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SG10201811116UA - Non-human animals having a humanized programmed cell death 1 gene - Google Patents

Non-human animals having a humanized programmed cell death 1 gene

Info

Publication number
SG10201811116UA
SG10201811116UA SG10201811116UA SG10201811116UA SG10201811116UA SG 10201811116U A SG10201811116U A SG 10201811116UA SG 10201811116U A SG10201811116U A SG 10201811116UA SG 10201811116U A SG10201811116U A SG 10201811116UA SG 10201811116U A SG10201811116U A SG 10201811116UA
Authority
SG
Singapore
Prior art keywords
human animals
gene
cell death
programmed cell
human
Prior art date
Application number
SG10201811116UA
Inventor
Elena Burova
Alexander O Mujica
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201811116UA publication Critical patent/SG10201811116UA/en

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Abstract

NON-HUMAN ANIMALS HAVING A HUMANIZED PROGRAMMED CELL DEATH 1 GENE Non-human animals, and methods and compositions for making and using the same, 5 are provided, wherein said non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that said non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion). 10 [No Figure]
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