SG10201912081RA - Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins - Google Patents

Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins

Info

Publication number: SG10201912081RA
Authority: SG; Singapore
Prior art keywords: glycosylation; overexpression; recombinant proteins; modulate; pathway regulators
Prior art date: 2014-01-29

Application number

SG10201912081RA

Inventor

Shivani Gupta

Sohye Kang

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-01-29

Filing date

2014-12-11

Publication date

2020-02-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53757626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201912081R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-12-11 Application filed by Amgen Inc filed Critical Amgen Inc

2020-02-27 Publication of SG10201912081RA publication Critical patent/SG10201912081RA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01101—Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.101)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01143—Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.143)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01094—Protein N-acetylglucosaminyltransferase (2.4.1.94)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

SG10201912081RA 2014-01-29 2014-12-11 Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins SG10201912081RA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461933137P	2014-01-29	2014-01-29

Publications (1)

Publication Number	Publication Date
SG10201912081RA true SG10201912081RA (en)	2020-02-27

Family

ID=53757626

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG10201912081RA SG10201912081RA (en)	2014-01-29	2014-12-11	Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins

Country Status (14)

Country	Link
US (3)	US10227627B2 (en)
EP (1)	EP3099806A1 (en)
JP (4)	JP6474420B2 (en)
KR (3)	KR102410393B1 (en)
CN (2)	CN113774084B (en)
AU (3)	AU2014380174B2 (en)
BR (1)	BR112016017606A2 (en)
CA (1)	CA2938079C (en)
CL (1)	CL2016001900A1 (en)
EA (2)	EA037565B1 (en)
IL (3)	IL282517B (en)
MX (2)	MX377780B (en)
SG (1)	SG10201912081RA (en)
WO (1)	WO2015116315A1 (en)

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KR20210005689A (en)	2018-05-01	2021-01-14	암젠 인크	Antibodies with a regulated glycan profile
CN109576212B (en) *	2018-12-14	2021-06-22	杭州奕安济世生物药业有限公司	Culture method of seed cells in high-density inoculation culture and application thereof
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CN113684322B (en) *	2021-09-09	2024-01-23	上海药明生物技术有限公司	Method for reducing high polymannan type level of antibody protein
CN114525252B (en) *	2022-03-10	2023-12-01	广州源井生物科技有限公司	Monoclonal enhancement culture medium for improving MDA-MB-231 monoclonal formation rate, culture method and application thereof
TW202426485A (en)	2022-10-26	2024-07-01	美商安進公司	Anti-tslp antibody compositions and uses thereof

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2014
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- 2014-12-11 MX MX2016009911A patent/MX377780B/en active IP Right Grant
- 2014-12-11 SG SG10201912081RA patent/SG10201912081RA/en unknown
- 2014-12-11 BR BR112016017606A patent/BR112016017606A2/en not_active Application Discontinuation
- 2014-12-11 CA CA2938079A patent/CA2938079C/en active Active
- 2014-12-11 KR KR1020217028516A patent/KR102410393B1/en active Active
- 2014-12-11 AU AU2014380174A patent/AU2014380174B2/en active Active
- 2014-12-11 WO PCT/US2014/069744 patent/WO2015116315A1/en active Application Filing
- 2014-12-11 JP JP2016549077A patent/JP6474420B2/en active Active
- 2014-12-11 KR KR1020167021676A patent/KR102301034B1/en active Active
- 2014-12-11 CN CN201480074585.XA patent/CN106170554B/en active Active
- 2014-12-11 IL IL282517A patent/IL282517B/en unknown
- 2014-12-11 KR KR1020227019897A patent/KR102519540B1/en active Active
- 2014-12-11 EP EP14821424.0A patent/EP3099806A1/en active Pending
- 2014-12-11 EA EA201691532A patent/EA037565B1/en unknown
- 2014-12-11 EA EA202190244A patent/EA202190244A3/en unknown
2016
- 2016-07-24 IL IL246914A patent/IL246914B/en active IP Right Grant
- 2016-07-26 CL CL2016001900A patent/CL2016001900A1/en unknown
- 2016-07-29 MX MX2020012356A patent/MX2020012356A/en unknown
2018
- 2018-09-13 US US16/130,879 patent/US10227627B2/en active Active
- 2018-11-15 AU AU2018264100A patent/AU2018264100B2/en active Active
2019
- 2019-01-28 JP JP2019011871A patent/JP6797950B2/en active Active
- 2019-01-29 US US16/261,311 patent/US10655156B2/en active Active
- 2019-11-24 IL IL270861A patent/IL270861B/en active IP Right Grant
2020
- 2020-05-15 US US16/875,832 patent/US10907186B2/en active Active
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- 2020-11-17 JP JP2020190707A patent/JP7034236B2/en active Active
2022
- 2022-02-28 JP JP2022029077A patent/JP2022068365A/en active Pending

Also Published As

Publication number	Publication date
KR102301034B1 (en)	2021-09-13
MX2020012356A (en)	2021-01-29
JP2019088305A (en)	2019-06-13
IL270861B (en)	2021-05-31
CN106170554A (en)	2016-11-30
CN113774084B (en)	2024-04-16
AU2014380174A1 (en)	2016-08-11
US10227627B2 (en)	2019-03-12
JP7034236B2 (en)	2022-03-11
EA202190244A2 (en)	2021-05-31
EP3099806A1 (en)	2016-12-07
JP6797950B2 (en)	2020-12-09
EA202190244A3 (en)	2021-08-31
US20190010532A1 (en)	2019-01-10
AU2020239681A1 (en)	2020-10-15
IL270861A (en)	2020-01-30
KR102410393B1 (en)	2022-06-16
EA037565B1 (en)	2021-04-14
AU2020239681B2 (en)	2022-06-23
JP6474420B2 (en)	2019-02-27
JP2017505620A (en)	2017-02-23
CA2938079C (en)	2022-10-11
CN106170554B (en)	2021-08-17
US20190153496A1 (en)	2019-05-23
CN113774084A (en)	2021-12-10
CA2938079A1 (en)	2015-08-06
IL246914A0 (en)	2016-09-29
JP2021040638A (en)	2021-03-18
CL2016001900A1 (en)	2017-05-12
EA201691532A1 (en)	2017-01-30
IL282517A (en)	2021-06-30
WO2015116315A1 (en)	2015-08-06
AU2014380174B2 (en)	2018-08-30
KR20210114549A (en)	2021-09-23
JP2022068365A (en)	2022-05-09
US10655156B2 (en)	2020-05-19
IL282517B (en)	2022-07-01
MX2016009911A (en)	2016-10-28
KR20220086703A (en)	2022-06-23
KR20160111943A (en)	2016-09-27
BR112016017606A2 (en)	2017-10-10
AU2018264100B2 (en)	2020-07-23
US10907186B2 (en)	2021-02-02
KR102519540B1 (en)	2023-04-10
US20200277642A1 (en)	2020-09-03
MX377780B (en)	2025-03-11
AU2018264100A1 (en)	2018-12-06
IL246914B (en)	2019-12-31

Publication	Publication Date	Title
IL282517A (en)	2021-06-30	Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
SG11201600734YA (en)	2016-02-26	Stabilization of fc-containing polypeptides
EP3236772A4 (en)	2018-10-17	Methods of purifying recombinant proteins
HK1252480A1 (en)	2019-05-24	Multimeric protein purity determination
HK1221263A1 (en)	2017-05-26	Quantitative control of sialylation
PL3434760T3 (en)	2023-09-11	Methods for increasing mannose content of recombinant proteins
GB201518792D0 (en)	2015-12-09	Production of proteins
GB201502818D0 (en)	2015-04-08	Metasurface for control of light propogation
HK1220492A1 (en)	2017-05-05	Recombinant polypeptide production
GB201607515D0 (en)	2016-06-15	Height of cut control system
IL295361A (en)	2022-10-01	Efficient selectivity of recombinant proteins
HK1255456A1 (en)	2019-08-16	Expression of fc-containing proteins
EP3068415A4 (en)	2017-09-13	Treatment or prophylaxis of circadian protein related conditions
IL265258A (en)	2019-05-30	Use of recombinant lymphocyte activation gene-3
GB201304973D0 (en)	2013-05-01	Recombinant protein
EP3122770A4 (en)	2017-08-23	Enhancement of recombinant protein expression with copper
EP3181135A4 (en)	2018-02-07	Adiponectin secretion regulator
IL256706B (en)	2022-05-01	Method for production of recombinant proteins
IL256707B (en)	2022-05-01	Method for production of recombinant proteins
EP3241908A4 (en)	2018-06-20	Method for regulating glycosylation of recombinant glycoprotein
EP3302067A4 (en)	2018-11-21	Use of proteins to control molluscs
GB201622073D0 (en)	2017-02-08	Improved recombinant protein production system
AU2015901161A0 (en)	2015-04-16	Enhanced recombinant protein expression
AU2014901383A0 (en)	2014-05-08	Control of protein activity
GB201300529D0 (en)	2013-02-27	Recombinant polypeptide