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SG10201811365RA - Slow-release conjugates of sn-38 - Google Patents

Slow-release conjugates of sn-38

Info

Publication number
SG10201811365RA
SG10201811365RA SG10201811365RA SG10201811365RA SG10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA
Authority
SG
Singapore
Prior art keywords
slow
conjugates
release
release conjugates
glucuronate
Prior art date
Application number
SG10201811365RA
Other languages
English (en)
Inventor
Gary Ashley
Eric L Schneider
Original Assignee
Prolynx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolynx Llc filed Critical Prolynx Llc
Publication of SG10201811365RA publication Critical patent/SG10201811365RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48Polymers modified by chemical after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002Dendritic macromolecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG10201811365RA 2013-10-04 2014-10-03 Slow-release conjugates of sn-38 SG10201811365RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361887111P 2013-10-04 2013-10-04

Publications (1)

Publication Number Publication Date
SG10201811365RA true SG10201811365RA (en) 2019-02-27

Family

ID=51871275

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201811365RA SG10201811365RA (en) 2013-10-04 2014-10-03 Slow-release conjugates of sn-38
SG11201602258WA SG11201602258WA (en) 2013-10-04 2014-10-03 Slow-release conjugates of sn-38

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201602258WA SG11201602258WA (en) 2013-10-04 2014-10-03 Slow-release conjugates of sn-38

Country Status (14)

Country Link
US (2) US10016411B2 (fr)
EP (1) EP3052101B1 (fr)
JP (2) JP6473145B2 (fr)
KR (1) KR102320753B1 (fr)
CN (1) CN106061483B (fr)
AU (2) AU2014331591B2 (fr)
BR (1) BR112016007410B1 (fr)
CA (1) CA2925132C (fr)
DK (1) DK3052101T3 (fr)
ES (1) ES2759905T3 (fr)
MX (1) MX371201B (fr)
SG (2) SG10201811365RA (fr)
TW (1) TWI716342B (fr)
WO (1) WO2015051307A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014331591B2 (en) * 2013-10-04 2018-08-16 Prolynx Llc Slow-release conjugates of SN-38
CN107375288B (zh) * 2016-05-16 2019-08-23 博瑞生物医药(苏州)股份有限公司 多臂的聚合靶向抗癌偶联物
US11191843B2 (en) 2017-04-21 2021-12-07 Brightgene Bio-Medical Technology Co., Ltd. Multi-arm targeting anti-cancer conjugate
EP3737383A4 (fr) * 2018-01-12 2021-12-15 Prolynx LLC Traitement synergique du cancer
US11253603B2 (en) 2018-09-17 2022-02-22 The Children's Hospital Of Philadelphia Polymer-based macromolecular prodrugs
JP2022526985A (ja) * 2019-04-05 2022-05-27 プロリンクス エルエルシー 改良されたコンジュゲーションリンカー
AU2020335917A1 (en) * 2019-08-28 2022-03-17 Prolynx Llc Conjugated inhibitors of DNA damage response
JP2023542382A (ja) 2020-09-28 2023-10-06 フンダシオ インスティトゥ デ レセルカ バイオメディカ (イーエレベー バルセロナ) がんの処置に有用なsn38のペプチド性コンジュゲート
US11976196B2 (en) * 2021-04-14 2024-05-07 Cambridge Crops, Inc. Silk packaging applications
CN119212729A (zh) 2022-03-28 2024-12-27 圣胡安德申医院 抗癌药物的肽水溶性递送系统

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US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
JP2005537266A (ja) * 2002-07-12 2005-12-08 バイオマリン ファーマシューティカル インコーポレイテッド 加水分解性活性物質であるバイオポリマーコンジュゲートを作製するためのイソシアネートリンカーの使用
CA2502870C (fr) 2002-10-31 2011-07-26 Nippon Kayaku Kabushiki Kaisha Derives de haut poids moleculaire de camptothecine
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
CA2537336C (fr) * 2003-09-17 2013-02-26 Nektar Therapeutics Al, Corporation Promedicaments a base de polymere a branches multiples
US7462627B2 (en) 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
BRPI0716812A2 (pt) * 2006-09-15 2013-11-05 Enzon Pharmaceuticals Inc Pro drogas polimericas direcionadas contendo ligantes multifuncionais
BRPI0919842A8 (pt) * 2008-10-21 2015-09-22 Enzon Pharmaceuticals Inc tratamento de neuroblastioma com conjugados poliméricos de múltiplos braços de 7-etil-10-hidroxicamptotecina
CA2743907A1 (fr) 2008-11-18 2010-05-27 Baxter International Inc. Methodes de determination de la polydispersite et/ou de la distribution de masse moleculaire d'un echantillon de polyethylene glycol
JP2012528240A (ja) 2009-05-28 2012-11-12 メルサナ セラピューティックス, インコーポレイテッド 可変速度放出リンカーを含むポリアル−薬物コンジュゲート
CN102711837B (zh) * 2009-11-18 2016-10-19 尼克塔治疗公司 盐形式的多-臂聚合物-药物偶联物
EP2571496A4 (fr) * 2010-05-05 2016-03-30 Prolynx Llc Libération contrôlée de médicament à partir de dendrimères
DK2566335T3 (en) * 2010-05-05 2016-10-03 Prolynx Llc Controlled release of active ingredients from macromolecular CONJUGATES
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AU2014331591B2 (en) * 2013-10-04 2018-08-16 Prolynx Llc Slow-release conjugates of SN-38

Also Published As

Publication number Publication date
BR112016007410A8 (pt) 2020-02-27
CA2925132A1 (fr) 2015-04-09
JP2019104739A (ja) 2019-06-27
AU2014331591B2 (en) 2018-08-16
DK3052101T3 (da) 2019-12-16
US10016411B2 (en) 2018-07-10
JP2016531895A (ja) 2016-10-13
TWI716342B (zh) 2021-01-21
MX371201B (es) 2020-01-22
KR20160065203A (ko) 2016-06-08
US20160243106A1 (en) 2016-08-25
JP6473145B2 (ja) 2019-02-20
SG11201602258WA (en) 2016-04-28
KR102320753B1 (ko) 2021-11-02
US20180289695A1 (en) 2018-10-11
EP3052101B1 (fr) 2019-11-20
EP3052101A1 (fr) 2016-08-10
AU2014331591A1 (en) 2016-05-19
CN106061483A (zh) 2016-10-26
ES2759905T3 (es) 2020-05-12
US10342792B2 (en) 2019-07-09
CN106061483B (zh) 2021-01-08
BR112016007410A2 (pt) 2017-08-01
MX2016004299A (es) 2016-10-04
TW201601759A (zh) 2016-01-16
AU2018256608A1 (en) 2018-11-22
BR112016007410B1 (pt) 2022-07-19
CA2925132C (fr) 2021-11-30
WO2015051307A1 (fr) 2015-04-09
JP6842479B2 (ja) 2021-03-17

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