[go: up one dir, main page]

SG10201902203VA - Eutectic formulations of cyclobenzaprine hydrochloride - Google Patents

Eutectic formulations of cyclobenzaprine hydrochloride

Info

Publication number
SG10201902203VA
SG10201902203VA SG10201902203VA SG10201902203VA SG10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA
Authority
SG
Singapore
Prior art keywords
eutectic
cyclobenzaprine hydrochloride
formulations
eutectic formulations
cyclobenzaprine
Prior art date
Application number
SG10201902203VA
Inventor
Seth Lederman
Marino Nebuloni
Original Assignee
Tonix Pharma Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tonix Pharma Holdings Ltd filed Critical Tonix Pharma Holdings Ltd
Publication of SG10201902203VA publication Critical patent/SG10201902203VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EUTECTIC FORMULATIONS OF CYCLOBENZAPRINE HYDROCHLORIDE The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol. Figure: 6
SG10201902203VA 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride SG10201902203VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462052238P 2014-09-18 2014-09-18

Publications (1)

Publication Number Publication Date
SG10201902203VA true SG10201902203VA (en) 2019-04-29

Family

ID=55533932

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201701995PA SG11201701995PA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride
SG10201902203VA SG10201902203VA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201701995PA SG11201701995PA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride

Country Status (13)

Country Link
US (2) US10357465B2 (en)
EP (1) EP3193854A4 (en)
JP (5) JP6614724B2 (en)
CN (2) CN112618494B (en)
AU (2) AU2015317336B2 (en)
BR (1) BR112017005231A2 (en)
CA (1) CA2961822A1 (en)
IL (2) IL251218B (en)
MX (1) MX387402B (en)
MY (1) MY186047A (en)
SG (2) SG11201701995PA (en)
WO (1) WO2016044796A1 (en)
ZA (1) ZA201701637B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2501234T3 (en) 2009-11-20 2018-01-31 Tonix Pharma Holdings Ltd METHODS AND COMPOSITIONS USED IN THE TREATMENT OF AILS RELATED TO POST-INJURY STRESS SYNDROME WITH THE USE OF CYCLOBENZAPRIN
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
AU2014233277B2 (en) 2013-03-15 2019-04-04 Tonix Pharma Holdings Limited Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
AU2015317336B2 (en) * 2014-09-18 2021-01-21 Tonix Pharma Holdings Limited Eutectic formulations of Cyclobenzaprine hydrochloride
US11826321B2 (en) * 2017-12-11 2023-11-28 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
JP7691739B2 (en) * 2018-08-20 2025-06-12 トニックス ファーマ ホールディングス リミテッド Methods for Treating Acute Stress Disorder and Post-Traumatic Stress Disorder
NL2023661B1 (en) * 2019-08-19 2021-04-21 Seranovo Holding B V Pharmaceutical Eutectic Salt Formulation
WO2021207561A1 (en) 2020-04-08 2021-10-14 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for sexual dysfunction
WO2022125572A1 (en) * 2020-12-07 2022-06-16 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for fibromyalgia
EP4412602A1 (en) 2021-10-06 2024-08-14 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients
AU2023286504A1 (en) 2022-06-21 2025-01-16 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for post-acute sequelae of (sars)-cov-2 infection (pasc)

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968507A (en) 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
WO1994018954A1 (en) 1993-02-22 1994-09-01 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of biologics and compositions useful therefor
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
US5834025A (en) 1995-09-29 1998-11-10 Nanosystems L.L.C. Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (en) * 1997-10-16 1999-04-22 Merck & Co., Inc. New cyclobenzaprine composition
CA2331542A1 (en) 1998-05-14 1999-11-18 Alza Corporation Antidepressant therapy
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
HK1047691B (en) 1999-08-13 2006-05-12 Krele Pharmaceuticals, Inc. Uses of compositions for treating or preventing sleep disturbances using very low doses of cyclobenzaprine
JP2003506483A (en) 1999-08-13 2003-02-18 ベラ・ファーマシューティカルズ・インコーポレイテッド Treatment of generalized anxiety disorder with cyclobenzaprine and its composition
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
WO2001089476A1 (en) 2000-05-19 2001-11-29 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
DE60231896D1 (en) 2001-11-05 2009-05-20 Krele Pharmaceuticals Llc COMPOSITIONS AND METHODS FOR INCREASING THE COMPLIANCE WITH THERAPIES USING ALDEHYDEDEHYDROGENASE INHIBITORS AND TREATING ALCOHOL MUSIC
US7223735B2 (en) 2003-05-29 2007-05-29 New River Pharmaceuticals Inc. Abuse resistant lysine amphetamine compounds
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7659253B2 (en) 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7038085B2 (en) 2002-10-25 2006-05-02 Collegium Pharmaceutical, Inc. Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
ES2685436T3 (en) 2002-12-09 2018-10-09 Abraxis Bioscience, Llc Compositions and procedures for administration of pharmacological agents
JP2007510642A (en) 2003-11-03 2007-04-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
US20050143350A1 (en) 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US9682043B2 (en) 2003-12-09 2017-06-20 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
KR20130116378A (en) 2004-02-17 2013-10-23 트랜스셉트 파마슈티칼스, 인코포레이티드 Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
US8216610B2 (en) 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
US20070196364A1 (en) * 2004-07-27 2007-08-23 Human Genome Sciences, Inc. Pharmaceutical Formulation and Process
US7532935B2 (en) 2005-07-29 2009-05-12 Cyberonics, Inc. Selective neurostimulation for treating mood disorders
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
US20080146672A1 (en) 2006-12-08 2008-06-19 Denton Marcia Marye Topical Eutectic Anesthetic Composition for Oral or Dermal Tissue
AU2008268667A1 (en) 2007-06-22 2008-12-31 Merck & Co., Inc. 6.5-pyrrolopiperidine tachykinin receptor antagonists
EP2182952A4 (en) 2007-07-23 2010-09-08 Synosia Therapeutics Treatment of post-traumatic stress disorder
US20090060983A1 (en) 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
EP2601935A1 (en) 2007-09-25 2013-06-12 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
EP2203158A4 (en) 2007-10-30 2012-12-26 Reddys Lab Ltd Dr Pharmaceutical formulations comprising telmisartan and hydrochlorothiazide
US20090148532A1 (en) 2007-12-06 2009-06-11 Venkatesh Gopi M Preparation of controlled release skeletal muscle relaxant dosage forms
JP5714910B2 (en) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド Pharmaceutical composition
US9314469B2 (en) 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
JP5380909B2 (en) 2008-05-30 2014-01-08 株式会社ブリヂストン Mold and molding method of resin foam molding
US20100266682A1 (en) 2008-12-10 2010-10-21 Nipun Davar Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
US20100247586A1 (en) 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
US8343533B2 (en) 2009-09-24 2013-01-01 Mcneil-Ppc, Inc. Manufacture of lozenge product with radiofrequency
PL2501234T3 (en) 2009-11-20 2018-01-31 Tonix Pharma Holdings Ltd METHODS AND COMPOSITIONS USED IN THE TREATMENT OF AILS RELATED TO POST-INJURY STRESS SYNDROME WITH THE USE OF CYCLOBENZAPRIN
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US20130165511A1 (en) 2010-09-01 2013-06-27 TONIX Pharmaceuticals Holding Corp Treatment for cocaine addiction
US11998516B2 (en) * 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
CN104684550A (en) * 2012-06-15 2015-06-03 通尼克斯制药有限公司 Compositions and methods for transmucosal absorption
AU2014233277B2 (en) * 2013-03-15 2019-04-04 Tonix Pharma Holdings Limited Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
AU2015317336B2 (en) 2014-09-18 2021-01-21 Tonix Pharma Holdings Limited Eutectic formulations of Cyclobenzaprine hydrochloride

Also Published As

Publication number Publication date
IL251218B (en) 2020-10-29
JP2017532374A (en) 2017-11-02
NZ768064A (en) 2023-10-27
MX2017003644A (en) 2017-10-31
BR112017005231A2 (en) 2018-03-13
WO2016044796A1 (en) 2016-03-24
IL251218A0 (en) 2017-05-29
MY186047A (en) 2021-06-17
ZA201701637B (en) 2020-11-25
EP3193854A1 (en) 2017-07-26
MX387402B (en) 2025-03-18
US20190336458A1 (en) 2019-11-07
SG11201701995PA (en) 2017-04-27
JP6717902B2 (en) 2020-07-08
IL277814B (en) 2021-12-01
JP2022001605A (en) 2022-01-06
AU2020289838B2 (en) 2022-11-24
AU2015317336B2 (en) 2021-01-21
EP3193854A4 (en) 2018-05-02
CA2961822A1 (en) 2016-03-24
CN112618494B (en) 2023-06-30
US10357465B2 (en) 2019-07-23
IL277814A (en) 2020-11-30
US20170281568A1 (en) 2017-10-05
JP2018193409A (en) 2018-12-06
NZ730379A (en) 2023-10-27
JP2020059757A (en) 2020-04-16
CN107072968B (en) 2021-01-12
CN107072968A (en) 2017-08-18
US11026898B2 (en) 2021-06-08
JP6717902B6 (en) 2020-08-05
AU2015317336A1 (en) 2017-04-13
AU2020289838A1 (en) 2021-01-28
JP2023126486A (en) 2023-09-07
JP6614724B2 (en) 2019-12-04
CN112618494A (en) 2021-04-09

Similar Documents

Publication Publication Date Title
MY196014A (en) Eutectic Formulations of Cyclobenzaprine Hydrochloride and Amitriptyline Hydrochloride
SG10201902203VA (en) Eutectic formulations of cyclobenzaprine hydrochloride
MX2021011906A (en) Delayed release compositions of linaclotide.
PH12016501841A1 (en) Immunosuppressant formulation
IL248785B (en) N-[1,5-dimethyl-3-oxo-(2,3-dihydro-1h-pyrazol-4-yl)]-4-methyl-isoxazole-3-carboxamide derivatives and pharmaceutical compositions comprising said derivatives
PH12016501686A1 (en) Pharmaceutical compositions of sitagliptin
IL252897A0 (en) Indenyl compounds, pharmaceutical compositions, and medical uses thereof
MX2016001422A (en) Pharmaceutical compositions of fingolimod.
IN2014CH00840A (en)
PH12017502148A1 (en) Pharmaceutical compositions and use thereof
MX2016013439A (en) Solid forms of a pharmaceutically active compound.
SI3381457T1 (en) Physiologically active composition
WO2016197042A8 (en) Modified or targeted release formulations of linaclotide
EA201691422A1 (en) ORIGINALLY FALLING TABLETED MEMANTINE COMPOSITIONS
IL256589B (en) 2,4,7-trimethyloct-6-en-1-ol as fragrance ingredient
TR201620309A2 (en) Pharmaceutical compositions of metformin hydrochloride and pioglitazone hydrochloride
WO2015136372A3 (en) Eutectic isometheptene mucate
AP2017009706A0 (en) Pharmaceutical compound comprising 13 glycerides, formulation and application thereof
EP2924024A3 (en) Solid forms of lorcaserin hydrochloride
IN2014CH00035A (en)
TR201721065A2 (en) Lyophilized pharmaceutical formulations comprising dexmedetomidine
HK1241726A1 (en) Eutectic formulations of cyclobenzaprine hydrochloride
IN2014CH01195A (en)