[go: up one dir, main page]

SG10201808833XA - Drug regulated transgene expression - Google Patents

Drug regulated transgene expression

Info

Publication number
SG10201808833XA
SG10201808833XA SG10201808833XA SG10201808833XA SG10201808833XA SG 10201808833X A SG10201808833X A SG 10201808833XA SG 10201808833X A SG10201808833X A SG 10201808833XA SG 10201808833X A SG10201808833X A SG 10201808833XA SG 10201808833X A SG10201808833X A SG 10201808833XA
Authority
SG
Singapore
Prior art keywords
polynucleotide
cells
expression
drug
genetically modified
Prior art date
Application number
SG10201808833XA
Inventor
Michael C Jensen
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54288361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201808833X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of SG10201808833XA publication Critical patent/SG10201808833XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01003—Dihydrofolate reductase (1.5.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2820/00—Vectors comprising a special origin of replication system
    • C12N2820/002—Vectors comprising a special origin of replication system inducible or controllable

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)

Abstract

DRUG RELATED TRANSGENE EXPRESSION The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor under the control of an inducible promoter. In some alternatives the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a chimeric antigen receptor comprising a ligand binding domain, a polynucleotide comprising a spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain under the control of a drug inducible promoter. Controlling the expression of the chimeric receptor provides for the ability to turn expression on and off depending on the status of the patient. Pharmaceutical formulations produced by the method, and methods of using the same, are also described. FIG.6A 157
SG10201808833XA 2014-04-10 2015-04-08 Drug regulated transgene expression SG10201808833XA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461977751P 2014-04-10 2014-04-10
US201461986479P 2014-04-30 2014-04-30
US201462058973P 2014-10-02 2014-10-02
US201462088363P 2014-12-05 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US201462090845P 2014-12-11 2014-12-11

Publications (1)

Publication Number Publication Date
SG10201808833XA true SG10201808833XA (en) 2018-11-29

Family

ID=54288361

Family Applications (8)

Application Number Title Priority Date Filing Date
SG10201808819XA SG10201808819XA (en) 2014-04-10 2015-04-08 Transgene genetic tags and methods of use
SG11201608395PA SG11201608395PA (en) 2014-04-10 2015-04-08 Defined composition gene modified t-cell products
SG11201608396YA SG11201608396YA (en) 2014-04-10 2015-04-08 Drug related transgene expression
SG11201608392WA SG11201608392WA (en) 2014-04-10 2015-04-08 Method and compositions for cellular immunotherapy
SG10201808811QA SG10201808811QA (en) 2014-04-10 2015-04-08 Method and compositions for cellular immunotherapy
SG10201808825XA SG10201808825XA (en) 2014-04-10 2015-04-08 Defined composition gene modified t-cell products
SG11201608393TA SG11201608393TA (en) 2014-04-10 2015-04-08 Transgene genetic tags and methods of use
SG10201808833XA SG10201808833XA (en) 2014-04-10 2015-04-08 Drug regulated transgene expression

Family Applications Before (7)

Application Number Title Priority Date Filing Date
SG10201808819XA SG10201808819XA (en) 2014-04-10 2015-04-08 Transgene genetic tags and methods of use
SG11201608395PA SG11201608395PA (en) 2014-04-10 2015-04-08 Defined composition gene modified t-cell products
SG11201608396YA SG11201608396YA (en) 2014-04-10 2015-04-08 Drug related transgene expression
SG11201608392WA SG11201608392WA (en) 2014-04-10 2015-04-08 Method and compositions for cellular immunotherapy
SG10201808811QA SG10201808811QA (en) 2014-04-10 2015-04-08 Method and compositions for cellular immunotherapy
SG10201808825XA SG10201808825XA (en) 2014-04-10 2015-04-08 Defined composition gene modified t-cell products
SG11201608393TA SG11201608393TA (en) 2014-04-10 2015-04-08 Transgene genetic tags and methods of use

Country Status (19)

Country Link
US (12) US10865242B2 (en)
EP (8) EP3129471A4 (en)
JP (12) JP2017515464A (en)
KR (8) KR20160144431A (en)
CN (7) CN106535934A (en)
AU (8) AU2015243849B2 (en)
BR (3) BR112016023523A2 (en)
CA (5) CA2945305C (en)
ES (2) ES2880932T3 (en)
IL (5) IL248238B2 (en)
MX (6) MX389797B (en)
MY (4) MY186846A (en)
NZ (3) NZ725079A (en)
PH (4) PH12016502011B1 (en)
RU (5) RU2751920C2 (en)
SA (1) SA516380056B1 (en)
SG (8) SG10201808819XA (en)
WO (5) WO2015157399A1 (en)
ZA (3) ZA201607053B (en)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100548667C (en) * 2003-01-20 2009-10-14 日本瑞翁株式会社 Laminates and manufacture method thereof
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
BR112016011459A2 (en) * 2013-11-21 2017-09-26 Ucl Business Plc cell
MY186846A (en) 2014-04-10 2021-08-26 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Method and compositions for cellular immunotherapy
PT4219687T (en) 2014-04-23 2024-10-02 Juno Therapeutics Inc Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
US10494422B2 (en) 2014-04-29 2019-12-03 Seattle Children's Hospital CCR5 disruption of cells expressing anti-HIV chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies
SG10202104804PA (en) 2014-10-20 2021-06-29 Juno Therapeutics Inc Methods and compositions for dosing in adoptive cell therapy
CN107249606A (en) 2014-10-31 2017-10-13 宾夕法尼亚大学董事会 Altering gene expression in modified T cells and uses thereof
KR101697473B1 (en) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 Method for Preparation of Natural Killer Cells Using T Cells
KR20170087514A (en) 2014-12-03 2017-07-28 주노 쎄러퓨티크스 인코퍼레이티드 Methods and compositions for adoptive cell therapy
HUE053995T2 (en) 2014-12-05 2021-08-30 Memorial Sloan Kettering Cancer Center Antibodies targeting b-cell maturation antigen and methods of use
FI3240805T3 (en) 2014-12-15 2025-02-17 Univ California CD19- AND CD20-RESPONSIVE BISPECIFIC OR-HYPER
MA41346A (en) 2015-01-12 2017-11-21 Juno Therapeutics Inc POST-TRANSCRIPTIONAL REGULATORY ELEMENTS OF MODIFIED HEPATITIS
AU2016206457B2 (en) 2015-01-16 2021-11-11 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ROR1
KR20170117095A (en) * 2015-02-24 2017-10-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 Genetically Modified T Cell Selection Method
EP3261651B1 (en) 2015-02-27 2022-05-04 iCell Gene Therapeutics LLC Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
SG10201913682QA (en) 2015-06-25 2020-03-30 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
US11173179B2 (en) 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
EP3331920A4 (en) 2015-08-07 2019-04-03 Seattle Children's Hospital, dba Seattle Children's Research Institute T CARRIER CARRIER CELLS FOR BISPECIFICATION OF SOLID TUMOR TARGETING
EA201890772A1 (en) * 2015-09-22 2018-10-31 Юлиус Максимилианс-Универзитет Вюрцбург METHOD OF HIGH-LEVEL AND STABLE TRANSFER OF GENES IN LYMPHOCYTES
ES2809550T3 (en) * 2015-10-06 2021-03-04 Hope City Chimeric antigen receptors directed against PSCA
JP2018532745A (en) * 2015-10-23 2018-11-08 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト Prognosis and treatment of squamous cell carcinoma
SG11201803098VA (en) 2015-10-30 2018-05-30 Nbe Therapeutics Ag Anti-ror1 antibodies
US11020429B2 (en) 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
MY184126A (en) * 2015-12-14 2021-03-19 Genomefrontier Therapeutics Inc Transposon system, kit comprising the same, and uses thereof
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
KR20180101554A (en) 2016-01-20 2018-09-12 더 스크립스 리서치 인스티튜트 ROR1 antibody composition and related methods
EP3202783A1 (en) * 2016-02-02 2017-08-09 Ecole Polytechnique Fédérale de Lausanne (EPFL) Engineered antigen presenting cells and uses thereof
US20190355459A1 (en) 2016-03-16 2019-11-21 Juno Therapeutics, Inc. Methods for adaptive design of a treatment regimen and related treatments
JP7282521B2 (en) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Methods and compositions for CAR T cell therapy
US12060394B2 (en) 2016-04-28 2024-08-13 The Trustees Of Dartmouth College Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof
EP3463396A1 (en) * 2016-06-07 2019-04-10 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
EP3468994A1 (en) 2016-06-08 2019-04-17 Intrexon Corporation Cd33 specific chimeric antigen receptors
CN109562126A (en) 2016-06-24 2019-04-02 美商生物细胞基因治疗有限公司 Chimeric antigen receptor (CAR), composition and its application method
US20190119636A1 (en) 2017-10-23 2019-04-25 Poseida Therapeutics, Inc. Modified stem cell memory t cells, methods of making and methods of using same
JP7623784B2 (en) 2016-10-13 2025-01-29 ジュノー セラピューティクス インコーポレイテッド Immunotherapeutic methods and compositions involving tryptophan metabolic pathway modulators - Patents.com
US11739129B2 (en) * 2016-10-21 2023-08-29 Washington University AP4 and methods of promoting T cell activation
AU2017368248A1 (en) * 2016-11-30 2019-06-06 Intrexon Corporation Steroid administration and immunotherapy
CA3045339A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
EP3551197B1 (en) * 2016-12-12 2023-11-22 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
CN106800601B (en) * 2017-01-19 2021-04-06 广东昭泰体内生物医药科技有限公司 Chimeric antigen receptor and application thereof
AU2018209400B2 (en) * 2017-01-20 2022-06-02 Juno Therapeutics Gmbh Cell surface conjugates and related cell compositions and methods
EP3585402B1 (en) 2017-02-27 2024-03-06 Juno Therapeutics, Inc. Compositions, articles of manufacture and methods related to dosing in cell therapy
EP4501352A3 (en) 2017-02-28 2025-04-16 Endocyte, Inc. Compositions and methods for car t cell therapy
JP7359751B2 (en) 2017-03-14 2023-10-11 ジュノー セラピューティクス インコーポレイテッド Methods for cryogenic storage
CN106963945A (en) * 2017-03-27 2017-07-21 山东兴瑞生物科技有限公司 A kind of reinforced HPV HPV 16/18 divalence DC vaccines
WO2018191490A1 (en) * 2017-04-13 2018-10-18 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy
JOP20180040A1 (en) 2017-04-20 2019-01-30 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
CN108728477B (en) * 2017-04-24 2022-02-22 华东理工大学 An efficient transposition mutation system and construction method
EP4389900A3 (en) * 2017-05-17 2024-12-18 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Generating mammalian t cell activation inducible synthetic promoters (syn+pro) to improve t cell therapy
US10780119B2 (en) 2017-05-24 2020-09-22 Effector Therapeutics Inc. Methods and compositions for cellular immunotherapy
KR102460173B1 (en) * 2017-05-26 2022-10-31 주식회사 지씨셀 Culturing method of natural killer cells using transformed T cells
EP3630132A1 (en) * 2017-06-02 2020-04-08 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
CN107335054B (en) * 2017-06-30 2021-01-15 山东兴瑞生物科技有限公司 Therapeutic DC vaccine for chronic hepatitis B
KR20230008269A (en) 2017-08-07 2023-01-13 엔비이-테라퓨틱스 아게 Antibody drug conjugates having high in vivo tolerability
CA3072569A1 (en) * 2017-08-11 2019-02-14 Tribiotica Llc Methods for generating epitopes for binding to recognition molecules by templated assembly
US11643468B2 (en) * 2017-08-23 2023-05-09 Max-Delbrück-Centrum für Molekulare Medizin in der Hemlholtz-Gemeinschaft Chimeric antigen receptors and CAR-T cells that bind CXCR5 and methods of use thereof to treat medical disorders
CN111433354A (en) * 2017-09-26 2020-07-17 朗沃德大学 PD 1-specific chimeric antigen receptor as immunotherapy
EP3697438A4 (en) 2017-10-18 2021-08-18 Intrexon Corporation POLYPEPTIDE COMPOSITIONS WITH SPACERS
CN107759700A (en) * 2017-10-18 2018-03-06 银丰生物工程集团有限公司 Transgenic T cell targeting CD19 antigen and its preparation method and application
US10329543B2 (en) 2017-10-23 2019-06-25 Poseida Therapeutics, Inc. Modified stem cell memory T cells, methods of making and methods of using same
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
JP7256197B2 (en) 2017-11-01 2023-04-11 ジュノー セラピューティクス インコーポレイテッド Antibodies and chimeric antigen receptors specific for B-cell maturation antigens
EP4512823A2 (en) 2017-11-01 2025-02-26 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
AU2018359907A1 (en) 2017-11-06 2020-05-07 Fred Hutchinson Cancer Center Combination of a cell therapy and a gamma secretase inhibitor
EP3707160A1 (en) 2017-11-10 2020-09-16 The U.S.A. as represented by the Secretary, Department of Health and Human Services Chimeric antigen receptors targeting tumor antigens
CN111655270A (en) * 2017-11-14 2020-09-11 纪念斯隆-凯特琳癌症中心 Immune response cells secreting IL-36 and uses thereof
CA3084446A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Phenotypic markers for cell therapy and related methods
AU2018392213B2 (en) 2017-12-20 2021-03-04 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
CA3084582A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
CN110028588A (en) * 2018-01-11 2019-07-19 上海细胞治疗研究院 Antigen-Fc fusion protein and its application for detecting positive CAR-T cell
US10561686B2 (en) 2018-01-12 2020-02-18 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
SG11202006886VA (en) 2018-01-22 2020-08-28 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Methods of use for car t cells
CN108103027B (en) * 2018-02-02 2021-12-24 中国医学科学院血液病医院（血液学研究所） Method for reprogramming blood cells with high efficiency and simultaneously realizing gene editing
CN118084940A (en) 2018-02-13 2024-05-28 吉利德科学公司 PD-1/PD-L1 inhibitors
WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
CN108383914A (en) * 2018-02-23 2018-08-10 北京美康基免生物科技有限公司 A kind of Chimeric antigen receptor and its application based on CD19
AU2019233929A1 (en) * 2018-03-16 2020-09-24 Immusoft Corporation B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
CN112041311B (en) 2018-04-19 2023-10-03 吉利德科学公司 PD-1/PD-L1 inhibitors
TW202014193A (en) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 2’3’-cyclic dinucleotides comprising carbocyclic nucleotide
US10703733B2 (en) 2018-05-14 2020-07-07 Gilead Sciences, Inc. MCL-1 inhibitors
CN112154204B (en) * 2018-05-15 2025-01-07 科济生物医药（上海）有限公司 Genetically engineered cells and their applications
WO2020003210A1 (en) 2018-06-29 2020-01-02 Kangwon National University University-Industry Cooperation Foundation Anti-l1cam antibodies and uses thereof
CN118221646A (en) 2018-07-13 2024-06-21 吉利德科学公司 PD-1/PD-L1 inhibitors
CN110845621A (en) * 2018-08-21 2020-02-28 上海恒润达生生物科技有限公司 Chimeric antigen receptor method targeting EGFR and CD19 double targets
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
WO2020047257A1 (en) * 2018-08-31 2020-03-05 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods and compositions comprising b7h3 chimeric antigen receptors
WO2020072656A1 (en) 2018-10-03 2020-04-09 Gilead Sciences, Inc. Imidozopyrimidine derivatives
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11071730B2 (en) 2018-10-31 2021-07-27 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
IL282535B2 (en) 2018-10-31 2024-05-01 Gilead Sciences Inc Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
EP3874030B1 (en) 2018-11-01 2025-03-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
BR112021009420A2 (en) * 2018-11-16 2021-11-23 Juno Therapeutics Inc Engineered t-cell dosing methods for the treatment of b-cell malignancies
US10918667B2 (en) 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
MX2021006244A (en) * 2018-11-30 2021-09-10 Juno Therapeutics Inc Methods for dosing and treatment of b cell malignancies in adoptive cell therapy.
WO2020113194A2 (en) * 2018-11-30 2020-06-04 Juno Therapeutics, Inc. Methods for treatment using adoptive cell therapy
MX2021006402A (en) * 2018-11-30 2021-08-11 Celularity Inc Placenta-derived allogeneic car-t cells and uses thereof.
SG11202107976SA (en) 2019-01-29 2021-08-30 Juno Therapeutics Inc Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
US11766447B2 (en) 2019-03-07 2023-09-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
KR102707808B1 (en) 2019-03-07 2024-09-19 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 2'3'-cyclic dinucleotides and prodrugs thereof
CN113574063B (en) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 3'3'-Cyclic dinucleotides and prodrugs thereof
WO2020191172A1 (en) * 2019-03-19 2020-09-24 Immatics US, Inc. Cd28 t cell cultures, compositions, and methods of using thereof
US20200308248A1 (en) * 2019-03-26 2020-10-01 ST Phi Therapeutics Chimeric Natural Killer Cell Receptors and Method of Using Thereof
EP3953383A4 (en) * 2019-04-08 2023-01-18 Russell Biotech, Inc. IMPROVED MANUFACTURING PROCESSES FOR CELL-BASED THERAPY
CN109872792A (en) * 2019-04-16 2019-06-11 北京中佰耀因医药科技有限公司 It is a kind of for instructing the genetic test intelligent reporting system of accurate medication
CN109979545A (en) * 2019-04-16 2019-07-05 北京中佰耀因医药科技有限公司 A kind of accurate medication intelligent reporting system of the module of state information management containing sample
CN109994156A (en) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 A kind of accurate medication intelligent reporting system of the information management module containing report template
CN110010222A (en) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 A kind of gene identities identifying system based on accurate knowledge on drug abuse library
CN110010200A (en) * 2019-04-16 2019-07-12 长沙三济生物科技有限公司 A kind of gene identities identifying system
CN109994180A (en) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 A kind of accurate medication intelligent reporting system of the information management module containing gene loci
CN109994176A (en) * 2019-04-16 2019-07-09 北京中佰耀因医药科技有限公司 A kind of accurate medication intelligent reporting system of the information management module containing sample type
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
BR112021025286A2 (en) * 2019-06-17 2022-04-26 Enochian Biopharma Inc Allogeneic t-cell-based HIV vaccine to induce cellular and humoral immunity
WO2020254591A1 (en) * 2019-06-19 2020-12-24 Julius-Maximilians-Universität Würzburg Ultramodular igg3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design
AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
CN110608991B (en) * 2019-09-09 2022-04-29 浙江普罗亭健康科技有限公司 Cell cycle detection kit based on mass flow detection technology and detection method
TW202124450A (en) 2019-10-18 2021-07-01 美商四十七股份有限公司 Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
KR20220091576A (en) 2019-10-31 2022-06-30 포티 세븐, 인코포레이티드 Anti-CD47 and Anti-CD20 Based Treatment of Hematological Cancers
TWI778443B (en) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1 inhibitors
PT4081305T (en) 2019-12-24 2024-12-04 Gilead Sciences Inc Diacylglycerol kinase modulating compounds
IL295023A (en) 2020-02-14 2022-09-01 Jounce Therapeutics Inc Antibodies and fusion proteins that bind to ccr8 and their uses
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
CN111533808B (en) * 2020-03-10 2021-02-09 南京医科大学 Chimeric antigen receptor modified T cell capable of autocrine TLR4 scFv and targeting cMet and application thereof
JP2023518293A (en) 2020-03-20 2023-04-28 ライル・イミュノファーマ，インコーポレイテッド A novel recombinant cell surface marker
CA3181922A1 (en) 2020-05-01 2021-11-04 Gilead Sciences, Inc. Cd73 inhibiting 2,4-dioxopyrimidine compounds
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
US20230338422A1 (en) * 2020-07-09 2023-10-26 Nanjing Legend Biotech Co., Ltd. Engineering gamma delta t cells with interleukin-36 for immunotherapy
WO2022016119A1 (en) 2020-07-17 2022-01-20 Simurx, Inc. Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods
WO2022125387A1 (en) * 2020-12-08 2022-06-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-egfr chimeric antigen receptors
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
US20240076351A1 (en) * 2021-01-15 2024-03-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Hybrid and truncated immune cell proteins
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
TW202302145A (en) 2021-04-14 2023-01-16 美商基利科學股份有限公司 Co-inhibition of cd47/sirpα binding and nedd8-activating enzyme e1 regulatory subunit for the treatment of cancer
US20220389394A1 (en) 2021-05-18 2022-12-08 Gilead Sciences, Inc. METHODS OF USING FLT3L-Fc FUSION PROTEINS
CN117377671A (en) 2021-06-23 2024-01-09 吉利德科学公司 Diacylglycerol kinase modulating compounds
PE20242071A1 (en) 2021-06-23 2024-10-18 Gilead Sciences Inc DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222277A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CN118056012A (en) * 2021-08-24 2024-05-17 赛斯尔擎生物技术（上海）有限公司 Method for modifying cells
KR20240099259A (en) 2021-10-14 2024-06-28 아스널 바이오사이언시스, 인크. Immune cells with co-expressed SHRNA and logic gate system
JP2024539252A (en) 2021-10-28 2024-10-28 ギリアード サイエンシーズ， インコーポレイテッド Pyridin-3(2H)-one derivatives
CR20240173A (en) 2021-10-29 2024-06-20 Gilead Sciences Inc CD73 COMPOUNDS
CN118488946A (en) 2021-12-22 2024-08-13 吉利德科学公司 IKAROS zinc finger family degraders and their uses
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (en) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7 inhibitors
WO2023173137A1 (en) * 2022-03-11 2023-09-14 Yale University Compositions and methods for efficient and stable genetic modification of eukaryotic cells
CR20240386A (en) 2022-03-17 2024-10-24 Gilead Sciences Inc Ikaros zinc finger family degraders and uses thereof
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
CN118973608A (en) * 2022-04-01 2024-11-15 美天施生物科技有限两合公司 Systems for drug-inducible expression of polynucleotides
EP4504256A1 (en) 2022-04-05 2025-02-12 Gilead Sciences, Inc. Combinations of antibody therapies for treating colorectal cancer
KR20250004824A (en) 2022-04-21 2025-01-08 길리애드 사이언시즈, 인코포레이티드 KRAS G12D Modulating Compounds
US20230348561A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof
US20230348548A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
EP4514821A1 (en) 2022-04-28 2025-03-05 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
CN114990069B (en) * 2022-05-17 2023-09-22 郑州大学第一附属医院 Preparation method and application of chimeric antigen receptor T cell over-expressing SLC43A2
EP4532701A1 (en) * 2022-05-27 2025-04-09 Autolus Limited Method
AR129552A1 (en) * 2022-06-10 2024-09-04 Joint Stock Company “Biocad” NUCLEIC ACID WITH PROMOTING ACTIVITY AND ITS USE
WO2024006702A1 (en) * 2022-06-27 2024-01-04 Foundation Medicine, Inc. Methods and systems for predicting genotypic calls from whole-slide images
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
CN116179495A (en) * 2022-11-28 2023-05-30 上海恩凯细胞技术有限公司 Transgenic immune cells and uses thereof
WO2024129984A1 (en) * 2022-12-15 2024-06-20 The Board Of Trustees Of The Leland Stanford Junior University Homology-independent targeted dna insertion in human t cells
WO2024137652A2 (en) * 2022-12-20 2024-06-27 Abata Therapeutics, Inc. Cell therapies for type 1 diabetes
US20240254118A1 (en) 2022-12-22 2024-08-01 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024153036A1 (en) * 2023-01-19 2024-07-25 武汉昭智生物技术有限公司 Car molecule, cell or exosome containing same, and use thereof
TW202442689A (en) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 Systems targeting psma and ca9
US20240383922A1 (en) 2023-04-11 2024-11-21 Gilead Sciences, Inc. KRAS Modulating Compounds
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025006720A1 (en) 2023-06-30 2025-01-02 Gilead Sciences, Inc. Kras modulating compounds
CN116844685B (en) * 2023-07-03 2024-04-12 广州默锐医药科技有限公司 Immunotherapeutic effect evaluation method, device, electronic equipment and storage medium
US20250100998A1 (en) 2023-07-26 2025-03-27 Gilead Sciences, Inc. Parp7 inhibitors
WO2025024663A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE913929A1 (en) 1990-11-13 1992-05-20 Immunex Corp Bifunctional selectable fusion genes
US20020111474A1 (en) 1990-12-14 2002-08-15 Capon Daniel J. Chimeric chains for receptor-associated signal transduction pathways
WO1994000143A1 (en) 1992-06-01 1994-01-06 New England Medical Center Hospitals, Inc. Blocking intercellular interactions with cd43 chimeric molecules
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US6133027A (en) * 1996-08-07 2000-10-17 City Of Hope Inducible expression system
US6660257B1 (en) 1996-10-25 2003-12-09 Pharmacia Corporation Circular permuteins of flt3 ligand
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
US20040037816A1 (en) 1999-04-15 2004-02-26 Monash University Graft acceptance through manipulation of thymic regeneration
US6912492B1 (en) * 1999-05-25 2005-06-28 University Of Medicine & Dentistry Of New Jersey Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
JP4045713B2 (en) 2000-01-31 2008-02-13 松下電器産業株式会社 Welding machine for automatic machine
GB0015119D0 (en) * 2000-06-20 2000-08-09 Angeletti P Ist Richerche Bio Methods and means for regulation of gene expression
EP1297168A2 (en) 2000-07-03 2003-04-02 Gala Design, Inc. Expression vectors
GB0025307D0 (en) * 2000-10-16 2000-11-29 Celltech Chiroscience Ltd Biological products
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
AU2002248571B2 (en) 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
WO2002097099A1 (en) * 2001-05-29 2002-12-05 Valentis, Inc. Regulated expression of ghrh
EP2060582A1 (en) 2001-05-31 2009-05-20 Novartis Ag Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
US20050004017A1 (en) * 2001-09-18 2005-01-06 Yuval Reiss Methods and compositions for treating hcap associated diseases
US20030148982A1 (en) 2001-11-13 2003-08-07 Brenner Malcolm K. Bi-spcific chimeric T cells
CA2481509A1 (en) 2002-04-11 2003-10-23 Suzanna Tatarewicz Her-2 receptor tyrosine kinase molecules and uses thereof
AU2003283995A1 (en) 2002-09-30 2004-04-19 Protein Design Labs, Inc. Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes
DK1594542T3 (en) * 2003-02-20 2010-10-11 Seattle Genetics Inc Anti-CD70 antibody-drug conjugates and their use in the treatment of cancer
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
WO2004092338A2 (en) 2003-04-11 2004-10-28 Diadexus, Inc. Compositions, splice variants and methods relating to cancer specific genes and proteins
CN1809277A (en) * 2003-04-18 2006-07-26 诺伍德免疫学有限公司 Tolerance to graft prior to thymic regeneration
US20070166318A1 (en) 2003-05-30 2007-07-19 Macina Roberto A Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins
AU2004261724B2 (en) * 2003-07-21 2010-06-17 Msd Italia S.R.L. Synthetic gene encoding human epidermal growth factor 2/neu antigen and uses thereof
US20070087346A1 (en) * 2003-10-24 2007-04-19 Gennaro Ciliberto Orthogonal gene switches
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
WO2005062881A2 (en) 2003-12-24 2005-07-14 Transgenrx, Inc. Gene therapy using transposon-based vectors
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
US7910101B2 (en) * 2004-10-25 2011-03-22 Centocor, Inc. Melanocortin receptor binding mimetibodies, compositions, methods and uses
DE202005002921U1 (en) 2005-02-23 2005-04-21 Magcode Ag Connection system, especially electrical connection system, with bayonet connection plug and socket has end of socket for connection to plug covered by cover adjustably arranged in socket so opening is exposed when plug inserted
US20070020237A1 (en) 2005-06-01 2007-01-25 Biotech Institute For International Innovation, Inc. Glucose inducible insulin expression and methods of treating diabetes
AU2006327175A1 (en) 2005-12-21 2007-06-28 Medimmune, Llc Epha2 bite molecules and uses thereof
CA2654415A1 (en) 2006-05-22 2007-11-29 Hiprocell, Llc. Protein production using eukaryotic cell lines
US8148129B2 (en) 2006-06-30 2012-04-03 The Regents Of The University Of California Generation of potent dominant negative transcriptional inhibitors
WO2008012237A1 (en) * 2006-07-24 2008-01-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Multi-antigen construct and uses thereof
US7709253B2 (en) 2006-08-04 2010-05-04 The Board Of Trustees Of The Leland Stanford Junior University Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists
WO2009013359A2 (en) 2007-07-25 2009-01-29 Fraunhofer Gesellschaft Zur Förderung Der Angewandten Forschung E. V. Self coupling recombinant antibody fusion proteins
WO2009091826A2 (en) 2008-01-14 2009-07-23 The Board Of Regents Of The University Of Texas System Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
JP5779090B2 (en) 2008-04-09 2015-09-16 マックスサイト インコーポレーティッド Manipulation and delivery of therapeutic compositions of newly isolated cells
SI3006459T1 (en) 2008-08-26 2022-01-31 City Of Hope Method and compositions for improved antitumor effector activity of T cells
US8829173B2 (en) 2008-09-26 2014-09-09 Tocagen Inc. Recombinant vectors
MY156333A (en) 2008-09-26 2016-02-15 Tocagen Inc Gene therapy vectors and cytosine deaminases
US8329882B2 (en) 2009-02-18 2012-12-11 California Institute Of Technology Genetic control of mammalian cells with synthetic RNA regulatory systems
WO2010141543A1 (en) * 2009-06-02 2010-12-09 Targeted Molecular Diagnostics, Llc Methods for the detection and quantitation of the p95 component of her2/neu (erbb2)
US9873035B2 (en) * 2009-07-09 2018-01-23 Cfph, Llc Amusement device for a game of chance involving one or more rolling indicators on a rotating element with position indicators
US8075895B2 (en) 2009-09-22 2011-12-13 Janssen Pharmaceutica N.V. Identification of antigenic peptides from multiple myeloma cells
US8465743B2 (en) * 2009-10-01 2013-06-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
DK2496698T3 (en) * 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
JP5285678B2 (en) 2010-06-18 2013-09-11 株式会社エヌ・ティ・ティ・ドコモ Mobile communication method and core network device
ES2602743T3 (en) * 2010-09-08 2017-02-22 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Chimeric antigen receptors with an optimized hinge region
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
KR20140004174A (en) 2011-01-18 2014-01-10 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Compositions and methods for treating cancer
CA2830953C (en) * 2011-03-23 2023-02-28 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
WO2012140130A1 (en) * 2011-04-13 2012-10-18 Immunicum Ab Method for proliferation of antigen-specific t cells
US20130071414A1 (en) * 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
DK2714936T3 (en) 2011-06-01 2019-03-25 Prec Biosciences Inc METHODS AND PRODUCTS FOR PRODUCING MANIPULATED MAMMAL CELL LINES WITH AMPLIFIED TRANSGENES
CA2835772C (en) * 2011-06-22 2020-12-01 F. Hoffmann-La Roche Ag Removal of target cells by circulating virus-specific cytotoxic t-cells using mhc class i comprising complexes
BR112014008849A2 (en) 2011-10-20 2017-09-12 Us Health chimeric anti-cd22 antigen receptors
DE102011118018B4 (en) 2011-10-25 2017-10-26 Plasmidfactory Gmbh & Co. Kg Minicircles with transposition cassettes and their use for transforming cells
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
EP2814846B1 (en) 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
ITRM20120058A1 (en) 2012-02-20 2013-08-21 Pisanelli Giovanni Codacci SUGAR-BASED MOLECULES FAMILY FOR THERAPEUTIC USE AND ITS PRODUCTION PROCEDURE
CA3205751A1 (en) * 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
CN110331154A (en) * 2012-04-11 2019-10-15 美国卫生和人力服务部 Target the Chimeric antigen receptor of B- cell maturation antigen
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
WO2013177533A1 (en) 2012-05-25 2013-11-28 California Institute Of Technology Expression of secreted and cell-surface polypeptides
US20150376645A1 (en) 2012-05-30 2015-12-31 Baylor College Of Medicine Supercoiled minivectors as a tool for dna repair, alteration and replacement
EP2669378A1 (en) 2012-05-31 2013-12-04 Helmut Hanenberg Cytochrome P450 suicide gene system
US9792559B2 (en) 2012-06-01 2017-10-17 Nec Corporation Switching system, line card, switch card, FDB learning method, FDB learning arbitration method and program
EP4537839A2 (en) * 2012-08-20 2025-04-16 Fred Hutchinson Cancer Center Method and compositions for cellular immunotherapy
WO2014039044A1 (en) * 2012-09-06 2014-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t memory stem cell populations
AU2013327136A1 (en) 2012-10-02 2015-04-16 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
US9598489B2 (en) * 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
AU2013329186B2 (en) 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
CN104781789B (en) 2012-12-20 2018-06-05 三菱电机株式会社 Car-mounted device
WO2014099671A1 (en) * 2012-12-20 2014-06-26 Bluebird Bio, Inc. Chimeric antigen receptors and immune cells targeting b cell malignancies
AU2014225365B2 (en) 2013-03-07 2019-09-12 Baylor College Of Medicine Targeting CD138 in cancer
EP2777711A1 (en) * 2013-03-11 2014-09-17 Icon Genetics GmbH Her2/Neu cancer vaccine
UY35468A (en) 2013-03-16 2014-10-31 Novartis Ag CANCER TREATMENT USING AN ANTI-CD19 CHEMERIC ANTIGEN RECEIVER
JP6463577B2 (en) * 2013-05-14 2019-02-06 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Human application of modified chimeric antigen receptor (CAR) T cells
US9701758B2 (en) 2013-05-24 2017-07-11 Board Of Regents, The University Of Texas System Anti-CD19 scFv (FMC63) polypeptide
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
RU2733652C2 (en) 2013-10-31 2020-10-06 Фред Хатчинсон Кэнсер Рисерч Сентер Modified hematopoietic stem cells/progenitor cells and non-t effector cells, and use thereof
BR112016011459A2 (en) 2013-11-21 2017-09-26 Ucl Business Plc cell
EP3808410A1 (en) 2013-12-20 2021-04-21 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
AU2014376328A1 (en) 2014-01-13 2016-07-21 Christine E. BROWN Chimeric antigen receptors (CARs) having mutations in the Fc spacer region and methods for their use
MX369513B (en) 2014-02-14 2019-11-11 Univ Texas Chimeric antigen receptors and methods of making.
EP3593812A3 (en) 2014-03-15 2020-05-27 Novartis AG Treatment of cancer using chimeric antigen receptor
MY186846A (en) 2014-04-10 2021-08-26 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Method and compositions for cellular immunotherapy
WO2015172339A1 (en) 2014-05-14 2015-11-19 科济生物医药（上海）有限公司 Nucleic acid for coding chimeric antigen receptor protein and t lymphocyte for expression of chimeric antigen receptor protein
US10287350B2 (en) 2014-06-02 2019-05-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting CD-19
TWI805109B (en) 2014-08-28 2023-06-11 美商奇諾治療有限公司 Antibodies and chimeric antigen receptors specific for cd19
NZ731279A (en) 2014-10-27 2021-12-24 Hutchinson Fred Cancer Res Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy
GB201503742D0 (en) 2015-03-05 2015-04-22 Ucl Business Plc Chimeric antigen receptor
SG10201914069SA (en) 2015-05-18 2020-03-30 Tcr2 Therapeutics Inc Compositions and methods for tcr reprogramming using fusion proteins
EP3307876B1 (en) 2015-06-10 2023-09-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
JP7269733B2 (en) 2015-06-12 2023-05-09 レンティジェン・テクノロジー・インコーポレイテッド Methods for treating cancer using engineered T cells
EP3331920A4 (en) 2015-08-07 2019-04-03 Seattle Children's Hospital, dba Seattle Children's Research Institute T CARRIER CARRIER CELLS FOR BISPECIFICATION OF SOLID TUMOR TARGETING
DK3411393T3 (en) 2016-02-05 2021-06-28 Hope City ADMINISTRATION OF MANIPULATED T-CELLS FOR THE TREATMENT OF CANCERS IN THE CENTRAL NERVOUS SYSTEM
WO2017172952A1 (en) 2016-04-01 2017-10-05 Promab Biotechnologies, Inc. Flag tagged cd19-car-t cells
TWI719894B (en) 2016-09-28 2021-02-21 美商凱特製藥公司 Antigen binding molecules and methods of use thereof
DK3757120T3 (en) 2016-10-04 2022-07-25 Prec Biosciences Inc CO-STIMULATORY DOMAINS FOR USE IN GENETICALLY MODIFIED CELLS
EP3551197B1 (en) 2016-12-12 2023-11-22 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
JOP20180042A1 (en) 2017-04-24 2019-01-30 Kite Pharma Inc Humanized Antigen-Binding Domains and Methods of Use
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
US10714296B2 (en) 2018-12-12 2020-07-14 Axcelis Technologies, Inc. Ion source with tailored extraction shape
US11104732B2 (en) 2019-04-24 2021-08-31 Innovative Cellular Therapeutics Holdings, Ltd. Reducing immune inhibition induced by SIGLEC-15

Also Published As

Publication number Publication date
AU2015243882C1 (en) 2024-07-25
EP3129471A4 (en) 2017-11-08
PH12016502009B1 (en) 2022-07-22
ES2880932T3 (en) 2021-11-26
US10266592B2 (en) 2019-04-23
JP6788573B2 (en) 2020-11-25
IL248238A0 (en) 2016-11-30
JP2017512484A (en) 2017-05-25
CA2945320A1 (en) 2015-10-15
US11155616B2 (en) 2021-10-26
CA2945308C (en) 2023-10-31
PH12016502012A1 (en) 2017-01-09
US20210371517A1 (en) 2021-12-02
JP2017515464A (en) 2017-06-15
AU2015243920B2 (en) 2020-10-08
AU2015243922B2 (en) 2021-08-05
RU2016143389A3 (en) 2018-12-04
AU2015243882B2 (en) 2020-03-12
US20190248891A1 (en) 2019-08-15
MY192522A (en) 2022-08-25
US20220064292A1 (en) 2022-03-03
MX387465B (en) 2025-03-18
RU2016143384A3 (en) 2018-11-30
EP3129405A1 (en) 2017-02-15
WO2015157391A1 (en) 2015-10-15
IL248229B1 (en) 2023-01-01
KR102600544B1 (en) 2023-11-09
IL248243B2 (en) 2024-04-01
IL248243A0 (en) 2016-11-30
CN106573969B (en) 2021-07-30
EP3129480A4 (en) 2017-08-16
EP3129053A4 (en) 2017-11-08
IL248229B2 (en) 2023-05-01
JP2022153456A (en) 2022-10-12
RU2016143385A3 (en) 2018-11-30
KR102730216B1 (en) 2024-11-14
CA2945305C (en) 2023-10-17
US12202897B2 (en) 2025-01-21
EP3129471A1 (en) 2017-02-15
CN106573969A (en) 2017-04-19
US20170029774A1 (en) 2017-02-02
KR20160144431A (en) 2016-12-16
SG10201808811QA (en) 2018-11-29
RU2751920C2 (en) 2021-07-20
MY184163A (en) 2021-03-24
JP2017518037A (en) 2017-07-06
AU2015243922A1 (en) 2016-11-03
SA516380056B1 (en) 2021-07-04
SG11201608393TA (en) 2016-11-29
JP7402933B2 (en) 2023-12-21
EP3129399A4 (en) 2017-11-08
CN106661570A (en) 2017-05-10
EP3129399A1 (en) 2017-02-15
US20180009891A1 (en) 2018-01-11
PH12016502010A1 (en) 2017-01-09
JP6765967B2 (en) 2020-10-14
JP7508516B2 (en) 2024-07-01
KR20160144432A (en) 2016-12-16
EP3954708A1 (en) 2022-02-16
MX2016013160A (en) 2017-02-09
KR102508166B1 (en) 2023-03-13
JP7106610B2 (en) 2022-07-26
KR20160144430A (en) 2016-12-16
BR112016023500A2 (en) 2017-10-17
CA2945302A1 (en) 2015-10-15
US20170267742A1 (en) 2017-09-21
ZA201607060B (en) 2024-05-30
RU2016143385A (en) 2018-05-15
KR102618955B1 (en) 2023-12-27
RU2016143388A (en) 2018-05-14
JP2020195380A (en) 2020-12-10
EP3129405A4 (en) 2017-08-09
SG11201608396YA (en) 2016-11-29
IL248238B1 (en) 2024-10-01
AU2015243927B2 (en) 2021-09-02
MX2016013158A (en) 2017-04-27
AU2015243927A1 (en) 2016-11-03
BR112016023500B1 (en) 2024-04-30
JP2022184989A (en) 2022-12-13
IL248238B2 (en) 2025-02-01
MY186846A (en) 2021-08-26
JP2022109953A (en) 2022-07-28
CA2945305A1 (en) 2015-10-15
ZA201607053B (en) 2025-03-26
KR102387243B1 (en) 2022-04-14
SG10201808825XA (en) 2018-11-29
IL297591B1 (en) 2025-01-01
NZ758289A (en) 2024-01-26
RU2016143389A (en) 2018-05-15
PH12016502009A1 (en) 2017-01-09
MY185678A (en) 2021-05-30
MX389797B (en) 2025-03-20
US12258397B2 (en) 2025-03-25
CN106574246A (en) 2017-04-19
EP3129399B1 (en) 2021-05-26
EP3129053A1 (en) 2017-02-15
US20170152297A1 (en) 2017-06-01
JP2021019589A (en) 2021-02-18
US20220380461A1 (en) 2022-12-01
NZ739448A (en) 2019-10-25
AU2015243882A1 (en) 2016-11-03
JP6772068B2 (en) 2020-10-21
AU2021273652A1 (en) 2021-12-16
JP2017513470A (en) 2017-06-01
AU2015243920A1 (en) 2016-11-03
AU2015243849B2 (en) 2020-12-17
BR112016023517A2 (en) 2017-10-17
KR20220051024A (en) 2022-04-25
US20170015746A1 (en) 2017-01-19
US20220372140A1 (en) 2022-11-24
JP7062720B2 (en) 2022-05-06
KR102618955B9 (en) 2024-08-12
KR20160143762A (en) 2016-12-14
RU2016143381A3 (en) 2018-11-30
KR20230038310A (en) 2023-03-17
AU2015243849A9 (en) 2019-07-25
EP3943507A1 (en) 2022-01-26
EP4056201A1 (en) 2022-09-14
MX2016013144A (en) 2017-04-27
KR102509481B1 (en) 2023-03-10
RU2751921C2 (en) 2021-07-20
CA2945303A1 (en) 2015-10-15
IL248235B (en) 2021-01-31
PH12016502011A1 (en) 2017-01-09
EP3129405B1 (en) 2021-02-24
ES2867224T3 (en) 2021-10-20
BR112016023507A2 (en) 2017-10-17
IL248243B1 (en) 2023-12-01
CA2945308A1 (en) 2015-10-15
US20210002364A1 (en) 2021-01-07
CN106535934A (en) 2017-03-22
NZ725079A (en) 2018-03-23
AU2021200007B2 (en) 2024-08-29
SG11201608395PA (en) 2016-11-29
JP6765968B2 (en) 2020-10-07
US11414486B2 (en) 2022-08-16
WO2015157384A1 (en) 2015-10-15
KR102387243B9 (en) 2023-07-10
JP7093385B2 (en) 2022-06-29
JP2021036867A (en) 2021-03-11
ZA201607061B (en) 2024-05-30
AU2015243849A1 (en) 2016-11-03
KR102463529B1 (en) 2022-11-07
CN113528581A (en) 2021-10-22
WO2015157399A1 (en) 2015-10-15
MX2016013159A (en) 2017-04-27
AU2021201679B2 (en) 2023-05-04
BR112016023523A2 (en) 2017-10-17
JP7542270B2 (en) 2024-08-30
JP7148580B2 (en) 2022-10-05
PH12016502011B1 (en) 2022-06-17
CN106661570A8 (en) 2017-07-04
MX2022010807A (en) 2022-09-27
CN106661570B (en) 2020-02-07
IL248229A (en) 2016-11-30
WO2015157386A1 (en) 2015-10-15
IL297591A (en) 2022-12-01
IL248235A0 (en) 2016-11-30
RU2016143384A (en) 2018-05-11
SG11201608392WA (en) 2016-11-29
JP6788573B6 (en) 2020-12-16
RU2729112C2 (en) 2020-08-04
KR20220153100A (en) 2022-11-17
KR102463529B9 (en) 2024-07-31
JP2017513520A (en) 2017-06-01
MX2016013149A (en) 2017-04-27
US10865242B2 (en) 2020-12-15
RU2016143381A (en) 2018-05-11
RU2752275C2 (en) 2021-07-26
EP3129480A1 (en) 2017-02-15
NZ725081A (en) 2018-02-23
JP2021000117A (en) 2021-01-07
WO2015157432A1 (en) 2015-10-15
CA2945303C (en) 2024-02-13
CN106536558A (en) 2017-03-22
KR20160138298A (en) 2016-12-02
WO2015157399A9 (en) 2016-11-24
PH12016502010B1 (en) 2023-08-16
BR112016023513A2 (en) 2017-10-17
US20210139583A1 (en) 2021-05-13
CN112877291A (en) 2021-06-01
AU2021201679A1 (en) 2021-04-08
US10611837B2 (en) 2020-04-07
RU2016143388A3 (en) 2018-11-30
AU2021200007A1 (en) 2021-03-04
SG10201808819XA (en) 2018-11-29
MX395574B (en) 2025-03-25

Similar Documents

Publication Publication Date Title
SG10201808833XA (en) Drug regulated transgene expression
MX2020012742A (en) Method and compositions for cellular immunotherapy.
ZA202306503B (en) Compositions and methods for immunotherapy
IL292650A (en) Chimeric antigen receptor T cells target il13ra2
MX2019006340A (en) Anti-ctla-4 antibodies and methods of use thereof.
MX2023000818A (en) Anti-ctla-4 antibodies and methods of use thereof.
NZ731279A (en) Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy
WO2014116846A3 (en) Methods and compositions for modulating an immune response
WO2017147383A8 (en) Modified cells for immunotherapy
MX2018010824A (en) Inducible binding proteins and methods of use.
WO2016100241A3 (en) Methods for controlled activation or elimination of therapeutic cells
WO2016014565A3 (en) Treatment of cancer using humanized anti-bcma chimeric antigen receptor
MY189028A (en) Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
MX390943B (en) CD33 CHIMERATIC ANTIGEN RECEPTORS AND THEIR USES.
MX2014012977A (en) Anti-cd22 antibodies.
PH12016501689A1 (en) Tatk-cdkl5 fusion proteins, compositions, formulations, and use thereof
PH12020550483A1 (en) Anti-apoc3 antibodies and methods of use thereof
NZ739445A (en) Drug regulated transgene expression
NZ739447A (en) Method and compositions for cellular immunotherapy