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SG10202012842SA - Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome - Google Patents

Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome

Info

Publication number
SG10202012842SA
SG10202012842SA SG10202012842SA SG10202012842SA SG10202012842SA SG 10202012842S A SG10202012842S A SG 10202012842SA SG 10202012842S A SG10202012842S A SG 10202012842SA SG 10202012842S A SG10202012842S A SG 10202012842SA SG 10202012842S A SG10202012842S A SG 10202012842SA
Authority
SG
Singapore
Prior art keywords
syndrome
treatment
attention deficit
glutamate receptor
metabotropic glutamate
Prior art date
Application number
SG10202012842SA
Other languages
English (en)
Inventor
Hakon Hakonarson
Charlly Kao
Original Assignee
Childrens Hospital Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Philadelphia filed Critical Childrens Hospital Philadelphia
Publication of SG10202012842SA publication Critical patent/SG10202012842SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG10202012842SA 2015-09-08 2016-09-07 Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome SG10202012842SA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562215673P 2015-09-08 2015-09-08
US201562215636P 2015-09-08 2015-09-08
US201562215628P 2015-09-08 2015-09-08
US201562215633P 2015-09-08 2015-09-08

Publications (1)

Publication Number Publication Date
SG10202012842SA true SG10202012842SA (en) 2021-01-28

Family

ID=56943962

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202012842SA SG10202012842SA (en) 2015-09-08 2016-09-07 Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome

Country Status (13)

Country Link
US (12) US11179378B2 (da)
EP (12) EP3347013B1 (da)
JP (9) JP7281280B2 (da)
CN (7) CN108601776A (da)
AU (10) AU2016318775B2 (da)
CA (5) CA2997189A1 (da)
DK (4) DK3347014T3 (da)
ES (7) ES2897953T3 (da)
HK (4) HK1258373A1 (da)
IL (12) IL303605A (da)
PL (4) PL3922249T3 (da)
SG (1) SG10202012842SA (da)
WO (4) WO2017044491A1 (da)

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JP6216486B2 (ja) 2010-08-24 2017-10-18 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia 低頻度反復性遺伝的変異の注意欠陥多動性障害への関連ならびに診断および治療のためのその使用方法
DK3347014T3 (da) 2015-09-08 2021-12-06 Childrens Hospital Philadelphia Fremgangsmåder til diagnosticering og behandling af Tourettes syndrom
US20200143922A1 (en) * 2016-06-03 2020-05-07 Yale University Methods and apparatus for predicting depression treatment outcomes
EP3509640A1 (en) * 2016-09-07 2019-07-17 The Children's Hospital of Philadelphia Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
US11684617B2 (en) * 2017-04-19 2023-06-27 The Children's Hospital Of Philadelphia Methods of diagnosing and treating ADHD in biomarker positive subjects
WO2018209328A1 (en) * 2017-05-11 2018-11-15 Miwa Julie M Compositions and methods for treating lynx2 disorders
CN107483425B (zh) * 2017-08-08 2020-12-18 北京盛华安信息技术有限公司 基于攻击链的复合攻击检测方法
EP3740204A4 (en) 2018-01-18 2021-10-06 The Children's Hospital Of Philadelphia SOLID STATE FORMS OF FASORACETAM
SG11202006813TA (en) 2018-01-18 2020-08-28 Childrens Hospital Philadelphia Fasoracetam crystalline forms
KR102250063B1 (ko) * 2019-06-14 2021-05-12 한국생명공학연구원 뚜렛증후군의 원인 유전자를 동정하는 방법
CN110955751A (zh) * 2019-11-13 2020-04-03 广州供电局有限公司 工作票文本去重方法、装置、系统及计算机存储介质
IL301500A (en) * 2020-09-21 2023-05-01 Reveragen Biopharma Inc TREATMENT OF NF-κB-MEDIATED DISEASE
WO2022065518A1 (ja) * 2020-09-23 2022-03-31 国立大学法人京都大学 神経突起伸長促進剤
KR20240112047A (ko) * 2023-01-11 2024-07-18 차의과학대학교 산학협력단 불안장애를 진단하기 위한 바이오마커 및 이의 용도
CN117594119B (zh) * 2024-01-17 2024-05-10 北京大学第六医院 用于预测帕罗西汀或其药用盐对抑郁或焦虑症患者疗效的装置

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Also Published As

Publication number Publication date
ES2898932T3 (es) 2022-03-09
ES2909329T3 (es) 2022-05-06
ES2981632T3 (es) 2024-10-09
IL290994A (en) 2022-05-01
CA2997187C (en) 2024-02-20
US20200306237A1 (en) 2020-10-01
WO2017044503A1 (en) 2017-03-16
JP2023011558A (ja) 2023-01-24
JP7532465B2 (ja) 2024-08-13
AU2022204324A1 (en) 2022-07-07
CN108348518A (zh) 2018-07-31
AU2022204355A1 (en) 2022-07-14
PL3922249T3 (pl) 2024-07-29
DK3347016T3 (da) 2021-07-12
JP2022078104A (ja) 2022-05-24
IL257746A (en) 2018-06-28
AU2016318780B2 (en) 2022-04-07
IL290985A (en) 2022-05-01
JP2018526394A (ja) 2018-09-13
IL316145A (en) 2024-12-01
EP4410289A1 (en) 2024-08-07
JP7152306B2 (ja) 2022-10-12
AU2016318775B2 (en) 2022-02-10
IL290985B2 (en) 2025-03-01
IL290993A (en) 2022-05-01
AU2022205142A1 (en) 2022-07-28
EP3977996B1 (en) 2024-03-13
AU2016318775A1 (en) 2018-04-12
AU2022205142B2 (en) 2024-08-29
IL300474A (en) 2023-04-01
EP3347015B1 (en) 2021-10-20
IL257744A (en) 2018-06-28
IL290992B1 (en) 2023-03-01
CA2997188A1 (en) 2017-03-16
DK3347014T3 (da) 2021-12-06
IL257747A (en) 2018-06-28
DK3347013T3 (da) 2022-04-04
JP2024164036A (ja) 2024-11-26
ES2976071T3 (es) 2024-07-22
JP7281279B2 (ja) 2023-05-25
PL3977996T3 (pl) 2024-07-01
CN116919961A (zh) 2023-10-24
US20220117954A1 (en) 2022-04-21
US11298347B2 (en) 2022-04-12
EP3964213A1 (en) 2022-03-09
CN108348517A (zh) 2018-07-31
EP3977996A1 (en) 2022-04-06
PL3964213T3 (pl) 2024-07-08
US20220117953A1 (en) 2022-04-21
EP3347014A1 (en) 2018-07-18
HK1258446A1 (zh) 2019-11-15
CA2997191A1 (en) 2017-03-16
EP3347013B1 (en) 2022-02-16
CN116919962A (zh) 2023-10-24
AU2022203039A1 (en) 2022-05-26
IL290993B2 (en) 2023-11-01
DK3347015T3 (da) 2021-12-06
HK1258448A1 (zh) 2019-11-15
EP3347014B1 (en) 2021-10-20
EP3922249A1 (en) 2021-12-15
AU2022204324B2 (en) 2024-08-29
US11179378B2 (en) 2021-11-23
EP3964213B1 (en) 2024-03-13
EP3922249B1 (en) 2024-02-28
US20220296582A1 (en) 2022-09-22
IL257744B (en) 2022-04-01
IL290992A (en) 2022-05-01
IL290993B1 (en) 2023-07-01
JP2023036671A (ja) 2023-03-14
HK1258373A1 (zh) 2019-11-08
EP4491238A2 (en) 2025-01-15
US11806341B2 (en) 2023-11-07
AU2016318785B2 (en) 2022-04-14
AU2016318786A1 (en) 2018-04-12
CA3225374A1 (en) 2017-03-16
US11806340B2 (en) 2023-11-07
IL257747B (en) 2022-04-01
US20180110767A1 (en) 2018-04-26
US10869861B2 (en) 2020-12-22
CN115919852A (zh) 2023-04-07
JP2018526396A (ja) 2018-09-13
IL257785A (en) 2018-06-28
US20170087139A1 (en) 2017-03-30
IL290994B1 (en) 2024-11-01
EP3347013A1 (en) 2018-07-18
JP2018526395A (ja) 2018-09-13
EP4023222A1 (en) 2022-07-06
EP4342493A2 (en) 2024-03-27
AU2024259882A1 (en) 2024-11-28
IL290992B2 (en) 2023-07-01
JP7027308B2 (ja) 2022-03-01
CN108601776A (zh) 2018-09-28
CN108495630A (zh) 2018-09-04
EP4023222B1 (en) 2024-12-18
WO2017044497A1 (en) 2017-03-16
EP3347016B1 (en) 2021-04-28
IL290994B2 (en) 2025-03-01
IL257746B (en) 2022-04-01
EP3347016A1 (en) 2018-07-18
US11173153B2 (en) 2021-11-16
JP7281280B2 (ja) 2023-05-25
IL303605A (en) 2023-08-01
CA2997189A1 (en) 2017-03-16
ES2876898T3 (es) 2021-11-15
ES2897953T3 (es) 2022-03-03
EP4342493A3 (en) 2024-07-03
EP3347015A1 (en) 2018-07-18
EP4410288A1 (en) 2024-08-07
ES2980894T3 (es) 2024-10-03
AU2024259877A1 (en) 2024-11-28
AU2016318786B2 (en) 2022-04-07
US20170087140A1 (en) 2017-03-30
AU2022203039B2 (en) 2024-08-22
US12121514B2 (en) 2024-10-22
US20170105985A1 (en) 2017-04-20
US20210205288A1 (en) 2021-07-08
HK1258447A1 (zh) 2019-11-15
JP2018526398A (ja) 2018-09-13
IL290985B1 (en) 2024-11-01
US20170087141A1 (en) 2017-03-30
WO2017044502A1 (en) 2017-03-16
AU2022204355B2 (en) 2024-08-29
US20240100036A1 (en) 2024-03-28
IL316004A (en) 2024-11-01
CN108348517B (zh) 2021-11-05
CA2997187A1 (en) 2017-03-16
US9884057B2 (en) 2018-02-06
JP2023051937A (ja) 2023-04-11
PL4023222T3 (pl) 2025-03-24
AU2016318785A1 (en) 2018-04-12
US20240075022A1 (en) 2024-03-07
AU2016318780A1 (en) 2018-04-12
WO2017044491A1 (en) 2017-03-16
IL257785B (en) 2022-04-01

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