SG10201901922VA - Compositions and methods for treating metabolic disorders - Google Patents
Compositions and methods for treating metabolic disordersInfo
- Publication number
- SG10201901922VA SG10201901922VA SG10201901922VA SG10201901922VA SG10201901922VA SG 10201901922V A SG10201901922V A SG 10201901922VA SG 10201901922V A SG10201901922V A SG 10201901922VA SG 10201901922V A SG10201901922V A SG 10201901922VA SG 10201901922V A SG10201901922V A SG 10201901922VA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- metabolic disorders
- treating metabolic
- compositions
- biguanide compounds
- Prior art date
Links
- 208000030159 metabolic disease Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000004283 biguanides Chemical class 0.000 abstract 3
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- -1 metformin Chemical class 0.000 abstract 1
- 229960003105 metformin Drugs 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 208000016261 weight loss Diseases 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
COMPOSITIONSAND METHODS FOR TREATING METABOLIC DISORDERS Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine. FIG. - 90 -
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US13/547,022 US8796338B2 (en) | 2011-01-07 | 2012-07-11 | Biguanide compositions and methods of treating metabolic disorders |
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