SG10201900144TA - Pyridone derivative having tetrahydropyranylmethyl group - Google Patents
Pyridone derivative having tetrahydropyranylmethyl groupInfo
- Publication number
- SG10201900144TA SG10201900144TA SG10201900144TA SG10201900144TA SG10201900144TA SG 10201900144T A SG10201900144T A SG 10201900144TA SG 10201900144T A SG10201900144T A SG 10201900144TA SG 10201900144T A SG10201900144T A SG 10201900144TA SG 10201900144T A SG10201900144T A SG 10201900144TA
- Authority
- SG
- Singapore
- Prior art keywords
- salt
- pyridone derivative
- ofaxl
- treatment
- hyperfunction
- Prior art date
Links
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title abstract 3
- 125000006173 tetrahydropyranylmethyl group Chemical group 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicinal Chemistry (AREA)
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- Endocrinology (AREA)
- Urology & Nephrology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Diabetes (AREA)
- Dermatology (AREA)
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- Hematology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETBYL GROUP It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction ofAxl, the treatment of a disease associated with hyperfunction ofAxl, and/or the treatment of a disease involving hyperfunction ofAxl. (Solution] The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R , R21 R3t R41 R51 W, X, Y , and Z are each as defined in the specification). Formula (I) H R I w 11 ~ (I) Figure for pUblication: None - 277 -
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014139628 | 2014-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201900144TA true SG10201900144TA (en) | 2019-02-27 |
Family
ID=55064330
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201700063RA SG11201700063RA (en) | 2014-07-07 | 2015-07-06 | Pyridone derivative having tetrahydropyranylmethyl group |
| SG10201900144TA SG10201900144TA (en) | 2014-07-07 | 2015-07-06 | Pyridone derivative having tetrahydropyranylmethyl group |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201700063RA SG11201700063RA (en) | 2014-07-07 | 2015-07-06 | Pyridone derivative having tetrahydropyranylmethyl group |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10442797B2 (en) |
| EP (2) | EP3168219B1 (en) |
| JP (2) | JP6086516B2 (en) |
| KR (1) | KR102348190B1 (en) |
| CN (2) | CN106604920B (en) |
| AU (1) | AU2015288648B2 (en) |
| CA (1) | CA2954488C (en) |
| CO (1) | CO2017001178A2 (en) |
| CY (1) | CY1124537T1 (en) |
| DK (1) | DK3168219T3 (en) |
| ES (1) | ES2875360T3 (en) |
| HR (1) | HRP20210899T1 (en) |
| HU (1) | HUE054534T2 (en) |
| IL (2) | IL249948B (en) |
| LT (1) | LT3168219T (en) |
| MX (1) | MX383928B (en) |
| MY (1) | MY194307A (en) |
| PH (2) | PH12022552034A1 (en) |
| PL (1) | PL3168219T3 (en) |
| PT (1) | PT3168219T (en) |
| RS (1) | RS61941B1 (en) |
| RU (1) | RU2707953C2 (en) |
| SG (2) | SG11201700063RA (en) |
| SI (1) | SI3168219T1 (en) |
| SM (1) | SMT202100303T1 (en) |
| TW (2) | TWI690525B (en) |
| WO (1) | WO2016006706A1 (en) |
| ZA (1) | ZA201700139B (en) |
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| TWI690525B (en) | 2014-07-07 | 2020-04-11 | 日商第一三共股份有限公司 | Pyridone derivatives containing tetrahydropyranylmethyl group and use thereof |
| US20190099413A1 (en) | 2016-02-26 | 2019-04-04 | Ono Pharmaceutical Co., Ltd. | Drug for cancer therapy characterized in that axl inhibitor and immune checkpoint inhibitor are administered in combination |
| CN108250200A (en) * | 2016-12-28 | 2018-07-06 | 中国科学院上海药物研究所 | A kind of compound and its preparation and application with Axl inhibitory activity |
| TWI796326B (en) | 2017-03-24 | 2023-03-21 | 日商第一三共股份有限公司 | Medicines containing axl inhibitor and egfr tyrosine kinase inhibitor and uses thereof |
| US20200197385A1 (en) | 2017-08-23 | 2020-06-25 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for cancer containing axl inhibitor as active ingredient |
| JP7223998B2 (en) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Solid cancer therapeutic agent containing an Axl inhibitor as an active ingredient |
| EP3728230A1 (en) * | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| CN110041316B (en) * | 2018-01-17 | 2022-04-19 | 药捷安康(南京)科技股份有限公司 | TAM family kinase/CSF 1R kinase inhibitors and uses thereof |
| AU2019212959A1 (en) | 2018-01-29 | 2020-09-17 | Capulus Therapeutics, Llc | SREBP inhibitors comprising a 6-membered central ring |
| TWI840378B (en) | 2018-07-04 | 2024-05-01 | 日商第一三共股份有限公司 | The manufacturing method of diarylpyridine derivatives |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| JPWO2022220227A1 (en) * | 2021-04-14 | 2022-10-20 | ||
| WO2024217587A1 (en) * | 2023-04-21 | 2024-10-24 | 南京正大天晴制药有限公司 | Substituted pyrazine compound having axl inhibitory activity |
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