SG11201400996SA - Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells - Google Patents
Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cellsInfo
- Publication number
- SG11201400996SA SG11201400996SA SG11201400996SA SG11201400996SA SG11201400996SA SG 11201400996S A SG11201400996S A SG 11201400996SA SG 11201400996S A SG11201400996S A SG 11201400996SA SG 11201400996S A SG11201400996S A SG 11201400996SA SG 11201400996S A SG11201400996S A SG 11201400996SA
- Authority
- SG
- Singapore
- Prior art keywords
- tumours
- epithelial
- response
- kinase inhibitor
- tumour cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542141P | 2011-09-30 | 2011-09-30 | |
| PCT/US2012/057777 WO2013055530A1 (en) | 2011-09-30 | 2012-09-28 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201400996SA true SG11201400996SA (en) | 2014-04-28 |
Family
ID=47071458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201400996SA SG11201400996SA (en) | 2011-09-30 | 2012-09-28 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130084287A1 (en) |
| EP (1) | EP2761025A1 (en) |
| JP (1) | JP2014531213A (en) |
| KR (1) | KR20140066783A (en) |
| CN (1) | CN104066851A (en) |
| AU (1) | AU2012321248A1 (en) |
| BR (1) | BR112014007569A2 (en) |
| CA (1) | CA2849120A1 (en) |
| IL (1) | IL231590A0 (en) |
| MX (1) | MX2014003698A (en) |
| RU (1) | RU2014110228A (en) |
| SG (1) | SG11201400996SA (en) |
| WO (1) | WO2013055530A1 (en) |
| ZA (1) | ZA201401968B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013082123A2 (en) * | 2011-11-28 | 2013-06-06 | University Of Chicago | Method, system, software and medium for advanced image-based arrays for analysis and display of biomedical information |
| WO2014193958A2 (en) * | 2013-05-31 | 2014-12-04 | Onconova Therapeutics, Inc. | Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders |
| EP3159695A3 (en) * | 2013-06-20 | 2017-07-05 | The Trustees of The University of Pennsylvania | Methods for diagnosing pancreatic cancer |
| MX362066B (en) * | 2013-11-04 | 2019-01-07 | Dow Agrosciences Llc | Optimal soybean loci. |
| US11008622B2 (en) * | 2014-07-29 | 2021-05-18 | Wellmarker Bio Co., Ltd. | Biomarker for predicting sensitivity to EGFR-targeting agent, and use thereof |
| JP6709541B2 (en) * | 2014-10-17 | 2020-06-17 | 国立大学法人東北大学 | Methods to predict the sensitivity of drug therapy to colorectal cancer |
| CN107003314B (en) | 2014-12-12 | 2021-10-15 | 精密科学公司 | Compositions and methods for performing methylation detection assays |
| EP3230476B1 (en) | 2014-12-12 | 2020-02-05 | Exact Sciences Development Company, LLC | Zdhhc1 for normalizing methylation detection assays |
| WO2016193151A1 (en) * | 2015-05-29 | 2016-12-08 | Vito Nv | Epigenetic markers for respiratory allergy |
| US12359258B2 (en) | 2016-07-06 | 2025-07-15 | Helio Health Inc. | Lung cancer methylation markers and uses thereof |
| JP7113842B2 (en) * | 2017-03-29 | 2022-08-05 | クラウン バイオサイエンス，インコーポレイテッド（タイツァン） | Systems and methods for determining cetuximab susceptibility of gastric cancer |
| CN107144695B (en) * | 2017-04-19 | 2019-02-26 | 南昌大学 | Application of Arl13b protein in cancer diagnosis |
| EP3630293A4 (en) * | 2017-05-22 | 2021-06-02 | The National Institute for Biotechnology in the Negev Ltd. | LUNG CANCER DIAGNOSIS BIOMARKERS |
| CN118086498A (en) * | 2018-01-18 | 2024-05-28 | 纽克莱克斯有限公司 | Methods used to diagnose lung cancer |
| CN112166202A (en) * | 2018-06-15 | 2021-01-01 | 荷兰联合利华有限公司 | Epigenetic method for assessing sun exposure |
| CA3119329A1 (en) * | 2018-11-27 | 2020-06-04 | Exact Sciences Development Company, Llc | Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia |
| CN111521810B (en) * | 2019-02-02 | 2024-06-21 | 中国科学院上海药物研究所 | Cancer patients stratified according to spleen tyrosine kinases |
| IL265451B (en) | 2019-03-18 | 2020-01-30 | Frumkin Dan | Methods and systems for detecting methylation changes in dna samples |
| CN110283910B (en) * | 2019-06-21 | 2021-04-20 | 浙江大学 | Application of target gene DNA methylation as a molecular marker in the preparation of a kit for discriminating the progression of colorectal tissue carcinogenesis |
| CN111304305B (en) * | 2020-03-30 | 2023-05-30 | 陕西科技大学 | A kit and method for detecting EGFR gene methylation |
| CN111676286B (en) * | 2020-05-29 | 2023-04-14 | 武汉爱基百客生物科技有限公司 | Multiplex PCR primer system, detection method and application for detection of plasma cell-free DNA methylation in lung cancer |
| CN114354927B (en) * | 2021-03-18 | 2025-04-22 | 中国人民解放军陆军特色医学中心 | New application of sialyltransferase ST3GAL4 as a marker of EGFR-TKI resistance |
| CN115772565B (en) * | 2021-09-08 | 2023-09-05 | 广州市基准医疗有限责任公司 | Methylation site for auxiliary detection of lung cancer somatic EGFR gene mutation and application thereof |
| CN114525281B (en) * | 2022-03-14 | 2024-03-12 | 右江民族医学院 | ESRP1 promoter reporter gene transcriptional activity visualization and application thereof in demethylation anticancer drug screening |
| CN115651984B (en) * | 2022-10-20 | 2023-04-14 | 山东大学 | Application of a biomarker in the evaluation of taxane chemotherapy resistance in tumors |
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-
2012
- 2012-09-28 SG SG11201400996SA patent/SG11201400996SA/en unknown
- 2012-09-28 US US13/630,363 patent/US20130084287A1/en not_active Abandoned
- 2012-09-28 MX MX2014003698A patent/MX2014003698A/en unknown
- 2012-09-28 BR BR112014007569A patent/BR112014007569A2/en not_active IP Right Cessation
- 2012-09-28 KR KR1020147011145A patent/KR20140066783A/en not_active Ceased
- 2012-09-28 AU AU2012321248A patent/AU2012321248A1/en not_active Abandoned
- 2012-09-28 CA CA2849120A patent/CA2849120A1/en not_active Abandoned
- 2012-09-28 CN CN201280058401.1A patent/CN104066851A/en active Pending
- 2012-09-28 RU RU2014110228/10A patent/RU2014110228A/en not_active Application Discontinuation
- 2012-09-28 WO PCT/US2012/057777 patent/WO2013055530A1/en not_active Ceased
- 2012-09-28 JP JP2014533357A patent/JP2014531213A/en active Pending
- 2012-09-28 EP EP12775890.2A patent/EP2761025A1/en not_active Ceased
-
2014
- 2014-03-18 ZA ZA2014/01968A patent/ZA201401968B/en unknown
- 2014-03-19 IL IL231590A patent/IL231590A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20130084287A1 (en) | 2013-04-04 |
| ZA201401968B (en) | 2018-05-30 |
| CA2849120A1 (en) | 2013-04-18 |
| EP2761025A1 (en) | 2014-08-06 |
| AU2012321248A1 (en) | 2014-04-24 |
| WO2013055530A1 (en) | 2013-04-18 |
| IL231590A0 (en) | 2014-05-28 |
| RU2014110228A (en) | 2015-11-10 |
| KR20140066783A (en) | 2014-06-02 |
| JP2014531213A (en) | 2014-11-27 |
| MX2014003698A (en) | 2014-07-28 |
| CN104066851A (en) | 2014-09-24 |
| BR112014007569A2 (en) | 2017-04-18 |
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