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SG10201909596RA - Synthesis of Tyrosine Kinase Inhibitors - Google Patents

Synthesis of Tyrosine Kinase Inhibitors

Info

Publication number
SG10201909596RA
SG10201909596RA SG10201909596RA SG10201909596RA SG10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA
Authority
SG
Singapore
Prior art keywords
synthesis
tyrosine kinase
kinase inhibitors
inhibitors
tyrosine
Prior art date
Application number
SG10201909596RA
Inventor
Abraham Rajkumar Gurubatham
Lin Xiangliang
Original Assignee
Esco Aster Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esco Aster Pte Ltd filed Critical Esco Aster Pte Ltd
Priority to SG10201909596RA priority Critical patent/SG10201909596RA/en
Priority to PCT/EP2020/078761 priority patent/WO2021074138A1/en
Priority to CN202080073377.3A priority patent/CN114585615A/en
Priority to TW109135376A priority patent/TWI832015B/en
Priority to JP2022547807A priority patent/JP7703547B2/en
Priority to US17/769,177 priority patent/US20230065387A1/en
Priority to AU2020366118A priority patent/AU2020366118A1/en
Priority to KR1020227014080A priority patent/KR20220124679A/en
Priority to EP20792606.4A priority patent/EP4045494B1/en
Priority to BR112022007107A priority patent/BR112022007107A2/en
Publication of SG10201909596RA publication Critical patent/SG10201909596RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10201909596RA 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors SG10201909596RA (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors
PCT/EP2020/078761 WO2021074138A1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
CN202080073377.3A CN114585615A (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-N1- (4- (pyridin-3-yl) pyrimidin-2-yl) benzene-1, 3-diamine
TW109135376A TWI832015B (en) 2019-10-14 2020-10-13 Synthesis of tyrosine kinase inhibitors
JP2022547807A JP7703547B2 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
US17/769,177 US20230065387A1 (en) 2019-10-14 2020-10-13 Synthesis of tyrosine kinase inhibitors
AU2020366118A AU2020366118A1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
KR1020227014080A KR20220124679A (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
EP20792606.4A EP4045494B1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
BR112022007107A BR112022007107A2 (en) 2019-10-14 2020-10-13 METHOD FOR SYNTHESIS OF A COMPOUND

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors

Publications (1)

Publication Number Publication Date
SG10201909596RA true SG10201909596RA (en) 2021-05-28

Family

ID=72895951

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors

Country Status (10)

Country Link
US (1) US20230065387A1 (en)
EP (1) EP4045494B1 (en)
JP (1) JP7703547B2 (en)
KR (1) KR20220124679A (en)
CN (1) CN114585615A (en)
AU (1) AU2020366118A1 (en)
BR (1) BR112022007107A2 (en)
SG (1) SG10201909596RA (en)
TW (1) TWI832015B (en)
WO (1) WO2021074138A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113419004B (en) * 2021-06-22 2023-04-18 海南鑫开源医药科技有限公司 Method for detecting impurities in methyl 3-amino-4-methylbenzoate
CN114853734A (en) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 A kind of preparation method of Nilotinib free base

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
AR052900A1 (en) * 2005-02-11 2007-04-11 Astrazeneca Ab DERIVATIVES OF TIAZOL, A METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY ECE-1
CN100537563C (en) * 2006-07-12 2009-09-09 浙江省医学科学院 The preparation method of N-phenyl-2-pyrimidinamine derivative
KR101286780B1 (en) * 2011-02-01 2013-07-17 에스티팜 주식회사 A bicarbonate salt and a method of preparing imatinib and salt using the same
WO2013035102A1 (en) * 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
CN102796074B (en) 2012-06-21 2015-04-08 苏州立新制药有限公司 Method for preparing imatinib mesylate intermediate
IN2013CH05653A (en) * 2013-12-09 2016-06-24
CN105801559B (en) * 2016-04-28 2019-03-01 北京化工大学 The preparation method of 4- methyl -3- [[4- (3- pyridyl group) -2- pyrimidine radicals] amino] ethyl benzoate
EP3404025B1 (en) * 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt

Also Published As

Publication number Publication date
WO2021074138A1 (en) 2021-04-22
CN114585615A (en) 2022-06-03
AU2020366118A1 (en) 2022-05-12
TWI832015B (en) 2024-02-11
JP2023503193A (en) 2023-01-26
EP4045494A1 (en) 2022-08-24
EP4045494C0 (en) 2023-10-11
KR20220124679A (en) 2022-09-14
EP4045494B1 (en) 2023-10-11
BR112022007107A2 (en) 2022-07-05
JP7703547B2 (en) 2025-07-07
US20230065387A1 (en) 2023-03-02
TW202128641A (en) 2021-08-01

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