[go: up one dir, main page]

SG10201804513WA - Antibodies Against Fcrn And Use Thereof - Google Patents

Antibodies Against Fcrn And Use Thereof

Info

Publication number
SG10201804513WA
SG10201804513WA SG10201804513WA SG10201804513WA SG10201804513WA SG 10201804513W A SG10201804513W A SG 10201804513WA SG 10201804513W A SG10201804513W A SG 10201804513WA SG 10201804513W A SG10201804513W A SG 10201804513WA SG 10201804513W A SG10201804513W A SG 10201804513WA
Authority
SG
Singapore
Prior art keywords
fcrn
antibodies against
against fcrn
proteins
immunoglobulins
Prior art date
Application number
SG10201804513WA
Inventor
Christopher Tenhoor
Arumugam Muruganandam
Robert Charles Ladner
Clive Wood
Alan J Bitonti
James Stattel
Kevin Mcdonnell
Liming Liu
Jennifer DUMONT
Aaron Sato
Original Assignee
Dyax Corp
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp, Bioverativ Therapeutics Inc filed Critical Dyax Corp
Publication of SG10201804513WA publication Critical patent/SG10201804513WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)

Abstract

ANTIBODIES AGAINST FCRN AND USE THEREOF This disclosure provides, inter alia, proteins that bind to FcRn, e.g. immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a 5 variety of disorders including autoimmune disorders. Figure 36
SG10201804513WA 2008-04-25 2009-04-24 Antibodies Against Fcrn And Use Thereof SG10201804513WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4815208P 2008-04-25 2008-04-25
US4850008P 2008-04-28 2008-04-28

Publications (1)

Publication Number Publication Date
SG10201804513WA true SG10201804513WA (en) 2018-07-30

Family

ID=41203902

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10202105499WA SG10202105499WA (en) 2008-04-25 2009-04-24 Antibodies Against Fcrn And Use Thereof
SG2014004063A SG196839A1 (en) 2008-04-25 2009-04-24 Antibodies against fcrn and use thereof
SG10201804513WA SG10201804513WA (en) 2008-04-25 2009-04-24 Antibodies Against Fcrn And Use Thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10202105499WA SG10202105499WA (en) 2008-04-25 2009-04-24 Antibodies Against Fcrn And Use Thereof
SG2014004063A SG196839A1 (en) 2008-04-25 2009-04-24 Antibodies against fcrn and use thereof

Country Status (17)

Country Link
US (10) US8273351B2 (en)
EP (3) EP2310415B8 (en)
JP (5) JP6106854B2 (en)
KR (4) KR102072896B1 (en)
CN (3) CN102149729B (en)
AU (1) AU2009238605B2 (en)
BR (2) BRPI0910622A2 (en)
CA (2) CA3131470A1 (en)
ES (1) ES2650804T3 (en)
HK (1) HK1207089A1 (en)
IL (2) IL208846A (en)
MX (1) MX2010011679A (en)
NZ (1) NZ589451A (en)
SG (3) SG10202105499WA (en)
TW (3) TWI547287B (en)
WO (1) WO2009131702A2 (en)
ZA (1) ZA201007873B (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202105499WA (en) * 2008-04-25 2021-07-29 Dyax Corp Antibodies Against Fcrn And Use Thereof
MX352889B (en) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Fcî“riib-specific fc antibody.
CA2837527C (en) 2011-06-02 2019-05-28 Dyax Corp. Fc receptor binding proteins
WO2013046722A1 (en) * 2011-09-30 2013-04-04 中外製薬株式会社 Ion concentration-dependent binding molecule library
JP6322411B2 (en) 2011-09-30 2018-05-09 中外製薬株式会社 Antigen-binding molecules that promote the disappearance of antigens with multiple physiological activities
JP6124800B2 (en) 2011-11-30 2017-05-10 中外製薬株式会社 Medicament containing carrier (carrier) into cells forming immune complex
MX370668B (en) * 2012-02-24 2019-12-19 Chugai Pharmaceutical Co Ltd ANTIGEN BINDING MOLECULE TO PROMOTE ANTIGEN LOSS THROUGH FC GAMMA RIIB.
BR112014026162A2 (en) 2012-04-23 2017-10-03 Nrl Pharma Inc FUSION PROTEIN OR VARIANT THEREOF, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST CELL, GENETICLY MODIFIED NON-HUMAN ANIMAL, GENETICALLY MODIFIED PLANT, THERAPEUTIC AGENT FOR DISEASES ENHANCED BY LACTOFERRIN, PHARMACEUTICAL COMPOSITION, AND METHOD FOR PREPARING PROTEIN FUSION OR A VARIANT THEREOF
GB201208370D0 (en) * 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
MY184251A (en) * 2012-12-21 2021-03-29 Biogen Int Neuroscience Gmbh Human anti-tau antibodies
ZA201506407B (en) * 2013-03-15 2018-11-28 Affibody Ab New polypeptides
AU2014230018B2 (en) 2013-03-15 2018-02-22 Affibody Ab New polypeptides
CN113621057A (en) 2013-04-02 2021-11-09 中外制药株式会社 Fc region variants
US20160075766A1 (en) * 2013-05-21 2016-03-17 Roche Diagnostics Operations, Inc. Method for producing antibodies using ovine b-cells and uses thereof
AU2014312215B2 (en) * 2013-08-28 2020-02-27 Abbvie Stemcentrx Llc Site-specific antibody conjugation methods and compositions
GB201320066D0 (en) * 2013-11-13 2013-12-25 Ucb Pharma Sa Biological products
EP3087095B1 (en) 2013-12-24 2019-08-07 argenx BVBA Fcrn antagonists and methods of use
JP6789117B2 (en) * 2014-04-25 2020-11-25 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Compositions and Methods for Treating Subjects with Immune-Mediated Diseases
NZ726089A (en) 2014-04-30 2017-12-22 Hanall Biopharma Co Ltd Antibody binding to fcrn for treating autoimmune diseases
US10336825B2 (en) 2014-04-30 2019-07-02 Hanall Biopharma Co., Ltd. Antibody binding to FcRn for treating autoimmune diseases
ES2944563T3 (en) * 2014-05-19 2023-06-22 Hoffmann La Roche Procedure for producing antibodies using ovine B lymphocytes and uses thereof
US10323066B2 (en) 2014-09-17 2019-06-18 Affibody Ab Neonatal Fc receptor binding dimer and methods of use
CA2963760A1 (en) 2014-12-19 2016-06-23 Yoshinao Ruike Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
CN118667011A (en) * 2015-01-30 2024-09-20 动量制药公司 FcRN antibodies and methods of use thereof
EP3253778A1 (en) 2015-02-05 2017-12-13 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
KR20180023900A (en) * 2015-05-12 2018-03-07 신티뮨, 인크. Humanized affinity matured anti-FcRn antibodies
GB201508180D0 (en) 2015-05-13 2015-06-24 Ucb Biopharma Sprl Antibodies
EP3341738A4 (en) 2015-08-24 2019-02-27 University of Cincinnati METHODS AND COMPOSITIONS FOR DETECTION OF FC RECEPTOR BINDING ACTIVITY OF ANTIBODIES
JP7141336B2 (en) 2015-12-25 2022-09-22 中外製薬株式会社 Anti-myostatin antibodies and methods of use
CN106957365B (en) * 2016-01-11 2021-03-16 上海交通大学 A kind of monoclonal antibody FnAb8 and its application
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
ES2968439T3 (en) * 2016-07-29 2024-05-09 Momenta Pharmaceuticals Inc FcRn antibodies and procedures for their use
AU2017305073B2 (en) 2016-08-05 2024-02-01 Chugai Seiyaku Kabushiki Kaisha Composition for prevention or treatment of IL-8 related diseases
CN110114460A (en) 2016-10-28 2019-08-09 Nrl制药股份有限公司 Lactoferrin/albumin fusion protein matter and preparation method thereof
GB201618424D0 (en) * 2016-11-01 2016-12-14 Argenix Bvba Treatment of antibody mediated disease
CA3066298A1 (en) * 2017-06-15 2018-12-20 UCB Biopharma SRL Method for the treatment of immune thrombocytopenia
EP3710589A4 (en) 2017-11-14 2021-11-10 Chugai Seiyaku Kabushiki Kaisha ANTI-C1S ANTIBODIES AND METHOD OF USING
CA3081144A1 (en) 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
CA3085751A1 (en) 2017-12-13 2019-06-20 Momenta Pharmaceuticals, Inc. Fcrn antibodies and methods of use thereof
AU2019283673B2 (en) 2018-06-08 2023-12-07 argenx BV Compositions and methods for treating immune thrombocytopenia
US20210340251A1 (en) * 2018-07-20 2021-11-04 Momenta Pharmaceuticals, Inc. Fcrn antibody compositions
UA128584C2 (en) 2018-08-10 2024-08-21 Чугаі Сейяку Кабусікі Кайся Anti-cd137 antigen-binding molecule and utilization thereof
WO2020079086A1 (en) 2018-10-16 2020-04-23 UCB Biopharma SRL Method for the treatment of myasthenia gravis
MX2021005048A (en) * 2018-10-31 2021-09-08 Bioatla Inc Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof.
PH12021552847A1 (en) 2019-06-07 2023-01-16 Argenx Bvba PHARMACEUTICAL FORMULATIONS OF FcRn INHIBITORS SUITABLE FOR SUBCUTANEOUS ADMINISTRATION
AU2020319897A1 (en) * 2019-08-01 2022-02-24 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
WO2021160116A1 (en) * 2020-02-10 2021-08-19 北京拓界生物医药科技有限公司 Anti-fcrn antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
KR102507515B1 (en) * 2020-08-26 2023-03-08 이화여자대학교 산학협력단 A novel method for generating an antibody library and the generated library therefrom
CN116234827A (en) * 2021-09-03 2023-06-06 舒泰神（北京）生物制药股份有限公司 Antibodies specifically recognizing FcRn and uses thereof
KR20250018382A (en) 2022-05-30 2025-02-05 한올바이오파마주식회사 Anti-FcRn antibody or antigen-binding fragment thereof with improved stability
CN119698429A (en) 2022-06-15 2025-03-25 阿根思有限公司 FCRN binding molecules and methods of use
CN115645537A (en) * 2022-10-25 2023-01-31 成都臻拓医药科技有限公司 Application of FcRn inhibitor in preparation of medicine for inhibiting recurrence of autoimmune disease
CN116047054A (en) * 2023-03-08 2023-05-02 江西赛基生物技术有限公司 Kit for detecting platelet antibody and its preparation method and use method
WO2025099576A1 (en) * 2023-11-06 2025-05-15 Momenta Pharmaceuticals, Inc. Compositions and methods for treating rheumatoid arthritis
GB202318512D0 (en) * 2023-12-04 2024-01-17 argenx BV Methods of determining potency

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
US4289747A (en) 1978-12-26 1981-09-15 E-Y Laboratories, Inc. Immunological determination using lectin
DE2901218A1 (en) 1979-01-13 1980-07-17 Byk Gulden Lomberg Chem Fab THEOPHYLLIN
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (en) 1985-06-26 1992-08-01 Liposome Co Inc LIPOSOMAS COUPLING METHOD.
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
ES2035317T5 (en) 1987-11-09 1998-03-16 Becton Dickinson Co METHOD FOR ANALYZING HEMATOPOYETIC CELLS IN A SAMPLE.
IL91501A (en) 1988-09-02 1998-03-10 Dyax Corp Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5030002A (en) 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
US5179107A (en) 1990-09-07 1993-01-12 Schering Corporation Antiviral quinolinone compounds
ATE164395T1 (en) 1990-12-03 1998-04-15 Genentech Inc METHOD FOR ENRICHMENT OF PROTEIN VARIANTS WITH MODIFIED BINDING PROPERTIES
US5370901A (en) 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
ATE363532T1 (en) 1991-03-01 2007-06-15 Dyax Corp METHOD FOR PRODUCING BINDING MINIPROTEINS
ATE414768T1 (en) 1991-04-10 2008-12-15 Scripps Research Inst LIBRARIES OF HETERODIMER RECEPTORS USING PHAGEMIDS
AU675916B2 (en) 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
SE9201984D0 (en) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab IMPROVEMENT IN OPTICAL ASSAYS
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
ES2304786T3 (en) 1995-04-27 2008-10-16 Amgen Fremont Inc. ANTI-IL-8 HUMAN ANTIBODIES, DERIVED FROM IMMUNIZED XENORATONES.
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc Human antibodies derived from immunized xenomice
JP4046354B2 (en) * 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Immunoglobulin-like domain with increased half-life
ATE549918T1 (en) 1996-12-03 2012-04-15 Amgen Fremont Inc HUMAN ANTIBODIES THAT EXPRESSLY BIND HUMAN TNF ALPHA
DE69835143T2 (en) 1997-01-21 2007-06-06 The General Hospital Corp., Boston SELECTION OF PROTEINS BY THE RNA PROTEIN FUSIONS
AU736549B2 (en) 1997-05-21 2001-08-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Method for the production of non-immunogenic proteins
AU3463699A (en) 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
ES2278463T3 (en) 1998-12-08 2007-08-01 Biovation Limited METHOD TO REDUCE THE IMMUNOGENICITY OF PROTEINS.
US6472147B1 (en) 1999-05-25 2002-10-29 The Scripps Research Institute Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
US6960178B2 (en) 2000-02-02 2005-11-01 Xepmed, Inc. Apparatus for enhanced plasmapheresis and methods thereof
WO2002043658A2 (en) 2000-11-06 2002-06-06 The Jackson Laboratory Fcrn-based therapeutics for the treatment of auto-immune disorders
DE60232672D1 (en) 2001-10-01 2009-07-30 Dyax Corp MULTILACKED EUKARYONTIC DISPLAY VECTORS AND THEIR USES
WO2003035842A2 (en) 2001-10-24 2003-05-01 Dyax Corporation Hybridization control of sequence variation
JP2007501847A (en) 2003-08-08 2007-02-01 ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク Anti-FcRn antibodies for the treatment of auto / alloimmune conditions
US7662928B2 (en) * 2003-08-08 2010-02-16 The Research Foundation Of State University Of New York Anti-FcRn antibodies for treatment of auto/allo immune conditions
CA2606378A1 (en) * 2005-04-29 2006-11-09 The Jackson Laboratory Fcrn antibodies and uses thereof
US20090092507A1 (en) * 2005-08-05 2009-04-09 Ramirez Jr Emilio A Fluid pump systems
JP2009524664A (en) * 2006-01-25 2009-07-02 ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク Anti-FCRN antibodies for the treatment of auto / alloimmune diseases
US8359965B2 (en) 2007-09-17 2013-01-29 Oxford J Craig Apparatus and method for broad spectrum radiation attenuation
KR102339457B1 (en) 2007-09-26 2021-12-14 추가이 세이야쿠 가부시키가이샤 Modified antibody constant region
AR068723A1 (en) 2007-10-05 2009-12-02 Glaxo Group Ltd PROTEIN THAT JOINS ANTIGENS THAT JOINS HUMAN IL-23 AND ITS USES
SG10202105499WA (en) * 2008-04-25 2021-07-29 Dyax Corp Antibodies Against Fcrn And Use Thereof
CA2837527C (en) * 2011-06-02 2019-05-28 Dyax Corp. Fc receptor binding proteins
CA3081144A1 (en) * 2017-12-08 2019-06-13 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
AU2019283673B2 (en) * 2018-06-08 2023-12-07 argenx BV Compositions and methods for treating immune thrombocytopenia
WO2020236695A1 (en) * 2019-05-17 2020-11-26 Alexion Pharmaceuticals, Inc. Use of anti-fcrn antibodies in the treatment of pemphighus and pemphigoid diseases

Also Published As

Publication number Publication date
AU2009238605A1 (en) 2009-10-29
KR101634719B1 (en) 2016-06-29
US20160222110A1 (en) 2016-08-04
EP2310415B8 (en) 2017-12-13
TWI547287B (en) 2016-09-01
KR101837329B1 (en) 2018-03-09
US20160222111A1 (en) 2016-08-04
JP6499132B2 (en) 2019-04-10
NZ589451A (en) 2012-07-27
TW201630626A (en) 2016-09-01
US8815246B2 (en) 2014-08-26
TWI593423B (en) 2017-08-01
EP2310415A2 (en) 2011-04-20
US20160222112A1 (en) 2016-08-04
KR20110044729A (en) 2011-04-29
CA2722082A1 (en) 2009-10-29
KR102072896B1 (en) 2020-02-03
US20160194397A1 (en) 2016-07-07
KR20190104432A (en) 2019-09-09
US20090324614A1 (en) 2009-12-31
ES2650804T3 (en) 2018-01-22
IL208846A0 (en) 2011-01-31
MX2010011679A (en) 2011-05-23
HK1207089A1 (en) 2016-01-22
SG196839A1 (en) 2014-02-13
SG10202105499WA (en) 2021-07-29
US20130045218A1 (en) 2013-02-21
EP3670538A1 (en) 2020-06-24
EP3348573A1 (en) 2018-07-18
JP5989159B2 (en) 2016-09-07
TWI453031B (en) 2014-09-21
US20160222109A1 (en) 2016-08-04
JP2015143230A (en) 2015-08-06
BRPI0910622A2 (en) 2020-03-10
EP3348573B1 (en) 2020-04-22
WO2009131702A2 (en) 2009-10-29
CN102149729B (en) 2014-08-20
TW201010720A (en) 2010-03-16
KR20170122286A (en) 2017-11-03
IL241091B (en) 2018-02-28
HK1160868A1 (en) 2012-08-17
IL241091A0 (en) 2015-11-30
CA2722082C (en) 2021-11-09
US20160222108A1 (en) 2016-08-04
US8273351B2 (en) 2012-09-25
TW201509430A (en) 2015-03-16
US20140248287A1 (en) 2014-09-04
JP2011523351A (en) 2011-08-11
WO2009131702A9 (en) 2010-09-23
ZA201007873B (en) 2012-02-29
KR20160079912A (en) 2016-07-06
CN108467431A (en) 2018-08-31
US9260520B2 (en) 2016-02-16
JP2022115960A (en) 2022-08-09
IL208846A (en) 2015-09-24
AU2009238605B2 (en) 2014-11-06
WO2009131702A3 (en) 2010-02-18
JP2019162105A (en) 2019-09-26
JP2017029149A (en) 2017-02-09
JP6106854B2 (en) 2017-04-05
CN104479017A (en) 2015-04-01
US20130078262A1 (en) 2013-03-28
CA3131470A1 (en) 2009-10-29
CN102149729A (en) 2011-08-10
BR122021026834B1 (en) 2022-11-08
EP2310415B1 (en) 2017-10-11

Similar Documents

Publication Publication Date Title
SG10201804513WA (en) Antibodies Against Fcrn And Use Thereof
ZA202109042B (en) Methods of reducing serum levels of fc-containing agents using fcrn antagonists
GB2509260A (en) Anti-complement C1s antibodies and uses thereof
MY156315A (en) Anti-vegf antibodies
CA2868907C (en) Anti-hla-b*27 antibodies and uses thereof
MA38498A1 (en) Anti-lag-3 binding proteins
MX354243B (en) Antibody polypeptides that antagonize cd40.
WO2006118772A3 (en) Fcrn antibodies and uses thereof
TN2010000213A1 (en) Wise binding antibodies and epitopes
MX2013013832A (en) Fc RECEPTOR BINDING PROTEINS.
MX2009008608A (en) Monoclonal anti-cxcl13 antibodies.
MX2009008104A (en) Hepcidin, hepcidin antagonists and methods of use.
MA40609B1 (en) Cd123 binding agents and their uses
EA201890907A1 (en) MUTED Fc ANTIBODIES WITH REMOVED EFFECTIVE FUNCTIONS
EA201300978A1 (en) ANTIBODIES TO CEA
EA201490745A1 (en) POLYPEPTIDES OF ANTIBODIES THAT CAUSE ANTAGONISM CD40L
WO2008150485A3 (en) Erbb2 binding proteins and use thereof
EP2937361A3 (en) Fc variants with altered binding to fcRn
WO2009052400A8 (en) Antibodies that bind to mammalian ngal and uses thereof
SG11201803989WA (en) Method for promoting efficiency of purification of fc region-containing polypeptide
MX2012002565A (en) Enhanced protein purification through a modified protein a elution.
NZ629553A (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof
MX2021009275A (en) SPECIFIC BINDING MOLECULES.
HK1198832A1 (en) Fn14 binding proteins and uses thereof
WO2014184545A3 (en) Engineered fc variants