en not_active Expired - Fee Related
- 2013-08-06 PT PT137478277T patent/PT2882742T/en unknown
- 2013-08-06 AU AU2013304212A patent/AU2013304212B2/en not_active Ceased
- 2013-08-06 HU HUE13747827A patent/HUE030237T2/en unknown
- 2013-08-06 PE PE2015000196A patent/PE20150685A1/en active IP Right Grant
- 2013-08-06 RS RS20161001A patent/RS55397B1/en unknown
- 2013-08-06 SG SG11201501055SA patent/SG11201501055SA/en unknown
- 2013-08-06 EP EP13747827.7A patent/EP2882742B1/en active Active
- 2013-08-06 ES ES13747827.7T patent/ES2601511T3/en active Active
- 2013-08-06 PL PL13747827T patent/PL2882742T3/en unknown
- 2013-08-06 SI SI201330420A patent/SI2882742T1/en unknown
- 2013-08-06 MX MX2015001599A patent/MX358011B/en active IP Right Grant
- 2013-08-06 HR HRP20161692TT patent/HRP20161692T1/en unknown
- 2013-08-06 CN CN201380042690.0A patent/CN104540815B/en active Active
- 2013-08-06 DK DK13747827.7T patent/DK2882742T3/en active
- 2013-08-06 BR BR112015002921A patent/BR112015002921A2/en not_active Application Discontinuation
- 2013-08-06 MY MYPI2015000358A patent/MY170255A/en unknown
- 2013-08-06 LT LTEP13747827.7T patent/LT2882742T/en unknown
- 2013-08-09 TW TW102128724A patent/TWI501958B/en not_active IP Right Cessation
- 2013-08-12 AR ARP130102851A patent/AR092097A1/en not_active Application Discontinuation
2015
- 2015-01-22 CR CR20150028A patent/CR20150028A/en unknown
- 2015-01-23 CO CO15013232A patent/CO7180198A2/en unknown
- 2015-01-26 ZA ZA2015/00582A patent/ZA201500582B/en unknown
- 2015-01-29 IL IL237015A patent/IL237015A/en active IP Right Grant
- 2015-02-06 CL CL2015000290A patent/CL2015000290A1/en unknown
- 2015-02-06 PH PH12015500261A patent/PH12015500261B1/en unknown
- 2015-02-13 US US14/622,232 patent/US9199971B2/en active Active
2016
- 2016-12-16 CY CY20161101305T patent/CY1118595T1/en unknown

Also Published As

Publication number	Publication date
CN104540815B (en)	2016-10-19
DK2882742T3 (en)	2016-12-12
MY170255A (en)	2019-07-13
HRP20161692T1 (en)	2017-02-24
RS55397B1 (en)	2017-04-28
JP2015528824A (en)	2015-10-01
CL2015000290A1 (en)	2015-07-03
MX358011B (en)	2018-08-02
LT2882742T (en)	2016-12-12
US9199971B2 (en)	2015-12-01
HUE030237T2 (en)	2017-04-28
HK1207378A1 (en)	2016-01-29
AR092097A1 (en)	2015-03-25
US20150158848A1 (en)	2015-06-11
TW201410671A (en)	2014-03-16
EA025165B1 (en)	2016-11-30
MX2015001599A (en)	2015-05-11
WO2014026880A1 (en)	2014-02-20
PH12015500261B1 (en)	2016-09-16
CA2880257A1 (en)	2014-02-20
TWI501958B (en)	2015-10-01
BR112015002921A2 (en)	2019-07-30
EA201590252A1 (en)	2015-06-30
IL237015A (en)	2016-11-30
ES2601511T3 (en)	2017-02-15
CA2880257C (en)	2020-07-21
CY1118595T1 (en)	2017-07-12
AU2013304212A1 (en)	2015-02-12
EP2882742A1 (en)	2015-06-17
MA37895A1 (en)	2016-12-30
CO7180198A2 (en)	2015-02-09
PL2882742T3 (en)	2017-03-31
CR20150028A (en)	2015-02-27
PE20150685A1 (en)	2015-05-11
PT2882742T (en)	2016-11-16
KR20150041132A (en)	2015-04-15
ZA201500582B (en)	2016-08-31
CN104540815A (en)	2015-04-22
PH12015500261A1 (en)	2015-03-30
UA113223C2 (en)	2016-12-26
JP5974179B2 (en)	2016-08-23
AU2013304212B2 (en)	2017-03-09
KR101747005B1 (en)	2017-06-27
NZ704858A (en)	2018-02-23
EP2882742B1 (en)	2016-09-21
MA37895B1 (en)	2017-08-31
SI2882742T1 (en)	2017-01-31

Publication	Publication Date	Title
IL239496A0 (en)	2015-08-31	Antiviral compounds
GB201403961D0 (en)	2014-04-23	No details
GB201304182D0 (en)	2013-04-24	No details
SG10201703451RA (en)	2017-06-29	Antiviral compounds
IL233800A0 (en)	2014-09-30	Fungicidal pyrimidine compounds
GB201411220D0 (en)	2014-08-06	No details
IL233799A0 (en)	2014-09-30	Fungicidal pyrimidine compounds
IL236362A (en)	2017-12-31	Arylethynyl derivatives
EP2862470A4 (en)	2016-02-10	Purse
IL237015A (en)	2016-11-30	Arylethynyl pyrimidines
ZA201501678B (en)	2016-01-27	Arylethynyl derivatives
GB2518990B (en)	2020-06-17	Controls
GB201313844D0 (en)	2013-09-18	No details
GB201403415D0 (en)	2014-04-16	No details
GB201205321D0 (en)	2012-05-09	Novel pyrimidines
GB201216152D0 (en)	2012-10-24	Rucksack
GB201322955D0 (en)	2014-02-12	No details
GB201400108D0 (en)	2014-02-19	No details
GB201302155D0 (en)	2013-03-27	No details
GB201300109D0 (en)	2013-02-20	No details
GB201310646D0 (en)	2013-07-31	No details
AU342207S (en)	2012-04-30	Jewelley setting
GB201214251D0 (en)	2012-11-07	Rule
GB201215711D0 (en)	2012-10-17	Higher
GB201203954D0 (en)	2012-04-18	Controls