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SG10201914005TA - Methods and compositions for producing hepatocyte-like cells - Google Patents

Methods and compositions for producing hepatocyte-like cells

Info

Publication number
SG10201914005TA
SG10201914005TA SG10201914005TA SG10201914005TA SG10201914005TA SG 10201914005T A SG10201914005T A SG 10201914005TA SG 10201914005T A SG10201914005T A SG 10201914005TA SG 10201914005T A SG10201914005T A SG 10201914005TA SG 10201914005T A SG10201914005T A SG 10201914005TA
Authority
SG
Singapore
Prior art keywords
compositions
cells
methods
producing hepatocyte
hepatocyte
Prior art date
Application number
SG10201914005TA
Inventor
Gary Peltz
Dan Xu
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of SG10201914005TA publication Critical patent/SG10201914005TA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C12N2500/62—DMSO
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/237—Oncostatin M [OSM]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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    • C12N2501/39—Steroid hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/603—Oct-3/4
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/604—Klf-4
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/606—Transcription factors c-Myc
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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SG10201914005TA 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells SG10201914005TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361880056P 2013-09-19 2013-09-19

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SG10201914005TA true SG10201914005TA (en) 2020-03-30

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SG10201802231RA SG10201802231RA (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells
SG11201707615YA SG11201707615YA (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells
SG10201914005TA SG10201914005TA (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells

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SG11201707615YA SG11201707615YA (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells

Country Status (8)

Country Link
US (3) US10004767B2 (en)
EP (2) EP3685884A1 (en)
JP (3) JP6683615B2 (en)
CA (1) CA2959117C (en)
DK (1) DK3046628T3 (en)
ES (1) ES2767062T3 (en)
SG (3) SG10201802231RA (en)
WO (1) WO2015042125A2 (en)

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WO2015042125A3 (en) 2015-11-05
US20190083545A1 (en) 2019-03-21
JP6683615B2 (en) 2020-04-22
EP3046628A2 (en) 2016-07-27
US11291691B2 (en) 2022-04-05
JP7057797B2 (en) 2022-04-20
CA2959117C (en) 2023-08-22
DK3046628T3 (en) 2020-02-10
US20160256499A1 (en) 2016-09-08
JP2016529920A (en) 2016-09-29
EP3046628B1 (en) 2019-11-06
US10004767B2 (en) 2018-06-26
JP2020114237A (en) 2020-07-30
SG10201802231RA (en) 2018-05-30
WO2015042125A2 (en) 2015-03-26
EP3046628A4 (en) 2017-03-08
JP2022088668A (en) 2022-06-14
ES2767062T3 (en) 2020-06-16
US20220168359A1 (en) 2022-06-02
SG11201707615YA (en) 2017-10-30
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